Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.32 extracted from

  • Schlesinger, M.J.; Coon, M.J.
    Reduction of mevaldic acid to mevalonic acid by a partially purified enzyme from liver (1961), J. Biol. Chem., 236, 2421-2424.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(R,S)-mevaldate 20 mM or higher Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
NADH
-
Sus scrofa
0.09
-
NADPH
-
Sus scrofa
4
-
mevaldate
-
Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH Sus scrofa
-
(R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
-
ir
(S)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH Sus scrofa
-
(S)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
-
ir

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation, calcium phosphate gel, DEAE-cellulose, bentonite precipitation Sus scrofa

Reaction

Reaction Comment Organism Reaction ID
(R)-mevalonate + NAD+ = mevaldate + NADH + H+ formation of mevalonic acid is strongly favoured Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-
liver
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.63
-
partially purified liver enzyme Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
-
Sus scrofa (R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
-
ir
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADPH
-
Sus scrofa (R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NADP+
-
ir
(S)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
-
Sus scrofa (S)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
-
ir
mevaldate + NADH + H+
-
Sus scrofa (R)-mevalonate + NAD+
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.4
-
-
Sus scrofa

pH Range

pH Minimum pH Maximum Comment Organism
4.6 6.9
-
Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NADH
-
Sus scrofa
NADPH
-
Rattus norvegicus