EC Number   |
General Information |
Reference |
|---|
   2.4.1.66 | malfunction |
an impairment of lysyl hydroxylase 3 function significantly affects type I collagen fibrillogenesis |
722764 |
| 2.4.1.66 | malfunction |
disorders of LH3 with a unique phenotype causing severe morbidity as a result of feauters that overlap with collagen disorders |
695440 |
| 2.4.1.66 | malfunction |
lysyl hydroxylase 3-mediated glucosylation occurs at specific sites in collagen, including cross-linking sites, and suppression of this modification results in defective collagen and mineralization |
722764 |
| 2.4.1.66 | metabolism |
lysyl hydroxylase 3 functions as glucosyltransferase in type I collagen |
722764 |
| 2.4.1.66 | metabolism |
the enzyme is commonly involved in biosynthesis of collagenous proteins |
737134 |
| 2.4.1.66 | physiological function |
fibroblast cell surface recruitment of matrix metalloproteinase-9 via its fibronectin-like domain by lysyl hydroxylase 3 induces transforming growth factor-beta activation and myofibroblast differentiation |
736472 |
| 2.4.1.66 | physiological function |
forms part of the many posttranslational modifications required during collagen biosynthesis |
695440 |
| 2.4.1.66 | physiological function |
organization of the extracellular matrix and cytoskeleton |
698942 |
| 2.4.1.66 | physiological function |
the lysyl hydroxylase 3-mediated glucosylation occurs at the specific molecular loci in the type I collagen molecule and plays critical roles in controlling collagen cross-linking, fibrillogenesis, and mineralization |
722764 |
| 2.4.1.66 | physiological function |
the major function of lysyl hydroxylase 3 in osteoblasts is to glucosylate galactosylhydroxylysine residues in type I collagen |
722764 |
