Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli M15 cells | Rhipicephalus microplus |
expressed in Escherichia coli M15 cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxybenzaldehyde | more than 95% inhibition at 0.05 mM | Mus musculus | |
4-hydroxybenzaldehyde | more than 95% inhibition at 0.05 mM | Rhipicephalus microplus | |
4-methoxybenzaldehyde | - |
Mus musculus | |
4-methoxybenzaldehyde | - |
Rhipicephalus microplus | |
4-tolualdehyde | - |
Mus musculus | |
4-tolualdehyde | - |
Rhipicephalus microplus | |
succinate semialdehyde | the enzyme loses more than 80% of its enzymatic potential at 0.5 mM and shows 8% residual activity at 3 mM succinate semialdehyde | Mus musculus | |
succinate semialdehyde | the enzyme loses more than 80% of its enzymatic potential at 0.5 mM and shows 8% residual activity at 3 mM succinate semialdehyde | Rhipicephalus microplus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00247 | - |
succinate semialdehyde | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Mus musculus | |
0.00256 | - |
succinate semialdehyde | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Rhipicephalus microplus | |
0.0151 | - |
4-carboxybenzaldehyde | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Mus musculus | |
0.0253 | - |
n-hexanal | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Mus musculus | |
0.0287 | - |
n-Pentanal | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Mus musculus | |
0.0312 | - |
4-carboxybenzaldehyde | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Rhipicephalus microplus | |
0.0331 | - |
3-carboxybenzaldehyde | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Mus musculus | |
0.0433 | - |
NAD+ | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Rhipicephalus microplus | |
0.0502 | - |
3-Nitrobenzaldehyde | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Rhipicephalus microplus | |
0.0514 | - |
n-octanal | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Rhipicephalus microplus | |
0.061 | - |
n-Butanal | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Mus musculus | |
0.096 | - |
n-Pentanal | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Rhipicephalus microplus | |
0.1035 | - |
3-(methoxycarbonyl)benzoate | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Rhipicephalus microplus | |
0.107 | - |
n-hexanal | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Rhipicephalus microplus | |
0.115 | - |
4-carboxybenzaldehyde | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Mus musculus | |
0.137 | - |
n-octanal | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Mus musculus | |
0.1418 | - |
3-carboxybenzaldehyde | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Rhipicephalus microplus | |
0.156 | - |
4-nitrobenzaldehyde | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Mus musculus | |
0.1612 | - |
4-nitrobenzaldehyde | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Rhipicephalus microplus | |
0.1668 | - |
4-carboxybenzaldehyde | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Rhipicephalus microplus | |
0.167 | - |
benzaldehyde | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Rhipicephalus microplus | |
0.218 | - |
methyl 3-formylbenzoate | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Mus musculus | |
0.227 | - |
NAD+ | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Mus musculus | |
0.287 | - |
3-Nitrobenzaldehyde | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Mus musculus | |
0.323 | - |
n-Butanal | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Rhipicephalus microplus | |
0.616 | - |
NADP+ | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Mus musculus | |
1.212 | - |
propanal | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Mus musculus | |
1.622 | - |
propanal | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Rhipicephalus microplus | |
2.797 | - |
acetaldehyde | in 100 mM Na2HPO4/NaH2PO4 buffer, 1 mM dithiothreitol, at pH 8.5 and 22°C | Rhipicephalus microplus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
98000 | - |
SDS-PAGE | Rhipicephalus microplus |
98000 | - |
SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8BWF0 | - |
- |
Rhipicephalus microplus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni2+-NTA agarose column chromatography | Rhipicephalus microplus |
Ni2+-NTA agarose column chromatography | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
larva | - |
Rhipicephalus microplus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-carboxybenzaldehyde + NAD+ + H2O | about 1% activity compared to succinate semialdehyde | Mus musculus | 2-carboxybenzoate + NADH + H+ | - |
? | |
2-hydroxybenzaldehyde + NAD+ + H2O | about 1% activity compared to succinate semialdehyde | Mus musculus | 2-hydroxybenzoate + NADH + H+ | - |
? | |
2-nitrobenzaldehyde + NAD+ + H2O | about 3% activity compared to succinate semialdehyde | Mus musculus | 2-nitrobenzoate + NADH + H+ | - |
? | |
2-phenylacetaldehyde + NAD+ + H2O | about 5% activity compared to succinate semialdehyde | Mus musculus | 2-phenylbenzoate + NADH + H+ | - |
? | |
2-tolualdehyde + NAD+ + H2O | about 1% activity compared to succinate semialdehyde | Mus musculus | 2-carboxytoluene + NADH + H+ | - |
? | |
3-carboxybenzaldehyde + NAD+ + H2O | about 20% activity compared to succinate semialdehyde | Mus musculus | 3-carboxybenzoate + NADH + H+ | - |
? | |
3-carboxybenzaldehyde + NAD+ + H2O | about 35% activity compared to succinate semialdehyde | Rhipicephalus microplus | 3-carboxybenzoate + NADH + H+ | - |
? | |
3-hydroxybenzaldehyde + NAD+ + H2O | about 1% activity compared to succinate semialdehyde | Mus musculus | 3-hydroxybenzoate + NADH + H+ | - |
? | |
3-hydroxybenzaldehyde + NAD+ + H2O | about 2% activity compared to succinate semialdehyde | Mus musculus | 3-hydroxybenzoate + NADH + H+ | - |
? | |
3-hydroxybenzaldehyde + NAD+ + H2O | about 3% activity compared to succinate semialdehyde | Rhipicephalus microplus | 3-hydroxybenzoate + NADH + H+ | - |
? | |
3-methoxy-benzaldehyde + NAD+ + H2O | about 10% activity compared to succinate semialdehyde | Rhipicephalus microplus | 3-methoxy-benzoate + NADH + H+ | - |
? | |
3-methoxy-benzaldehyde + NAD+ + H2O | about 5% activity compared to succinate semialdehyde | Mus musculus | 3-methoxy-benzoate + NADH + H+ | - |
? | |
3-methylbenzaldehyde + NAD+ + H2O | about 10% activity compared to succinate semialdehyde | Rhipicephalus microplus | 3-methylbenzoate + NADH + H+ | - |
? | |
3-methylbenzaldehyde + NAD+ + H2O | about 3% activity compared to succinate semialdehyde | Mus musculus | 3-methylbenzoate + NADH + H+ | - |
? | |
3-nitrobenzaldehyde + NAD+ + H2O | about 15% activity compared to succinate semialdehyde | Rhipicephalus microplus | 3-nitrobenzoate + NADH + H+ | - |
? | |
3-nitrobenzaldehyde + NAD+ + H2O | about 20% activity compared to succinate semialdehyde | Mus musculus | 3-nitrobenzoate + NADH + H+ | - |
? | |
4-carboxybenzaldehyde + NAD+ + H2O | about 10% activity compared to succinate semialdehyde | Mus musculus | 4-carboxybenzoate + NADH + H+ | - |
? | |
4-carboxybenzaldehyde + NAD+ + H2O | about 65% activity compared to succinate semialdehyde | Rhipicephalus microplus | 4-carboxybenzoate + NADH + H+ | - |
? | |
4-methoxy-benzaldehyde + NAD+ + H2O | about 1% activity compared to succinate semialdehyde | Mus musculus | 4-methoxy-benzoate + NADH + H+ | - |
? | |
4-methoxy-benzaldehyde + NAD+ + H2O | about 5% activity compared to succinate semialdehyde | Rhipicephalus microplus | 4-methoxy-benzoate + NADH + H+ | - |
? | |
4-nitrobenzaldehyde + NAD+ + H2O | about 15% activity compared to succinate semialdehyde | Mus musculus | 4-nitrobenzoate + NADH + H+ | - |
? | |
4-nitrobenzaldehyde + NAD+ + H2O | about 30% activity compared to succinate semialdehyde | Rhipicephalus microplus | 4-nitrobenzoate + NADH + H+ | - |
? | |
acetaldehyde + NAD+ + H2O | about 10% activity compared to succinate semialdehyde | Rhipicephalus microplus | acetate + NADH + H+ | - |
? | |
acetaldehyde + NAD+ + H2O | about 5% activity compared to succinate semialdehyde | Mus musculus | acetate + NADH + H+ | - |
? | |
benzaldehyde + NAD+ + H2O | about 30% activity compared to succinate semialdehyde | Rhipicephalus microplus | benzoate + NADH + H+ | - |
? | |
benzaldehyde + NAD+ + H2O | about 5% activity compared to succinate semialdehyde | Mus musculus | benzoate + NADH + H+ | - |
? | |
glyoxylic acid + NAD+ + H2O | about 1% activity compared to succinate semialdehyde | Mus musculus | 2-phenylbenzoate + NADH + H+ | - |
? | |
iso-butanal + NAD+ + H2O | less than 10% activity compared to succinate semialdehyde | Mus musculus | ? + NADH + H+ | - |
? | |
iso-butanal + NAD+ + H2O | less than 10% activity compared to succinate semialdehyde | Rhipicephalus microplus | isobutanoate + NADH + H+ | - |
? | |
iso-pentanal + NAD+ + H2O | about 2% activity compared to succinate semialdehyde | Mus musculus | ? + NADH + H+ | - |
? | |
iso-pentanal + NAD+ + H2O | less than 5% activity compared to succinate semialdehyde | Rhipicephalus microplus | isopentanoate + NADH + H+ | - |
? | |
methyl 3-formylbenzoate + NAD+ + H2O | about 20% activity compared to succinate semialdehyde | Mus musculus | 3-(methoxycarbonyl)benzoate + NADH + H+ | - |
? | |
methyl 3-formylbenzoate + NAD+ + H2O | about 45% activity compared to succinate semialdehyde | Rhipicephalus microplus | 3-(methoxycarbonyl)benzoate + NADH + H+ | - |
? | |
methyl 4-formylbenzoate + NAD+ + H2O | about 15% activity compared to succinate semialdehyde | Mus musculus | 4-(methoxycarbonyl)benzoate + NADH + H+ | - |
? | |
methyl 4-formylbenzoate + NAD+ + H2O | about 30% activity compared to succinate semialdehyde | Rhipicephalus microplus | 4-(methoxycarbonyl)benzoate + NADH + H+ | - |
? | |
additional information | no activity with NADP+ | Rhipicephalus microplus | ? | - |
? | |
additional information | no activity towards 2-methoxybenzaldehyde, 2-nitrobenzaldehyde, 2-carboxybenzaldehyde, 2-tolualdehyde, 4-tolualdehyde, 2-hydroxybenzaldehyde, 4-hydroxybenzaldehyde, 2-phenylacetaldedyde, and glyoxylic acid | Rhipicephalus microplus | ? | - |
? | |
additional information | no activity towards 2-methoxybenzaldehyde, and 4-tolualdehyde | Mus musculus | ? | - |
? | |
n-butanal + NAD+ + H2O | about 10% activity compared to succinate semialdehyde | Mus musculus | butanoate + NADH + H+ | - |
? | |
n-butanal + NAD+ + H2O | less than 60% activity compared to succinate semialdehyde | Rhipicephalus microplus | butanoate + NADH + H+ | - |
? | |
n-hexanal + NAD+ + H2O | about 110% activity compared to succinate semialdehyde | Rhipicephalus microplus | hexanoate + NADH + H+ | - |
? | |
n-hexanal + NAD+ + H2O | less than 10% activity compared to succinate semialdehyde | Mus musculus | hexanoate + NADH + H+ | - |
? | |
n-octanal + NAD+ + H2O | less than 10% activity compared to succinate semialdehyde | Mus musculus | n-octanoate + NADH + H+ | - |
? | |
n-octanal + NAD+ + H2O | less than 80% activity compared to succinate semialdehyde | Rhipicephalus microplus | n-octanoate + NADH + H+ | - |
? | |
n-pentanal + NAD+ + H2O | 100% activity | Rhipicephalus microplus | n-pentanoate + NADH + H+ | - |
? | |
n-pentanal + NAD+ + H2O | less than 20% activity compared to succinate semialdehyde | Mus musculus | n-pentanoate + NADH + H+ | - |
? | |
propanal + NAD+ + H2O | less than 10% activity compared to succinate semialdehyde | Mus musculus | propanoate + NADH + H+ | - |
? | |
propanal + NAD+ + H2O | less than 20% activity compared to succinate semialdehyde | Rhipicephalus microplus | propanoate + NADH + H+ | - |
? | |
succinate semialdehyde + NAD+ + H2O | 100% activity with succinate semialdehyde | Rhipicephalus microplus | succinate + NADH + H+ | - |
? | |
succinate semialdehyde + NAD+ + H2O | 100% activity with succinate semialdehyde | Mus musculus | succinate + NADH + H+ | - |
? | |
succinate semialdehyde + NADP+ + H2O | NAD+ is the more efficient coenzyme compared to NADP+, but the preference is not exclusive | Mus musculus | succinate + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SSADH | - |
Rhipicephalus microplus |
SSADH | - |
Mus musculus |
succinic semialdehyde dehydrogenase | - |
Rhipicephalus microplus |
succinic semialdehyde dehydrogenase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | no activity with NADP+ | Rhipicephalus microplus | |
NAD+ | - |
Rhipicephalus microplus | |
NAD+ | NAD+ is the more efficient coenzyme compared to NADP+, but the preference is not exclusive | Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.1 | - |
- |
Rhipicephalus microplus | 4-methoxybenzaldehyde | |
0.1 | - |
- |
Rhipicephalus microplus | 4-tolualdehyde | |
1 | - |
- |
Mus musculus | 4-tolualdehyde | |
2 | - |
- |
Mus musculus | 4-methoxybenzaldehyde |