Literature summary for 2.1.1.348 extracted from

Xie, W.; Ma, L.; Xu, Y.; Wang, B.; Li, S.
METTL3 inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism (2019), Biochem. Biophys. Res. Commun., 518, 120-126 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8C3P7	-	-

Synonyms

Synonyms	Comment	Organism
METTL3	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	m6A methylated RNA level and its N6-methyladenosine methylase METTL3 are consistently up-regulated in the liver tissues from patients with type 2 diabetes. The m6A methylated RNA and METTL3 levels are up-regulated in mouse with 16 weeks high-fat diet, compared with mice fed a standard chow diet	up

General Information

General Information	Comment	Organism
malfunction	hepatocyte-specific knockout of the enzyme (METTL3) in mice fed a high-fat diet improves insulin sensitivity and decreases fatty acid synthesis. Furthermore, mechanism analysis demonstrates that METTL3 silence decreases the m6A methylated and total mRNA level of fatty acid synthase (Fasn), subsequently inhibits fatty acid metabolism	Mus musculus
physiological function	the enzyme (METTL3) inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism	Mus musculus

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Release 2023.1 (January 2023)