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Information on EC 1.14.13.120 - costunolide synthase for references in articles please use BRENDA:EC1.14.13.120
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EC Tree
Synonyms
CcaCOS, COS, CYP71Bl5,
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COS
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germacra-1(10),4,11(13)-trien-12-oate + NADPH + H+ + O2
(+)-costunolide + NADP+ + 2 H2O
germacra-1(10),4,11(13)-trien-12-oate + NADPH + H+ + O2
(+)-costunolide + NADP+ + 2 H2O
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germacra-1(10),4,11(13)-trien-12-oate + NADPH + H+ + O2
(+)-costunolide + NADP+ + 2 H2O
hydroxylase reaction
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germacra-1(10),4,11(13)-trien-12-oate + NADPH + H+ + O2
(+)-costunolide + NADP+ + 2 H2O
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?
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germacra-1(10),4,11(13)-trien-12-oate + NADPH + H+ + O2
(+)-costunolide + NADP+ + 2 H2O
germacra-1(10),4,11(13)-trien-12-oate + NADPH + H+ + O2
(+)-costunolide + NADP+ + 2 H2O
A0A059WMF6
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germacra-1(10),4,11(13)-trien-12-oate + NADPH + H+ + O2
(+)-costunolide + NADP+ + 2 H2O
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Mg2+
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required for parthenolide biosynthesis in plants, activates the enzyme
Mn2+
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required for parthenolide biosynthesis in plants, activates the enzyme
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UniProt
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cv. Zardband
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metabolism
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the enzyme is one of the key players in the parthenolide biosynthesis, pathway overview
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COS expression analysis in plants with Mg2+ or Mn2+ feeding or without, overview
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gene CYP71Bl5, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, transient expression in Nicotiana benthamiana leaves via Agrobacterium tumefaciens strain AGL0 electrotransformation leading to production of costunolide in tabacco leaves determined as costunolide-cysteine and costunolide-glutathione
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Farzadfar, S.; Zarinkamar, F.; Behmanesh, M.; Hojati, M.
Magnesium and manganese interactively modulate parthenolide accumulation and the antioxidant defense system in the leaves of Tanacetum parthenium
J. Plant Physiol.
202
10-20
2016
Tanacetum parthenium
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Eljounaidi, K.; Cankar, K.; Comino, C.; Moglia, A.; Hehn, A.; Bourgaud, F.; Bouwmeester, H.; Menin, B.; Lanteri, S.; Beekwilder, J.
Cytochrome P450s from Cynara cardunculus L. CYP71AV9 and CYP71BL5, catalyze distinct hydroxylations in the sesquiterpene lactone biosynthetic pathway
Plant Sci.
223
59-68
2014
Cynara cardunculus var. altilis (A0A059WMF6)
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