2.7.7.31: DNA nucleotidylexotransferase
This is an abbreviated version!
For detailed information about DNA nucleotidylexotransferase, go to the full flat file.
Word Map on EC 2.7.7.31
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2.7.7.31
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dutp
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nick
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tunel
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nick-end
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caspase-3
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leukemia
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tdt-mediated
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necrosis
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bcl-2
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marrow
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tunel-positive
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lymphoblast
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lymphocyte
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neuroprotective
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sham
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lymphoid
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ischemia
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eosin
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infarct
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b-cell
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hematoxylin
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end-labeling
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deoxyuridine
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cerebral
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thymus
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polymerases
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malondialdehyde
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reperfusion
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thymocytes
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ladder
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cardiomyocytes
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anti-apoptotic
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ischemia-reperfusion
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immunophenotype
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myeloid
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immunoglobulin
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dutp-biotin
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occlusion
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nissl
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labeling-positive
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analysis
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french-american-british
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3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium
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blastic
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internucleosomal
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t-lymphoblastic
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apoptosis-related
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transcriptases
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2'-deoxyuridine
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biotechnology
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klenow
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calla
-
medicine
- 2.7.7.31
- dutp
- nick
-
tunel
-
nick-end
- caspase-3
- leukemia
-
tdt-mediated
- necrosis
- bcl-2
- marrow
-
tunel-positive
- lymphoblast
- lymphocyte
-
neuroprotective
-
sham
-
lymphoid
- ischemia
- eosin
- infarct
- b-cell
- hematoxylin
-
end-labeling
- deoxyuridine
- cerebral
- thymus
- polymerases
- malondialdehyde
-
reperfusion
- thymocytes
-
ladder
-
cardiomyocytes
-
anti-apoptotic
-
ischemia-reperfusion
-
immunophenotype
- myeloid
- immunoglobulin
-
dutp-biotin
- occlusion
-
nissl
-
labeling-positive
- analysis
-
french-american-british
-
3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium
-
blastic
-
internucleosomal
-
t-lymphoblastic
-
apoptosis-related
- transcriptases
- 2'-deoxyuridine
- biotechnology
-
klenow
- calla
- medicine
Reaction
Synonyms
addase, bTdT, deoxynucleotidyl terminal transferase, deoxynucleotidyl transferase, deoxyribonucleic acid nucleotidyltransferase, deoxyribonucleic nucleotidyltransferase, DNA-polymerizing enzyme, DNTT, hTdT, hTdTL1, hTdTL2, hTdTS, mTdT, nucleotidyltransferase, terminal deoxyribo-, Rep75, TdT, terminal addition enzyme, terminal deoxynucleotide transferase, terminal deoxynucleotidyl transferase, terminal deoxynucleotidyl transferase (TDT), terminal deoxynucleotidyltransferase, terminal deoxynucleotiyl transferase, terminal deoxyribonucleotidyl transferase, terminal deoxyribonucleotidyltransferase
ECTree
2.7.7.31 DNA nucleotidylexotransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.7.7.31 - DNA nucleotidylexotransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
a 2'-deoxyribonucleoside 5'-triphosphate + single stranded DNAn
diphosphate + single stranded DNAn+1
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
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the long murine terminal deoxynucleotidyltransferase isoform does not play a role in the control of V(D)J junctional diversity
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-
?
additional information
?
-
-
alternative splicing seems to regulate TdT isoform expression. Both long isoforms, hTdTL1 and hTdTL2 have 3'-5' exonuclease activity. Overexpression of the short isoform hTdTS or the long isoform hTdTL2 greatly reduces the efficiency of recombinantion, which is reverted to normal levels by simultaneous expression of both enzymes
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-
?
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
-
-
-
?
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
diphosphate + DNAn+1
-
-
-
?
a 2'-deoxyribonucleoside 5'-triphosphate + single stranded DNAn
diphosphate + single stranded DNAn+1
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the enzyme catalyzes the elongation of a DNA with the length of three or more nucleotides by the isothermal and repetitive addition of deoxyribonucleotides to the 3'-OH terminus of DNA molecules
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-
?
a 2'-deoxyribonucleoside 5'-triphosphate + single stranded DNAn
diphosphate + single stranded DNAn+1
-
-
-
?
deoxynucleoside triphosphate + DNA
diphosphate + DNAn+1
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hypothesis: terminal transferase acts as a somatic mutator, diversifying the amino acid sequence in the variable region of immunoglobulin molecules by changing one of the nucleotides
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-
?
deoxynucleoside triphosphate + DNA
diphosphate + DNAn+1
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enzyme may act as a random-sequence generator in highly localized regions of the DNA, enzyme may be an intracellular marker for a subpopulation of cells
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-
?
deoxynucleoside triphosphate + DNA
diphosphate + DNAn+1
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the enzyme has a key role in V(D)J recombination during lymphocyte and repertoire development
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-
?
deoxynucleoside triphosphate + DNA
diphosphate + DNAn+1
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involved in creating somatic diversity of immunoglobulin and T-cell receptor genes
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-
?
deoxynucleoside triphosphate + DNA
diphosphate + DNAn+1
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roles in DNA replication and repair processes
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-
?
deoxynucleoside triphosphate + DNA
diphosphate + DNAn+1
-
hypothesis: terminal transferase acts as a somatic mutator, diversifying the amino acid sequence in the variable region of immunoglobulin molecules by changing one of the nucleotides
-
-
?
deoxynucleoside triphosphate + DNA
diphosphate + DNAn+1
-
hypothesis: terminal transferase acts as a somatic mutator, diversifying the amino acid sequence in the variable region of immunoglobulin molecules by changing one of the nucleotides
-
-
?
