1.14.14.14: aromatase
This is an abbreviated version!
For detailed information about aromatase, go to the full flat file.
Word Map on EC 1.14.14.14
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1.14.14.14
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estrogen
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women
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androgen
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steroid
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postmenopausal
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ovarian
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tamoxifen
-
ovary
-
progesterone
-
letrozole
-
granulosa
-
follicle
-
gonad
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anastrozole
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receptor-positive
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fsh
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steroidogenic
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exemestane
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androstenedione
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gonadotropin
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steroidogenesis
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endometrial
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lutein
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follicular
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testicular
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antiestrogens
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fulvestrant
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er-positive
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nonsteroidal
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endometriosis
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neoadjuvant
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preoptic
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third-generation
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hormone-dependent
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follicle-stimulating
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gnrh
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estrogen-dependent
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oestradiol
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dihydrotestosterone
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premenopausal
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mastectomy
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arthralgia
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17beta-hydroxysteroid
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everolimus
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5alpha-reductase
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cyp17a1
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raloxifene
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medicine
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virilization
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progestin
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her2-negative
- 1.14.14.14
- estrogen
- women
- androgen
- steroid
-
postmenopausal
- ovarian
- tamoxifen
- ovary
- progesterone
- letrozole
-
granulosa
- follicle
- gonad
- anastrozole
-
receptor-positive
- fsh
-
steroidogenic
- exemestane
- androstenedione
- gonadotropin
- steroidogenesis
- endometrial
- lutein
- follicular
- testicular
-
antiestrogens
-
fulvestrant
-
er-positive
-
nonsteroidal
- endometriosis
-
neoadjuvant
-
preoptic
-
third-generation
-
hormone-dependent
-
follicle-stimulating
- gnrh
-
estrogen-dependent
- oestradiol
- dihydrotestosterone
-
premenopausal
-
mastectomy
- arthralgia
-
17beta-hydroxysteroid
-
everolimus
-
5alpha-reductase
- cyp17a1
- raloxifene
- medicine
-
virilization
- progestin
-
her2-negative
Reaction
Synonyms
AROM, Cyp19a, CYP19A1, Cyp19a1a, Cyp19a1b, Cyp19A3, cytochrome P450 aromatase, P450arom
ECTree
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Substrates Products
Substrates Products on EC 1.14.14.14 - aromatase
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REACTION DIAGRAM
16alpha-hydroxytestosterone + 3 O2 + 3 reduced flavoprotein
(16alpha,17beta)-estra-1(10),2,4-triene-3,16,17-triol + formate + 4 H2O + 3 oxidized flavoprotein
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overall reaction
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-
?
19-hydroxyandrost-4-ene-3,17-dione + O2 + a reduced flavoprotein
19-oxo-androst-4-ene-3,17-dione + 2 H2O + an oxidized flavoprotein
19-oxoandrost-4-ene-3,17-dione + O2 + a reduced flavoprotein
estrone + formate + H2O + an oxidized flavoprotein
-
-
-
-
?
7-methoxy-4-trifluoromethyl coumarin + H2O + oxidized flavoprotein
? + O2 + reduced flavoprotein
-
-
-
-
?
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins
estrone + formate + 4 H2O + 3 oxidized flavoproteins
androst-4-ene-3,17-dione + O2 + a reduced flavoprotein
19-hydroxyandrost-4-ene-3,17-dione + H2O + an oxidized flavoprotein
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-
-
-
?
testosterone + 3 O2 + 3 reduced flavoproteins
17beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins
19-oxo-androst-4-ene-3,17-dione + 2 H2O + an oxidized flavoprotein
-
-
-
?
19-hydroxyandrost-4-ene-3,17-dione + O2 + a reduced flavoprotein
19-oxo-androst-4-ene-3,17-dione + 2 H2O + an oxidized flavoprotein
-
-
-
-
?
estrone + formate + 4 H2O + 3 oxidized flavoproteins
-
-
-
?
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins
estrone + formate + 4 H2O + 3 oxidized flavoproteins
-
-
-
-
?
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins
estrone + formate + 4 H2O + 3 oxidized flavoproteins
-
-
-
?
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins
estrone + formate + 4 H2O + 3 oxidized flavoproteins
-
-
-
-
?
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins
estrone + formate + 4 H2O + 3 oxidized flavoproteins
-
-
-
?
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins
estrone + formate + 4 H2O + 3 oxidized flavoproteins
-
-
-
-
?
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins
estrone + formate + 4 H2O + 3 oxidized flavoproteins
-
-
overall reaction
-
?
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins
estrone + formate + 4 H2O + 3 oxidized flavoproteins
-
overall reaction
-
-
?
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins
estrone + formate + 4 H2O + 3 oxidized flavoproteins
-
-
-
?
17beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins
-
-
-
?
testosterone + 3 O2 + 3 reduced flavoproteins
17beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins
-
-
-
-
?
testosterone + 3 O2 + 3 reduced flavoproteins
17beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins
-
overall reaction
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-
?
?
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androstenedione is the preferred substrate, the affinity of the intermediates progressively decrease with increased oxidation
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-
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additional information
?
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androstenedione is the preferred substrate, the affinity of the intermediates progressively decrease with increased oxidation
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-
-
additional information
?
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-
19-oxygenated androgen intermediates are biosynthesized sequentially in a step-wise fashion as the cytochrome P450 and NADPH-cytochrome P450 reductase form transient complexes, and the amount of isolatable 19-oxygenated androgen is proportional to the amount of excess cytochrome P450 component
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-
?
additional information
?
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-
the aromatization of androstenedione probably involves two successive hydroxylations at the C-19 methyl group, mediated by a common catalytic site with the third and rate-determining 2beta-hydroxylation taking place at a different enzyme site
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-
?
additional information
?
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-
the rate of entry of the first electron into the oxidized P450 substrate complex may be rate limiting in the aromatization of C19 but not C18 steroids
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-
?