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Literature summary for 1.1.1.71 extracted from
- Structural insights into alcohol dehydrogenases catalyzing asymmetric reductions (2019), Crit. Rev. Biotechnol., 39, 366-379 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| hexane | in asymmetric reduction by TeSADH in pure hexane, the organic solvent makes the process more efficient by allowing high concentrations of substrates to be used | Thermoanaerobacter ethanolicus |  |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| G198D | site-directed mutagenesis, the variant of the NAD(P)H-dependent ADH, TeSADH, shows a significant switch of cofactor dependence from NADPH towards NADH compared to the wild-type enzyme | Thermoanaerobacter ethanolicus |
| W110A | site-directed mutagenesis, the mutant is able not only to reduce phenyl-ring-containing ketones with high enantioselectivity, but it can also racemize the corresponding enantiopure alcohols | Thermoanaerobacter ethanolicus |
| W110A/I86A | site-directed mutagenesis, the mutant of TeSADH reduces phenyl-ring-containing ketones with high enantioselectivity and racemizes the corresponding enantiopure alcohols, and it expands substrate specificity to accommodate ketones bearing two sterically demanding groups | Thermoanaerobacter ethanolicus |
Organic Solvent Stability
| Organic Solvent | Comment | Organism |
|---|---|---|
| hexane | in asymmetric reduction by TeSADH in pure hexane, the organic solvent makes the process more efficient by allowing high concentrations of substrates to be used | Thermoanaerobacter ethanolicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Thermoanaerobacter ethanolicus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NAD(P)H-dependent ADH | - |
Thermoanaerobacter ethanolicus |
| TeSADH | - |
Thermoanaerobacter ethanolicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Thermoanaerobacter ethanolicus | |
| NADH | - |
Thermoanaerobacter ethanolicus | |
| NADP+ | - |
Thermoanaerobacter ethanolicus | |
| NADPH | - |
Thermoanaerobacter ethanolicus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | ADHs structure and function comparisons, SDR family enzymes structure-function comparisons, overview | Thermoanaerobacter ethanolicus |
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Release 2023.1 (January 2023)
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