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Literature summary for 1.14.14.94 extracted from

  • Kikuta, Y.; Miyauchi, Y.; Kusunose, E.; Kusunose, M.
    Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene (1999), DNA Cell Biol., 18, 723-730.
    View publication on PubMed
Search for more literature for 1.14.14.94

Cloned(Commentary)

Cloned (Comment) Organism
CYP4F2 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens inactivation of leukotriene B4, a mediator of inflammation (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell constitutively expressed in hepatoma cell line Hep-G2 Homo sapiens
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kidney CYP4F2 Homo sapiens
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liver CYP4F2 Homo sapiens
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neutrophil CYP4F2 not expressed in neutrophils Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH-hemoprotein reductase] + O2 inactivation of leukotriene B4, a mediator of inflammation Homo sapiens (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 leukotriene B4 is identical with (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate Homo sapiens 20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?

Synonyms

Synonyms Comment Organism
CYP4F2
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 Homo sapiens
CYP4F3
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 Homo sapiens