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Literature summary for 2.4.1.83 extracted from

  • Marchese, M.; Pappalardo, A.; Baldacci, J.; Verri, T.; Doccini, S.; Cassandrini, D.; Bruno, C.; Fiorillo, C.; Garcia-Gil, M.; Bertini, E.; Pitto, L.; Santorelli, F.M.
    Dolichol-phosphate mannose synthase depletion in zebrafish leads to dystrophic muscle with hypoglycosylated alpha-dystroglycan (2016), Biochem. Biophys. Res. Commun., 477, 137-143 .
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Danio rerio Q6DEJ9 and Q561S6 and Q1LXA2 Q6DEJ9 i.e. subunit Dpm1, Q561S6 i.e. regulatory protein Dpm2, Q1LXA2 i.e. subunit Dpm3
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Source Tissue

Source Tissue Comment Organism Textmining
hindbrain
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 Danio rerio
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midbrain
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 Danio rerio
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somite
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 Danio rerio
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General Information

General Information Comment Organism
physiological function transient depletion of the Dpm genes, the resulting morphant embryos show early death, muscle disorganization, low dolichol-phosphate mannose synthase complex activity, and increased levels of apoptotic nuclei, together with hypoglycosylated alpha-dystroglycan in muscle fibers Danio rerio