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EC 4.2.1.24 Details
EC number
4.2.1.24
Accepted name
porphobilinogen synthase
Reaction
2 5-aminolevulinate = porphobilinogen + 2 H2O
Other name(s)
aminolevulinate dehydratase, δ-aminolevulinate dehydratase, δ-aminolevulinic acid dehydrase, δ-aminolevulinic acid dehydratase, aminolevulinic dehydratase, δ-aminolevulinic dehydratase, 5-levulinic acid dehydratase, 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing), hemB (gene name)
Systematic name
5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)
CAS registry number
9036-37-7
Comment
The enzyme catalyses the asymmetric condensation and cyclization of two 5-aminolevulinate molecules, which is the first common step in the biosynthesis of tetrapyrrole pigments such as porphyrin, chlorophyll, vitamin B12, siroheme, phycobilin, and cofactor F430. The enzyme is widespread, being essential in organisms that carry out respiration, photosynthesis, or methanogenesis. The enzymes from most organisms utilize metal ions (Zn2+, Mg2+, K+, and Na+) as cofactors that reside at multiple sites, including the active site and allosteric sites. Enzymes from archaea, yeast, and metazoa (including human) contain Zn2+ at the active site. In humans, the enzyme is a primary target for the environmental toxin Pb. The enzymes from some organisms utilize a dynamic equilibrium between architecturally distinct multimeric assemblies as a means for allosteric regulation.
History
created 1961
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
4 Lyases
4.1 Carbon-carbon lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.1 carbonic anhydrase
4.2.1.2 fumarate hydratase
4.2.1.3 aconitate hydratase
4.2.1.4 citrate dehydratase
4.2.1.5 arabinonate dehydratase
4.2.1.6 galactonate dehydratase
4.2.1.7 altronate dehydratase
4.2.1.8 mannonate dehydratase
4.2.1.9 dihydroxy-acid dehydratase
4.2.1.10 3-dehydroquinate dehydratase
4.2.1.11 phosphopyruvate hydratase
4.2.1.12 phosphogluconate dehydratase
4.2.1.13 created 1961, deleted 2001
4.2.1.14 created 1961, deleted 2001
4.2.1.15 created 1961, deleted 1972
4.2.1.16 created 1961, deleted 2001
4.2.1.17 enoyl-CoA hydratase
4.2.1.18 methylglutaconyl-CoA hydratase
4.2.1.19 imidazoleglycerol-phosphate dehydratase
4.2.1.20 tryptophan synthase
4.2.1.21 created 1961, deleted 1964
4.2.1.22 cystathionine β-synthase
4.2.1.23 created 1961, deleted 1972
4.2.1.24 porphobilinogen synthase
4.2.1.25 L-arabinonate dehydratase
4.2.1.26 created 1965, deleted 2002
4.2.1.27 acetylenecarboxylate hydratase
4.2.1.28 propanediol dehydratase
4.2.1.29 created 1965, deleted 2004
4.2.1.30 glycerol dehydratase
4.2.1.31 maleate hydratase
4.2.1.32 L(+)-tartrate dehydratase
4.2.1.33 3-isopropylmalate dehydratase
4.2.1.34 (S)-2-methylmalate dehydratase
4.2.1.35 (R)-2-methylmalate dehydratase
4.2.1.36 homoaconitate hydratase
4.2.1.37 created 1972, deleted 1992
4.2.1.38 created 1972, deleted 2001
4.2.1.39 gluconate dehydratase
4.2.1.40 glucarate dehydratase
4.2.1.41 5-dehydro-4-deoxyglucarate dehydratase
4.2.1.42 galactarate dehydratase
4.2.1.43 2-dehydro-3-deoxy-L-arabinonate dehydratase
4.2.1.44 myo-inosose-2 dehydratase
4.2.1.45 CDP-glucose 4,6-dehydratase
4.2.1.46 dTDP-glucose 4,6-dehydratase
4.2.1.47 GDP-mannose 4,6-dehydratase
4.2.1.48 D-glutamate cyclase
4.2.1.49 urocanate hydratase
4.2.1.50 pyrazolylalanine synthase
4.2.1.51 prephenate dehydratase
4.2.1.52 dihydrodipicolinate synthase
4.2.1.53 oleate hydratase
4.2.1.54 lactoyl-CoA dehydratase
4.2.1.55 3-hydroxybutyryl-CoA dehydratase
4.2.1.56 itaconyl-CoA hydratase
4.2.1.57 isohexenylglutaconyl-CoA hydratase
4.2.1.58 crotonoyl-[acyl-carrier-protein] hydratase
4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
4.2.1.60 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
4.2.1.61 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase
4.2.1.62 5α-hydroxysteroid dehydratase
4.2.1.63 created 1972, deleted 1978
4.2.1.64 created 1972, deleted 1978
4.2.1.65 3-cyanoalanine hydratase
4.2.1.66 cyanide hydratase
4.2.1.67 D-fuconate dehydratase
4.2.1.68 L-fuconate dehydratase
4.2.1.69 cyanamide hydratase
4.2.1.70 pseudouridylate synthase
4.2.1.71 created 1978, modified 1989, modified 2000, deleted 2004
4.2.1.72 created 1978, deleted 2000
4.2.1.73 protoaphin-aglucone dehydratase (cyclizing)
4.2.1.74 medium-chain-enoyl-CoA hydratase
4.2.1.75 uroporphyrinogen-III synthase
4.2.1.76 UDP-glucose 4,6-dehydratase
4.2.1.77 trans-L-3-hydroxyproline dehydratase
4.2.1.78 (S)-norcoclaurine synthase
4.2.1.79 2-methylcitrate dehydratase
4.2.1.80 2-oxopent-4-enoate hydratase
4.2.1.81 D(-)-tartrate dehydratase
4.2.1.82 xylonate dehydratase
4.2.1.83 4-oxalomesaconate hydratase
4.2.1.84 nitrile hydratase
4.2.1.85 dimethylmaleate hydratase
4.2.1.86 created 1989, deleted 2004
4.2.1.87 octopamine dehydratase
4.2.1.88 synephrine dehydratase
4.2.1.89 carnitine dehydratase
4.2.1.90 L-rhamnonate dehydratase
4.2.1.91 arogenate dehydratase
4.2.1.92 hydroperoxide dehydratase
4.2.1.93 ATP-dependent NAD(P)H-hydrate dehydratase
4.2.1.94 scytalone dehydratase
4.2.1.95 kievitone hydratase
4.2.1.96 4a-hydroxytetrahydrobiopterin dehydratase
4.2.1.97 phaseollidin hydratase
4.2.1.98 16α-hydroxyprogesterone dehydratase
4.2.1.99 2-methylisocitrate dehydratase
4.2.1.100 cyclohexa-1,5-dienecarbonyl-CoA hydratase
4.2.1.101 trans-feruloyl-CoA hydratase
4.2.1.102 created 2001, deleted 2001
4.2.1.103 cyclohexyl-isocyanide hydratase
4.2.1.104 cyanase
4.2.1.105 2-hydroxyisoflavanone dehydratase
4.2.1.106 bile-acid 7α-dehydratase
4.2.1.107 3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA hydratase
4.2.1.108 ectoine synthase
4.2.1.109 methylthioribulose 1-phosphate dehydratase
4.2.1.110 aldos-2-ulose dehydratase
4.2.1.111 1,5-anhydro-D-fructose dehydratase
4.2.1.112 acetylene hydratase
4.2.1.113 o-succinylbenzoate synthase
4.2.1.114 methanogen homoaconitase
4.2.1.115 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting)
4.2.1.116 3-hydroxypropionyl-CoA dehydratase
4.2.1.117 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
4.2.1.118 3-dehydroshikimate dehydratase
4.2.1.119 enoyl-CoA hydratase 2
4.2.1.120 4-hydroxybutanoyl-CoA dehydratase
4.2.1.121 colneleate synthase
4.2.1.122 tryptophan synthase (indole-salvaging)
4.2.1.123 tetrahymanol synthase
4.2.1.124 arabidiol synthase
4.2.1.125 dammarenediol II synthase
4.2.1.126 N-acetylmuramic acid 6-phosphate etherase
4.2.1.127 linalool dehydratase
4.2.1.128 lupan-3β,20-diol synthase
4.2.1.129 squalene—hopanol cyclase
4.2.1.130 D-lactate dehydratase
4.2.1.131 carotenoid 1,2-hydratase
4.2.1.132 2-hydroxyhexa-2,4-dienoate hydratase
4.2.1.133 copal-8-ol diphosphate hydratase
4.2.1.134 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
4.2.1.135 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)
4.2.1.136 ADP-dependent NAD(P)H-hydrate dehydratase
4.2.1.137 sporulenol synthase
4.2.1.138 (+)-caryolan-1-ol synthase
4.2.1.139 pterocarpan synthase
4.2.1.140 gluconate/galactonate dehydratase
4.2.1.141 2-dehydro-3-deoxy-D-arabinonate dehydratase
4.2.1.142 5′-oxoaverantin cyclase
4.2.1.143 versicolorin B synthase
4.2.1.144 3-amino-5-hydroxybenzoate synthase
4.2.1.145 capreomycidine synthase
4.2.1.146 L-galactonate dehydratase
4.2.1.147 5,6,7,8-tetrahydromethanopterin hydro-lyase
4.2.1.148 2-methylfumaryl-CoA hydratase
4.2.1.149 crotonobetainyl-CoA hydratase
4.2.1.150 short-chain-enoyl-CoA hydratase
4.2.1.151 chorismate dehydratase
4.2.1.152 hydroperoxy icosatetraenoate dehydratase
4.2.1.153 3-methylfumaryl-CoA hydratase
4.2.1.154 tetracenomycin F2 cyclase
4.2.1.155 (methylthio)acryloyl-CoA hydratase
4.2.1.156 L-talarate dehydratase
4.2.1.157 (R)-2-hydroxyisocaproyl-CoA dehydratase
4.2.1.158 galactarate dehydratase (D-threo-forming)
4.2.1.159 dTDP-4-dehydro-6-deoxy-α-D-glucopyranose 2,3-dehydratase
4.2.1.160 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase
4.2.1.161 bisanhydrobacterioruberin hydratase
4.2.1.162 6-deoxy-6-sulfo-D-gluconate dehydratase
4.2.1.163 2-oxo-hept-4-ene-1,7-dioate hydratase
4.2.1.164 dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase
4.2.1.165 chlorophyllide a 31-hydratase
4.2.1.166 phosphinomethylmalate isomerase
4.2.1.167 (R)-2-hydroxyglutaryl-CoA dehydratase
4.2.1.168 GDP-4-dehydro-6-deoxy-α-D-mannose 3-dehydratase
4.2.1.169 3-vinyl bacteriochlorophyllide d 31-hydratase
4.2.1.170 2-(ω-methylthio)alkylmalate dehydratase
4.2.1.171 cis-L-3-hydroxyproline dehydratase
4.2.1.172 trans-4-hydroxy-L-proline dehydratase
4.2.1.173 ent-8α-hydroxylabd-13-en-15-yl diphosphate synthase
4.2.1.174 peregrinol diphosphate synthase
4.2.1.175 (R)-3-(aryl)lactoyl-CoA dehydratase
4.2.1.176 L-lyxonate dehydratase
4.2.1.177 (2S)-3-sulfopropanediol dehydratase
4.2.1.178 difructose-dianhydride-III synthase
4.2.1.179 difructose-anhydride-I synthase
4.2.1.180 (E)-benzylidenesuccinyl-CoA hydratase
4.2.2 Acting on polysaccharides
4.2.3 Acting on phosphates
4.2.99 Other carbon-oxygen lyases
4.3 Carbon-nitrogen lyases
4.4 Carbon-sulfur lyases
4.5 Carbon-halide lyases
4.6 Phosphorus-oxygen lyases
4.7 carbon-phosphorus lyases
4.8 Nitrogen-oxygen lyases
4.98 ATP-independent chelatases
4.99 Other lyases
5 Isomerases
6 Ligases
6.1 Forming carbon-oxygen bonds
6.2 Forming carbon-sulfur bonds
6.3 Forming carbon-nitrogen bonds
6.4 Forming carbon-carbon bonds
6.5 Forming phosphoric-ester bonds
6.6 Forming nitrogen—metal bonds
6.7 Forming nitrogen-nitrogen bonds
7 Translocases