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Literature summary for 1.3.1.118 extracted from
- Structure-based design of a novel class of potent inhibitors of InhA, the enoyl acyl carrier protein reductase from Mycobacterium tuberculosis A computer modelling approach (2008), Chem. Biol. Drug Des., 72, 444-449 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| isoniazid | - |
Mycobacterium tuberculosis |  |
| Trp-Tyr-Trp | structure-based computer modelling approach to design a tripeptide inhibitor. Docking studies indicate that the designed peptide has potency 100 times higher than the best known inhibitor. The results suggest that the designed inhibitor is a suitable lead compound for the development of novel anti-TB drugs | Mycobacterium tuberculosis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | P9WGR1 | cf. EC 1.3.1.9 | - |
| Mycobacterium tuberculosis ATCC 25618 | P9WGR1 | cf. EC 1.3.1.9 | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| InhA | - |
Mycobacterium tuberculosis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | key enzyme in the biosynthesis of mycolic acids | Mycobacterium tuberculosis |
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