1.14.13.154: erythromycin 12-hydroxylase
This is an abbreviated version!
For detailed information about erythromycin 12-hydroxylase, go to the full flat file.

Word Map on EC 1.14.13.154
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1.14.13.154
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editing
-
inosine
-
a-to-i
-
deaminases
-
deamination
-
symmetrica
-
hereditaria
-
dyschromatosis
-
rna-editing
-
rna-specific
-
adenosine-to-inosine
-
interferon-inducible
-
ifn-inducible
-
glur-b
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site-selective
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zalpha
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left-handed
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adar2-mediated
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hypopigmented
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dsrbds
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recoding
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hyperediting
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synthesis
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macules
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z-dna-binding
-
genodermatosis
-
dsrna-binding
- 1.14.13.154
-
editing
- inosine
-
a-to-i
- deaminases
-
deamination
-
symmetrica
-
hereditaria
-
dyschromatosis
-
rna-editing
-
rna-specific
-
adenosine-to-inosine
-
interferon-inducible
-
ifn-inducible
-
glur-b
-
site-selective
-
zalpha
-
left-handed
-
adar2-mediated
-
hypopigmented
-
dsrbds
-
recoding
-
hyperediting
- synthesis
-
macules
-
z-dna-binding
-
genodermatosis
-
dsrna-binding
Reaction
Synonyms
CYP113A1, EryK, erythromycin C-12 hydroxylase
ECTree
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51
Systematic Name
Systematic Name on EC 1.14.13.154 - erythromycin 12-hydroxylase
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erythromycin-D,NADPH:oxygen oxidoreductase (12-hydroxylating)
The enzyme is responsible for the C-12 hydroxylation of the macrolactone ring, one of the last steps in erythromycin biosynthesis. It shows 1200-1900-fold preference for erythromycin D over the alternative substrate erythromycin B [1].