Crystallization (Comment) | Organism |
---|---|
crystal structure analysis | Homo sapiens |
crystal structure analysis | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
coproporphyrinogen III + O2 + 2 H+ | Gallus gallus | - |
protoporphyrinogen IX + 2 CO2 + 2 H2O | - |
? | |
coproporphyrinogen III + O2 + 2 H+ | Homo sapiens | - |
protoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? | |
coproporphyrinogen III + O2 + 2 H+ | Saccharomyces cerevisiae | - |
protoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Homo sapiens | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Gallus gallus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17-ethyl harderoporphyrinogen-III + O2 + 2 H+ | - |
Gallus gallus | ? | - |
? | |
17-ethylharderoporphyrinogen-III + O2 + 2 H+ | - |
Homo sapiens | 17-ethylprotoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? | |
17-ethylharderoporphyrinogen-III + O2 + 2 H+ | - |
Saccharomyces cerevisiae | 17-ethylprotoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? | |
coproporphyrinogen III + O2 + 2 H+ | - |
Gallus gallus | protoporphyrinogen IX + 2 CO2 + 2 H2O | - |
? | |
coproporphyrinogen III + O2 + 2 H+ | - |
Homo sapiens | protoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? | |
coproporphyrinogen III + O2 + 2 H+ | - |
Saccharomyces cerevisiae | protoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? | |
coproporphyrinogen III + O2 + 2 H+ | two oxidative decarboxylations sequentially to give a monovinylporphyrinogen intermediate Regiospecific generation of harderoporphyrinogen as an intermediate by first converting the A ring side chain to a vinyl unit. Type isomers of coproporphyrinogen, overview | Saccharomyces cerevisiae | protoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? | |
coproporphyrinogen III + O2 + 2 H+ | two oxidative decarboxylations sequentially to give a monovinylporphyrinogen intermediate. Regiospecific generation of harderoporphyrinogen as an intermediate by first converting the A ring side chain to a vinyl unit. Type isomers of coproporphyrinogen, overview | Homo sapiens | protoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? | |
harderoporphyrinogen-III + O2 + 2 H+ | - |
Gallus gallus | ? | - |
? | |
harderoporphyrinogen-IV + O2 + 2 H+ | - |
Gallus gallus | ? | - |
? | |
harderoporphyrinogen-VII + O2 + 2 H+ | a monovinyl intermediate in the metabolism of coproporphyrinogen-IV | Gallus gallus | ? | - |
? | |
harderoporphyrinogen-VII + O2 + 2 H+ | - |
Homo sapiens | ? + 2 CO2 + 2 H2O | - |
? | |
harderoporphyrinogen-VII + O2 + 2 H+ | - |
Saccharomyces cerevisiae | ? + 2 CO2 + 2 H2O | - |
? | |
isoharderoporphyrinogen + O2 + 2 H+ | very low activity | Gallus gallus | ? | - |
? | |
isoharderoporphyrinogen + O2 + 2 H+ | - |
Homo sapiens | ? + 2 CO2 + 2 H2O | - |
? | |
isoharderoporphyrinogen + O2 + 2 H+ | - |
Saccharomyces cerevisiae | ? + 2 CO2 + 2 H2O | - |
? | |
additional information | a nonnatural type I isomer of harderoporphyrinogen is also a substrate of CPO, no activity with 13-ethyl harderoporphyrinogen-III, substrate specificity with vinylic porphyrinogen derivatives, harderoporphyrinogen derivatives, and reaction mechanism, detailed overview | Gallus gallus | ? | - |
? | |
additional information | the 17-ethyl analogue of harderoporphyrinogen-III, but not its 13-ethyl isomer, is an excellent substrate for the enzyme in accord with a proposed model for the active site of the enzyme. Harderoporphyrinogen-VII, the monovinyl intermediate in the metabolism of coproporphyrinogen-IV, is an equally good substrate | Homo sapiens | ? | - |
? | |
additional information | the 17-ethyl analogue of harderoporphyrinogen-III, but not its 13-ethyl isomer, is an excellent substrate for the enzyme in accord with a proposed model for the active site of the enzyme. Harderoporphyrinogen-VII, the monovinyl intermediate in the metabolism of coproporphyrinogen-IV, is an equally good substrate | Saccharomyces cerevisiae | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CPO | - |
Gallus gallus |
CPO | - |
Homo sapiens |
CPO | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
metabolism | porphyrinogen derivative metabolis pathway, overview | Gallus gallus |
additional information | model for the active site, overview | Gallus gallus |
additional information | active-site models for substrate binding by coproporphyrinogen oxidase, overview. The invariant amino acids aspartate 400, arginine 262, and arginine 401 are essential for significant catalytic activity | Homo sapiens |
additional information | active-site models for substrate binding by coproporphyrinogen oxidase, overview. The invariant amino acids aspartate 400, arginine 262, and arginine 401 are essential for significant catalytic activity | Saccharomyces cerevisiae |