2.5.1.72: quinolinate synthase
This is an abbreviated version!
For detailed information about quinolinate synthase, go to the full flat file.
Word Map on EC 2.5.1.72
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2.5.1.72
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nada
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nicotinamide
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dihydroxyacetone
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iminoaspartate
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iron-sulfur
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pyrococcus
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dhap
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horikoshii
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qa
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cluster-containing
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oxygen-sensitive
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desulfurase
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drug development
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synthesis
- 2.5.1.72
-
nada
- nicotinamide
- dihydroxyacetone
- iminoaspartate
-
iron-sulfur
-
pyrococcus
- dhap
- horikoshii
- qa
-
cluster-containing
-
oxygen-sensitive
-
desulfurase
- drug development
- synthesis
Reaction
Synonyms
Fe4S4 quinolinate synthase, NadA, Old5, PfQS, quinolinate synthetase, SufE3, TM_1644
ECTree
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Systematic Name
Systematic Name on EC 2.5.1.72 - quinolinate synthase
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glycerone phosphate:iminosuccinate alkyltransferase (cyclizing)
An iron-sulfur protein that requires a [4Fe-4S] cluster for activity [1]. Quinolinate synthase catalyses the second step in the de novo biosynthesis of NAD+ from aspartate in some bacteria, with EC 1.4.3.16 (L-aspartate oxidase) catalysing the first step and EC 2.4.2.19 [nicotinate-nucleotide diphosphorylase (carboxylating)] the third step. In Escherichia coli, two of the residues that are involved in the [4Fe-4S] cluster binding appear to undergo reversible disulfide-bond formation that regulates the activity of the enzyme [5].