2.5.1.7: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

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For detailed information about UDP-N-acetylglucosamine 1-carboxyvinyltransferase, go to the full flat file.

Reaction

Synonyms

enol-pyruvyltransferase, enolpyruvyl UDP-GlcNAc synthase, enoylpyruvate transferase, enoylpyruvatetransferase, EPT, More, MurA, MurA enzyme, MurA transferase, MurAA, MurZ, phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase, phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase, phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase, phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose-3-enolpyruvyltransferase, phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase, pyruvate-UDP-acetylglucosamine transferase, pyruvate-uridine diphospho-N-acetyl-glucosamine transferase, pyruvate-uridine diphospho-N-acetylglucosamine transferase, pyruvatetransferase, phosphoenolpyruvate-uridine diphosphoacetylglucosamine, pyruvic-uridine diphospho-N-acetylglucosaminyltransferase, UDP-GlcNAc enolpyruvyl transferase, UDP-N-acetylglucosamine 1-carboxyvinyl transferase, UDP-N-acetylglucosamine 1-carboxyvinyl-transferase, UDP-N-acetylglucosamine 1-carboxyvinyltransferase, UDP-N-acetylglucosamine enolpyruvyl transferase, UDP-N-acetylglucosamine enolpyruvyle transferase, UDP-N-acetylglucosamine enolpyruvyltransferase, UDP-N-acetylglucosamine enoylpyruvyltransferase, UDP-N-acetylglucosamine-enolpyruvyl transferase, UDP-NAG enolpyruvyl transferase, UNAG enolpyruvyl transferase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.7 UDP-N-acetylglucosamine 1-carboxyvinyltransferase

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Results	in table
4	Activating Compound
45128	AA Sequence
12	Application
1	CAS Registry Number
33	Cloned(Commentary)
12	Crystallization (Commentary)
29	General Information
3	General Stability
71	IC50 Value
374	Inhibitors
21	kcat/KM [mM/s]
38	Ki Value [mM]
50	KM Value [mM]
2	Localization
6	Metals/Ions
21	Molecular Weight [Da]
40	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
387	Organism
9	Pathway
166	PDB ID
13	pH Optimum
4	pH Range
1	pI Value
56	Protein Variants
31	Purification (Commentary)
37	Reaction
1	Reaction Type
104	Reference
10	Specific Activity [micromol/min/mg]
7	Storage Stability
115	Substrates and Products (Substrate)
24	Subunits
126	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
32	Turnover Number [1/s]

Organic Solvent Stability

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Organic Solvent Stability on EC 2.5.1.7 - UDP-N-acetylglucosamine 1-carboxyvinyltransferase

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ORGANIC SOLVENT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

urea

Acinetobacter baumannii

-

the urea-induced unfolding of the enzyme is a three-state process, where a metastable intermediate conformation state is populated between 3.0-4.0 M. Above 6.0 M urea, the enzyme gets completely unfolded. The transition from the native structure to the partially unfolded metastable state involves about 30% loss of native contacts but little change in the radius of gyration or core hydration properties. The intermediate-to-unfolded state transition is characterized by a large increase in the radius of gyration. Molecular dynamics trajectories simulated in different unfolding conditions suggest that urea destabilizes the enzyme structure weakening hydrophobic interactions and the hydrogen bond network

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