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1.1.3.46: 4-hydroxymandelate oxidase

This is an abbreviated version!
For detailed information about 4-hydroxymandelate oxidase, go to the full flat file.

Word Map on EC 1.1.3.46

Reaction

(S)-4-hydroxymandelate
+
O2
=
2-(4-hydroxyphenyl)-2-oxoacetate
 +
H2O2

Synonyms

4HmO, fegC, HmO, hydroxymandelate oxidase, L-4-hydroxymandelate oxidase, p-hydroxymandelate oxidase, Sco3228

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.3 With oxygen as acceptor
                1.1.3.46 4-hydroxymandelate oxidase

Crystallization

Crystallization on EC 1.1.3.46 - 4-hydroxymandelate oxidase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
structures of Hmo and its mutants in complex with physiological/nonphysiological substrates, products and inhibitors
structures of wild-type and mutant Y128F with and without substrate. Cofactor FMNox possesses an electrophilic/nucleophilic duality. In the Y128F mutant the active-site perturbation ensemble facilitates the polarization of FMNox to a nucleophilic ylide, which is in a position to act on an alpha-ketoacid, forming an N5-acyl-FMNred dead-end adduct. In four-electron oxidation of mutant Y128F, an intramolecular disproportionation reaction via an N5-alkanol-FMNred C'alpha carbanion intermediate may account for the ThDP/PLP/NADPH-independent oxidative decarboxylation reaction