2.6.1.101: L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase
This is an abbreviated version!
For detailed information about L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase, go to the full flat file.
Reaction
Synonyms
btrR, BtrS, Gln:DOI aminotransferase, L-glutamine: 2-deoxy-scyllo-inosamine aminotransferase, L-glutamine:DOI aminotransferase, neo-6, Neo6, neoB
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General Information
General Information on EC 2.6.1.101 - L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase
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evolution
metabolism
physiological function
additional information
BtrR and StsC are the two homologues of Neo-6 in butirosin and streptamycin biosynthetic pathways
evolution
BtrR has a fold characteristic of the aspartate aminotransferase family and is a member of the class of aminotransferases that function primarily in the biosynthesis of secondary metabolites, SMAT, i.e. the secondary metabolite aminotransferases subfamily
evolution
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BtrR and StsC are the two homologues of Neo-6 in butirosin and streptamycin biosynthetic pathways
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purified Neo-6 also catalyses the amino transfer from L-glutamine to 2-deoxyscyllo-inosose to produce 2-deoxyscyllo-inosamine when coupled with BtrC in the presence of G6P, NAD+, Co2+ and L-glutamine, EC 2.6.1.100
metabolism
the aminotransferase BtrR is involved in the biosynthesis of butirosin
metabolism
the enzyme is involved in the biosynthesis of the 2-deoxystreptamine (DOS)-containing aminoglycoside neomycin. 3-Amino-2,3-dideoxy-scyllo-inosose produced by the NeoA reaction is continuously used as substrate for the natural forward transamination catalyzed by NeoB in the 2-deoxystreptamine biosynthesis. NeoB also shows L-glutamine:2-deoxy-scyllo-inosose aminotransferase activity resulting in formation of 2-deoxy-scyllo-inosamine, EC 2.6.1.100
metabolism
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purified Neo-6 also catalyses the amino transfer from L-glutamine to 2-deoxyscyllo-inosose to produce 2-deoxyscyllo-inosamine when coupled with BtrC in the presence of G6P, NAD+, Co2+ and L-glutamine, EC 2.6.1.100
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metabolism
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the enzyme is involved in the biosynthesis of the 2-deoxystreptamine (DOS)-containing aminoglycoside neomycin. 3-Amino-2,3-dideoxy-scyllo-inosose produced by the NeoA reaction is continuously used as substrate for the natural forward transamination catalyzed by NeoB in the 2-deoxystreptamine biosynthesis. NeoB also shows L-glutamine:2-deoxy-scyllo-inosose aminotransferase activity resulting in formation of 2-deoxy-scyllo-inosamine, EC 2.6.1.100
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the aminotransferase BtrR is involved in the biosynthesis of butirosin, a 2-deoxystreptamine-containing aminoglycoside antibiotic produced by Bacillus circulans, catalyzing the pyridoxal 5'-phosphate-dependent transamination reaction both of 2-deoxy-scylloinosose to 2-deoxy-scyllo-inosamine, cf. EC 2.6.1.100, and of amino-dideoxy-scyllo-inosose to 2-deoxystreptamine
physiological function
the enzyme produces 2-deoxystreptamine (DOS), which is the aglycone in neomycins, overview. Neo-6 is also the enzyme catalysing the transamination of 2-deoxy-scyllo-inosose, DOI, using L-glutamine as an amino donor to produce 2-deoxyscyllo-inosamine as required for 2-deoxystreptamine biosynthesis, function of Neo-6 as the L-glutamine:DOI aminotransferase
physiological function
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the enzyme produces 2-deoxystreptamine (DOS), which is the aglycone in neomycins, overview. Neo-6 is also the enzyme catalysing the transamination of 2-deoxy-scyllo-inosose, DOI, using L-glutamine as an amino donor to produce 2-deoxyscyllo-inosamine as required for 2-deoxystreptamine biosynthesis, function of Neo-6 as the L-glutamine:DOI aminotransferase
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active site structure of BtrR, homodimer with two active sites per dimer, BtrR with bound pyridoxamine 5'-phosphate lacks the covalent bond to Lys192. The active site of the BtrR protomer is located in a cleft between an alpha-helical N-terminus, a central alphabetaalpha-sandwich domain and an alphabeta-C-terminal domain
additional information
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gene neo6 of the neo gene cluster and btrR from the btr gene cluster are equivalent, genetic organization, overview
additional information
gene neo6 of the neo gene cluster and btrR from the btr gene cluster are equivalent, genetic organization, overview
additional information
the equivalent of gene neoB, from neo gene cluster, in the btr gene cluster is gene btrS
additional information
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gene neo6 of the neo gene cluster and btrR from the btr gene cluster are equivalent, genetic organization, overview
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additional information
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the equivalent of gene neoB, from neo gene cluster, in the btr gene cluster is gene btrS
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