1.2.1.B25: long-chain-fatty-acyl-CoA reductase

This is an abbreviated version!
For detailed information about long-chain-fatty-acyl-CoA reductase, go to the full flat file.

Reaction

Synonyms

Acr, aldehyde-forming fatty acyl-CoA reductase, cACR, cyanobacterial acyl-CoA reductase, FAR1, FAR4, FAR5, FAR6, long-chain ACR

ECTree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.B25 long-chain-fatty-acyl-CoA reductase

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Results	in table
5	Activating Compound
4	AA Sequence
2	Application
2	Cloned(Commentary)
2	Cofactor
4	Expression
4	General Information
8	Inhibitors
3	KM Value [mM]
2	Localization
5	Metals/Ions
2	Natural Substrates/ Products (Substrates)
7	Organism
1	pH Optimum
1	Purification (Commentary)
3	Reaction
4	Reference
13	Source Tissue
2	Storage Stability
16	Substrates and Products (Substrate)
2	Subunits
14	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.2.1.B25 - long-chain-fatty-acyl-CoA reductase

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CHAPS

Synechococcus elongatus

activates about by 75% at 0.2%, inhibitory at above 0.5%

742484

Digitonin

Synechococcus elongatus

activates about at 0.1%, inhibitory at above 0.5%

742484

dithiothreitol

Synechococcus elongatus

inhibits the enzyme at 5 mM

742484

glutathione

Synechococcus elongatus

inhibits the enzyme at 5 mM

742484

iodoacetamide

Synechococcus elongatus

inactivation at 1 mM, stearoyl-CoA protects, probably due to competition between the two reagents for the active site cysteine

742484

octyl glucoside

Synechococcus elongatus

activates slightly about at 0.2%, inhibitory at above 0.5%

742484

Triton

Synechococcus elongatus

inhibitory at above 0.5%

742484

additional information

Synechococcus elongatus

once acylated by stearoyl-CoA the enzyme is protected from inactivation by iodoacetamide and the cACR activity remains unchanged

742484