disruption of PARP1 enzymatic activity causes nucleolar disintegration and aberrant localization of nucleolar-specific proteins. PARP1 mutants have increased accumulation of rRNA intermediates and a decrease in ribosome levels
enzyme deletion results in teratozoospermia and male infertility in mice due to the formation of abnormally shaped fertilization-incompetent sperm, despite normal testis weights and sperm counts
the lowest PARP activity, as well as the lowest quantum yield of PSII linear electron transport (FPSII) and photochemical quenching (qP), is found in outdoor during winter plants. In outdoor spring plants the recovery of photochemical activity associated to a poly(ADP-ribose)polymerase activity increase of about 50%, as compared to greenhouse plants, is observed
the enzyme inhibits the activation of NF-kappaB and downstream target genes in response to interleukin-1beta and tumour necrosis factor-alpha, dependent on catalytic activity and poly-ubiquitin binding
enzyme binding to human epithelial cells leads to protein internalization, impairs human epithelial monolayer integrity, induces cell rounding, and impacts on actin cytoskeleton
enzyme binding to proliferating cell nuclear antigen is required for translesion DNA synthesis. The enzyme is required for genomic stability, DNA damage tolerance and mutagenesis
the enzyme displays functional relevance for nuclear envelope stability and nuclear reorganization during spermiogenesis and is important for proper sperm head shaping
the enzyme is a potent regulator of interferon-I antiviral efficacy. The enzyme inhibits the interferon-I-activated signalling pathway. Mono-ADP-ribosylation of beta-transducin repeat-containing protein promotes interferon alpha/beta receptor subunit 1 ubiquitination and degradation