2.4.2.30: NAD+ ADP-ribosyltransferase

This is an abbreviated version!
For detailed information about NAD+ ADP-ribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.30

2.4.2.30

polyadp-ribose

caspase-3

agonist

bcl-2

camp

cyclase

g-proteins

adp-ribosylation

phospholipase

ovarian

necrosis

endothelial

toxin-sensitive

leukemia

adenylate

cholera

cyclin

gtp-binding

inositol

bordetella

guanine

annexin

gtp

erk

pro-apoptotic

anti-apoptotic

mapks

chromatin

apoptosis-inducing

phosphoinositide

muscarinic

tunel

phorbol

adenylyl

forskolin

receptor-mediated

protein-coupled

pkc

heterotrimeric

caspase-dependent

acellular

forskolin-stimulated

survivin

aif

sub-g1

xiap

rad51

carbachol

brca1/2

molecular biology

drug development

pharmacology

toxoid

analysis

Reaction

Synonyms

(adenosine diphosphoribose)transferase, nicotinamide adenine dinucleotide-protein, 193-kDa vault protein , 2,3,7,8-tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase, adenosine diphosphate ribosyltransferase, ADP-ribosylating thermozyme, ADP-ribosyltransferase, ADP-ribosyltransferase (polymerizing), ADP-ribosyltransferase 3, ADP-ribosyltransferase C3cer, ADP-ribosyltransferase-1, ADPr, ADPRT, ADPRT , ART, ART1, ARTC2.2, ARTD10, ARTD10/PARP10, ARTD11, ARTD14, ARTD3, ARTD7/PARP15, ARTD8, asparagine-specific ADP-ribosyltransferase, B aggressive lymphoma protein 2, C3 exoenzyme, C3-like toxin, C3larvin toxin, C3lim, CRM66, diphtheria toxin-like ADP-ribosyltranferase, ecto-ADP-ribosyltransferase, ecto-ADP-ribosyltransferase 2.2, ecto-ADP-ribosyltransferase ART2.2, EspJ, Exo53, exoenzyme C3, exoenzyme S, exoenzyme T, ExoS, ExoT, exotoxin-S, mART, ModA, ModB, mono ADP-ribosyltransferase, mono(ADP-ribosyl) transferase, mono-ADP-ribosyl transferase C3, mono-ADP-ribosyltransferase, More, msPARP , NAD(+) ADP-ribosyltransferase , NAD+:ADP-ribosyltransferase (polymerizing), NAD-dependent ADP-ribosyltransferase, NAD-protein ADP-ribosyltransferase, NarE, pADPRT, PAR polymerase, PARP, PARP , PARP-1, PARP-7, PARP-related/IalphaI-related H5/proline-rich , PARP1, PARP10, PARP11, PARP14, PARP3, PARPss, pertussis toxin, PH5P , poly (ADP-ribose) polymerase, poly (ADP-ribose) polymerase-1, poly(ADP-ribose) polymerase, poly(ADP-ribose) polymerase family member 11, poly(ADP-ribose) polymerase-1, poly(ADP-ribose) polymerase-11, poly(ADP-ribose) polymerase-like enzyme, poly(ADP-ribose) synthase, poly(ADP-ribose) transferase, poly(ADP-ribosyl)transferase, poly[ADP-ribose] synthetase , PTx, PtxS1, scabin, TANK1, TANK1 , TANK2 , tankyrase I, Tankyrase-like protein , Tankyrase-related protein , TbSIR2RP1, TiPARP, TNKS-1, TRF1-interacting ankyrin-related ADP-ribose polymerase, TRF1-interacting ankyrin-related ADP-ribose polymerase , TTS-ExoS, type III-secreted toxin, VahC, VPARP , vsdc, YART

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.2 Pentosyltransferases

2.4.2.30 NAD+ ADP-ribosyltransferase

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Results	in table
26	Activating Compound
1297	AA Sequence
6	Application
1	CAS Registry Number
37	Cloned(Commentary)
3	Cofactor
5	Crystallization (Commentary)
54703	Disease/ Diagnostics
1	Expression
17	General Information
1	General Stability
210	IC50 Value
305	Inhibitors
12	Ki Value [mM]
37	KM Value [mM]
28	Localization
13	Metals/Ions
18	Molecular Weight [Da]
101	Natural Substrates/ Products (Substrates)
162	Organism
2	Pathway
984	PDB ID
18	pH Optimum
1	pH Range
8	pI Value
1	Posttranslational Modification
133	Protein Variants
23	Purification (Commentary)
6	Reaction
1	Reaction Type
129	Reference
42	Source Tissue
7	Specific Activity [micromol/min/mg]
1	Storage Stability
206	Substrates and Products (Substrate)
32	Subunits
271	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
2	Temperature Stability [°C]
24	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 2.4.2.30 - NAD+ ADP-ribosyltransferase

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3-amino-1-methyl-5H-pyrido[4,3-b]indole

Bos taurus

i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM

675627

4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]-N,N-dimethylpiperidine-1-carboxamide

Bos taurus

activates in presence of Mg2+, inhibits in absence of Mg2+

637997

ATP

Mesocricetus auratus

5-10 mM, 20-30% stimulation

637995

Bmh1p

Pseudomonas aeruginosa

a yeast homologue of the human FAS, acts as an activating ExoS cofactor, overview

694800

DNA

6 entries

FAS

Pseudomonas aeruginosa

exoenzyme S absolutely requires a soluble eukaryotic protein, named FAS (Factor Activating exoenzyme E), in order to ADP-ribosylate all substrates. In the presence of FAS, exoenzyme S ADP-ribosylates several proteins in lysates of Pseudomonas aeruginosa. Purification and characterization of FAS

662089

GDP

Clostridium botulinum

increases activity in absence of Mg2+

637994

GTP

Clostridium botulinum

increases activity in absence of Mg2+

637994

GTP(gammaS)

Clostridium botulinum

increases activity in absence of Mg2+

637994

harmaline hydrochloride

Bos taurus

activates more strongly in absence of Mg2+ than in presence of Mg2+

637997

Mg2+

Saccharolobus solfataricus

B3EWG9

5 mM, 6.3fold activation

725034

oligodeoxyribonucleotides

Saccharolobus solfataricus

B3EWG9

slightly enhance enzyme activity with the maximal increase of 50% as compared to the control

725600

peptide 14-3-3beta

Pseudomonas aeruginosa

736518

Phenanthroline

Saccharolobus solfataricus

B3EWG9

0.1 mM, 1.1fold activation

725034

Phthalic acid

Bos taurus

activates more strongly in absence of Mg2+ than in presence of Mg2+

637997

protein 14-3-3

2 entries

additional information

4 entries