2.3.2.20: cyclo(L-leucyl-L-phenylalanyl) synthase
This is an abbreviated version!
For detailed information about cyclo(L-leucyl-L-phenylalanyl) synthase, go to the full flat file.
Word Map on EC 2.3.2.20
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2.3.2.20
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cdpss
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diketopiperazine
-
synthetases
-
aminoacylated
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2,5-diketopiperazines
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nonribosomal
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trna-dependent
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prenyltransferase
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aa-trnas
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aarss
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class-i
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nocardiopsis
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prenylation
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hijack
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bond-forming
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ping-pong
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synthesis
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tryptophan-containing
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synthetase-like
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noursei
- 2.3.2.20
-
cdpss
-
diketopiperazine
- synthetases
-
aminoacylated
-
2,5-diketopiperazines
-
nonribosomal
-
trna-dependent
- prenyltransferase
-
aa-trnas
-
aarss
-
class-i
- nocardiopsis
-
prenylation
-
hijack
-
bond-forming
-
ping-pong
- synthesis
-
tryptophan-containing
-
synthetase-like
- noursei
Reaction
Synonyms
AlbC, BcmA, CDP, CDPS, CDPS 22, CDPS39, cFL synthase, cyclodipeptide synthase, cyclodipeptide synthases, Fdum-CDPS, Nbra-CDPS, NcdA, NCTC11370_02388, Ndas_1148, NozA, O3I_025450, Rgry-CDPS, RICGR_0139
ECTree
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Engineering
Engineering on EC 2.3.2.20 - cyclo(L-leucyl-L-phenylalanyl) synthase
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E182D
mutation in putative catalytic pocket, about 1% of wild-type activity
G35A
mutation in putative catalytic pocket, about 5% of wild-type activity
S37C
mutation in putative catalytic pocket, about 5% of wild-type activity
Y178F
mutation in putative catalytic pocket, about 10% of wild-type activity
Y202F
mutation in putative catalytic pocket, about 15% of wild-type activity
Y202F
the mutation does not affect the formation of the aminoacyl enzyme intermediate5, but leads to the accumulation of the covalent dipeptidyl enzyme intermediate, which is not observed with the wild-type enzyme