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Information on EC 1.1.1.71 - alcohol dehydrogenase [NAD(P)+]
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EC Tree
1.1.1.71 alcohol dehydrogenase [NAD(P)+]IUBMB Comments
Reduces aliphatic aldehydes of carbon chain length from 2 to 14, with greatest activity on C4, C6 and C8 aldehydes; also reduces retinal to retinol.
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Word Map
- 1.1.1.71
-
retinoids
- all-trans-retinaldehyde
-
retinyl
-
cyp26a1
- all-trans-retinol
- akr1b10
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
dhrs3, retinaldehyde reductase, retsdr1, nadph-dependent alcohol dehydrogenase, adh12, tsib_0319, retinol-active alcohol dehydrogenase, nad(p)h-dependent aldehyde reductase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ADH
ADH2
Adh319
HvADH2
HVO_B0071
NAD(P)+-dependent alcohol dehydrogenase
NAD(P)H-dependent aldehyde reductase
NADPH-dependent alcohol dehydrogenase
RADH
TsAdh319
Tsib_0319
VNG_2617G
YqhD
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+
enzyme is stereospecific for the pro-R hydride of NADPH
-
a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+
enzyme is stereospecific for the pro-R hydride of NADPH
-
a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+
the defence-related alcohol dehydrogenase DRD-1 is an alcohol:NADP+ oxidoreductase with preference for various aromatic and aliphatic aldehydes
a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+
the enzyme is an aldo-keto reductase
-
a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+
the human pancreas protein 2 has a retinal reductase activity
a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+
enzyme is stereospecific for the pro-R hydride of NADPH
-
a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SYSTEMATIC NAME
IUBMB Comments
alcohol:NAD(P)+ oxidoreductase
Reduces aliphatic aldehydes of carbon chain length from 2 to 14, with greatest activity on C4, C6 and C8 aldehydes; also reduces retinal to retinol.
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CAS REGISTRY NUMBER
COMMENTARY
37250-10-5
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(1R)-1-hydroxy-1-phenylpropan-2-one + NADPH + H+
(1R)-1-phenylpropane-1,2-diol + NADP+
-
-
-
?
(2R)-2-hydroxy-1-(4-methoxyphenyl)propan-1-one + NADPH + H+
(2R)-1-(4-methoxyphenyl)propane-1,2-diol + NADP+
-
-
-
?
(2S)-2-hydroxy-1-(4-methoxyphenyl)propan-1-one + NADPH + H+
(2S)-1-(4-methoxyphenyl)propane-1,2-diol + NADP+
-
-
-
?
(RS)-1-phenylethanol + NAD+
1-phenylethanone + NADH + H+
-
100% activity
-
?
(RS)-1-phenylethanol + NADP+
1-phenylethanone + NADPH + H+
-
100% activity
-
?
(S)-2-butanol + NADP+
butanone + NADPH
196% relative activity as compared to 2-propanol
-
?
(S)-2-butanol + NADP+
butanone + NADPH + H+
196% of the activity with 2-propanol, 2fold preference for (S)-2-butanol over (RS)-2-butanol
-
?
1,3-butanediol + NADP+
? + NADPH + H+
91% relative activity as compared to 2-propanol
-
?
1-(2-bromophenyl)ethanol + NAD(P)+
1-(2-bromophenyl)ethanone + NAD(P)H + H+
-
11.3% activity compared to (RS)-1-phenylethanol
-
?
1-(2-chlorophenyl)ethanol + NAD(P)+
1-(2-chlorophenyl)ethanone + NAD(P)H + H+
-
16.4% activity compared to (RS)-1-phenylethanol
-
?
1-(3-bromophenyl)ethanol + NAD(P)+
1-(3-bromophenyl)ethanone + NAD(P)H + H+
-
315% activity compared to (RS)-1-phenylethanol
-
?
1-(3-chlorophenyl)ethanol + NAD(P)+
1-(3-chlorophenyl)ethanone + NAD(P)H + H+
-
205% activity compared to (RS)-1-phenylethanol
-
?
1-(4-bromophenyl)ethanol + NAD(P)+
1-(4-bromophenyl)ethanone + NAD(P)H + H+
-
167% activity compared to (RS)-1-phenylethanol
-
?
1-(4-chlorophenyl)ethanone + NAD(P)+
1-(4-chlorophenyl)ethanone + NAD(P)H + H+
-
151% activity compared to (RS)-1-phenylethanol
-
?
1-(4-fluorophenyl)ethanol + NAD(P)+
1-(4-fluorophenyl)ethanol + NAD(P)H + H+
-
119% activity compared to (RS)-1-phenylethanol
-
?
1-(4-methylphenyl)ethanone + NAD(P)+
1-(4-methylphenyl)ethanol + NAD(P)H + H+
-
189% activity compared to (RS)-1-phenylethanol
-
?
1-butanol + NAD(P)+
butanal + NAD(P)H + H+
-
2.3% activity compared to (RS)-1-phenylethanol
-
?
1-butanol + NADP+
butanal + NADPH
80% relative activity as compared to 2-propanol
-
?
1-heptanol + NAD(P)+
heptanal + NAD(P)H + H+
-
3.3% activity compared to (RS)-1-phenylethanol
-
?
1-hexanol + NAD(P)+
hexanal + NAD(P)H + H+
-
2.8% activity compared to (RS)-1-phenylethanol
-
?
1-octanol + NAD(P)+
octanal + NAD(P)H + H+
-
2.3% activity compared to (RS)-1-phenylethanol
-
?
1-pentanol + NAD(P)+
pentanal + NAD(P)H + H+
-
2.8% activity compared to (RS)-1-phenylethanol
-
?
1-phenyl-1,2-ethanediol + NAD(P)+
?
-
3.4% activity compared to (RS)-1-phenylethanol
-
?
1-phenyl-1-propanol + NAD(P)+
1-phenylpropionaldehyde + NAD(P)H + H+
-
13.1% activity compared to (RS)-1-phenylethanol
-
?
1-phenyl-2-propanol + NAD(P)+
1-phenylpropan-2-one + NAD(P)H + H+
-
39.1% activity compared to (RS)-1-phenylethanol
-
?
1-phenylethanol + NADP+
1-phenylethanone + NADPH + H+
35% of the activtiy with 1-propanol
-
?
1-phenylethanol + NADP+
acetophenone + NADPH + H+
35% compared to activity with 1-propanol
-
?
1-phenylmethanol + NADP+
benzaldehyde + NADPH + H+
180% relative activity as compared to 2-propanol
-
?
1-propanol + NAD(P)+
propionaldehyde + NAD(P)H + H+
-
1.2% activity compared to (RS)-1-phenylethanol
-
?
2,2,2-trifluoroacetophenone + NAD(P)H + H+
2,2,2-trifluoro-1-phenylethan-1-ol + NAD(P)+
-
180% activity compared to acetoin
-
?
2-bromoacetophenone + NAD(P)H + H+
1-(2-bromophenyl)ethanone + NAD(P)+
-
8.7% activity compared to acetoin
-
?
2-butanol + NAD(P)+
butan-2-one + NAD(P)H + H+
-
22.3% activity compared to (RS)-1-phenylethanol
-
?
2-butanol + NADP+
2-butanone + NADPH + H+
43% of the activity compared to ethanol
-
?
2-chloro-1-phenylethanol + NAD(P)+
2-chloro-1-phenylethan-1-one + NAD(P)H + H+
-
0.3% activity compared to (RS)-1-phenylethanol
-
?
2-heptanol + NAD(P)+
heptan-2-one + NAD(P)H + H+
-
61.6% activity compared to (RS)-1-phenylethanol
-
?
2-hexanol + NAD(P)+
hexan-2-one + NAD(P)H + H+
-
38.7% activity compared to (RS)-1-phenylethanol
-
?
2-hexanone + NAD(P)H + H+
hexan-2-ol + NAD(P)+
-
3.6% activity compared to acetoin
-
?
2-hydroxy-2-methyl-1-phenylpropan-1-one + NADPH + H+
2-methyl-1-phenylpropan-1,2-diol + NADP+
-
-
-
?
2-hydroxy-3-methoxybenzaldehyde + NADPH + H+
2-hydroxy-3-methoxybenzyl alcohol + NADP+
-
-
?
2-methoxybenzaldehyde + NADPH + H+
2-methoxybenzalcohol + NADP+
highest activity
-
?
2-octanol + NAD(P)+
octan-2-one + NAD(P)H + H+
-
45.8% activity compared to (RS)-1-phenylethanol
-
?
2-pentanol + NAD(P)+
pentan-2-one + NAD(P)H + H+
-
30.2% activity compared to (RS)-1-phenylethanol
-
?
2-pentanol + NADP+
2-pentanone + NADPH + H+
67% relative activity as compared to 2-propanol
-
?
2-pentanol + NADP+
pentan-2-one + NADPH + H+
67% of the activity with 2-propanol
-
?
2-phenylethanol + NAD(P)+
phenylacetaldehyde + NAD(P)H + H+
-
0.3% activity compared to (RS)-1-phenylethanol
-
?
2-propanol + NAD(P)+
propan-2-one + NAD(P)H + H+
-
5.3% activity compared to (RS)-1-phenylethanol
-
?
3,4-dimethoxybenzaldehyde + NADPH + H+
3,4-dimethoxybenzyl alcohol + NADP+
-
-
?
3-methyl-2-pentanone + NADPH + H+
? + NADP+
13% relative activity as compared to pyruvaldehyde
-
?
3-methylbutanal + NADP+
? + NADPH + H+
about% of the activity with 1-butanol
-
?
4-methoxybenzaldehyde + NADPH + H+
4-methoxybenzalcohol + NADP+
-
-
?
acetoin + NAD(P)+
2,3-butanediol + NAD(P)H + H+
-
4.5% activity compared to (RS)-1-phenylethanol
-
?
acetoin + NAD(P)H + H+
butan-2,3-dione + NAD(P)H + H+
-
100% activity
-
?
acetoin + NADPH + H+
?
-
1.9% activity compared to 3-hydroxypropionaldehyde
-
?
acetone + NAD(P)H + H+
propan-2-ol + NAD(P)+
-
4.1% activity compared to acetoin
-
?
acrolein + NADPH + H+
prop-2-en-1-ol + NADP+
-
41.8% activity compared to 3-hydroxypropionaldehyde
-
?
butan-1,4-diol + NADP+
butandialdehyde + NADPH
-
29% of activity with hexan-1-ol
-
r
butanal + NADPH + H+
1-butanol + NAD(P)+
44% activity compared to pentanal
-
?
cis-4-cyclopentene-1,3-diol + NADP+
(R)-4-hydroxy-2-cyclopentenone + NADPH + H+
-
-
-
?
cis-hex-3-en-1-ol + NADP+
cis-hex-3-en-1-al + NADPH
-
18.7% of activity with hexan-1ol
-
r
cyclohexanol + NAD(P)+
cyclohexanone + NAD(P)H + H+
-
52.3% activity compared to (RS)-1-phenylethanol
-
?
cyclohexanone + NAD(P)H + H+
cyclohexanol + NAD(P)+
-
19.1% activity compared to acetoin
-
?
D-arabinose + NAD(P)+
?
-
21.4% activity compared to (RS)-1-phenylethanol
-
?
D-arabinose + NADP+
? + NADPH + H+
200% relative activity as compared to 2-propanol
-
?
D-arabinose + NADP+
D-arabitol + NADPH + H+
200% of the activity with 2-propanol. D-arabinose is preferred over L-arabinose
-
?
D-mannose + NADP+
? + NADPH + H+
48% relative activity as compared to 2-propanol
-
?
D-ribose + NADP+
? + NADPH + H+
35% relative activity as compared to 2-propanol
-
?
decan-1-ol + NADP+
decanal + NADPH
-
decrease in enzyme activity with increase in chain length
-
r
dihydroxyacetone + NAD(P)H + H+
?
-
34.8% activity compared to acetoin
-
?
dodecan-1-ol + NADP+
dodecanal + NADPH
-
decrease in enzyme activity with increase in chain length
-
r
ethanol + NAD(P)+
acetaldehyde + NAD(P)H + H+
-
0.5% activity compared to (RS)-1-phenylethanol
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
enzyme appears to preferentially catalyze the reductive reaction. Activity with NAD+ is 75% less than that detected with NADP+
-
?
ethyl pyruvate + NAD(P)H + H+
?
-
294% activity compared to acetoin
-
?
furfural + NADPH + H+
(furan-2-yl)methanol + NAD(P)+
5% activity compared to pentanal
-
?
glycerol + NADP+
glyceraldehyde + NADPH + H+
16% relative activity as compared to 2-propanol
-
?
glycoaldehyde + NADPH + H+
?
5% activity compared to pentanal
-
?
glyoxylic acid + NADPH + H+
? + NADP+
36% relative activity as compared to pyruvaldehyde
-
?
heptanal + NADPH + H+
1-heptanol + NAD(P)+
56% activity compared to pentanal
-
?
hexanal + NAD(P)H + H+
hexan-1-ol + NAD(P)+
-
12.9% activity compared to acetoin
-
?
hexanal + NADPH + H+
1-hexanol + NAD(P)+
62% activity compared to pentanal
-
?
hydrocinnamaldehyde + NADPH + H+
hydrocinnamyl alcohol + NADP+
-
-
?
isoamyl alcohol + NADP+
? + NADPH + H+
about 80% of the activity with 1-butanol
-
?
L-arabinose + NAD(P)+
?
-
5.2% activity compared to (RS)-1-phenylethanol
-
?
L-arabinose + NADP+
? + NADPH + H+
17% relative activity as compared to 2-propanol
-
?
mannitol + NADP+
D-mannose + NADPH
-
6.5% of activity with hexan-1-ol
-
r
meso-2,3-butanediol + NAD+
?
-
272% activity compared to (RS)-1-phenylethanol
-
?
meso-2,3-butanediol + NADP+
?
-
272% activity compared to (RS)-1-phenylethanol
-
?
methanol + NAD(P)+
formaldehyde + NAD(P)H + H+
-
0.2% activity compared to (RS)-1-phenylethanol
-
?
methyl benzoylformate + NAD(P)H + H+
?
-
67% activity compared to acetoin
-
?
methylglyoxal + NADPH + H+
?
29% activity compared to pentanal
-
?
octan-1-ol + NADP+
octanal + NADPH
-
decrease in enzyme activity with increase in chain length
-
r
octanal + NADPH + H+
1-octanol + NAD(P)+
55% activity compared to pentanal
-
?
pentanal + NADPH + H+
1-pentanol + NAD(P)+
100% activity
-
?
phenylacetaldehyde + NAD(P)H + H+
2-phenylethan-1-ol + NAD(P)+
-
18.6% activity compared to acetoin
-
?
propanal + NADPH + H+
1-propanol + NAD(P)+
14% activity compared to pentanal
-
?
pyruvic aldehyde + NAD(P)H + H+
?
-
328% activity compared to acetoin
-
?
rac-1-nonen-4-ol + NADP+
(S)-1-nonen-4-ol + 1-nonen-4-one + NADPH + H+
-
-
-
?
rac-1-phenylethanol + NAD(P)+
acetophenone + (R)-1-phenylethanol + NAD(P)H + H+
-
-
-
?
rac-1-phenylethanol + NADP+
(R)-1-phenylethanol + (S)-1-phenylethanol + NADPH + H+
-
-
-
?
ribitol + NADP+
D-ribose + NADPH
-
4% of activity with hexan-1-ol
-
r
trans-2,cis-6-nonadienal + NAD(P)+
trans-2,cis-6-nonadienol + NAD(P)H
-
-
-
?
trans-2,cis-6-nonadienal + NADPH + H+
trans-2,cis-6-nonadienol + NADP+
-
-
?
trans-2-pentenol + NAD(P)+
trans-2-pentenal + NAD(P)H
-
-
-
?
trans-trans-2,4-decadienal + NADPH
trans-trans-2,4-decadienol + NADPH
-
-
-
?
(2S,5S)-2,5-hexanediol + NADP+
? + NADPH + H+
-
-
?
1-butanol + NADP+
butanal + NADPH + H+
117% of the activity compared to ethanol
-
?
1-butanol + NADP+
butanal + NADPH + H+
80% compared to activity with 1-propanol
-
?
1-butanol + NADP+
butanal + NADPH + H+
80% compared to activity with 1-propanol
-
?
1-butanol + NADP+
butanal + NADPH + H+
80% of the activtiy with 1-propanol
-
?
1-butanol + NADP+
butanal + NADPH + H+
80% of the activtiy with 1-propanol
-
?
1-pentanol + NADP+
pentanal + NADPH + H+
74% of the activity compared to ethanol
-
?
1-pentanol + NADP+
pentanal + NADPH + H+
about 75% of the activity with 1-butanol
-
?
1-pentanol + NADP+
pentanal + NADPH + H+
about 75% of the activity with 1-butanol
-
?
1-propanol + NAD+
propanal + NADH + H+
dual cofactor dependency, NAD+ shows 60% of the activity with NADP+
-
?
1-propanol + NAD+
propanal + NADH + H+
dual cofactor dependency, NAD+ shows 60% of the activity with NADP+
-
?
1-propanol + NADP+
propanal + NADPH + H+
137% of the activity compared to ethanol
-
?
1-propanol + NADP+
propanal + NADPH + H+
dual cofactor dependency, NAD+ shows 60% of the activity with NADP+
-
?
1-propanol + NADP+
propanal + NADPH + H+
about 60% of the activity with 1-butanol
-
?
1-propanol + NADP+
propanal + NADPH + H+
about 60% of the activity with 1-butanol
-
?
2-butanol + NADP+
butanone + NADPH + H+
30% compared to activity with 1-propanol
-
?
2-butanol + NADP+
butanone + NADPH + H+
30% of the activtiy with 1-propanol
-
?
2-butanol + NADP+
butanone + NADPH + H+
about 25% of the activity with 1-butanol
-
?
2-methoxybenzaldehyde + NADPH + H+
2-methoxybenzyl alcohol + NADP+
-
-
-
?
2-propanol + NADP+
acetone + NADPH + H+
25% compared to activity with 1-propanol
-
?
2-propanol + NADP+
acetone + NADPH + H+
25% compared to activity with 1-propanol
-
?
3-hydroxypropionaldehyde + NADPH + H+
propan-1,3-diol + NADP+
-
100% activity
-
?
3-hydroxypropionaldehyde + NADPH + H+
propan-1,3-diol + NADP+
-
100% activity
-
?
4-methoxybenzaldehyde + NADPH + H+
4-methoxybenzyl alcohol + NADP+
-
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
2.2% activity compared to 3-hydroxypropionaldehyde
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
2.2% activity compared to 3-hydroxypropionaldehyde
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
?
allyl alcohol + NADP+
acrylaldehyde + NADPH
-
28% of activity with hexan-1-ol
-
r
allyl alcohol + NADP+
acrylaldehyde + NADPH
-
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
20% compared to activity with 1-propanol
-
?
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
about% of the activity with 1-butanol
-
?
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
about% of the activity with 1-butanol
-
?
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
180% of the activity with 2-propanol
-
?
butan-1-ol + NADP+
butanal + NADPH
-
36.3% of activity with hexan-1-ol
-
r
butyraldehyde + NADPH + H+
butanol + NADP+
-
118.4% activity compared to 3-hydroxypropionaldehyde
-
?
butyraldehyde + NADPH + H+
butanol + NADP+
-
118.4% activity compared to 3-hydroxypropionaldehyde
-
?
cellobiose + NADP+
? + NADPH + H+
71% relative activity as compared to 2-propanol
-
?
cellobiose + NADP+
? + NADPH + H+
71% of the activity with 2-propanol
-
?
cis-2-butenol + NAD(P)H
trans-2-butenal + NAD(P)+
-
-
-
?
D-glucose + NADP+
? + NADPH + H+
146% relative activity as compared to 2-propanol
-
?
D-glucose + NADP+
? + NADPH + H+
146% of the activity with 2-propanol
-
?
D-xylose + NADP+
? + NADPH + H+
246% relative activity as compared to 2-propanol
-
?
D-xylose + NADP+
? + NADPH + H+
246% of the activity with 2-propanol
-
?
dimethylglyoxal + NADPH + H+
? + NADP+
270% relative activity as compared to pyruvaldehyde
-
?
dimethylglyoxal + NADPH + H+
? + NADP+
270% of the activity with pyruvaldehyde
-
?
ethanediol + NADP+
glyoxal + NADPH
-
8.5% of activity with hexan-1-ol
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
enzyme appears to preferentially catalyze the reductive reaction. Activity with NAD+ is 75% less than that detected with NADP+
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
85% compared to activity with 1-propanol
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
85% compared to activity with 1-propanol
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
84% of the activtiy with 1-propanol
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
84% of the activtiy with 1-propanol
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
about 50% of the activity with 1-butanol
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
about 50% of the activity with 1-butanol
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
36% relative activity as compared to 2-propanol
-
?
ethanol + NADP+
ethanal + NADPH + H+
-
8.5% of activity with hexan-1-ol
-
r
ethanol + NADP+
ethanal + NADPH + H+
-
oxidation rate at 5% of reduction rate
-
r
pentan-1-ol + NADP+
pentanal + NADPH
-
4% of activity with hexan-1-ol
-
r
propan-1-ol + NADP+
propanal + NADPH
-
28% of activity with hexan-1-ol
-
r
propan-1-ol + NADP+
propanal + NADPH
-
oxidation rate at 5% of reduction rate
-
r
propionaldehyde + NADPH + H+
propanol + NADP+
-
37.1% activity compared to 3-hydroxypropionaldehyde
-
?
propionaldehyde + NADPH + H+
propanol + NADP+
-
37.1% activity compared to 3-hydroxypropionaldehyde
-
?
pyruvaldehyde + NADPH + H+
lactaldehyde + NADP+
-
-
?
retinaldehyde + NADH
retinol + NAD+
-
the enzyme is involved in retinol and vitamin A metabolism, retinoic acid is important in intestinal epithelial cell proliferation and differentiation, the enzyme also plays a role in dietary conversion of beta-carotene to retinol via retinaldehyde
-
r
additional information
?
-
the enzyme does not accept methanol, 2-propanol, glycerol or glucose as substrates
-
?
additional information
?
-
-
the enzyme does not accept methanol, 2-propanol, glycerol or glucose as substrates
-
?
additional information
?
-
preference for short-chain alcohol substrates, particularly for 1-propanol (100%) and ethanol (84%), no activity with glycerol or methanol
-
?
additional information
?
-
preference for short-chain alcohol substrates, particularly for 1-propanol (100%) and ethanol (84%), no activity with glycerol or methanol
-
?
additional information
?
-
no substrates: methanol, glycerol
-
?
additional information
?
-
HvADH2 accepts a broad range of substrates, no activity with methanol
-
?
additional information
?
-
HvADH2 accepts a broad range of substrates, no activity with methanol
-
?
additional information
?
-
-
4-nitroacetophenone, benzyl, cortisone and progesterone are no substrates
-
?
additional information
?
-
in wild-type strains, NADH is the preferred cofactor for both aldehyde dehydrogenase ALDH and alcohol dehydrogenase ADH activities. The AdhE protein of the ethanologenic strain of Clostridium thermocellum has acquired high NADPH-linked ADH activity while maintaining NADH-linked ALDH and ADH activities at wild-type levels
-
?
additional information
?
-
-
no activity with dihydroxyacetone, hydroxyacetone, and acetone
-
?
additional information
?
-
-
no activity with dihydroxyacetone, hydroxyacetone, and acetone
-
?
additional information
?
-
no activity with glyoxal, methanal, and ethanal
-
?
additional information
?
-
the enzyme shows no oxidative activities towards alcoholic compounds
-
?
additional information
?
-
-
no activity with glyoxal, methanal, and ethanal
-
?
additional information
?
-
-
the enzyme shows no oxidative activities towards alcoholic compounds
-
?
additional information
?
-
no activity with glyoxal, methanal, and ethanal
-
?
additional information
?
-
the enzyme shows no oxidative activities towards alcoholic compounds
-
?
additional information
?
-
-
no activity with methanol and ethanol
-
?
additional information
?
-
the enzyme plays an important role in potato defence response to Erwinia carotovora
-
?
additional information
?
-
not: conferyl aldehyde and sinapaldehyde, the enzyme exhibits an absolute requirement for NADPH as cofactor and can not be substituted by NADH
-
?
additional information
?
-
in wild-type strains, NADH is the preferred cofactor for both aldehyde dehydrogenase ALDH and alcohol dehydrogenase ADH activities. In high-ethanol-producing (ethanologen) strains of Thermoanaerobacterium saccharolyticum, both ALDH and ADH activities show increased NADPH-linked activity
-
?
additional information
?
-
-
no activity with D-arabinose, L-arabinose, acetophenone, and 4-chloroacetophenone
-
?
additional information
?
-
no oxidation of methanol, methoxyethanol, ethylene glycol, or D-galactose. No reduction of acetone, cyclopentanone, D-arabinose, D-xylose, D-glucose or cellobiose
-
?
additional information
?
-
-
no oxidation of methanol, methoxyethanol, ethylene glycol, or D-galactose. No reduction of acetone, cyclopentanone, D-arabinose, D-xylose, D-glucose or cellobiose
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(RS)-1-phenylethanol + NAD+
1-phenylethanone + NADH + H+
-
100% activity
-
-
?
(RS)-1-phenylethanol + NADP+
1-phenylethanone + NADPH + H+
-
100% activity
-
-
?
1-(2-bromophenyl)ethanol + NAD(P)+
1-(2-bromophenyl)ethanone + NAD(P)H + H+
-
11.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-(2-chlorophenyl)ethanol + NAD(P)+
1-(2-chlorophenyl)ethanone + NAD(P)H + H+
-
16.4% activity compared to (RS)-1-phenylethanol
-
-
?
1-(3-bromophenyl)ethanol + NAD(P)+
1-(3-bromophenyl)ethanone + NAD(P)H + H+
-
315% activity compared to (RS)-1-phenylethanol
-
-
?
1-(3-chlorophenyl)ethanol + NAD(P)+
1-(3-chlorophenyl)ethanone + NAD(P)H + H+
-
205% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-bromophenyl)ethanol + NAD(P)+
1-(4-bromophenyl)ethanone + NAD(P)H + H+
-
167% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-chlorophenyl)ethanone + NAD(P)+
1-(4-chlorophenyl)ethanone + NAD(P)H + H+
-
151% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-fluorophenyl)ethanol + NAD(P)+
1-(4-fluorophenyl)ethanol + NAD(P)H + H+
-
119% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-methylphenyl)ethanone + NAD(P)+
1-(4-methylphenyl)ethanol + NAD(P)H + H+
-
189% activity compared to (RS)-1-phenylethanol
-
-
?
1-butanol + NAD(P)+
butanal + NAD(P)H + H+
-
2.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-heptanol + NAD(P)+
heptanal + NAD(P)H + H+
-
3.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-hexanol + NAD(P)+
hexanal + NAD(P)H + H+
-
2.8% activity compared to (RS)-1-phenylethanol
-
-
?
1-octanol + NAD(P)+
octanal + NAD(P)H + H+
-
2.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-pentanol + NAD(P)+
pentanal + NAD(P)H + H+
-
2.8% activity compared to (RS)-1-phenylethanol
-
-
?
1-phenyl-1,2-ethanediol + NAD(P)+
?
-
3.4% activity compared to (RS)-1-phenylethanol
-
-
?
1-phenyl-1-propanol + NAD(P)+
1-phenylpropionaldehyde + NAD(P)H + H+
-
13.1% activity compared to (RS)-1-phenylethanol
-
-
?
1-phenyl-2-propanol + NAD(P)+
1-phenylpropan-2-one + NAD(P)H + H+
-
39.1% activity compared to (RS)-1-phenylethanol
-
-
?
1-propanol + NAD(P)+
propionaldehyde + NAD(P)H + H+
-
1.2% activity compared to (RS)-1-phenylethanol
-
-
?
2,2,2-trifluoroacetophenone + NAD(P)H + H+
2,2,2-trifluoro-1-phenylethan-1-ol + NAD(P)+
-
180% activity compared to acetoin
-
-
?
2-bromoacetophenone + NAD(P)H + H+
1-(2-bromophenyl)ethanone + NAD(P)+
-
8.7% activity compared to acetoin
-
-
?
2-butanol + NAD(P)+
butan-2-one + NAD(P)H + H+
-
22.3% activity compared to (RS)-1-phenylethanol
-
-
?
2-chloro-1-phenylethanol + NAD(P)+
2-chloro-1-phenylethan-1-one + NAD(P)H + H+
-
0.3% activity compared to (RS)-1-phenylethanol
-
-
?
2-heptanol + NAD(P)+
heptan-2-one + NAD(P)H + H+
-
61.6% activity compared to (RS)-1-phenylethanol
-
-
?
2-hexanol + NAD(P)+
hexan-2-one + NAD(P)H + H+
-
38.7% activity compared to (RS)-1-phenylethanol
-
-
?
2-hexanone + NAD(P)H + H+
hexan-2-ol + NAD(P)+
-
3.6% activity compared to acetoin
-
-
?
2-octanol + NAD(P)+
octan-2-one + NAD(P)H + H+
-
45.8% activity compared to (RS)-1-phenylethanol
-
-
?
2-pentanol + NAD(P)+
pentan-2-one + NAD(P)H + H+
-
30.2% activity compared to (RS)-1-phenylethanol
-
-
?
2-phenylethanol + NAD(P)+
phenylacetaldehyde + NAD(P)H + H+
-
0.3% activity compared to (RS)-1-phenylethanol
-
-
?
2-propanol + NAD(P)+
propan-2-one + NAD(P)H + H+
-
5.3% activity compared to (RS)-1-phenylethanol
-
-
?
acetoin + NAD(P)+
2,3-butanediol + NAD(P)H + H+
-
4.5% activity compared to (RS)-1-phenylethanol
-
-
?
acetoin + NAD(P)H + H+
butan-2,3-dione + NAD(P)H + H+
-
100% activity
-
-
?
acetone + NAD(P)H + H+
propan-2-ol + NAD(P)+
-
4.1% activity compared to acetoin
-
-
?
cyclohexanol + NAD(P)+
cyclohexanone + NAD(P)H + H+
-
52.3% activity compared to (RS)-1-phenylethanol
-
-
?
cyclohexanone + NAD(P)H + H+
cyclohexanol + NAD(P)+
-
19.1% activity compared to acetoin
-
-
?
D-arabinose + NAD(P)+
?
-
21.4% activity compared to (RS)-1-phenylethanol
-
-
?
dihydroxyacetone + NAD(P)H + H+
?
-
34.8% activity compared to acetoin
-
-
?
ethanol + NAD(P)+
acetaldehyde + NAD(P)H + H+
-
0.5% activity compared to (RS)-1-phenylethanol
-
-
?
ethyl pyruvate + NAD(P)H + H+
?
-
294% activity compared to acetoin
-
-
?
hexanal + NAD(P)H + H+
hexan-1-ol + NAD(P)+
-
12.9% activity compared to acetoin
-
-
?
L-arabinose + NAD(P)+
?
-
5.2% activity compared to (RS)-1-phenylethanol
-
-
?
meso-2,3-butanediol + NAD+
?
-
272% activity compared to (RS)-1-phenylethanol
-
-
?
meso-2,3-butanediol + NADP+
?
-
272% activity compared to (RS)-1-phenylethanol
-
-
?
methanol + NAD(P)+
formaldehyde + NAD(P)H + H+
-
0.2% activity compared to (RS)-1-phenylethanol
-
-
?
methyl benzoylformate + NAD(P)H + H+
?
-
67% activity compared to acetoin
-
-
?
phenylacetaldehyde + NAD(P)H + H+
2-phenylethan-1-ol + NAD(P)+
-
18.6% activity compared to acetoin
-
-
?
pyruvic aldehyde + NAD(P)H + H+
?
-
328% activity compared to acetoin
-
-
?
retinaldehyde + NADH
retinol + NAD+
-
the enzyme is involved in retinol and vitamin A metabolism, retinoic acid is important in intestinal epithelial cell proliferation and differentiation, the enzyme also plays a role in dietary conversion of beta-carotene to retinol via retinaldehyde
-
-
r
additional information
?
-
the enzyme plays an important role in potato defence response to Erwinia carotovora
-
-
?
additional information
?
-
-
no activity with D-arabinose, L-arabinose, acetophenone, and 4-chloroacetophenone
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NAD(P)H
-
strains B592 and B593, higher activities with NADP(H) than with NAD(H)
NAD+
dual cofactor dependency, NAD+ shows 60% of the activity with NADP+
NAD+
dual cofactor specificity, activity with NAD+ is 14% compared to the activity with NADP+ at pH 11.0 with 4 M KCl
NADH
in wild-type strains, NADH is the preferred cofactor for both aldehyde dehydrogenase ALDH and alcohol dehydrogenase ADH activities. In high-ethanol-producing (ethanologen) strains of Thermoanaerobacterium saccharolyticum, both ALDH and ADH activities show increased NADPH-linked activity
NADH
in wild-type strains, NADH is the preferred cofactor for both aldehyde dehydrogenase ALDH and alcohol dehydrogenase ADH activities. The AdhE protein of the ethanologenic strain of Clostridium thermocellum has acquired high NADPH-linked ADH activity while maintaining NADH-linked ALDH and ADH activities at wild-type levels
NADP+
preferred cofactor. Activity with NAD+ is 75% less than that detected with NADP+
NADP+
dual cofactor dependency, NAD+ shows 60% of the activity with NADP+
NADP+
dual cofactor specificity, activity with NAD+ is 14% compared to the activity with NADP+ at pH 11.0 with 4 M KCl
NADPH
-
the specifity towards NADP(H) is determined by residues Gly198, Ser199, Arg200 and Tyr218
NADPH
-
the specifity towards NADP(H) is determined by residues Gly198, Ser199, Arg200 and Tyr218
NADPH
in wild-type strains, NADH is the preferred cofactor for both aldehyde dehydrogenase ALDH and alcohol dehydrogenase ADH activities. In high-ethanol-producing (ethanologen) strains of Thermoanaerobacterium saccharolyticum, both ALDH and ADH activities show increased NADPH-linked activity
NADPH
the ethanol tolerant phenotype of Clostridium thermocellum is primarily due to a mutated bifunctional acetaldehyde-CoA/alcohol dehydrogenase gene (adhE). The mutant displays a complete loss of NADH-dependent activity with concomitant acquisition of NADPH-dependent activity
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
-
Ca2+ has an stabilizing effect. With 1.0 mM CaCl2, the enzyme is completely stable at 0°C for 2 h and after 3.5 h almost 90% of the initial activity is retained
KCl
NaCl
additional information
KCl
a preference for KCl over NaCl is observed, with best activity at 4 M KCl
KCl
maximally active with ethanol with 4 M KCl. It is maximally active with 1-propanol with 2 M KCl and with 1-butanol and 1-pentanol with 1 M KCl. Optimum activity with the secondary alcohols, 2-propanol and 2-butanol, is observed with 3 M KCl and 2 M KCl, respectively, and with isoamyl alcohol in the presence of 1 M KCl. Maximum activity with benzyl alcohol is detected with 2 M KCl. Catalyzed the reductive reaction optimally at pH 6.0 with 1 M KCl
KCl
activity increases in the presence of KCl is maintained even at concentration of 3 M
NaCl
the enzyme requires high salt concentrations for its activity, a preference for KCl over NaCl is observed
NaCl
activity increases in the presence of NaCl is maintained even at concentration of 4 M
NaCl
activity is increased in the presence of NaCl and remains at the elevated level up to 4 M of NaCl. The rates of 2-propanol and 2,5-hexanediol oxidation are increased by more than 2fold after the addition of NaCl up to 1 M to the assay mixture and is retained at the increased level up to 4 M of NaCl
additional information
metal independency is supported by the absence of a significant effect of TsAdh319 preincubation with 10 mM Me2+ for 30 min before measuring the activity in the presence of 1 mM Me2+ or EDTA
additional information
-
metal independency is supported by the absence of a significant effect of TsAdh319 preincubation with 10 mM Me2+ for 30 min before measuring the activity in the presence of 1 mM Me2+ or EDTA
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
8-hydroxyquinoline
-
1 mM, 100% inhibition with NAD+ as cofactor, 40% with NADP+ as cofactor
acetonitrile
complete inhibition in buffer without NaCl and in buffer with 600 mM NaCl
chloroform
21% inhibition in buffer without NaCl, 19% inhibition in buffer with 600 mM NaCl
CuSO4
-
1 mM, 75% inhibition with NAD+ as cofactor, 56% with NADP+ as cofactor
Dimethyl formamide
87% inhibition in buffer without NaCl, 59% inhibition in buffer with 600 mM NaCl
dimethyl sulfoxide
complete inhibition in buffer without NaCl, 60% inhibition in buffer with 600 mM NaCl
ethyl acetate
complete inhibition in buffer without NaCl, 67% inhibition in buffer with 600 mM NaCl
iodoacetic acid
-
1 mM, 29% inhibition with NAD+ as cofactor, 80% with NADP+ as cofactor
methanol
75% inhibition in buffer without NaCl, 81% inhibition in buffer with 600 mM NaCl
n-decane
9% inhibition in buffer without NaCl, slight activation in buffer with 600 mM NaCl
n-hexane
40% inhibition in buffer without NaCl, slight activation in buffer with 600 mM NaCl
additional information
-
dithiothreitol and EDTA have no effect on either oxidative or reductive activity
-
4-chloromercuribenzoate
-
0.01 mM, complete inhibition; some protection of partial inhibition resulting from 0.001 mM 4-chloromercuribenzoate in the presence of 1 mM NADP+, almost complete protection with 10 mM hexan-1-ol
FeSO4
-
1 mM, 75% inhibition with NAD+ as cofactor, 46% with NADP+ as cofactor
o-phenanthroline
-
1 mM, 100% inhibition with NAD+ as cofactor, 40% with NADP+ as cofactor
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Melanoma
Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas.
Neoplasm Metastasis
Gene expression profiling of papillary thyroid carcinoma identifies transcripts correlated with BRAF mutational status and lymph node metastasis.
Neoplasm Metastasis
Induction of cell cycle arrest and inflammatory genes by combined treatment with epigenetic, differentiating, and chemotherapeutic agents in triple-negative breast cancer.
Neoplasms
Biological role of aldo-keto reductases in retinoic Acid biosynthesis and signaling.
Neoplasms
Evaluation of genes identified by microarray analysis in favorable neuroblastoma.
Neoplasms
Identification of allelic expression imbalance genes in human hepatocellular carcinoma through massively parallel DNA and RNA sequencing.
Neoplasms
Induction of cell cycle arrest and inflammatory genes by combined treatment with epigenetic, differentiating, and chemotherapeutic agents in triple-negative breast cancer.
Neoplasms
p53-inducible DHRS3 Is an Endoplasmic Reticulum Protein Associated with Lipid Droplet Accumulation.
Neoplasms
retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines.
Neoplasms
Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase.
Neoplasms
The retinal dehydrogenase/reductase retSDR1/DHRS3 gene is activated by p53 and p63 but not by mutants derived from tumors or EEC/ADULT malformation syndromes.
Neuroblastoma
retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines.
Non-alcoholic Fatty Liver Disease
Genetic analysis of expression profile involved in retinoid metabolism in non-alcoholic fatty liver disease.
Obesity
p53-inducible DHRS3 Is an Endoplasmic Reticulum Protein Associated with Lipid Droplet Accumulation.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
244
(RS)-1-phenylethanol
-
with NAD+ as cosubstrate, at pH 6.0 and 70°C
6.7
1-butanol
pH 10.0, temperature not specified in the publication
61.3
meso-2,3-butanediol
-
with NAD+ as cosubstrate, at pH 6.0 and 70°C
1.4
acetaldehyde
cosubstrate NADH, moderately ethanol producing strain, pH 7.0, 55°C
1.4
acetaldehyde
cosubstrate NADPH, moderately ethanol producing strain, pH 7.0, 55°C
9.2
acetaldehyde
pH 6.0, temperature not specified in the publication
0.089
NAD+
-
with (RS)-1-phenylethanol as cosubstrate, at pH 6.0 and 70°C
0.127
NAD+
-
with meso-2,3-butanediol as cosubstrate, at pH 6.0 and 70°C
0.17
NADH
moderately ethanol producing strain, pH 7.0, 55°C
0.066
NADP+
-
with (RS)-1-phenylethanol as cosubstrate, at pH 6.0 and 70°C
0.113
NADP+
-
with meso-2,3-butanediol as cosubstrate, at pH 6.0 and 70°C
0.2 - 1
NADP+
pH 10.0, temperature not specified in the publication
0.075
NADPH
moderately ethanol producing strain, pH 7.0, 55°C
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
35.7
(RS)-1-phenylethanol
-
with NAD+ as cosubstrate, at pH 6.0 and 70°C
43.8
meso-2,3-butanediol
-
with NAD+ as cosubstrate, at pH 6.0 and 70°C
210
acetaldehyde
cosubstrate NADPH, moderately ethanol producing strain, pH 7.0, 55°C
220
acetaldehyde
cosubstrate NADH, moderately ethanol producing strain, pH 7.0, 55°C
10.4
NAD+
-
with (RS)-1-phenylethanol as cosubstrate, at pH 6.0 and 70°C
30.8
NAD+
-
with meso-2,3-butanediol as cosubstrate, at pH 6.0 and 70°C
220
NADH
moderately ethanol producing strain, pH 7.0, 55°C
10.5
NADP+
-
with (RS)-1-phenylethanol as cosubstrate, at pH 6.0 and 70°C
30
NADP+
-
with meso-2,3-butanediol as cosubstrate, at pH 6.0 and 70°C
280
NADPH
moderately ethanol producing strain, pH 7.0, 55°C
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.15
(RS)-1-phenylethanol
-
with NAD+ as cosubstrate, at pH 6.0 and 70°C
0.479
1-butanol
pH 10.0, temperature not specified in the publication
0.71
meso-2,3-butanediol
-
with NAD+ as cosubstrate, at pH 6.0 and 70°C
0.744
acetaldehyde
pH 6.0, temperature not specified in the publication
150
acetaldehyde
cosubstrate NADH, moderately ethanol producing strain, pH 7.0, 55°C
150
acetaldehyde
cosubstrate NADPH, moderately ethanol producing strain, pH 7.0, 55°C
117
NAD+
-
with (RS)-1-phenylethanol as cosubstrate, at pH 6.0 and 70°C
243
NAD+
-
with meso-2,3-butanediol as cosubstrate, at pH 6.0 and 70°C
1300
NADH
moderately ethanol producing strain, pH 7.0, 55°C
159
NADP+
-
with (RS)-1-phenylethanol as cosubstrate, at pH 6.0 and 70°C
265
NADP+
-
with meso-2,3-butanediol as cosubstrate, at pH 6.0 and 70°C
3700
NADPH
moderately ethanol producing strain, pH 7.0, 55°C
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.052
mutant P704L/H734R, cofoactor NADH, pH 7.6, 55°C
0.12
mutant P704L/H734R, cofoactor NADPH, pH 7.6, 55°C
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
10
10.2
6.8
7.5
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5 - 9
-
aldehyde reduction, cofactor NADH, NADP dependent activity occurs only at pHs below 7
6 - 8
the enzyme shows around 50% of activity at pH 6.0, pH 6.5, and pH 8.0
6.4 - 7.15
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
60
70
oxidation of (2S,5S)-2,5-hexanediol, in presence of 1 M NaCl
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
10 - 50
30 to 60% of activity is observed between 20° and 30°C and 20% activity at 10 and 50°C, respectively
40 - 80
40°C: about 50% of maximal activity, 80°C: about 70% of maximal activity
50 - 75
50°C: about 50% of maximal activity, 75°C: about 60% of maximal activity, oxidation of (2S,5S)-2,5-hexanediol, in presence of 1 M NaCl
65 - 86
65°C: about 50% of maximal activity, 86°C: about 50% of maximal activity, oxidation of (2S,5S)-2,5-hexanediol, no addition of NaCl
70 - 95
70°C: 60% of maximal activity, 95°C: 70% of maximal activity
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
bifunctional enzyme, C-terminal section belongs to the iron-containing alcohol dehydrogenase family, N-terminal section belongs to the aldehyde dehydrogenase family
UniProt
brenda
bifunctional enzyme, C-terminal section belongs to the iron-containing alcohol dehydrogenase family, N-terminal section belongs to the aldehyde dehydrogenase family
UniProt
brenda
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
additional information
-
no or very low expression in lungs, spleen, pancreas, large intestine and eye
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). A0A396HW29_MEDTR
65
0
7342
TrEMBL
other Location (Reliability: 2)
A0A2P6S185_ROSCH
123
0
13997
TrEMBL
Mitochondrion (Reliability: 5)
A0A0H3W5U9_HUNTH
873
0
96010
TrEMBL
-
A0A0H3W5V0_THESA
859
0
94862
TrEMBL
-
C6A190_THESM
Thermococcus sibiricus (strain DSM 12597 / MM 739)
234
0
26151
TrEMBL
-
D4GP73_HALVD
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
349
0
36992
TrEMBL
-
Q5V676_HALMA
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)
384
0
40611
TrEMBL
-
RDH14_HUMAN
336
1
36865
Swiss-Prot
Secretory Pathway (Reliability: 3)
Q9HMB6_HALSA
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
347
0
36203
TrEMBL
-
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
41600
x * 41600, His-tagged protein, SDS-PAGE, mass spectrometry
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
dimer
monomer
tetramer
tetramer