BRENDA - Enzyme Database
show all sequences of 1.14.13.9

Dual role of the carboxyl-terminal region of pig liver L-kynurenine 3-monooxygenase: mitochondrial-targeting signal and enzymatic activity

Hirai, K.; Kuroyanagi, H.; Tatebayashi, Y.; Hayashi, Y.; Hirabayashi-Takahashi, K.; Saito, K.; Haga, S.; Uemura, T.; Izumi, S.; J. Biochem. 148, 639-650 (2010)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
DNA and amino acid sequence determnination and analysis, sequence comparisons, expression of FLAG-tagged wild-type enzyme and of C-terminal truncation mutants in COS-7 cells. The FLAG tag directs the wild-type enzyme to mitochondria but also to the cytosol and the plasma mambrane, overview
Sus scrofa
Engineering
Protein Variants
Commentary
Organism
additional information
construction of C-terminal truncation mutants KMODELTAC10, KMODELTAC20, KMODELTAC30, KMODELTAC50, and KMODELTAC70, that are all localized in the cytosol after recombinant expression in COS-7 cells, exept for KMODELTAC10. Two forms of C-terminal truncation, KMODELTAC10D and KMODELTAC20D retain almost full activity but KMODELTAC30D shows 1.6fold higher activity than the wild-type. The activities of KMODELTAC50 and KMODELTAC70 is highly reduced, overview. The quantity of expressed KMODELTA30D in COS-7 cellsis 1.3fold higher than the wild-type KMO
Sus scrofa
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrial outer membrane
the C-terminal region functions as a mitochondrial targeting signal
Sus scrofa
5741
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
L-kynurenine + NADH + H+ + O2
Sus scrofa
-
3-hydroxy-L-kynurenine + NAD+ + H2O
-
-
?
L-kynurenine + NADPH + H+ + O2
Sus scrofa
-
3-hydroxy-L-kynurenine + NADP+ + H2O
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Sus scrofa
Q9MZS9
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Sus scrofa
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
L-kynurenine + NADH + H+ + O2
-
712322
Sus scrofa
3-hydroxy-L-kynurenine + NAD+ + H2O
-
-
-
?
L-kynurenine + NADPH + H+ + O2
-
712322
Sus scrofa
3-hydroxy-L-kynurenine + NADP+ + H2O
-
-
-
?
Subunits
Subunits
Commentary
Organism
More
the C-terminal region is required for the enzymatic activity and functions as a mitochondrial targeting signal
Sus scrofa
Synonyms
Synonyms
Commentary
Organism
KMO
-
Sus scrofa
L-kynurenine 3-monooxygenase
-
Sus scrofa
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Sus scrofa
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Sus scrofa
Cofactor
Cofactor
Commentary
Organism
Structure
FAD
-
Sus scrofa
NADH
-
Sus scrofa
NADPH
-
Sus scrofa
Cloned(Commentary) (protein specific)
Commentary
Organism
DNA and amino acid sequence determnination and analysis, sequence comparisons, expression of FLAG-tagged wild-type enzyme and of C-terminal truncation mutants in COS-7 cells. The FLAG tag directs the wild-type enzyme to mitochondria but also to the cytosol and the plasma mambrane, overview
Sus scrofa
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
FAD
-
Sus scrofa
NADH
-
Sus scrofa
NADPH
-
Sus scrofa
Engineering (protein specific)
Protein Variants
Commentary
Organism
additional information
construction of C-terminal truncation mutants KMODELTAC10, KMODELTAC20, KMODELTAC30, KMODELTAC50, and KMODELTAC70, that are all localized in the cytosol after recombinant expression in COS-7 cells, exept for KMODELTAC10. Two forms of C-terminal truncation, KMODELTAC10D and KMODELTAC20D retain almost full activity but KMODELTAC30D shows 1.6fold higher activity than the wild-type. The activities of KMODELTAC50 and KMODELTAC70 is highly reduced, overview. The quantity of expressed KMODELTA30D in COS-7 cellsis 1.3fold higher than the wild-type KMO
Sus scrofa
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrial outer membrane
the C-terminal region functions as a mitochondrial targeting signal
Sus scrofa
5741
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
L-kynurenine + NADH + H+ + O2
Sus scrofa
-
3-hydroxy-L-kynurenine + NAD+ + H2O
-
-
?
L-kynurenine + NADPH + H+ + O2
Sus scrofa
-
3-hydroxy-L-kynurenine + NADP+ + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Sus scrofa
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
L-kynurenine + NADH + H+ + O2
-
712322
Sus scrofa
3-hydroxy-L-kynurenine + NAD+ + H2O
-
-
-
?
L-kynurenine + NADPH + H+ + O2
-
712322
Sus scrofa
3-hydroxy-L-kynurenine + NADP+ + H2O
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
More
the C-terminal region is required for the enzymatic activity and functions as a mitochondrial targeting signal
Sus scrofa
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Sus scrofa
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Sus scrofa
General Information
General Information
Commentary
Organism
additional information
the C-terminal region of pig liver KMO plays a dual role. First, it is required for the enzymatic activity. Second, it functions as a mitochondrial targeting signal
Sus scrofa
General Information (protein specific)
General Information
Commentary
Organism
additional information
the C-terminal region of pig liver KMO plays a dual role. First, it is required for the enzymatic activity. Second, it functions as a mitochondrial targeting signal
Sus scrofa
Other publictions for EC 1.14.13.9
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741802
Tashiro
Kynurenine 3-monooxygenase is ...
Mus musculus
Behav. Brain Res.
317
279-285
2017
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
742039
Erhardt
Adaptive and behavioral chang ...
Mus musculus
Biol. Psychiatry
82
756-765
2017
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
742081
Phillips
Substrate and inhibitor speci ...
Cytophaga hutchinsonii
Bioorg. Med. Chem. Lett.
27
1705-1708
2017
-
2
-
-
-
-
8
3
-
-
-
1
-
4
-
-
-
-
-
-
-
-
3
-
-
-
-
-
3
-
-
-
-
7
-
-
-
2
-
-
-
-
-
-
8
7
3
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
3
-
-
-
-
-
1
1
-
3
3
742082
Liddle
The discovery of potent and s ...
Homo sapiens
Bioorg. Med. Chem. Lett.
27
2023-2028
2017
-
-
-
-
-
-
31
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
31
-
-
-
1
-
-
-
31
31
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
742478
Gao
Biochemistry and structural s ...
Homo sapiens, Pseudomonas fluorescens
FASEB J.
32
2036-2045
2017
-
1
1
1
25
-
2
-
-
-
2
-
-
5
-
1
1
-
-
-
-
-
2
-
-
2
-
-
-
2
-
-
-
1
-
-
-
1
1
-
1
25
-
-
2
1
-
-
-
2
-
-
-
1
1
-
-
-
-
2
-
2
-
-
-
2
-
-
-
-
1
1
-
-
-
743067
Walker
Development of a series of ky ...
Pseudomonas fluorescens
J. Med. Chem.
60
3383-3404
2017
-
-
-
-
-
-
34
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
33
-
-
-
-
-
-
-
33
34
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
743342
Hutchinson
Structural and mechanistic ba ...
Homo sapiens, Pseudomonas fluorescens
Nat. Commun.
8
15827
2017
-
2
-
-
-
-
12
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
8
-
2
-
2
-
-
-
8
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
743358
Gonzalez Esquivel
Kynurenine pathway metabolite ...
Homo sapiens, Rattus norvegicus
Neuropharmacology
112
331-345
2017
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
742349
Smith
Kynurenine-3-monooxygenase a ...
Homo sapiens, Rattus norvegicus, Pseudomonas fluorescens, Sus scrofa
Drug Discov. Today
21
315-324
2016
-
1
-
-
-
-
2
-
2
-
-
-
-
7
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
1
-
4
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
743747
Wilson
Bacterial expression of human ...
Homo sapiens
Protein Expr. Purif.
95
96-103
2014
-
-
1
-
-
-
-
4
1
-
-
-
-
6
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
4
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
724908
Stephens
Kynurenine 3-monooxygenase med ...
Mus musculus
Eur. J. Immunol.
43
1727-1734
2013
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
725567
Winkler
Development of LC/MS/MS, high- ...
Homo sapiens
J. Biomol. Screen.
18
879-889
2013
-
1
-
-
-
-
3
1
-
-
-
-
-
7
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
1
-
-
-
-
-
3
3
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
726040
Amaral
Structural basis of kynurenine ...
Saccharomyces cerevisiae
Nature
496
382-385
2013
-
-
1
1
-
-
1
-
-
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
1
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
712322
Hirai
Dual role of the carboxyl-term ...
Sus scrofa
J. Biochem.
148
639-650
2010
-
-
1
-
1
-
-
-
3
-
-
2
-
11
-
-
-
-
-
3
-
-
2
1
2
1
-
-
-
1
-
-
3
-
-
-
-
-
1
3
-
1
-
-
-
-
-
3
-
-
2
-
-
-
-
-
3
-
-
2
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
705250
Amori
On the relationship between th ...
Rattus norvegicus
J. Neurochem.
109
316-325
2009
-
-
-
-
-
-
2
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684812
Gregoire
Prolonged kynurenine 3-hydroxy ...
Macaca fascicularis
Behav. Brain Res.
186
161-167
2008
-
-
-
-
-
-
1
-
-
-
-
1
-
8
-
-
-
-
-
1
-
-
2
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689224
Connor
Induction of indolamine 2,3-di ...
Rattus norvegicus
Neurosci. Lett.
441
29-34
2008
1
-
-
-
-
-
-
-
-
-
-
1
-
9
-
-
-
-
-
6
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702221
Crozier-Reabe
Kynurenine 3-monooxygenase fro ...
Pseudomonas fluorescens
Biochemistry
47
12420-12433
2008
-
-
1
-
-
-
3
-
-
1
-
-
-
6
-
-
1
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
3
-
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675556
Ceresoli-Borroni
Perinatal kynurenine 3-hydroxy ...
Mus musculus, Rattus norvegicus
J. Neurosci. Res.
85
845-854
2007
-
-
-
-
-
-
2
-
-
-
-
4
-
12
-
-
-
-
-
4
2
-
6
-
2
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
4
-
-
-
-
-
4
2
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676975
Crozier
Heterologous expression and pu ...
Pseudomonas fluorescens, Pseudomonas fluorescens 17400
Protein Expr. Purif.
51
324-333
2007
-
1
1
-
-
1
1
7
-
-
1
2
-
5
-
-
1
-
-
1
1
-
4
1
1
1
-
-
2
1
1
4
2
-
-
-
-
1
1
2
-
-
1
-
1
-
7
-
-
1
2
-
-
-
1
-
1
1
-
4
1
1
-
-
2
1
1
4
-
-
-
-
-
-
-
687098
Quan
-
Rescue of white egg 1 mutant b ...
Bombyx mori, Bombyx mori C108
Insect Sci.
14
85-92
2007
-
2
-
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
-
7
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
7
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
742657
Quan
-
Rescue of white egg 1 mutant ...
Bombyx mori
Insect Sci.
14
85-92
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
675745
Ragazzi
Cloricromene effect on the enz ...
Oryctolagus cuniculus
Life Sci.
78
785-794
2006
-
-
-
-
-
-
1
-
1
-
-
1
-
5
-
-
-
-
-
2
2
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
2
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659985
Giorgini
A genomic screen in yeast impl ...
Saccharomyces cerevisiae, Homo sapiens
Nat. Genet.
37
526-531
2005
-
1
-
-
-
-
2
-
2
-
-
4
-
7
-
-
-
-
-
-
-
-
6
-
4
-
-
-
-
-
-
-
2
-
-
-
-
1
-
2
-
-
-
-
2
-
-
2
-
-
4
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660112
Ligam
Localisation of indoleamine 2, ...
Homo sapiens
Placenta
26
498-504
2005
-
-
-
-
-
-
-
-
-
-
-
1
-
6
-
-
-
-
-
10
-
-
2
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
10
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673130
Comai
The effect of age on the enzym ...
Rattus norvegicus
Clin. Chim. Acta
360
67-80
2005
-
-
-
-
-
-
-
-
1
-
-
2
-
2
-
-
-
-
-
3
1
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
3
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657495
Allegri
Kynurenine pathway enzymes in ...
Cavia porcellus, Oryctolagus cuniculus, Mus musculus, Rattus norvegicus
Adv. Exp. Med. Biol.
527
455-463
2003
-
-
-
-
-
-
-
-
4
-
-
4
-
16
-
-
-
-
-
20
7
-
8
-
4
-
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
-
-
-
-
-
-
4
-
-
4
-
-
-
-
-
20
7
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658919
Han
Analysis of the wild-type and ...
Aedes aegypti, Aedes aegypti Liverpool
Insect Mol. Biol.
12
483-490
2003
-
-
1
-
1
-
2
4
1
-
1
2
-
7
-
-
1
-
-
-
-
-
6
1
4
1
-
-
3
1
-
-
3
4
-
-
-
-
1
3
-
1
-
-
2
4
4
1
-
1
2
-
-
-
1
-
-
-
-
6
1
1
-
-
3
1
-
-
-
-
-
-
-
-
-
658826
Lorenzen
Cloning and characterization o ...
Drosophila melanogaster, Tribolium castaneum
Genetics
160
225-234
2002
-
1
1
-
1
-
-
-
-
-
-
1
-
17
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658918
Hirai
cDNA cloning, functional expre ...
Anopheles stephensi
Insect Mol. Biol.
11
497-504
2002
-
-
1
-
-
1
-
-
-
-
1
1
-
8
-
-
1
-
-
4
2
1
2
2
2
-
-
-
-
1
-
-
2
-
-
-
-
-
1
2
-
-
1
-
-
-
-
-
-
1
1
-
-
-
1
-
4
2
1
2
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
348532
Chiarugi
Kynurenine 3-momo-oxygenase ac ...
Rattus norvegicus
Neuroscience
102
687-695
2001
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
2
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348531
Breton
Functional characterization an ...
Rattus norvegicus
Eur. J. Biochem.
267
1092-1099
2000
-
-
1
-
-
-
3
-
2
-
2
-
-
4
-
-
1
-
-
1
2
1
1
-
-
-
-
1
-
1
1
-
3
2
-
-
-
-
1
3
-
-
-
-
3
2
-
2
-
2
-
-
-
-
1
-
1
2
1
1
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
348533
Drysdale
Synthesis and SAR of 4-aryl-2- ...
Homo sapiens
J. Med. Chem.
43
123-127
2000
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348534
Urenjak
Kynurenine 3-hydroxylase inhib ...
Rattus norvegicus
J. Neurochem.
75
2427-2433
2000
-
-
-
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348528
Uemura
Purification of L-kynurenine 3 ...
Sus scrofa
Adv. Exp. Med. Biol.
467
619-623
1999
-
-
-
-
-
-
-
-
4
-
1
-
-
4
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
1
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348529
Cozzi
Kynurenine hydroxylase inhibit ...
Meriones unguiculatus, Rattus norvegicus
J. Cereb. Blood Flow Metab.
19
771-777
1999
-
-
-
-
-
-
4
-
-
-
-
-
-
14
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348530
Heidempergher
Pyrrolo[3,2-c]quinoline deriva ...
Rattus norvegicus
Farmaco
54
152-160
1999
-
-
-
-
-
-
2
-
1
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348525
Giordani A.; Pevarello P.; Cini
4-phenyl-4-oxo-butanoic acid d ...
Rattus norvegicus
Bioorg. Med. Chem. Lett.
8
2907-2012
1998
-
-
-
-
-
-
2
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348527
Rover
Synthesis and biochemical eval ...
Rattus norvegicus
J. Med. Chem.
40
4378-4385
1997
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348535
Alberati-Giani
Cloning and functional express ...
Homo sapiens
FEBS Lett.
410
407-412
1997
-
-
1
-
-
-
-
-
-
-
1
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348526
Speciale
Kynurenic acid-enhancing and a ...
Rattus norvegicus
Adv. Exp. Med. Biol.
398
221-227
1996
-
-
-
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348536
Pellicciari
Modulation of the kynurenine p ...
Rattus norvegicus
J. Med. Chem.
37
647-655
1994
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348521
Saito
Kynurenine 3-hydroxylase in br ...
Meriones unguiculatus, Homo sapiens, Macaca mulatta, Mus musculus, Rattus norvegicus
Arch. Biochem. Biophys.
307
104-109
1993
-
-
-
-
-
-
5
1
-
-
-
2
-
20
-
-
-
-
-
11
5
1
4
-
-
-
1
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
1
-
-
-
2
-
-
-
-
-
11
5
1
4
-
-
1
2
-
1
-
-
-
-
-
-
-
-
-
348524
Shin
Inhibition of L-kynurenine 3-h ...
Saccharomyces pastorianus
J. Nutr. Sci. Vitaminol.
28
191-201
1982
-
-
-
-
-
-
4
-
3
-
-
-
-
4
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
1
-
-
-
-
4
2
-
3
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348519
McLean-Bowen
Corresponding changes in kynur ...
Saccharomyces cerevisiae
J. Bacteriol.
145
1325-1333
1981
-
-
-
-
-
-
-
-
6
-
-
-
-
4
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348523
Stratakis
-
Subcellular localization and p ...
Ephestia kuehniella
J. Comp. Physiol.
141
451-456
1981
-
-
-
-
-
-
3
2
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
3
-
2
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
348518
Nishimoto
Purification of L-kynurenine 3 ...
Rattus norvegicus
J. Chromatogr.
169
357-364
1979
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
1
-
-
1
1
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
1
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
348516
Nisimoto
Molecular properties of L-kynu ...
Rattus norvegicus
J. Biochem.
81
1413-1425
1977
-
-
-
-
-
1
-
1
1
-
2
-
-
1
-
-
1
-
-
1
1
-
2
1
-
1
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
-
1
-
-
-
1
1
-
2
-
-
-
-
1
-
1
1
-
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
348517
Nisimoto
Isolation of L-kynurenine 3-hy ...
Rattus norvegicus
J. Biochem.
78
573-581
1975
-
-
-
-
-
1
-
-
2
-
1
-
-
3
-
-
1
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
2
-
1
-
-
-
-
1
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348522
Pinamonti
-
Kynurenine-3-hydroxylase of Sc ...
Schistocerca gregaria
Insect Biochem.
4
9-16
1974
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348520
Schott
The regulatory function of L-k ...
Saccharomyces cerevisiae
Hoppe-Seyler's Z. Physiol. Chem.
352
1654-1658
1971
-
-
-
-
-
-
2
4
1
-
-
1
-
3
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
2
-
-
-
-
2
-
4
1
-
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
348514
Okamoto
Flavin adenine dinucleotide re ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
29
394-399
1967
-
-
-
-
-
-
-
1
3
-
-
-
-
3
-
-
-
-
-
2
2
-
1
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
1
3
-
-
-
-
-
-
-
-
2
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
348515
Saito
Studies on oxygenases: Enzymat ...
Rattus norvegicus, Rattus norvegicus Osborne-Mendel
J. Biol. Chem.
229
921-934
1957
2
-
-
-
-
-
1
2
1
5
-
2
-
2
-
-
1
-
-
1
-
-
6
-
-
1
-
-
-
1
1
-
2
-
-
-
2
-
-
2
-
-
-
-
1
-
2
1
5
-
2
-
-
-
1
-
1
-
-
6
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-