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2.4.2.21: nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase

This is an abbreviated version!
For detailed information about nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.21

Reaction

beta-nicotinate D-ribonucleotide
+
5,6-Dimethylbenzimidazole
=
nicotinate
 +
alpha-ribazole 5'-phosphate
 +
H+

Synonyms

5,6-dimethylbenzimidazole phosphoribosyltransferase, ArsAB, CblT, CobT, CobT2, N(1)-alpha-phosphoribosyltransferase, N1-alpha-phosphoribosyltransferase, NaMN:DMB phosphoribosyltransferase, nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase, nicotinate mononucleotide:5,6-dimethylbenzimidazolyl phosphoribosyltransferase, nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase, NN:DBI PRT, phosphoribosyltransferase, nicotinate mononucleotide-dimethylbenzimidazole, SoArsAB

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.21 nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase

Crystallization

Crystallization on EC 2.4.2.21 - nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
in complex with different substrate analogs, reaction pathway
-
in complex with substrate and with reaction product
-
phloroglucinol is identified from an additive screen as a compound that dramatically improves the size, stability, and diffraction properties of the crystals. Subsequent structural studies show that phloroglucinol binds in the active site of ArsA
the three-dimensional crystal structure of Sporomusa ovata ArsAB in its substrate-free form (2.1 A), and in complex with DMB (1.5 A), p-cresol (2.1 A), phloroglucinol (1.6 A), and phenol (2.4 A) is reported. Only the active site in ArsA is occupied by substrate. Analysis of the ArsB active site identified an arginyl side chain that may block access to the site