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Information on EC 1.11.1.17 - glutathione amide-dependent peroxidase

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EC Tree
     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.17 glutathione amide-dependent peroxidase
IUBMB Comments
This enzyme, which has been characterized from the proteobacterium Marichromatium gracile, is a chimeric protein, containing a peroxiredoxin-like N-terminus and a glutaredoxin-like C terminus. The enzyme has peroxidase activity towards hydrogen peroxide and several small alkyl hydroperoxides, and is thought to represent an early adaptation for fighting oxidative stress . The glutathione amide disulfide produced by this enzyme can be restored to glutathione amide by EC 1.8.1.16 (glutathione amide reductase).
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The expected taxonomic range for this enzyme is: Marichromatium gracile
Synonyms
garB, More, Prx-containing peroxidase, Prx/Grx chimeric enzyme, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 glutathione amide + H2O2 = glutathione amide disulfide + 2 H2O
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PATHWAY SOURCE
PATHWAYS
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