2.5.1.43: nicotianamine synthase

This is an abbreviated version!
For detailed information about nicotianamine synthase, go to the full flat file.

Reaction

3 S-adenosyl-L-methionine = 3 S-methyl-5'-thioadenosine +

Synonyms

AtNAS, AtNAS1, AtNAS2, AtNAS3, AtNAS4, chloronerva, HvNAS1, HvNAS2, HvNAS3, HvNAS4, HvNAS6, HvNAS7, HvNAS8, HvNAS9, LeNAS, LjNAS1, LjNAS2, MtNAS, MxNAS2, NA synthase, NA synthase 2, NAS, NAS1, NAS2, NAS3, NAS4, NASHOR1, NASHOR2, nicotianamine synthase, nicotianamine synthase 1, nicotianamine synthase 2, nicotianamine synthase 4, OsNA S2, OsNAS1, OsNAS2, OsNAS3, S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-methionine 3-amino-3-carboxypropyltransferase, synthase, nicotianamine, TaNAS1, TaNAS1-A, TaNAS1-B, TaNAS2, TaNAS2-A, TaNAS2-D1, TaNAS2-D2, TaNAS3-A, TaNAS3-B, TaNAS4-A, TaNAS4-D, TaNAS4-U, TaNAS5-B, TaNAS6-A, TaNAS6-B, TaNAS6-D, TaNAS7-A1, TaNAS7-A2, TaNAS7-D, TaNAS9-A, TaNAS9-B, TaNAS9-D, TmNAS, TmNAS1, TmNAS2, TmNAS3, TmNAS4, TmNAS5, TmNAS6, TmNAS7, TmNAS8, ZmNAS1, ZmNAS10, ZmNAS1;1, ZmNAS1;2, ZmNAS2, ZmNAS2;1, ZmNAS2;2, ZmNAS3, ZmNAS4, ZmNAS5, ZmNAS6, ZmNAS6;1, ZmNAS6;2, ZmNAS7, ZmNAS8, ZmNAS9

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.43 nicotianamine synthase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1147	AA Sequence
6	Application
1	CAS Registry Number
47	Cloned(Commentary)
5	Cofactor
3	Crystallization (Commentary)
53	Expression
48	General Information
1	General Stability
10	Localization
13	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
131	Organism
4	Pathway
1	pH Optimum
1	pH Range
3	pH Stability
9	pI Value
3	Posttranslational Modification
13	Protein Variants
4	Purification (Commentary)
2	Reaction
1	Reaction Type
63	Reference
97	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
58	Substrates and Products (Substrate)
24	Subunits
236	Synonyms
1	Systematic Name

Natural Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Natural Substrates Products on EC 2.5.1.43 - nicotianamine synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Natural Substrate Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2 S-adenosyl-L-methionine + glutamate

2 S-methyl-5'-thioadenosine + thermoNicotianamine + 2 H+

Methanothermobacter thermautotrophicus

-

-

722028

the archaeal product analogue thermoNicotianamine differs from nicotianamine in the carboxy azetidine moiety of nicotianamine that is replaced by a glutamate moiety in thermoNicotianamine, overview

-

?

3 S-adenosyl-L-methionine

3 S-methyl-5'-thioadenosine + nicotianamine

14 entries

S-adenosyl-L-methionine

5'-S-methyl-5'-thioadenosine + nicotianamine

3 entries

S-adenosyl-L-methionine

?

11 entries

3 S-adenosyl-L-methionine

3 S-methyl-5'-thioadenosine + nicotianamine

Arabidopsis thaliana

Q6L5P3

-

739365

-

-

?

3 S-adenosyl-L-methionine

3 S-methyl-5'-thioadenosine + nicotianamine

Arabidopsis thaliana Col-0

Q6L5P3

-

739365

-

-

?

3 S-adenosyl-L-methionine

3 S-methyl-5'-thioadenosine + nicotianamine

Hordeum vulgare

Q9ZQV9

-

759997

-

-

?

3 S-adenosyl-L-methionine

3 S-methyl-5'-thioadenosine + nicotianamine

Hordeum vulgare

Q9ZQV7, Q9ZQV8, Q9ZQV9

important role in production of nicotianamine under Fe-deficient conditions

759282

-

-

?

3 S-adenosyl-L-methionine

3 S-methyl-5'-thioadenosine + nicotianamine

Malus baccata

A3DUI9

-

739648

-

-

?

3 S-adenosyl-L-methionine

3 S-methyl-5'-thioadenosine + nicotianamine

Medicago truncatula

-

-

759261

-

-

?

3 S-adenosyl-L-methionine

3 S-methyl-5'-thioadenosine + nicotianamine

Oryza sativa

-

-

759924

-

-

?

3 S-adenosyl-L-methionine

3 S-methyl-5'-thioadenosine + nicotianamine

Oryza sativa

Q10MI9

-

739307

-

-

?

3 S-adenosyl-L-methionine

3 S-methyl-5'-thioadenosine + nicotianamine

Oryza sativa

Q0D3F2, Q0DSH9, Q10MI9

important role in production of nicotianamine under Fe-deficient conditions

759282

-

-

?

3 S-adenosyl-L-methionine

3 S-methyl-5'-thioadenosine + nicotianamine

Oryza sativa

Q0D3F2

rice synthesizes nicotianamine with OsNAS3 under Fe excess in roots and shoots. Nicotianamine and deoxymugineic acid synthesized by OsNAS3 under excess Fe conditions contribute to Fe detoxification in rice

759265

-

-

?

3 S-adenosyl-L-methionine

3 S-methyl-5'-thioadenosine + nicotianamine

Triticum monococcum subsp. monococcum

A0A2Z4HQI8, A0A2Z4HQI9, A0A2Z4HQJ0, A0A2Z4HQJ4, A0A2Z4HQJ8, A0A2Z4HQJ9, A0A2Z4HQK0, A0A2Z4HQK1

-

759294

-

-

?

3 S-adenosyl-L-methionine

3 S-methyl-5'-thioadenosine + nicotianamine

Zea mays

A0A1D6GLB9, A0A1D6IP14, A0A1D6K0A7, A0A1D6K0A8, B4FAC0, K7VEJ7, K7VIY6, K7WE51, Q8LT22, Q8S9C5

-

738308

-

-

?

3 S-adenosyl-L-methionine

3 S-methyl-5'-thioadenosine + nicotianamine

Zea mays

A0A1D6GLB9, A0A1D6IP14, A0A1D6K0A7, A0A1D6K0A8, B4FAC0, K7VIY6, K7WE51, Q8LT22, Q8S9C5

-

739374

-

-

?

3 S-adenosyl-L-methionine

3 S-methyl-5'-thioadenosine + nicotianamine

Zea mays B73

A0A1D6GLB9, A0A1D6IP14, A0A1D6K0A7, A0A1D6K0A8, B4FAC0, K7VEJ7, K7VIY6, K7WE51, Q8LT22, Q8S9C5

-

738308

-

-

?

S-adenosyl-L-methionine

5'-S-methyl-5'-thioadenosine + nicotianamine

Hordeum vulgare

-

the product nictotinamine plays a critical role in metal detoxification

660151

-

-

?

S-adenosyl-L-methionine

5'-S-methyl-5'-thioadenosine + nicotianamine

Methanothermobacter thermautotrophicus

-

-

706512

-

-

?

S-adenosyl-L-methionine

5'-S-methyl-5'-thioadenosine + nicotianamine

Oryza sativa

-

nicotinamine synthase and nicotinamine play an important role in long-distance transport of Fe in rice plants, in addition to their roles in phytosiderophore secretion from roots

660172

-

-

?

S-adenosyl-L-methionine

?

Hordeum vulgare

-

enzyme activity is induced at the 3rd day after withholding Fe supply and declines within one day following the supply of Fe3+-epihydroxymugineic acid

639733

-

-

?

S-adenosyl-L-methionine

?

Hordeum vulgare

-

synthesis of nicotianamide, the key precursor of the mugineic acid family phytosiderophores

639734

-

-

?

S-adenosyl-L-methionine

?

Hordeum vulgare

-

key enzyme in the biosynthetic pathway for the mugineic acid family of phytosiderophores

639736

-

-

?

S-adenosyl-L-methionine

?

Hordeum vulgare

-

strongly induced by Fe-deficiency treatment

639734

-

-

?

S-adenosyl-L-methionine

?

Hordeum vulgare

-

enzyme in the biosynthetic pathway of mugineic acids

639733

-

-

?

S-adenosyl-L-methionine

?

Nicotiana debneyi

-

enzyme activity is not induced by Fe-deficiency

639735

-

-

?

S-adenosyl-L-methionine

?

Nicotiana megalosiphon

-

enzyme activity is not induced by Fe-deficiency

639735

-

-

?

S-adenosyl-L-methionine

?

Nicotiana plumbaginifolia

-

enzyme activity is not induced by Fe-deficiency

639735

-

-

?

S-adenosyl-L-methionine

?

Nicotiana rustica

-

enzyme activity is not induced by Fe-deficiency

639735

-

-

?

S-adenosyl-L-methionine

?

Nicotiana tabacum

-

enzyme activity is not induced by Fe-deficiency

639735

-

-

?

S-adenosyl-L-methionine

?

Zea mays

-

in agreement with the increased secretion of phytosiderophores with Fe deficiency, ZmNAS1 and ZmNAS2 are positively expressed only in Fe-deficient roots. In contrast ZmNAS3 is expressed under Fe-sufficient conditions, and is negatively regulated by Fe deficiency

639738

-

-

?