BRENDA - Enzyme Database show
show all sequences of 1.14.19.67

Systematic knockdown of morphine pathway enzymes in opium poppy using virus-induced gene silencing

Wijekoon, C.P.; Facchini, P.J.; Plant J. 69, 1052-1063 (2012)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(R)-reticuline + [reduced NADPH-hemoprotein reductase] + O2
Papaver somniferum
-
salutaridine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Papaver somniferum
B1NF18
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(R)-norreticuline + [reduced NADPH-hemoprotein reductase] + O2
-
720707
Papaver somniferum
norsalutaridine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
(R)-reticuline + [reduced NADPH-hemoprotein reductase] + O2
-
720707
Papaver somniferum
salutaridine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(R)-reticuline + [reduced NADPH-hemoprotein reductase] + O2
Papaver somniferum
-
salutaridine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(R)-norreticuline + [reduced NADPH-hemoprotein reductase] + O2
-
720707
Papaver somniferum
norsalutaridine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
(R)-reticuline + [reduced NADPH-hemoprotein reductase] + O2
-
720707
Papaver somniferum
salutaridine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
General Information
General Information
Commentary
Organism
malfunction
enzyme silencing causes a profound increase in the absolute accumulation of reticuline at the expense of downstream products, especially morphine
Papaver somniferum
General Information (protein specific)
General Information
Commentary
Organism
malfunction
enzyme silencing causes a profound increase in the absolute accumulation of reticuline at the expense of downstream products, especially morphine
Papaver somniferum
Other publictions for EC 1.14.19.67
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
743574
Fossati
Synthesis of morphinan alkalo ...
Papaver somniferum
PLoS ONE
10
e0124459
2015
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-
1
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3
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1
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1
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1
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728475
Onoyovwe
Morphine biosynthesis in opium ...
Papaver somniferum
Plant Cell
25
4110-4122
2013
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-
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-
-
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1
1
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2
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5
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1
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1
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5
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1
1
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720707
Wijekoon
Systematic knockdown of morphi ...
Papaver somniferum
Plant J.
69
1052-1063
2012
-
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-
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1
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2
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1
1
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698930
Gesell
CYP719B1 is salutaridine synth ...
Papaver somniferum
J. Biol. Chem.
284
24432-24442
2009
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1
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-
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1
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1
1
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4
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1
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2
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2
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1
2
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1
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1
1
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1
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1
1
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1
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2
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2
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1
2
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393876
Amann
-
Purification and characterizat ...
Bos taurus, Homo sapiens, Mus musculus, Ovis aries, Rattus norvegicus, Sus scrofa
Heterocycles
1
425-440
1995
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-
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1
9
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1
1
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6
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1
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1
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3
1
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7
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7
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1
9
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1
1
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1
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1
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3
1
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393875
Gerardy R.; Zenk
-
Formation of salutaridine from ...
Papaver somniferum
Phytochemistry
32
79-86
1993
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-
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3
2
2
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1
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1
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1
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5
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4
2
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1
1
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1
1
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1
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1
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3
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2
2
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1
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5
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4
2
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1
1
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1
1
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