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Literature summary for 2.1.1.348 extracted from

  • Miao, W.; Chen, J.; Jia, L.; Ma, J.; Song, D.
    The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1 (2019), Biochem. Biophys. Res. Commun., 516, 719-725 .
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q86U44
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-

Source Tissue

Source Tissue Comment Organism Textmining
MG-63 cell
-
 Homo sapiens
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osteoblast
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 Homo sapiens
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SAOS-2 cell
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 Homo sapiens
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U2-OS cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
METTL3
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens m6A level for RNA methylation and the expression level of METTL3 are up-regulated in human osteosarcoma tissues and osteosarcoma cell lines up

General Information

General Information Comment Organism
drug target the enzyme (METTL3) may be a therapeutic target which is potential to be used for the treatment of human osteosarcoma Homo sapiens
physiological function the enzyme (METTL3) promotes osteosarcoma progression by regulating the m6A level of lymphoid enhancer binding factor 1 (LEF1) and activating Wnt/beta-catenin signaling pathway Homo sapiens