2.4.1.88: globoside alpha-N-acetylgalactosaminyltransferase

This is an abbreviated version!
For detailed information about globoside alpha-N-acetylgalactosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.88

2.4.1.88

glycolipids

fs

glycosyltransferases

histo-blood

transfusion

oligosaccharide

glycosphingolipids

n-acetylgalactosamine

galnac

gene-encoded

Reaction

N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

N-acetyl-alpha-D-galactosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Synonyms

acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-globoside alpha-, cis-AB-transferase, Forss-S, Forssman synthase, Forssman synthetase, Forssmann glycolipid synthetase, FS, GBGT1, globoside acetylgalactosaminyltransferase, globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, glycosyltransferase 6 (GT6) family member, GT6m5, GT6m6, GT6m7, histo-blood group ABO system transferase, More, uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.88 globoside alpha-N-acetylgalactosaminyltransferase

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Results	in table
15	Activating Compound
9	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
1	Crystallization (Commentary)
10	Disease/ Diagnostics
2	Expression
4	General Information
4	General Stability
34	Inhibitors
1	Ki Value [mM]
6	KM Value [mM]
8	Localization
16	Metals/Ions
7	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
19	Organism
3	Pathway
6	pH Optimum
1	pH Range
2	Protein Variants
2	Purification (Commentary)
2	Reaction
1	Reaction Type
16	Reference
24	Source Tissue
5	Specific Activity [micromol/min/mg]
3	Storage Stability
24	Substrates and Products (Substrate)
2	Subunits
30	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]

Expression

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Expression on EC 2.4.1.88 - globoside alpha-N-acetylgalactosaminyltransferase

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GBGT1 expression is epigenetically silenced through promoter hypermethylation in ovarian cancer. The extent of DNA methylation inversely correlates with GBGT1 mRNA and protein expression

Homo sapiens

Q8N5D6

735858

restoration of GBGT1 mRNA and protein expression in low GBGT1-expressing A2780 cells is achieved by 5-aza-2'-deoxycytidine treatment

Homo sapiens

Q8N5D6

735858