Literature summary for 2.4.1.83 extracted from

Labeau, A.; Simon-Loriere, E.; Hafirassou, M.L.; Bonnet-Madin, L.; Tessier, S.; Zamborlini, A.; Dupre, T.; Seta, N.; Schwartz, O.; Chaix, M.; Delaugerre, C.; Amara, A.; Meertens, L.
A genome-wide CRISPR-Cas9 screen identifies the dolichol-phosphate mannose synthase complex as a host dependency factor for dengue virus infection (2020), J. Virol., 94, e01751 .

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Application

Application	Comment	Organism
medicine	subunits Dpm1 and Dpm3 function as host dependency factors for Dengue virus and other related flaviviruses such as Zika virus. Mutation in the DXD motif of Dpm1, which is essential for its catalytic activity, abolishes DPMS-mediated Dengue virus infection. Genetic ablation of mannosyltransferase ALG3 renders cells poorly susceptible to Dengue virus. In cells deficient for DPMS activity, viral RNA amplification is hampered and truncated oligosaccharides are transferred to the viral precursor of the M protein and E glycoproteins, affecting their proper folding	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O60762 and Q9P2X0	O60762 i.e. subunit Dpm1, Q9P2X0 i.e. subunit Dpm3	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HAP-1 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	subunits Dpm1 and Dpm3 function as host dependency factors for Dengue virus and other related flaviviruses such as Zika virus. Mutation in the DXD motif of Dpm1, which is essential for its catalytic activity, abolishes DPMS-mediated Dengue virus infection. Genetic ablation of mannosyltransferase ALG3 renders cells poorly susceptible to Dengue virus. In cells deficient for DPMS activity, viral RNA amplification is hampered and truncated oligosaccharides are transferred to the viral precursor of the M protein and E glycoproteins, affecting their proper folding	Homo sapiens

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Release 2023.1 (January 2023)