2.7.1.149: 1-phosphatidylinositol-5-phosphate 4-kinase

This is an abbreviated version!
For detailed information about 1-phosphatidylinositol-5-phosphate 4-kinase, go to the full flat file.

Reaction

Synonyms

1-phosphatidylinositol-4-phosphate 5-kinase, 1-phosphatidylinositol-4-phosphate kinase, 1-phosphatidylinositol-5-phosphate 4-kinase, Diphosphoinositide kinase, MSS4p, pan-phosphatidylinositol 5-phosphate 4-kinase, pan-PI5P4K, phosphatidylinositol 4-kinase, phosphatidylinositol 4-phosphate 5-kinase gamma, phosphatidylinositol 5 phosphate 4-kinase, phosphatidylinositol 5-phosphate 4-kinase, phosphatidylinositol 5-phosphate 4-kinase gamma, phosphatidylinositol 5-phosphate 4-kinase-alpha, phosphatidylinositol 5-phosphate, 4-kinase alpha, phosphatidylinositol 5-phosphate, 4-kinase beta, phosphatidylinositol phosphate kinase II gamma, phosphatidylinositol-5-phosphate 4-kinase, phosphatidylinositol-5-phosphate 4-kinase alpha, phosphatidylinositol-5-phosphate 4-kinase gamma, phosphatidylinositol-5-phosphate 4-kinase type II, phosphatidylinositol-5-phosphate 4-kinase type II beta, phosphatidylinositol-5-phosphate 4-kinase type-2 gamma, phosphatidylinositol-5-phosphate 4-kinase, type II, beta, PI-5-phosphate 4-kinase type II, PI4Kgamma5, PI4P-5 kinase, PI5P 4-kinase, PI5P4K, PI5P4Kalpha, PI5P4Kbeta, PI5P4Kgamma, PIP(4)K, PIP4K, PIP4K II, Pip4k2a, Pip4k2b, PIP4K2C, PIP4Kalpha, PIP4Kbeta, PIP4Kgamma, PIP4KIIalpha, PIP4KIIgamma, PIP5K2B, PIP5Kgamma, PIP5KII-alpha, PIP5KIII, PIPKII, PIPKIIalpha, PIPKIIbeta, PIPkinIIbeta, PtdIns(4)P-5-kinase B isoform, PtdIns(4)P-5-kinase C isoform, PtdIns5P 4-kinase, PtdIns5P-4-kinase, PtdIns5P4-kinase, type II alpha phosphatidylinositol-5-phosphate 4-kinase, type II kinase, type II phosphatidylinositol 4-kinase, type II phosphatidylinositol 4-kinase beta, type II PI-5-P 4-kinase, type II PIP kinase, type II PtdIns 4-kinase, type II PtdIns 4-kinase beta, type IIbeta phosphatidylinositol 5-phosphate 4-kinase, type IIbeta PIPkin

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.149 1-phosphatidylinositol-5-phosphate 4-kinase

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Results	in table
53	AA Sequence
1	Application
2	CAS Registry Number
18	Cloned(Commentary)
11	Cofactor
1	Crystallization (Commentary)
313	Disease/ Diagnostics
2	Expression
31	General Information
86	IC50 Value
82	Inhibitors
30	Ki Value [mM]
6	KM Value [mM]
40	Localization
10	Metals/Ions
9	Molecular Weight [Da]
40	Natural Substrates/ Products (Substrates)
203	Organism
4	Pathway
74	PDB ID
3	pH Optimum
3	Posttranslational Modification
9	Protein Variants
12	Purification (Commentary)
1	Reaction
3	Reaction Type
39	Reference
70	Source Tissue
3	Specific Activity [micromol/min/mg]
46	Substrates and Products (Substrate)
8	Subunits
133	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
3	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.7.1.149 - 1-phosphatidylinositol-5-phosphate 4-kinase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.014

(2E)-2-(3,4-dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile

Homo sapiens

-

pH 7.4, 22°C, isozyme PI5P4Kalpha

723602

0.002

(2E)-2-(3,4-dihydroxybenzoyl)-3-(4-hydroxy-3-iodo-5-methoxyphenyl)prop-2-enenitrile

Homo sapiens

-

pH 7.4, 22°C, isozyme PI5P4Kalpha

723602

0.013

(3E)-5-amino-3-[(2Z)-1-cyano-2-(3H-indol-3-ylidene)ethylidene]-2,3-dihydro-1H-pyrazole-4-carbonitrile

Homo sapiens

-

pH 7.4, 22°C, isozyme PI5P4Kalpha

723602

0.005

(3Z)-2-amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile

Homo sapiens

-

pH 7.4, 22°C, isozyme PI5P4Kalpha

723602

0.0061 - 0.027

(E)-N-(4-(5-((2,5-dioxopyrrolidin-3-ylidene)methyl)pyridin-3-yl)phenyl)methanesulfonamide

2 entries

0.0018 - 0.0086

(Z)-1-(4-(5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)-3-methylurea

2 entries

0.035 - 0.05

(Z)-2-imino-5-((5-(4-(methylsulfonyl)phenyl)pyridin-3-yl)methylene)thiazolidin-4-one

2 entries

0.011 - 0.05

(Z)-2-imino-5-((5-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)methylene)thiazolidin-4-one

2 entries

0.026 - 0.05

(Z)-2-imino-5-((5-(4-(trifluoromethyl)phenyl)pyridin-3-yl)methylene)thiazolidin-4-one

2 entries

0.0039 - 0.05

(Z)-2-imino-5-((5-(4-methoxynaphthalen-1-yl)pyridin-3-yl)methylene)thiazolidin-4-one

2 entries

0.0014 - 0.0043

(Z)-4-(5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)-N-methylbenzenesulfonamide

2 entries

0.0088 - 0.05

(Z)-5-((5-(4-(dimethylamino)phenyl)pyridin-3-yl)methylene)-2-iminothiazolidin-4-one

2 entries

0.028 - 0.05

(Z)-5-((5-(4-fluorophenyl)pyridin-3-yl)methylene)-2-iminothiazolidin-4-one

2 entries

0.011 - 0.05

(Z)-N-(3-(5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)acetamide

2 entries

0.00066 - 0.0027

(Z)-N-(4-(2-amino-5-((2-imino-4-oxothiazolidin-5-ylidene)-methyl)pyridin-3-yl)phenyl)methanesulfonamide

2 entries

0.021 - 0.05

(Z)-N-(4-(5-((2,4-dioxo-oxazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)methanesulfonamide

2 entries

0.00013 - 0.0019

(Z)-N-(4-(5-((2,4-dioxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)methanesulfonamide

2 entries

0.011 - 0.05

(Z)-N-(4-(5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)acetamide

2 entries

0.00027 - 0.0017

(Z)-N-(4-(5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)methanesulfonamide

2 entries

0.004 - 0.025

(Z)-N-(4-(6-amino-5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)methanesulfonamide

2 entries

0.03

2,4-diamino-N-[3-(trifluoromethyl)phenyl]pyrimidine-5-carboxamide

Homo sapiens

P78356

IC50 above 0.03 mM, at pH 7.4 and 26°C

737598

0.03

3-(trifluoromethyl)phenyl 4-amino-2-(4,4-dimethyl-2-oxoimidazolidin-1-yl)pyrimidine-5-carboxylate

Homo sapiens

P78356

IC50 above 0.03 mM, at pH 7.4 and 26°C

737598

0.0054

4-amino-2-(4,4-dimethyl-2-oxoimidazolidin-1-yl)-N-(3-phenoxyphenyl)pyrimidine-5-carboxamide

Homo sapiens

P78356

at pH 7.4 and 26°C

737598

0.03

4-amino-2-(4,4-dimethyl-2-oxoimidazolidin-1-yl)-N-methyl-N-[3-(trifluoromethyl)phenyl]pyrimidine-5-carboxamide

Homo sapiens

P78356

IC50 above 0.03 mM, at pH 7.4 and 26°C

737598

0.0081

4-amino-2-(4,4-dimethyl-2-oxoimidazolidin-1-yl)-N-[3-(2,2,2-trifluoroethoxy)phenyl]pyrimidine-5-carboxamide

Homo sapiens

P78356

at pH 7.4 and 26°C

737598

0.013

4-amino-2-(4,4-dimethyl-2-oxoimidazolidin-1-yl)-N-[4-methyl-3-(trifluoromethyl)phenyl]pyrimidine-5-carboxamide

Homo sapiens

P78356

at pH 7.4 and 26°C

737598

0.025

4-amino-2-(benzylamino)-N-[3-(trifluoromethyl)phenyl]pyrimidine-5-carboxamide

Homo sapiens

P78356

at pH 7.4 and 26°C

737598

0.03

4-amino-2-(dimethylamino)-N-[3-(trifluoromethyl)phenyl]pyrimidine-5-carboxamide

Homo sapiens

P78356

IC50 above 0.03 mM, at pH 7.4 and 26°C

737598

0.03

4-amino-2-(methylsulfanyl)-N-[3-(trifluoromethyl)phenyl]pyrimidine-5-carboxamide

Homo sapiens

P78356

IC50 above 0.03 mM, at pH 7.4 and 26°C

737598

0.03

4-amino-2-(piperidin-1-yl)-N-[3-(trifluoromethyl)phenyl]pyrimidine-5-carboxamide

Homo sapiens

P78356

IC50 above 0.03 mM, at pH 7.4 and 26°C

737598

0.03

4-amino-2-hydroxy-N-[3-(trifluoromethyl)phenyl]pyrimidine-5-carboxamide

Homo sapiens

P78356

IC50 above 0.03 mM, at pH 7.4 and 26°C

737598

0.03

4-amino-2-methoxy-N-[3-(trifluoromethyl)phenyl]pyrimidine-5-carboxamide

Homo sapiens

P78356

IC50 above 0.03 mM, at pH 7.4 and 26°C

737598

0.008

4-amino-2-[(2,2-dimethylpropyl)amino]-N-[3-(trifluoromethyl)phenyl]pyrimidine-5-carboxamide

Homo sapiens

P78356

at pH 7.4 and 26°C

737598

0.03

4-amino-2-[(tert-butylcarbamoyl)amino]-N-[3-(trifluoromethyl)phenyl]pyrimidine-5-carboxamide

Homo sapiens

P78356

IC50 above 0.03 mM, at pH 7.4 and 26°C

737598

0.0041

4-amino-2-[[(1-methyl-1H-pyrazol-5-yl)methyl]amino]-N-[3-(trifluoromethyl)phenyl]pyrimidine-5-carboxamide

Homo sapiens

P78356

at pH 7.4 and 26°C

737598

0.025

4-amino-N-(1,3-benzothiazol-5-yl)-2-(4,4-dimethyl-2-oxoimidazolidin-1-yl)pyrimidine-5-carboxamide

Homo sapiens

P78356

at pH 7.4 and 26°C

737598

0.013

4-amino-N-(1-benzothiophen-5-yl)-2-(4,4-dimethyl-2-oxoimidazolidin-1-yl)pyrimidine-5-carboxamide

Homo sapiens

P78356

at pH 7.4 and 26°C

737598

0.03

4-amino-N-[3-(trifluoromethyl)phenyl]-2-(3,4,4-trimethyl-2-oxoimidazolidin-1-yl)pyrimidine-5-carboxamide

Homo sapiens

P78356

IC50 above 0.03 mM, at pH 7.4 and 26°C

737598

0.03

4-amino-N-[3-(trifluoromethyl)phenyl]pyrimidine-5-carboxamide

Homo sapiens

P78356

IC50 above 0.03 mM, at pH 7.4 and 26°C

737598

0.014 - 0.045

N-(3-((5-(4-(methylsulfonamido)phenyl)pyridin-3-yl)amino)phenyl)acetamide

2 entries

0.009 - 0.025

N-(3-((5-(4-(Mmthylsulfonamido)phenyl)pyridin-3-yl)oxy)phenyl)acetamide

2 entries

0.0053 - 0.036

N-(3-(5-(4-(methylsulfonamido)phenyl)pyridin-3-yl)phenyl)acetamide

2 entries

0.002 - 0.0094

N-(4-(5-(1H-indol-4-yl)pyridin-3-yl)phenyl)methanesulfonamide

2 entries

0.0089 - 0.015

N-(4-(5-(2-oxoindolin-4yl)pyridin-3-yl)phenyl)methanesulfonamide

2 entries

0.0037 - 0.043

N-(4-(5-(4-(3-methylureido)phenyl)pyridin-3-yl)phenyl)methanesulfonamide

2 entries

0.0021 - 0.022

N-(5-(5-(1H-indol-4-yl)pyridin-3-yl)phenyl)methanesulfonamide

2 entries

0.0032 - 0.029

N-(6-(5-(1H-indol-4-yl)pyridin-3-yl)phenyl)methanesulfonamide

2 entries

0.001

NIH-12848

2 entries

0.0038

SAR088

Homo sapiens

P78356

at pH 7.4 and 26°C

737598

0.00095 - 0.0059

THZ-P1-2

2 entries

0.001

tyrphostin

Homo sapiens

-

pH 7.4, 22°C, isozyme PI5P4Kalpha

723602

0.045

tyrphostin 23

Homo sapiens

-

pH 7.4, 22°C, isozyme PI5P4Kalpha

723602

0.02

tyrphostin 47

Homo sapiens

-

pH 7.4, 22°C, isozyme PI5P4Kalpha

723602

0.1

tyrphostin AG 1478

Homo sapiens

-

pH 7.4, 22°C, isozyme PI5P4Kalpha

723602

0.089

tyrphostin AG 490

Homo sapiens

-

pH 7.4, 22°C, isozyme PI5P4Kalpha

723602

0.089

tyrphostin AG 494

Homo sapiens

-

pH 7.4, 22°C, isozyme PI5P4Kalpha

723602

0.032

tyrphostin AG 537

Homo sapiens

-

pH 7.4, 22°C, isozyme PI5P4Kalpha

723602

0.055

tyrphostin AG 555

Homo sapiens

-

pH 7.4, 22°C, isozyme PI5P4Kalpha

723602

0.05

tyrphostin AG 698

Homo sapiens

-

pH 7.4, 22°C, isozyme PI5P4Kalpha

723602

0.018

tyrphostin AG 808

Homo sapiens

-

pH 7.4, 22°C, isozyme PI5P4Kalpha

723602

0.0061

(E)-N-(4-(5-((2,5-dioxopyrrolidin-3-ylidene)methyl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.027

(E)-N-(4-(5-((2,5-dioxopyrrolidin-3-ylidene)methyl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.0018

(Z)-1-(4-(5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)-3-methylurea

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.0086

(Z)-1-(4-(5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)-3-methylurea

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.035

(Z)-2-imino-5-((5-(4-(methylsulfonyl)phenyl)pyridin-3-yl)methylene)thiazolidin-4-one

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.05

(Z)-2-imino-5-((5-(4-(methylsulfonyl)phenyl)pyridin-3-yl)methylene)thiazolidin-4-one

Homo sapiens

-

IC50 above 0.05 mM, isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.011

(Z)-2-imino-5-((5-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)methylene)thiazolidin-4-one

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.05

(Z)-2-imino-5-((5-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)methylene)thiazolidin-4-one

Homo sapiens

-

IC50 above 0.05 mM, isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.026

(Z)-2-imino-5-((5-(4-(trifluoromethyl)phenyl)pyridin-3-yl)methylene)thiazolidin-4-one

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.05

(Z)-2-imino-5-((5-(4-(trifluoromethyl)phenyl)pyridin-3-yl)methylene)thiazolidin-4-one

Homo sapiens

-

IC50 above 0.05 mM, isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.0039

(Z)-2-imino-5-((5-(4-methoxynaphthalen-1-yl)pyridin-3-yl)methylene)thiazolidin-4-one

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.05

(Z)-2-imino-5-((5-(4-methoxynaphthalen-1-yl)pyridin-3-yl)methylene)thiazolidin-4-one

Homo sapiens

-

IC50 above 0.05 mM, isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.0014

(Z)-4-(5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)-N-methylbenzenesulfonamide

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.0043

(Z)-4-(5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)-N-methylbenzenesulfonamide

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.0088

(Z)-5-((5-(4-(dimethylamino)phenyl)pyridin-3-yl)methylene)-2-iminothiazolidin-4-one

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.05

(Z)-5-((5-(4-(dimethylamino)phenyl)pyridin-3-yl)methylene)-2-iminothiazolidin-4-one

Homo sapiens

-

IC50 above 0.05 mM, isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.028

(Z)-5-((5-(4-fluorophenyl)pyridin-3-yl)methylene)-2-iminothiazolidin-4-one

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.05

(Z)-5-((5-(4-fluorophenyl)pyridin-3-yl)methylene)-2-iminothiazolidin-4-one

Homo sapiens

-

IC50 above 0.05 mM, isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.011

(Z)-N-(3-(5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)acetamide

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.05

(Z)-N-(3-(5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)acetamide

Homo sapiens

-

IC50 above 0.05 mM, isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.00066

(Z)-N-(4-(2-amino-5-((2-imino-4-oxothiazolidin-5-ylidene)-methyl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.0027

(Z)-N-(4-(2-amino-5-((2-imino-4-oxothiazolidin-5-ylidene)-methyl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.021

(Z)-N-(4-(5-((2,4-dioxo-oxazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.05

(Z)-N-(4-(5-((2,4-dioxo-oxazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

IC50 above 0.05 mM, isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.00013

(Z)-N-(4-(5-((2,4-dioxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.0019

(Z)-N-(4-(5-((2,4-dioxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.011

(Z)-N-(4-(5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)acetamide

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.05

(Z)-N-(4-(5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)acetamide

Homo sapiens

-

IC50 above 0.05 mM, isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.00027

(Z)-N-(4-(5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.0017

(Z)-N-(4-(5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.004

(Z)-N-(4-(6-amino-5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.025

(Z)-N-(4-(6-amino-5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.014

N-(3-((5-(4-(methylsulfonamido)phenyl)pyridin-3-yl)amino)phenyl)acetamide

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.045

N-(3-((5-(4-(methylsulfonamido)phenyl)pyridin-3-yl)amino)phenyl)acetamide

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.009

N-(3-((5-(4-(Mmthylsulfonamido)phenyl)pyridin-3-yl)oxy)phenyl)acetamide

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.025

N-(3-((5-(4-(Mmthylsulfonamido)phenyl)pyridin-3-yl)oxy)phenyl)acetamide

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.0053

N-(3-(5-(4-(methylsulfonamido)phenyl)pyridin-3-yl)phenyl)acetamide

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.036

N-(3-(5-(4-(methylsulfonamido)phenyl)pyridin-3-yl)phenyl)acetamide

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.002

N-(4-(5-(1H-indol-4-yl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.0094

N-(4-(5-(1H-indol-4-yl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.0089

N-(4-(5-(2-oxoindolin-4yl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.015

N-(4-(5-(2-oxoindolin-4yl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.0037

N-(4-(5-(4-(3-methylureido)phenyl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.043

N-(4-(5-(4-(3-methylureido)phenyl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.0021

N-(5-(5-(1H-indol-4-yl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.022

N-(5-(5-(1H-indol-4-yl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.0032

N-(6-(5-(1H-indol-4-yl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.4 and 25°C

759615

0.029

N-(6-(5-(1H-indol-4-yl)pyridin-3-yl)phenyl)methanesulfonamide

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.4 and 25°C

759615

0.001

NIH-12848

Mus musculus

-

at pH 7.5 and 30°C

737648

0.001

NIH-12848

Mus musculus

-

at 22°C, pH not specified in the publication

737648

0.00095

THZ-P1-2

Homo sapiens

-

isoform PI5P4Kalpha, at pH 7.5 and 37°C

758575

0.0059

THZ-P1-2

Homo sapiens

-

isoform PI5P4Kbeta, at pH 7.5 and °C

758575