Disease on EC 3.4.22.28 - picornain 3C
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DISEASE 
TITLE OF PUBLICATION
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Arteritis
Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design.
Bronchitis
Association of the infectious bronchitis virus 3c protein with the virion envelope.
Bronchitis
Proteolytic processing of the coronavirus infectious bronchitis virus 1a polyprotein: identification of a 10-kilodalton polypeptide and determination of its cleavage sites.
Common Cold
Structure-activity relationships of heteroaromatic esters as human rhinovirus 3C protease inhibitors.
COVID-19
Shape-based Machine Learning Models for the Potential Novel COVID-19 Protease Inhibitors Assisted by Molecular Dynamics Simulation
Dengue
Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design.
Encephalomyelitis
Expression of Theiler's murine encephalomyelitis virus protease 3C and polymerase 3D in Escherichia coli and characterization of monospecific sera.
Feline Infectious Peritonitis
3C protein of feline coronavirus inhibits viral replication independently of the autophagy pathway.
Foot-and-Mouth Disease
A Recombinant Adenovirus Expressing P12A and 3C Protein of the Type O Foot-and-Mouth Disease Virus Stimulates Systemic and Mucosal Immune Responses in Mice.
Foot-and-Mouth Disease
Development of transgenic alfalfa plants containing the foot and mouth disease virus structural polyprotein gene P1 and its utilization as an experimental immunogen.
Foot-and-Mouth Disease
FMD subunit vaccine produced using a silkworm-baculovirus expression system: Protective efficacy against two type Asia1 isolates in cattle.
Foot-and-Mouth Disease
Foliar extracts from transgenic tomato plants expressing the structural polyprotein, P1-2A, and protease, 3C, from foot-and-mouth disease virus elicit a protective response in guinea pigs.
Foot-and-Mouth Disease
Foot-and-mouth disease virus induces lysosomal degradation of host protein kinase PKR by 3C proteinase to facilitate virus replication.
Foot-and-Mouth Disease
Foot-and-mouth disease virus protease 3C induces specific proteolytic cleavage of host cell histone H3.
Foot-and-Mouth Disease
Foot-and-mouth disease virus protease 3C inhibits cellular transcription and mediates cleavage of histone H3.
Foot-and-Mouth Disease
Identification of the active-site residues of the 3C proteinase of foot-and-mouth disease virus.
Foot-and-Mouth Disease
Immune responses and protection against foot-and-mouth disease virus (FMDV) challenge in swine vaccinated with adenovirus-FMDV constructs.
Foot-and-Mouth Disease
Immunopotentiation of a foot-and-mouth disease virus subunit vaccine by interferon alpha.
Foot-and-Mouth Disease
Rapid protection of cattle from direct challenge with foot-and-mouth disease virus (FMDV) by a single inoculation with an adenovirus-vectored FMDV subunit vaccine.
Foot-and-Mouth Disease
Role of RNA structure and RNA binding activity of foot-and-mouth disease virus 3C protein in VPg uridylylation and virus replication.
Foot-and-Mouth Disease
Synthesis of empty capsid-like particles of Asia I foot-and-mouth disease virus in insect cells and their immunogenicity in guinea pigs.
Foot-and-Mouth Disease
The DDX23 Negatively Regulates Translation and Replication of Foot-and-Mouth Disease Virus and Is Degraded by 3C Proteinase.
Foot-and-Mouth Disease
Translation driven by picornavirus IRES is hampered from Sindbis virus replicons: rescue by poliovirus 2A protease.
Foot-and-Mouth Disease
[Screening and stability of Madin-Darby bovine kidney cell strain co-expressing the capsid precursor protein P1-2A gene and the protease 3C gene of foot-and-mouth disease virus]
Foot-and-Mouth Disease
[Use of protease 3c and foot-and-mouth disease virus RNA polymerase hybrid proteins, synthesized in Escherichia coli, for diagnosis]
Hand, Foot and Mouth Disease
Caspase-3 Inhibition Attenuates the Cytopathic Effects of EV71 Infection.
Hepatitis A
A comparative volatilomic characterization of Florence fennel from different locations: antiviral prospects.
Hepatitis A
A rapid method for determination of endoproteinase substrate specificity: specificity of the 3C proteinase from hepatitis A virus.
Hepatitis A
Active site properties of the 3C proteinase from hepatitis A virus (a hybrid cysteine/serine protease) probed by Raman spectroscopy.
Hepatitis A
An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors.
Hepatitis A
Antiviral potential of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea.
Hepatitis A
Beta-lactones as a new class of cysteine proteinase inhibitors: inhibition of hepatitis A virus 3C proteinase by N-Cbz-serine beta-lactone.
Hepatitis A
Cleavage specificity of purified recombinant hepatitis A virus 3C proteinase on natural substrates.
Hepatitis A
Crystal structure of an inhibitor complex of the 3C proteinase from hepatitis A virus (HAV) and implications for the polyprotein processing in HAV.
Hepatitis A
Detection of antibodies to the nonstructural 3C proteinase of hepatitis A virus.
Hepatitis A
Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site.
Hepatitis A
Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design.
Hepatitis A
Genetic heterogeneity in the foot-and-mouth disease virus Leader and 3C proteinases.
Hepatitis A
Hepatitis A virus 3C proteinase: some properties, crystallization and preliminary crystallographic characterization.
Hepatitis A
Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: Evaluation of mode of action.
Hepatitis A
Identification of active-site residues in protease 3C of hepatitis A virus by site-directed mutagenesis.
Hepatitis A
Identification of hepatitis A virus non-structural protein 2B and its release by the major virus protease 3C.
Hepatitis A
In vitro and ex vivo inhibition of hepatitis A virus 3C proteinase by a peptidyl monofluoromethyl ketone.
Hepatitis A
Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases.
Hepatitis A
Protease 3C of hepatitis A virus induces vacuolization of lysosomal/endosomal organelles and caspase-independent cell death.
Hepatitis A
Structural variations in keto-glutamines for improved inhibition against hepatitis A virus 3C proteinase.
Hepatitis A
Synthesis and evaluation of keto-glutamine analogues as inhibitors of hepatitis A virus 3C proteinase.
Hepatitis A
Synthesis and testing of azaglutamine derivatives as inhibitors of hepatitis A virus (HAV) 3C proteinase.
Hepatitis A
The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition.
Hepatitis C
Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design.
Herpes Simplex
Antiviral potential of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea.
Infections
Biochemical characterization of recombinant Avihepatovirus 3C protease and its localization.
Infections
Comparison of Strategies for the Production of FMDV Empty Capsids Using the Baculovirus Vector System.
Infections
Cytoplasmic translocation, aggregation, and cleavage of TDP-43 by enteroviral proteases modulate viral pathogenesis.
Infections
Downregulation of microRNA miR-526a by enterovirus inhibits RIG-I-dependent innate immune response.
Infections
Expression of foot and mouth disease virus non-structural polypeptide 3ABC induces histone H3 cleavage in BHK21 cells.
Infections
Feline Calicivirus Infection Disrupts Assembly of Cytoplasmic Stress Granules and Induces G3BP1 Cleavage.
Infections
Long-Range Communication between Different Functional Sites in the Picornaviral 3C Protein.
Infections
Nuclear entry of poliovirus protease-polymerase precursor 3CD: implications for host cell transcription shut-off.
Infections
Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death.
Infections
Shape-based Machine Learning Models for the Potential Novel COVID-19 Protease Inhibitors Assisted by Molecular Dynamics Simulation
Infections
The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses.
Infections
The Stress Granule Protein G3BP1 Recruits Protein Kinase R To Promote Multiple Innate Immune Antiviral Responses.
Infections
[Progress in Research on Structure, Function and Antiviral of Enterovirus A71 3C Protein].
Mouth Diseases
Development of transgenic alfalfa plants containing the foot and mouth disease virus structural polyprotein gene P1 and its utilization as an experimental immunogen.
Myocarditis
Coxsackievirus B3 protease 3C: expression, purification, crystallization and preliminary structural insights.
Neoplasms
Poliovirus 3C protease-mediated degradation of transcriptional activator p53 requires a cellular activity.
Paramyxoviridae Infections
Evidence for phosphorylation of human parainfluenza virus type 3C protein: mutant C proteins exhibit variable inhibitory activities in vitro.
Peritonitis
3C protein of feline coronavirus inhibits viral replication independently of the autophagy pathway.
Vaccinia
Identification and site-directed mutagenesis of the primary (2A/2B) cleavage site of the hepatitis A virus polyprotein: functional impact on the infectivity of HAV RNA transcripts.
Vaccinia
Maturation of the hepatitis A virus capsid protein VP1 is not dependent on processing by the 3Cpro proteinase.
Virus Diseases
Effect of expression of the aphthovirus protease 3C on viral infection and gene expression.
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