This is an abbreviated version! For detailed information about N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase, go to the full flat file.
by in situ hybridization and real time RT-PCR of developing cartilage, CSGal-NAcT-1 exhibits the highest level of expression among other glycosyltransferases involved in chondroitin sulphate synthesis
CHSY1 is strongly expressed in myxofibrosarcoma and malignant peripheral nerve sheath tumor compared with other tumors and significantly associated with higher, rather than lower-grade tumors. High expression of CHSY1 is also significantly associated with poorer patient outcomes and higher stages, overview. Enzyme CHSY1 expression correlates with malignant potential of soft tissue sarcomas with myxoid substance
RT-PCR expression analysis of CHSY1, CHSY3 and CSGlcA-T from macroscopically normal and pathological specimens, overview. CHSY1 expression is increased by about 7fold in the adjacent normal tissue of the benign tumors compared to the tumor and healthy control tissues. In the tumor specimens, CHSY1 expression is high during the early stages. The CHSY3 gene is expressed equally and at very low levels in the macroscopically normal and tumor specimens. In benign tumors, CSGlcA-T is markedly elevated by about 40fold compared to the adjacent normal and healthy tissues, while in the cancer specimens it is decreased