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1.1.1.417: 3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating)

This is an abbreviated version!
For detailed information about 3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating), go to the full flat file.

Reaction

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a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate
+
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NAD(P)+
=
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a 4alpha-methyl-3-oxosteroid
+
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NAD(P)H
+
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CO2
+
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H+

Synonyms

sdmB

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                EC 1.1.1.4171.1.1.417 3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating)

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Resultsin table
2Cofactor
2General Information
4Natural Substrates/ Products (Substrates)
2Organism
1Pathway
1Reaction
2Reference
4Substrates and Products (Substrate)
3Synonyms
1Systematic Name
All data fields related to EC 1.1.1.417

Systematic Name

Systematic Name on EC 1.1.1.417 - 3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating)

for references in articles please use BRENDA:EC1.1.1.417

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SYSTEMATIC NAME
IUBMB Comments
3beta-hydroxysteroid-4beta-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)
This bacterial enzyme participates in the biosynthesis of bacterial sterols. Together with EC 1.14.13.246, 4beta-methylsterol monooxygenase (SdmA) it forms an enzyme system that removes one methyl group from the C-4 position of 4,4-dimethylated steroid molecules. SdmA catalyses three successive oxidations of the C-4beta methyl group, turning it into a carboxylate group; SdmB is a bifunctional enzyme that catalyses two different activities. As EC 1.1.1.417 it catalyses an oxidative decarboxylation that results in reduction of the 3beta-hydroxy group at the C-3 carbon to an oxo group. As EC 1.1.1.270, 3beta-hydroxysteroid 3-dehydrogenase, it reduces the 3-oxo group back to a 3beta-hydroxyl. Since the remaining methyl group at C-4 is in an alpha orientation, it cannot serve as a substrate for a second round of demethylation by this system.