2.7.1.22: ribosylnicotinamide kinase

This is an abbreviated version!
For detailed information about ribosylnicotinamide kinase, go to the full flat file.

Word Map on EC 2.7.1.22

2.7.1.22

salvage

mononucleotide

nmnat

phosphoribosyltransferase

sirtuins

nampt

analysis

Reaction

Synonyms

kinase, ribosylnicotinamide (phosphorylating), More, muscle-specific beta1 integrin binding protein, NadR, nicotinamide ribose kinase, nicotinamide riboside kinase, nicotinamide riboside kinase 1, nicotinamide riboside kinase 2, nicotinamide riboside kinase-2, NmR-K, NMRK1, NMRK2, NR kinase 1, Nrk, NRK-2, NRK1, Nrk2, Nrk2b

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.22 ribosylnicotinamide kinase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
1041	AA Sequence
1	Application
1	CAS Registry Number
12	Cloned(Commentary)
8	Cofactor
2	Crystallization (Commentary)
17	Disease/ Diagnostics
9	Expression
35	General Information
1	Inhibitors
4	kcat/KM [mM/s]
9	KM Value [mM]
2	Localization
6	Metals/Ions
3	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
24	Organism
5	Pathway
2	PDB ID
2	pH Optimum
1	pH Range
11	Protein Variants
7	Purification (Commentary)
5	Reaction
1	Reaction Type
21	Reference
31	Source Tissue
7	Specific Activity [micromol/min/mg]
1	Storage Stability
29	Substrates and Products (Substrate)
1	Subunits
55	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
5	Turnover Number [1/s]

Expression

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Expression on EC 2.7.1.22 - ribosylnicotinamide kinase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Expression Search

depression of NAD+ availability leads to activation of NRK2. In cardiomyocytes, the NRK2 gene is activated by energy stress and NAD+ depletion through AMP-activated protein kinase and peroxisome proliferator-activated receptor alpha dependant mechanisms

2 entries

following injury to dorsal root ganglion neurons, Nmrk2 is the most upregulated NAD+ biosynthetic gene (by over 20fold). Mice with a loss of hexose-6-phosphate dehydrogenase (H6PDH) function, an ER-based enzyme required for local NADPH generation, manifest with severe muscle myopathy and on transcriptional analysis Nmrk2 expression is the most dysregulated gene (upregulated by over 60fold mRNA level). Nmrk2 mRNA expression is substantially induced (over 80fold) in models of lethal cardiomyopathy

Mus musculus

Q91W63, Q9D7C9

761705

nicotinamide riboside kinase 2 (NRK2) expression is decreased in wild-type muscle

2 entries

Nmrk2 mRNA expression is substantially induced (over 80fold) in models of lethal cardiomyopathy

Homo sapiens

Q9NPI5, Q9NWW6

761705

NRK-2 expression dramatically increases in ischemic heart

3 entries