Reference on EC 3.1.1.25 - 1,4-lactonase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fishbein, W.N.; Bessman, S.P.
Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of gamma-lactones. I. Tissue localization, stoichiometry, specificity, distinction from esterase
J. Biol. Chem.
241
4835-4841
1966
Homo sapiens, Rattus norvegicus
Fishbein, W.N.; Bessman, S.P.
Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of gamma-lactones. II. Metal ion effects, kinetics, and equilibria
J. Biol. Chem.
241
4842-4847
1966
Homo sapiens, Rattus norvegicus
Rodrigo, L.; Gil, F.; Hernandez, A.F.; Lopez, O.; Pla, A.
Identification of paraoxonase 3 in rat liver microsomes: purification and biochemical properties
Biochem. J.
376
261-268
2003
Rattus norvegicus (Q68FP2)
Kataoka, M.; Nomura, J.I.; Shinohara, M.; Nose, K.; Sakamoto, K.; Shimizu, S.
Purification and characterization of a novel lactonohydrolase from Agrobacterium tumefaciens
Biosci. Biotechnol. Biochem.
64
1255-1262
2000
Agrobacterium tumefaciens, Agrobacterium tumefaciens AKU 316
Billecke, S.; Draganov, D.; Counsell, R.; Stetson, P.; Watson, C.; Hsu, C.; La Du, B.N.
Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters
Drug Metab. Dispos.
28
1335-1342
2000
Homo sapiens (P27169)
Simizu, S.; Ogawa, J.; Kataoka, M.; Kobayashi, M.
Screening of novel microbial enzymes for the production of biologically and chemically useful compounds
New Enzymes for Organic Synthesis
1
45-88
1997
Fusarium oxysporum
-
Lu, H.; Zhu, J.; Zang, Y.; Ze, Y.; Qin, J.
Cloning, high level expression of human paraoxonase-3 in Sf9 cells and pharmacological characterization of its product
Biochem. Pharmacol.
70
1019-1025
2005
Homo sapiens (Q15166)
Gaidukov, L.; Tawfik, D.S.
High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I
Biochemistry
44
11843-11854
2005
Homo sapiens (P27169)
Khersonsky, O.; Tawfik, D.S.
Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase
Biochemistry
44
6371-6382
2005
Homo sapiens (P27169)
Thomas, P.W.; Stone, E.M.; Costello, A.L.; Tierney, D.L.; Fast, W.
The quorum-quenching lactonase from Bacillus thuringiensis is a metalloprotein
Biochemistry
44
7559-7569
2005
Bacillus thuringiensis serovar kurstaki (P0CJ63), Bacillus thuringiensis serovar kurstaki 4A3 (P0CJ63)
Khersonsky, O.; Tawfik, D.S.
The histidine 115-histidine 134 dyad mediates the lactonase activity of mammalian serum paraoxonases
J. Biol. Chem.
281
7649-7656
2006
Homo sapiens (P27169), Oryctolagus cuniculus (Q9BGN0)
Draganov, D.I.; Teiber, J.F.; Speelman, A.; Osawa, Y.; Sunahara, R.; La Du, B.N.
Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities
J. Lipid Res.
46
1239-1247
2005
Homo sapiens (P27169), Homo sapiens (Q15165), Homo sapiens (Q15166)
Lu, H.; Zhu, J.; Zang, Y.; Ze, Y.; Qin, J.
Cloning, purification, and refolding of human paraoxonase-3 expressed in Escherichia coli and its characterization
Protein Expr. Purif.
46
92-99
2006
Homo sapiens (Q15166)
Zhang, X.; Xu, J.H.; Xu, Y.; Pan, J.
Isolation and properties of a levo-lactonase from Fusarium proliferatum ECU2002: a robust biocatalyst for production of chiral lactones
Appl. Microbiol. Biotechnol.
75
1087-1094
2007
Fusarium proliferatum
Gaidukov, L.; Tawfik, D.S.
The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity
J. Lipid Res.
48
1637-1646
2007
Homo sapiens (P27169)
Tavori, H.; Khatib, S.; Aviram, M.; Vaya, J.
Characterization of the PON1 active site using modeling simulation, in relation to PON1 lactonase activity
Bioorg. Med. Chem.
16
7504-7509
2008
Homo sapiens (P27169)
Rozenberg, O.; Shiner, M.; Aviram, M.; Hayek, T.
Paraoxonase 1 (PON1) attenuates diabetes development in mice through its antioxidative properties
Free Radic. Biol. Med.
44
1951-1959
2008
Mus musculus (P52430)
Liu, Y.; Mackness, B.; Mackness, M.
Comparison of the ability of paraoxonases 1 and 3 to attenuate the in vitro oxidation of low-density lipoprotein and reduce macrophage oxidative stress
Free Radic. Biol. Med.
45
743-748
2008
Homo sapiens (Q15166)
Rock, W.; Rosenblat, M.; Miller-Lotan, R.; Levy, A.P.; Elias, M.; Aviram, M.
Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities
J. Agric. Food Chem.
56
8704-8713
2008
Homo sapiens (P27169)
Stoltz, D.A.; Ozer, E.A.; Taft, P.J.; Barry, M.; Liu, L.; Kiss, P.J.; Moninger, T.O.; Parsek, M.R.; Zabner, J.
Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1
J. Clin. Invest.
118
3123-3131
2008
Homo sapiens (P27169)
Hu, X.; Jiang, X.; Lenz, D.E.; Cerasoli, D.M.; Wallqvist, A.
In silico analyses of substrate interactions with human serum paraoxonase 1
Proteins
75
486-498
2009
Homo sapiens
Nguyen, S.D.; Hung, N.D.; Cheon-Ho, P.; Ree, K.M.; Dai-Eun, S.
Oxidative inactivation of lactonase activity of purified human paraoxonase 1 (PON1)
Biochim. Biophys. Acta
1790
155-160
2009
Homo sapiens
Renault, F.; Carus, T.; Clery-Barraud, C.; Elias, M.; Chabriere, E.; Masson, P.; Rochu, D.
Integrative analytical approach by capillary electrophoresis and kinetics under high pressure optimized for deciphering intrinsic and extrinsic cofactors that modulate activity and stability of human paraoxonase (PON1)
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
878
1346-1355
2010
Homo sapiens, synthetic construct
Chen, B.; Fan, L.; Xu, J.; Zhao, J.; Zhang, X.; Ouyang, L.
Biocatalytic properties of a recombinant Fusarium proliferatum lactonase with significantly enhanced production by optimal expression in Escherichia coli
Appl. Biochem. Biotechnol.
162
744-756
2010
Fusarium proliferatum (B2LYJ5), Fusarium proliferatum
Chen, B.; Yin, H.F.; Wang, Z.S.; Liu, J.Y.; Xu, J.H.
A new chemo-enzymatic route to chiral 2-hydroxy-4-phenylbutyrates by combining lactonase-mediated resolution with hydrogenation over Pd/C
Chem. Commun. (Camb. )
46
2754-2756
2010
Fusarium proliferatum
Bayrak, A.; Bayrak, T.; Demirpence, E.; Kilinc, K.
Differential hydrolysis of homocysteine thiolactone by purified human serum (192)Q and (192)R PON1 isoenzymes
J. Chromatogr. B
879
49-55
2011
Homo sapiens
Chen, B.; Yin, H.; Wang, Z.; Xu, J.
New synthesis of harzialactone A via kinetic resolution using recombinant Fusarium proliferatum lactonase
Tetrahedron Asymmetry
21
237-240
2010
Fusarium proliferatum
-
Porzio, E.; Di, Gennaro, S.; Palma, A.; Manco, G.
Mn2+ modulates the kinetic properties of an archaeal member of the PLL family
Chem. Biol. Interact.
203
251-256
2013
Sulfolobus acidocaldarius
Hiblot, J.; Gotthard, G.; Chabriere, E.; Elias, M.
Structural and enzymatic characterization of the lactonase SisLac from Sulfolobus islandicus
PLoS One
7
e47028
2012
Sulfolobus islandicus (C4KKZ9), Sulfolobus islandicus M.16.4 (C4KKZ9)
Hiblot, J.; Gotthard, G.; Elias, M.; Chabriere, E.
Differential active site loop conformations mediate promiscuous activities in the lactonase SsoPox
PLoS One
8
e75272
2013
Saccharolobus solfataricus (Q97VT7), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97VT7)
Hiblot, J.; Gotthard, G.; Champion, C.; Chabriere, E.; Elias, M.
Crystallization and preliminary X-ray diffraction analysis of the lactonase VmoLac from Vulcanisaeta moutnovskia
Acta Crystallogr. Sect. F
69
1235-1238
2013
Vulcanisaeta moutnovskia (F0QXN6), Vulcanisaeta moutnovskia, Vulcanisaeta moutnovskia 768-28 (F0QXN6)
Bajaj, P.; Aggarwal, G.; Tripathy, R.K.; Pande, A.H.
Interplay between amino acid residues at positions 192 and 115 in modulating hydrolytic activities of human paraoxonase 1
Biochimie
105
202-210
2014
Homo sapiens (P27169)
Rosenblat, M.; Ward, S.; Volkova, N.; Hayek, T.; Aviram, M.
VLDL triglycerides inhibit HDL-associated paraoxonase 1 (PON1) activity: in vitro and in vivo studies
Biofactors
38
292-299
2012
Homo sapiens
Bzdrenga, J.; Hiblot, J.; Gotthard, G.; Champion, C.; Elias, M.; Chabriere, E.
SacPox from the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius is a proficient lactonase
BMC Res. Notes
7
333
2014
Sulfolobus acidocaldarius (Q4J6Z8), Sulfolobus acidocaldarius DSM 639 (Q4J6Z8)
Kallnik, V.; Bunescu, A.; Sayer, C.; Brsen, C.; Wohlgemuth, R.; Littlechild, J.; Siebers, B.
Characterization of a phosphotriesterase-like lactonase from the hyperthermoacidophilic crenarchaeon Vulcanisaeta moutnovskia
J. Biotechnol.
190
11-17
2014
Vulcanisaeta moutnovskia (F0QXN6), Vulcanisaeta moutnovskia
Ben-David, M.; Elias, M.; Filippi, J.J.; Dunach, E.; Silman, I.; Sussman, J.L.; Tawfik, D.S.
Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1
J. Mol. Biol.
418
181-196
2012
synthetic construct
Charendoff, M.; Shah, H.; Briggs, J.
New insights into the binding and catalytic mechanisms of Bacillus thuringiensis lactonase: insights into B. thuringiensis AiiA mechanism
PLoS ONE
8
e75395
2013
Bacillus thuringiensis (P0CJ63)
Bajaj, P.; Tripathy, R.K.; Aggarwal, G.; Pande, A.H.
Characterization of human paraoxonase 1 variants suggest that His residues at 115 and 134 positions are not always needed for the lactonase/arylesterase activities of the enzyme
Protein Sci.
22
1799-1807
2013
Homo sapiens (P27169)
Hiblot, J.; Bzdrenga, J.; Champion, C.; Chabriere, E.; Elias, M.
Crystal structure of VmoLac, a tentative quorum quenching lactonase from the extremophilic crenarchaeon Vulcanisaeta moutnovskia
Sci. Rep.
5
8372
2015
Vulcanisaeta moutnovskia (F0QXN6), Vulcanisaeta moutnovskia, Vulcanisaeta moutnovskia 768-28 (F0QXN6)
Tripathy, R.K.; Aggarwal, G.; Bajaj, P.; Kathuria, D.; Bharatam, P.V.; Pande, A.H.
Towards understanding the catalytic mechanism of human paraoxonase 1 experimental and in silico mutagenesis studies
Appl. Biochem. Biotechnol.
182
1642-1662
2017
Homo sapiens
Solmaz Avcikurt, A.; Korkut, O.
Effect of certain non-steroidal anti-inflammatory drugs on the paraoxonase 2 (PON2) in human monocytic cell line U937
Arch. Physiol. Biochem.
124
378-382
2018
Homo sapiens
Arulkumar, M.; Vijayan, R.; Penislusshiyan, S.; Sathishkumar, P.; Angayarkanni, J.; Palvannan, T.
Alteration of paraoxonase, arylesterase and lactonase activities in people around fluoride endemic area of Tamil Nadu, India
Clin. Chim. Acta
471
206-215
2017
Homo sapiens
Bizon, A.; Milnerowicz, H.
The effect of divalent metal chelators and cadmium on serum phosphotriesterase, lactonase and arylesterase activities of paraoxonase 1
Environ. Toxicol. Pharmacol.
58
77-83
2018
Homo sapiens
Zhang, Y.; Liu, H.; He, J.; Xu, K.; Bai, H.; Wang, Y.; Zhang, F.; Zhang, J.; Cheng, L.; Fan, P.
Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome
Eur. J. Endocrinol.
172
391-402
2015
Homo sapiens
Perla-Kajan, J.; Borowczyk, K.; Glowacki, R.; Nygard, O.; Jakubowski, H.
Paraoxonase 1 Q192R genotype and activity affect homocysteine thiolactone levels in humans
FASEB J.
32
6019
2018
Homo sapiens
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