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EC 6.1.2.1 Details
EC number
6.1.2.1
Accepted name
D-alanine—(R)-lactate ligase
Reaction
D-alanine + (R)-lactate + ATP = D-alanyl-(R)-lactate + ADP + phosphate
Other name(s)
VanA, VanB, VanD
Systematic name
D-alanine:(R)-lactate ligase (ADP-forming)
Comment
The product of this enzyme, the depsipeptide D-alanyl-(R)-lactate, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4, D-alanine—D-alanine ligase. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
History
created 2010
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EC Tree
1 Oxidoreductases
2 Transferases
2.1 Transferring one-carbon groups
2.2 Transferring aldehyde or ketonic groups
2.3 Acyltransferases
2.4 Glycosyltransferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.6 Transferring nitrogenous groups
2.7 Transferring phosphorus-containing groups
2.8 Transferring sulfur-containing groups
2.8.1 Sulfurtransferases
2.8.2 Sulfotransferases
2.8.2.1 aryl sulfotransferase
2.8.2.2 alcohol sulfotransferase
2.8.2.3 amine sulfotransferase
2.8.2.4 estrone sulfotransferase
2.8.2.5 chondroitin 4-sulfotransferase
2.8.2.6 choline sulfotransferase
2.8.2.7 UDP-N-acetylgalactosamine-4-sulfate sulfotransferase
2.8.2.8 [heparan sulfate]-glucosamine N-sulfotransferase
2.8.2.9 tyrosine-ester sulfotransferase
2.8.2.10 Renilla-luciferin sulfotransferase
2.8.2.11 galactosylceramide sulfotransferase
2.8.2.12 created 1972, deleted 2001
2.8.2.13 psychosine sulfotransferase
2.8.2.14 bile-salt sulfotransferase
2.8.2.15 steroid sulfotransferase
2.8.2.16 thiol sulfotransferase
2.8.2.17 chondroitin 6-sulfotransferase
2.8.2.18 cortisol sulfotransferase
2.8.2.19 triglucosylalkylacylglycerol sulfotransferase
2.8.2.20 protein-tyrosine sulfotransferase
2.8.2.21 keratan sulfotransferase
2.8.2.22 aryl-sulfate sulfotransferase
2.8.2.23 [heparan sulfate]-glucosamine 3-sulfotransferase 1
2.8.2.24 aromatic desulfoglucosinolate sulfotransferase
2.8.2.25 flavonol 3-sulfotransferase
2.8.2.26 quercetin-3-sulfate 3′-sulfotransferase
2.8.2.27 quercetin-3-sulfate 4′-sulfotransferase
2.8.2.28 quercetin-3,3′-bissulfate 7-sulfotransferase
2.8.2.29 [heparan sulfate]-glucosamine 3-sulfotransferase 2
2.8.2.30 [heparan sulfate]-glucosamine 3-sulfotransferase 3
2.8.2.31 petromyzonol sulfotransferase
2.8.2.32 scymnol sulfotransferase
2.8.2.33 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
2.8.2.34 glycochenodeoxycholate sulfotransferase
2.8.2.35 dermatan 4-sulfotransferase
2.8.2.36 desulfo-A47934 sulfotransferase
2.8.2.37 trehalose 2-sulfotransferase
2.8.2.38 aliphatic desulfoglucosinolate sulfotransferase
2.8.2.39 hydroxyjasmonate sulfotransferase
2.8.2.40 ω-hydroxy-β-dihydromenaquinone-9 sulfotransferase
2.8.3 CoA-transferases
2.8.3.1 propionate CoA-transferase
2.8.3.2 oxalate CoA-transferase
2.8.3.3 malonate CoA-transferase
2.8.3.4 created 1961, deleted 1964
2.8.3.5 3-oxoacid CoA-transferase
2.8.3.6 3-oxoadipate CoA-transferase
2.8.3.7 succinate—citramalate CoA-transferase
2.8.3.8 acetate CoA-transferase
2.8.3.9 butyrate—acetoacetate CoA-transferase
2.8.3.10 citrate CoA-transferase
2.8.3.11 citramalate CoA-transferase
2.8.3.12 glutaconate CoA-transferase
2.8.3.13 succinate—hydroxymethylglutarate CoA-transferase
2.8.3.14 5-hydroxypentanoate CoA-transferase
2.8.3.15 succinyl-CoA:(R)-benzylsuccinate CoA-transferase
2.8.3.16 formyl-CoA transferase
2.8.3.17 3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase
2.8.3.18 succinyl-CoA:acetate CoA-transferase
2.8.3.19 CoA:oxalate CoA-transferase
2.8.3.20 succinyl-CoA—D-citramalate CoA-transferase
2.8.3.21 L-carnitine CoA-transferase
2.8.3.22 succinyl-CoA—L-malate CoA-transferase
2.8.3.23 caffeate CoA-transferase
2.8.3.24 (R)-2-hydroxy-4-methylpentanoate CoA-transferase
2.8.3.25 bile acid CoA-transferase
2.8.3.26 succinyl-CoA:mesaconate CoA transferase
2.8.3.27 propanoyl-CoA:succinate CoA transferase
2.8.3.28 phenylsuccinyl-CoA transferase
2.8.4 Transferring alkylthio groups
2.8.5 Thiosulfotransferases
2.9 Transferring selenium-containing groups
2.10 Transferring molybdenum- or tungsten-containing groups
3 Hydrolases
4 Lyases
5 Isomerases
6 Ligases
7 Translocases