Cloned (Comment) | Organism |
---|---|
expression of mutant R83C in wild-type astrocytes | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
R83C | a naturally occuring mutation, c.319C>T, of SCAD involved in SCAD deficiency, SCADD | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Homo sapiens | - |
SVGp12 cell | an astrocyte cell line | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
SCAD | - |
Homo sapiens |
short-chain acyl-CoA dehydrogenase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | SCAD misfolding leads to production of reactive oxygen species, which in turn leads to fission and a grain-like structure of the mitochondrial reticulum, indicating a toxic response elicited by misfolded R83C SCAD proteins, detailed overview | Homo sapiens |