Literature summary for 1.2.7.1 extracted from

Chen, P.Y.; Aman, H.; Can, M.; Ragsdale, S.W.; Drennan, C.L.
Binding site for coenzyme A revealed in the structure of pyruvate ferredoxin oxidoreductase from Moorella thermoacetica (2018), Proc. Natl. Acad. Sci. USA, 115, 3846-3851 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
native structure, those of lactyl-TPP and acetyl-TPP reaction intermediates, and with CoA bound. CoA binds to domain III and CoA binding and domain III movement drive electron transfer from the TPP, which is coordinated by domains I and IV, into the domain V [4Fe-4S] clusters	Moorella thermoacetica

Inhibitors

Inhibitors	Comment	Organism	Structure
thiamin diphosphate	CoA binds to domain III and CoA binding and domain III movement drive electron transfer from the TPP, which is coordinated by domains I and IV, into the domain V [4Fe-4S] clusters	Moorella thermoacetica
[4Fe-4S]-center	CoA binds to domain III and CoA binding and domain III movement drive electron transfer from the TPP, which is coordinated by domains I and IV, into the domain V [4Fe-4S] clusters	Moorella thermoacetica

Organism

Organism	UniProt	Comment	Textmining
Moorella thermoacetica	Q2RMD6	-	-

Synonyms

Synonyms	Comment	Organism
Moth_0064	-	Moorella thermoacetica

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Release 2023.1 (January 2023)