Literature summary for 2.1.1.348 extracted from

Cai, X.; Wang, X.; Cao, C.; Gao, Y.; Zhang, S.; Yang, Z.; Liu, Y.; Zhang, X.; Zhang, W.; Ye, L.
HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor et-7g (2018), Cancer Lett., 415, 11-19 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q86U44	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
methyltransferase-like 3	-	Homo sapiens
METTL3	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	hepatitis B X-interacting protein (HBXIP) up-regulates METTL3 by suppressing let-7g, in which METTL3 increases HBXIP expression forming a positive feedback loop of HBXIP/let-7g/METTL3/HBXIP, leading to accelerated cell proliferation in breast cancer. Expression of METTL3 is positively related to that of HBXIP in clinical breast cancer tissues	up

General Information

General Information	Comment	Organism
physiological function	the enzyme (METTL3) is involved in RNA metabolism through N6-methyladenosine modification. The oncoprotein HBXIP up-regulates METTL3 by inhibiting the expression of tumor suppressor let-7g in breast cancer. METTL3 increases the expression of HBXIP, forming a positive feedback loop of HBXIP/let-7g/METTL3/HBXIP in breast cancer cells	Homo sapiens

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Release 2023.1 (January 2023)