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Information on EC 1.3.3.3 - coproporphyrinogen oxidase
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1.3.3.3 coproporphyrinogen oxidaseSpecify your search results
Word Map
- 1.3.3.3
- heme
- protoporphyrinogen
- coproporphyria
- protoporphyrin
- porphyria
-
ferrochelatase
- uroporphyrinogen
-
5-aminolevulinic
- porphobilinogen
- tetrapyrrole
-
porphyrinogens
- medicine
-
oxygen-independent
-
coproporphyrinuria
- mg-protoporphyrin
-
ala-pdt
-
delta-aminolaevulinic
-
uroporphyrin
-
cutanea
- analysis
The enzyme appears in viruses and cellular organisms
Synonyms
coproporphyrinogen oxidase, coproporphyrinogen iii oxidase, hem13, cpox4, copro'gen oxidase, klhem13, coprogen oxidase, oxygen-dependent coproporphyrinogen iii oxidase, sll1185, hemn1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
copro'gen oxidase
Coprogen oxidase
coproporphyrinogen III oxidase
coproporphyrinogen oxidase
coproporphyrinogenase
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COX
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CPO
CPOX
HemF
LIN2
oxygen-dependent coproporphyrinogen III oxidase
Coprogen oxidase
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coproporphyrinogen III oxidase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O
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coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O
active site structure
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coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O
2 possible catalytic pathways of the reaction, overview, Tyrp274 is catalytically important, the following residues are not important for enzyme activity: Cys167, Tyr135, Tyr160, Tyr170, Tyr213, Tyr240, Tyr276, Trp36, Trp123, Trp166, and Trp198
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coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O
analysis of catalytic mechanism, modeling of active site structure
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coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O
substrate binding at the active site, structure and mechanism, catalytic mechanism
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coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O
substrate binding at the active site, structure and mechanism, catalytic mechanism
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coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O
CPO catalyzes two sequential oxidative decarboxylations of propionate moieties on coproporphyrinogen-III forming protoporphyrinogen-IX through the monovinyl intermediate harderoporphyrinogen
coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O
reaction starts by O2 addition to the pyrrole substrate yielding a hydroperoxide, which then abstracts a proton from the reactive propionate substituent, and the reaction may then proceed through H2O elimination, followed by decarboxylation
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coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O
reaction mechanism, substrate docking study and binding mode, involving residues H131, R135, D274, and R275, and active site analysis using crystal structures, molecular dynamics simulations, overview. Selectivity of the active site, formed by His131, Asn133, and Ser117, toward substituted tetrapyrroles, nonoccurrence of catalysis on the C and D rings of the tetrapyrrole. The carbonyl oxygen of G276 intervenes in the substrate anchoring by hydrogen bonding of the ring D pyrrole NH group. The pyrrole ring is very unlikely to undergo deprotonation during the catalytic cycle
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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oxidative decarboxylation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
coproporphyrinogen:oxygen oxidoreductase (decarboxylating)
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CAS REGISTRY NUMBER
COMMENTARY
9076-84-0
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
17-(3-carboxypropyl)-5,10,15,20,22,24-hexahydro-3,7,13,18-tetramethyl-21H,23H-porphine-2,8,12-tripropanoic acid + O2
? + CO2
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generates a vinyl group on ring-A
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?
17-ethylharderoporphyrinogen-III + O2 + 2 H+
17-ethylprotoporphyrinogen-IX + 2 CO2 + 2 H2O
2,4-bis-(beta-hydroxypropionic acid) deuteroporphyrinogen IX + O2
protoporphyrinogen IX + CO2
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one sixth of the rate compared to coproporhyrinogen-III
-
?
2-beta-hydroxypropionic acid-4-propionic acid deuteroporphyrinogen IX + O2
protoporphyrinogen IX + CO2
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80% of the activity compared to coproporphyrinogen-III
-
?
2-propionic acid-4-beta-hydroxypropionic acid deuteroporphyrinogen IX + O2
protoporphyrinogen IX + CO2
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8% of the activity compared to coproporphyrinogen-III
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?
3-[7,13-di(2-carboxy-ethyl)-17-benzyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13-(2-carboxy-ethyl)-17-benzyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
-
-
-
?
3-[7,13-di(2-carboxy-ethyl)-17-ethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13-(2-carboxy-ethyl)-17-ethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + 3-[7,13-divinyl-17-ethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
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-
-
-
?
3-[7,17-di(2-carboxy-ethyl)-13-benzyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-17-(2-carboxy-ethyl)-13-benzyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
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-
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?
3-[7,17-di(2-carboxy-ethyl)-13-ethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-17-(2-carboxy-ethyl)-13-ethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
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-
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?
3-[7-(2-carboxy-ethyl)-13,17-di-tert-butyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-di-tert-butyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
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-
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?
3-[7-(2-carboxy-ethyl)-13,17-dibutyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-dibutyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
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-
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?
3-[7-(2-carboxy-ethyl)-13,17-diethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-diethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
3-[7-(2-carboxy-ethyl)-13,17-diisopropyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-diisopropyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
-
-
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?
3-[7-(2-carboxy-ethyl)-13,17-dipropyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-dipropyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
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-
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?
3-[7-(2-carboxy-ethyl)-3,8,12,13,17,18-hexamethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-3,8,12,13,17,18-hexamethyl-porphyrinogen-2-yl]-propionic acid + CO2
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?
3-[7-(2-carboxy-ethyl)-3,8,12,13,17,18-hexamethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-3,8,12,13,17,18-hexamethyl-porphyrinogen-2-yl]-propionic acid + CO2 + CO2
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?
3-[7-vinyl-17-(2-carboxy-ethyl)-13-benzyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[2,7-divinyl-13-benzyl-3,8,12,18-tetramethyl-porphyrinogen-17-yl]-propionic acid + CO2
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?
4,4'-[7,12-bis(2-carboxyethyl)-3,8,13,17-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,18-diyl]dibutanoic acid + O2 + 2 H+
? + 2 CO2 + 2 H2O
5,10,15,20,22,24-hexahydro-3,7,13,18-tetramethyl-21H,23H-porphine-2,8,12,17-tripropanoic acid 17-methyl ester + O2
? + CO2
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very poor substrate
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?
harderoporphyrinogen + O2 + 2 H+
protoporphyrinogen + CO2 + H2O
substrate undergoes only the second decarboxylation
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?
harderoporphyrinogen-VII + O2 + 2 H+
?
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a monovinyl intermediate in the metabolism of coproporphyrinogen-IV
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?
mesoporphyrinogen-VI + O2 + H+
? + CO2 + H2O
substrate undergoes only the first oxidative decarboxylation
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?
pentacarboxylate porphyrinogen 5dab + O2
dehydroisocoproporphyrinogen
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poorer substrate than coproporphyrinogen-III
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?
pentacarboxylate porphyrinogen III + O2
dehydroisocoproporphyrinogen + CO2
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half of the activity compared to coproporphyrinogen oxidase-III
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?
protoporphyrinogen-IX + O2
protoporphyrin IX + CO2
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capacity to oxidize not only coproporphyrinogen-III but also protoporphyrinogen-IX
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?
protoporphyrinogen-IX + O2
protoporphyrin-IX + CO2
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capacity to oxidize not only coproporphyrinogen-III but also protoporphyrinogen-IX
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?
17-ethylharderoporphyrinogen-III + O2 + 2 H+
17-ethylprotoporphyrinogen-IX + 2 CO2 + 2 H2O
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-
-
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?
17-ethylharderoporphyrinogen-III + O2 + 2 H+
17-ethylprotoporphyrinogen-IX + 2 CO2 + 2 H2O
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?
3-[7-(2-carboxy-ethyl)-13,17-diethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-diethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
-
-
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?
3-[7-(2-carboxy-ethyl)-13,17-diethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-diethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
-
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?
4,4'-[7,12-bis(2-carboxyethyl)-3,8,13,17-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,18-diyl]dibutanoic acid + O2 + 2 H+
? + 2 CO2 + 2 H2O
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major product is a monovinylporphyrinogen, but some divinyl product is also generated. The incubation products are converted into the corresponding porphyrin methyl esters, and characterized by proton NMR spectroscopy and mass spectrometry
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?
4,4'-[7,12-bis(2-carboxyethyl)-3,8,13,17-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,18-diyl]dibutanoic acid + O2 + 2 H+
? + 2 CO2 + 2 H2O
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major product is a monovinylporphyrinogen, but some divinyl products are also generated. The incubation products are converted into the corresponding porphyrin methyl esters, and characterized by proton NMR spectroscopy and mass spectrometry
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?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen IX + 2 CO2 + 2 H2O
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?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen IX + 2 CO2 + 2 H2O
-
-
-
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?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen IX + 2 CO2 + 2 H2O
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-
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?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen IX + 2 CO2 + 2 H2O
-
-
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?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen IX + 2 CO2 + 2 H2O
recombinant Sll1185 shows CPO activity under both aerobic and anaerobic conditions
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?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
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-
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?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
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-
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?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
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?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
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-
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?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
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-
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?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
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-
-
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?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
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-
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?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
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-
-
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?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
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two oxidative decarboxylations sequentially to give a monovinylporphyrinogen intermediate. Regiospecific generation of harderoporphyrinogen as an intermediate by first converting the A ring side chain to a vinyl unit. Type isomers of coproporphyrinogen, overview
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-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
via harderoporphyrinogen intermediate production, overall reaction
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?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
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-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
two oxidative decarboxylations sequentially to give a monovinylporphyrinogen intermediate Regiospecific generation of harderoporphyrinogen as an intermediate by first converting the A ring side chain to a vinyl unit. Type isomers of coproporphyrinogen, overview
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-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
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-
-
-
?
coproporphyrinogen III + O2 + H+
protoporphyrinogen IX + CO2 + H2O
-
-
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?
coproporphyrinogen III + O2 + H+
protoporphyrinogen IX + CO2 + H2O
-
-
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?
coproporphyrinogen-III + 2 NADP+
protoporphyrinogen-IX + 2 CO2 + 2 NADPH + 2 H+
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oxidation under anaerobic conditions strictly requires NADP+ as electron acceptor
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?
coproporphyrinogen-III + 2 NADP+
protoporphyrinogen-IX + 2 CO2 + 2 NADPH + 2 H+
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oxidation under anaerobic conditions strictly requires NADP+ as electron acceptor
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?
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
-
anaerobic oxidation only in the presence of ATP, NADP+, Mg2+, L-Met, 5-10% of the aerobic activity
-
?
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
-
anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+
-
?
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
-
anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+
-
-
?
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
-
anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+
-
?
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
Chromatium sp.
-
anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+
-
?
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
-
anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
essential enzyme, catalyzes the 6th step in heme biosynthesis
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
O2-dependent enzyme Hem13p
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
enzyme is involved in heme and chlorophyll biosynthesis
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
step in heme biosynthesis
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
HemF is absolutely dependent on oxygen
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
pathway overview
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
coproporphyrinogen analogues with modified propionate side chains bearing methyl substitutents are moderate substrates for the enzyme giving divinylic products, overview
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
pathway overview
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
6th step in heme biosynthesis, pathway overview
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
key enzyme in the biosynthesis of heme, metabolism overview
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
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conversion of 2 propionate groups to 2 vinyl groups by oxidative decarboxylation
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
coproporphyrinogen conversion via tripropionate intermediate harderoporphyrinogen, selective conversion of propionate residues at the A and B rings into vinyl moieties by oxidation and decarboxylation resulting in a trivinylic compound
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
sequential oxidative decarboxylations at the A and B rings, synthetic coproporphyrinogen analogues with modified methylated propionate side chains are moderate substrates for the enzyme giving divinylic products, overview
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
enzyme is involved in heme and chlorophyll biosynthesis
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
6th step in heme biosynthesis
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
enzyme catalyzes the 6th step in heme biosynthesis, heme might be a feed-back regulator of its synthesis by inhibiting the import of th enzyme into mitochondria
-
-
?
coproporphyrinogen-III + O2 + 2 H+
harderoporphyrinogen + CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
harderoporphyrinogen + CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
highly specific for oxygen as electron acceptor
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
Chromatium sp.
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
Chromatium sp.
-
highly specific for oxygen as electron acceptor
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
highly specific for oxygen as electron acceptor
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
oxygen-independent enzyme has also an aerobic function
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
acts on analogues which possess normal substituents on ring-A to generate a vinyl group on that ring, not active if the ring-A propionate group is changed
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
Arg400, Arg262 and Arg401 are active amino acids critical for substrate binding and/or catalysis, Arg262 and 401 may coordinate carboxylate groups of coproporphyrinogen-III, while Asp400 may initiate deprotonation of substrate, resulting in oxidative decarboxylation
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
small amount of the monovinyl intermediate
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
CPO converts coproporphyrinogen III to protoporphyrinogen IX through harderoporphyrinogen IX
-
-
ir
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
O2 is added to the (preferentially deprotonated) pyrrole substrate (yielding a hydroperoxide, which then abstracts a proton from the reactive propionate substituent), the reaction may then proceed through HO2- elimination, followed by decarboxylation
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
sixths enzyme in heme biosynthetic pathway
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
sixths enzyme in heme biosynthetic pathway
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
6th enzyme in heme biosynthetic pathway
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
6th enzyme in heme biosynthetic pathway
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
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