Literature summary for 2.1.1.348 extracted from

Dorn, L.E.; Lasman, L.; Chen, J.; Xu, X.; Hund, T.J.; Medvedovic, M.; Hanna, J.H.; van Berlo, J.H.; Accornero, F.
The N6-methyladenosine mRNA methylase METTL3 controls cardiac homeostasis and hypertrophy (2019), Circulation, 139, 533-545 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8C3P7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cardiomyocyte	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
m6A RNA methylase methyltransferase-like 3	-	Mus musculus
METTL3	-	Mus musculus

General Information

General Information	Comment	Organism
drug target	targeting m6A through its writer enzyme METTL3 may represent a therapeutic strategy for managing maladaptive cardiac hypertrophy and remodeling during the progression of heart failure	Mus musculus
malfunction	METTL3 knockdown induces maladaptive eccentric remodeling and leads to morphological and functional signs of heart failure	Mus musculus
physiological function	the enzyme METTL3 controls cardiac homeostasis, function, stress responses and hypertrophy	Mus musculus

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Release 2023.1 (January 2023)