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2.4.1.226: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase

This is an abbreviated version!
For detailed information about N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.226

Reaction

UDP-alpha-D-glucuronate
+
[protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
=
UDP
+
[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine

Synonyms

AcbD, ApCS, bifunctional CS synthase, ChGn-1, ChGn-2, chondroitin beta-glucuronyltransferase, chondroitin glucuronyltransaferase II, chondroitin glucuronyltransferase, chondroitin glucuronyltransferase II, chondroitin sulfate beta-1,4-N-acetylgalactosaminyltransferase-1, chondroitin sulfate glucoronyltransferase, chondroitin sulfate glucuronyltransferase, chondroitin sulfate glucuronyltransferase/chondroitin synthase-3, chondroitin sulfate N-acetylgalactosaminyltransferase-1, chondroitin sulfate N-acetylgalactosaminyltransferase-2, chondroitin sulfate synthase 1, chondroitin sulfate synthase-1, chondroitin sulfate synthase-2, chondroitin sulfate synthase-3, chondroitin synthase, chondroitin synthase-3, CHPF, ChSy, ChSy-1, ChSy-3, CHSY1, CHSY2, CHSY3, CS N-acetylgalactosaminyltransferase-1, CS synthase 1, CSGalNAcT-1, CSGlcA-T, CSGlcAT, CSGlcAT-II, CSGlcAT/ChSy-3, CSS1, CSS2, GlcAT-II, glucuronyltransferase, uridine diphosphoglucuronate-chondroitin, glucuronyltransferase-II, More, UDP-glucuronate:chondroitin glucuronyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.226 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase

Source Tissue

Source Tissue on EC 2.4.1.226 - N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
in nontumorous cartilages
Manually annotated by BRENDA team
CHSY1 is frequently upregulated in glioblastoma and correlates with high tumor grade and poor survival
Manually annotated by BRENDA team
CSS2, high level expression
Manually annotated by BRENDA team
CSS2, high level expression
Manually annotated by BRENDA team
CSS2, high level expression
Manually annotated by BRENDA team
soft tissue sarcomas. Soft tissue sarcoma is a malignant tumor of nonepithelial extraskeletal origin classified by specific, differentiated cell types
Manually annotated by BRENDA team
CSS2, high level expression
Manually annotated by BRENDA team
CSS2, high level expression
Manually annotated by BRENDA team
additional information