BRENDA - Enzyme Database show
show all sequences of 1.14.14.139

Hydroxylations in biosynthesis and metabolism of bile acids. Catalytic properties of different cytochrome P-450

Hansson, R.; Wikvall, K.; J. Biol. Chem. 255, 1643-1649 (1980)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Oryctolagus cuniculus
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Oryctolagus cuniculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5beta-cholestane-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
-
659115
Oryctolagus cuniculus
5beta-cholestane-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
cytochrome P-450
-
Oryctolagus cuniculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
cytochrome P-450
-
Oryctolagus cuniculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Oryctolagus cuniculus
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5beta-cholestane-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
-
659115
Oryctolagus cuniculus
5beta-cholestane-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Other publictions for EC 1.14.14.139
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
727973
Pathak
Retinoic acid related orphan r ...
Mus musculus
J. Biol. Chem.
288
37154-37165
2013
-
-
-
-
-
-
-
-
-
-
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1
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1
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1
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2
-
-
2
-
-
686253
Lundell
Species-specific and age-depen ...
Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
Curr. Drug Metab.
9
323-331
2008
-
-
5
-
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5
-
10
-
5
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10
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5
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5
5
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5
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10
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10
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688997
Lee
Liver receptor homolog-1 regul ...
Mus musculus
Mol. Endocrinol.
22
1345-1356
2008
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1
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3
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695473
Wooton-Kee
Increased cholesterol 7alpha-h ...
Rattus norvegicus
Am. J. Physiol. Gastrointest. Liver Physiol.
294
G1009-G1016
2008
-
-
-
-
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1
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1
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1
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1
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700579
Liu
Dexamethasone exposure of neon ...
Rattus norvegicus
Pediatr. Res.
63
375-381
2008
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1
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1
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1
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2
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-
2
-
-
673917
Wang
Differential hepatocellular zo ...
Mus musculus
Histochem. Cell Biol.
127
253-261
2007
-
-
1
-
1
-
1
-
1
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-
1
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1
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1
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2
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1
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1
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1
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2
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688559
Li
Human and murine hepatic stero ...
Homo sapiens, Mus musculus
J. Nutr.
137
1705-1712
2007
2
-
2
-
-
-
2
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-
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4
-
4
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2
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4
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2
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4
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2
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4
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-
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688776
Zollner
Expression of bile acid synthe ...
Homo sapiens
Liver Int.
27
920-929
2007
-
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1
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-
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2
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1
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1
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3
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1
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1
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3
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689757
Sanyal
Involvement of corepressor com ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
104
15665-15670
2007
-
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1
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1
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2
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2
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1
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2
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-
659672
Inoue
Regulation of bile acid biosyn ...
Mus musculus
J. Lipid Res.
47
215-227
2006
-
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-
-
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-
-
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1
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1
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1
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675268
Sehayek
Two loci on chromosome 9 contr ...
Mus musculus
J. Lipid Res.
47
2020-2027
2006
-
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1
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1
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1
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1
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1
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2
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677257
Ellis
Suppression of bile acid synth ...
Homo sapiens
World J. Gastroenterol.
12
4640-4645
2006
-
-
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-
1
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1
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1
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1
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2
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2
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2
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2
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657518
Jahan
Cytokine regulation of human s ...
Homo sapiens
Am. J. Physiol.
288
G685-695
2005
-
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1
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1
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1
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1
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1
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658876
Wang
Human sterol 12alpha-hydroxyla ...
Homo sapiens
Histochem. Cell Biol.
123
441-446
2005
-
-
-
-
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-
-
1
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1
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2
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672338
Murphy
Cholic acid as key regulator o ...
Mus musculus
Biochim. Biophys. Acta
1735
167-175
2005
-
-
-
-
1
-
1
-
1
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-
1
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1
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1
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2
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1
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1
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1
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1
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2
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675742
Chen
Comparative regulation of majo ...
Mus musculus, Rattus norvegicus
Life Sci.
77
746-757
2005
2
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2
-
2
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2
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2
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2
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677112
Abrahamsson
Polymorphism in the coding par ...
Homo sapiens
Scand. J. Clin. Lab. Invest.
65
595-600
2005
-
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1
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2
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2
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657770
Yang
Mechanisms of cholesterol and ...
Mus musculus, Rattus norvegicus
Biochem. Biophys. Res. Commun.
320
1204-1210
2004
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2
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4
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2
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658183
Lundell
Gene structure of pig sterol 1 ...
Sus scrofa
Biochim. Biophys. Acta
1634
86-96
2003
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1
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1
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1
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1
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658170
Yang
On the mechanism of bile acid ...
Rattus norvegicus
Biochim. Biophys. Acta
1583
63-73
2002
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1
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659160
Zhang
Transcriptional regulation of ...
Homo sapiens
J. Biol. Chem.
276
41690-41699
2001
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1
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1
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4
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1
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658809
Vlahcevic
Regulation of sterol 12alpha-h ...
Rattus norvegicus
Gastroenterology
118
599-607
2000
-
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1
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1
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1
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659144
del Castillo-Olivares
alpha1-Fetoprotein transcripti ...
Rattus norvegicus
J. Biol. Chem.
275
17793-17799
2000
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1
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1
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1
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658154
Andersson
Thyroid hormone suppresses hep ...
Rattus norvegicus
Biochim. Biophys. Acta
1438
167-174
1999
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1
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1
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1
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1
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1
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1
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659575
Gustafsson
Bile acid synthesis during dev ...
Homo sapiens
J. Clin. Invest.
75
604-607
1985
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1
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659115
Hansson
Hydroxylations in biosynthesis ...
Oryctolagus cuniculus
J. Biol. Chem.
255
1643-1649
1980
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