1.3.1.124: 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
This is an abbreviated version!
For detailed information about 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], go to the full flat file.
Word Map on EC 1.3.1.124
Reaction
Synonyms
2,4-dienoyl coenzyme A reductase, 2,4-dienoyl-CoA reductase, 4-enoyl-CoA reductase, DCR, DECR, DECR1, DECR2, DELTA2,DELTA4-dienoyl-CoA reductase, More, pDCR, SPS19
ECTree
1.3.1.124 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]Advanced search results
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results (Substrates Products
Substrates Products on EC 1.3.1.124 - 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2E,4E)-2,4-hexadienoyl-CoA + NADPH + H+
(3E)-3-hexenoyl-CoA + NADP+
-
-
-
?
(2E,4E)-hexa-2,4-dienoyl-CoA + NADPH + H+
(3E)-hex-3-enoyl-CoA + NADP+
-
-
-
-
?
2,4,7,10,13,16,19-docosaheptaenoyl-CoA + NADPH
?
-
assay contains additionally 0.06% Triton X-100
-
-
?
2,4,7,10,13,16,19-docosaheptaenoyl-CoA + NADPH + H+
(3E)-3,7,10,13,16,19-docosahexaenoyl-CoA + NADP+
2-cis,4-cis/trans-dienoyl-CoA + NADPH + H+
3-trans-enoyl-CoA + NADP+
-
-
-
-
?
2-fluoro-trans-trans-2,4-octadienoyl-CoA + NADPH
2-fluoro-trans-3-octenoyl-CoA + NADP+
-
substrate analogue, recombinant enzyme, reaction mechanism
-
-
?
2-trans,4-cis-decadienoylcarnitine + ?
?
-
abnormal unsaturated fatty acid oxidation
-
-
?
5-methyl-trans-trans-2,4-hexadienoyl-CoA + NADPH
5-methyl-trans-3-hexenoyl-CoA + NADP+
-
substrate analogue, recombinant enzyme
-
-
?
5-phenyl-(2E,4E)-2,4-pentadienoyl-CoA + NADPH + H+
5-phenyl-(3E)-penta-3-enoyl-CoA + NADP+
-
-
-
-
?
trans, trans-2,4-decadienoyl-CoA + NADPH + H+
trans-deca-3-enoyl-CoA + NADP+
-
-
-
-
?
trans-2,3-didehydroacyl-CoA + NADP+
trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+
-
-
-
-
?
(2E,4E)-2,4-decadienoyl-CoA + NADPH + H+
(3E)-3-decaenoyl-CoA + NADP+
-
-
-
-
?
(2E,4E)-2,4-decadienoyl-CoA + NADPH + H+
(3E)-3-decaenoyl-CoA + NADP+
-
-
-
?
(2E,4E)-2,4-decadienoyl-CoA + NADPH + H+
(3E)-3-decaenoyl-CoA + NADP+
-
-
-
-
?
(2E,4E)-2,4-decadienoyl-CoA + NADPH + H+
(3E)-deca-3-enoyl-CoA + NADP+
preferred substrate
-
-
?
(2E,4E)-2,4-decadienoyl-CoA + NADPH + H+
(3E)-deca-3-enoyl-CoA + NADP+
preferred substrate
-
-
?
(2E,4E)-2,4-decadienoyl-CoA + NADPH + H+
(3E)-deca-3-enoyl-CoA + NADP+
preferred substrate
-
-
?
(2E,4E)-2,4-hexadienoyl-CoA + NADPH + H+
(3E)-hexa-3-enoyl-CoA + NADP+
-
-
-
?
(2E,4E)-2,4-hexadienoyl-CoA + NADPH + H+
(3E)-hexa-3-enoyl-CoA + NADP+
-
-
-
?
(2E,4E)-2,4-hexadienoyl-CoA + NADPH + H+
(3E)-hexa-3-enoyl-CoA + NADP+
-
-
-
?
(2E,4E)-2,4-octadienoyl-CoA + NADPH + H+
(3E)-3-octaenoyl-CoA + NADP+
-
-
-
?
(2E,4E)-2,4-octadienoyl-CoA + NADPH + H+
(3E)-3-octaenoyl-CoA + NADP+
-
-
-
-
?
(2E,4Z)-2,4-decadienoyl-CoA + NADPH + H+
(3E)-3-decaenoyl-CoA + NADP+
-
-
-
-
?
(2E,4Z)-2,4-decadienoyl-CoA + NADPH + H+
(3E)-3-decaenoyl-CoA + NADP+
-
preferred over substrate (2E,4E)-2,4-decadienoyl-CoA
-
-
?
2,4,7,10,13,16,19-docosaheptaenoyl-CoA + NADPH + H+
(3E)-3,7,10,13,16,19-docosahexaenoyl-CoA + NADP+
-
-
-
?
2,4,7,10,13,16,19-docosaheptaenoyl-CoA + NADPH + H+
(3E)-3,7,10,13,16,19-docosahexaenoyl-CoA + NADP+
-
-
-
?
2-trans,4-cis-decadienoyl-CoA + NADPH
3-trans-decenoyl-CoA + NADP+
-
-
-
-
?
2-trans,4-cis-decadienoyl-CoA + NADPH
3-trans-decenoyl-CoA + NADP+
-
-
stereochemistry not determined
?
2-trans,4-trans-decadienoyl-CoA + NADPH
3-decenoyl-CoA + NADP+
-
-
-
?
trans-trans-2,4-hexadienoyl-CoA + NADPH
trans-3-hexenoyl-CoA + NADP+
-
reaction mechanism
-
-
?
trans-trans-2,4-hexadienoyl-CoA + NADPH
trans-3-hexenoyl-CoA + NADP+
-
substrate binding mechanism and structure
-
-
r
additional information
?
-
-
the 3',5'-ADP moiety of 2,4-dienoyl-CoA thioesters contributes a substantial part to the binding of these compounds to 2,4-dienoyl-CoA reductases
-
-
-
additional information
?
-
-
enzyme is the key enzyme of beta-oxidation of unsaturated fatty acid in mitochondria and to a lesser extent in peroxisomes, three accessory proteins are involved in the pathway
-
-
?
additional information
?
-
-
key enzyme in the beta-oxidation of unsaturated fatty acids, naturally occuring lethal enzyme deficiency
-
-
?
additional information
?
-
-
2,4-dienoyl-CoA reductase as an auxiliary enzyme in the mitochondrial beta-oxidation of unsaturated fatty acids
-
-
?
additional information
?
-
-
DECR may also play a role in the degradation of fatty acids containing odd-numbered double bonds because the intermediate 2,5-dienoyl-CoA may be isomerized by enoyl-CoA isomerase to 3,5-dienoyl-CoA and then converted to 2,4-dienoyl-CoA by a specific delta3,5,delta2,4-dienoyl-CoA isomerase
-
-
?
additional information
?
-
-
in eukaryotes, double bonds in even-numbered positions are reduced by an NADPH-dependent 2,4-dienoyl-CoA reductase to 3-enoyl-CoA, which is then isomerized by enoyl-CoA isomerase to trans-2-enoyl-CoA, suitable for further oxidation
-
-
?
additional information
?
-
products are DELTA3-enoyl-CoAs but not Delta2-enoyl-CoAs
-
-
-
