Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bestatin | inhibits the enzyme, and the melanoma cell-induced angiogenesis in a dorsal air sac assay after oral administration to mice, intraperitoneal administration after orthotopic implantation of B16-B16 melanoma cells into mice reduces the number of vessels oriented towards the established primary tumor on the dorsal side | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | anchored by its N-terminal segment | Mus musculus | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc-metallopeptidase | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
female C57BL/8 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B16-BL6 cell | melanoma cell line | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Ala-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | L-Ala + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase N | - |
Mus musculus |
APN | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |