Information on EC 1.14.13.120 - costunolide synthase

for references in articles please use BRENDA:EC1.14.13.120
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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.14.13.120
transgferred to EC 1.14.14.150
RECOMMENDED NAME
GeneOntology No.
costunolide synthase
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Sesquiterpenoid and triterpenoid biosynthesis
-
-
Biosynthesis of secondary metabolites
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
cv. Zardband
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
-
the enzyme is one of the key players in the parthenolide biosynthesis, pathway overview
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
germacra-1(10),4,11(13)-trien-12-oate + NADPH + H+ + O2
(+)-costunolide + NADP+ + 2 H2O
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
germacra-1(10),4,11(13)-trien-12-oate + NADPH + H+ + O2
(+)-costunolide + NADP+ + 2 H2O
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
required for parthenolide biosynthesis in plants, activates the enzyme
Mn2+
-
required for parthenolide biosynthesis in plants, activates the enzyme
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
COS expression analysis in plants with Mg2+ or Mn2+ feeding or without, overview
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gene CYP71Bl5, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, transient expression in Nicotiana benthamiana leaves via Agrobacterium tumefaciens strain AGL0 electrotransformation leading to production of costunolide in tabacco leaves determined as costunolide-cysteine and costunolide-glutathione