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3-OH-L-Pro-2-NaI-7-amido-4-carbamoylmethylcoumarin + H2O
3-OH-L-Pro + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
4-Br-L-Phe-7-amido-4-carbamoylmethylcoumarin + H2O
4-Br-L-Phe + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
4-Cl-L-Phe-7-amido-4-carbamoylmethylcoumarin + H2O
4-Cl-L-Phe + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
4-hydroxy-2-nonenal-[Cys-Gly] conjugate + H2O
4-hydroxy-2-nonenal-[L-Cys] conjugate + glycine
-
-
-
-
?
6-O-Bzl-L-Nle-7-amido-4-carbamoylmethylcoumarin + H2O
6-O-Bzl-L-Nle + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
7-N-(beta-alanyl)amino-1,2,4-trimethyl-3H-phenoxazin-3-one + H2O
7-N-amino-1,2,4-trimethyl-3H-phenoxazin-3-one + beta-alanine
7-N-(beta-alanyl)amino-1,2-dimethyl-3H-phenoxazin-3-one + H2O
7-N-amino-1,2-dimethyl-3H-phenoxazin-3-one + beta-alanine
7-N-(beta-alanyl)amino-1-pentylphenoxazin-3-one + H2O
alanine + 7-amino-1-pentylphenoxazin-3-one
-
chromogenic substrate
-
-
?
7-N-(beta-alanyl)amino-2-pentyl-3H-phenoxazin-3-one + H2O
beta-alanine + 7-amino-2-pentyl-3H-phenoxazin-3-one
-
compound displays selective beta-alanyl aminopeptidase sensitivity, producing colored bacterial colonies with Pseudomonas aeruginosa and Serratia marcescens, which is enhanced after 48 h of incubation
-
-
?
8-N-(beta-alanyl)amino-2-butyl-3H-phenoxazin-3-one + H2O
beta-alanine + 8-amino-2-butyl-3H-phenoxazin-3-one
-
compound displays selective beta-alanyl aminopeptidase sensitivity, producing colored bacterial colonies with Pseudomonas aeruginosa and Serratia marcescens, which is enhanced after 48 h of incubation
-
-
?
8-N-(beta-alanyl)amino-2-pentyl-3H-phenoxazin-3-one + H2O
beta-alanine + 8-amino-2-pentyl-3H-phenoxazin-3-one
-
compound displays selective beta-alanyl aminopeptidase sensitivity, producing colored bacterial colonies with Pseudomonas aeruginosa and Serratia marcescens, which is enhanced after 48 h of incubation
-
-
?
9-(L-leucylamino)-5H-benzo[a]phenoxazin-5-iminium + H2O
9-amino-5H-benzo[a]phenoxazin-5-iminium + L-leucine
the substrate displays high selectivity for LAP over various other substances (including biothiols and co-existing enzymes) at their physiological concentrations. It is an excellent specific substrate for enzyme LAP
-
-
ir
Ala-2-naphthylamide + H2O
Ala + 2-naphthylamine
Ala-4-nitroanilide + H2O
Ala + 4-nitroaniline
Ala-beta-naphthylamide + H2O
Ala + beta-naphthylamine
Ala-Gly
Ala + Gly
-
-
-
?
Ala-p-nitroanilide + H2O
Ala + p-nitroaniline
Ala-Phe-Tyr-Glu + H2O
Ala + Phe + Tyr + Glu
-
sequential release of N-terminal amino acids
-
-
?
amino acid amides + H2O
amine + amino acid
-
-
-
?
aminoacyl peptide + H2O
alanyl peptides + H2O
aminoacyl-2-naphthylamide + H2O
amino acid + 2-naphthylamine
aminoacyl-4-methylcoumarin 7-amide + H2O
amino acid + 7-amino-4-methylcoumarin
-
Ala-, Met-, Tyr-, Leu-, Phe-, Arg-, Lys-, Gly-, Lys-Ala-, Arg-Arg- derivatives, not: Pro-, Pyr-, Gly-Pro-derivatives
-
?
aminoacyl-p-nitroanilide + H2O
amino acid + nitroaniline
angiotensin III + H2O
angiotensin IV + Arg
angiotensin III + H2O
angiotensin IV + L-Arg
Arg-beta-naphthylamide + H2O
Arg + beta-naphthylamine
-
16.9% activity compared to Ala-beta-naphthylamide
-
-
?
beta-alanyl-7-amino-1-pentyl-3H-phenoxazin-3-one + H2O
7-amino-1-pentyl-3H-phenoxazin-3-one + beta-alanine
Boc-L-Lys-4-nitroanilide + H2O
Boc-L-Lys + 4-nitroaniline
-
21% of the activity with L-Lys-4-nitroanilide
-
-
?
bradykinin + H2O
?
-
-
-
-
?
casein + H2O
?
-
assay at pH 8.0, 37°C
-
-
?
dipeptides + H2O
amino acids
DL-Ala-2-naphthylamide + H2O
?
-
-
-
-
?
entactin + H2O
?
-
-
-
-
?
Glu-Ala-Ala-4-methoxynaphthylamide + H2O
?
-
-
-
-
?
Gly-2-naphthylamide + H2O
Gly + 2-naphthylamine
Gly-4-nitroanilide + H2O
Gly + 4-nitroaniline
Gly-7-amido-4-carbamoylmethylcoumarin + H2O
Gly + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
Gly-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + Gly
-
assay at pH 8.0, 37°C
-
-
?
Gly-7-amido-4-methylcoumarin + H2O
Gly + 7-amino-4-methylcoumarin
-
-
-
?
insecticidal crystal protein
?
interleukin-8 + H2O
?
-
-
-
-
?
kallidin + H2O
?
-
-
-
-
?
L-2-amino-3-(2-benzothiazolyl)butyric acid-7-amido-4-carbamoylmethylcoumarin + H2O
L-2-amino-3-(2-benzothiazolyl)butyric acid + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-2-NaI-7-amido-4-carbamoylmethylcoumarin + H2O
L-2-NaI + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Abu(Bth)-7-amido-4-carbamoylmethylcoumarin + H2O
L-Abu(Bth) + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Ala-2-naphthylamide + H2O
L-Ala + 2-naphthylamine
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
L-Ala-7-amido-4-carbamoylmethylcoumarin + H2O
L-Ala + 7-amino-4-carbamoylmethylcoumarin
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
L-Ala-D-iso-Gln-meso-DAP(omegaNH2)-D-Ala-D-Ala + H2O
L-Ala + D-iso-Gln-meso-DAP(omegaNH2)-D-Ala-D-Ala
-
-
product identification and stereochemic determination
-
?
L-Ala-L-Ala-L-Phe-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Ala-L-Ala-L-Phe
-
assay at pH 8.0, 37°C
-
-
?
L-Ala-L-Phe + H2O
L-Ala + L-Phe
-
-
-
?
L-Ala-p-nitroanilide + H2O
L-Ala + p-nitroaniline
L-alanine 4-methylcoumaryl-7-amide + H2O
L-alanine + 7-amino-4-methylcoumarin
Ala-MCA
-
-
?
L-alanine beta-naphthylamide + H2O
L-alanine + beta-naphthylamine
-
-
-
?
L-alaninyl 4-methoxy-2-naphthylamide + H2O
L-alanine + 4-methoxy-2-naphthylamine
L-alanyl-2-naphthylamide + H2O
L-alanine + 2-naphthylamine
L-alanyl-L-alanyl-L-7-amido-4-carbamoylmethylcoumarin + H2O
L-alanyl-L-alanine + 7-amino-4-carbamoylmethylcoumarin
substrate for use with tripeptidyl peptidases
-
-
?
L-alanyl-L-alanyl-L-phenylalanine 4-methylcoumaryl-7-amide + H2O
L-alanyl-L-alanyl-L-phenylalanine + 7-amino-4-methylcoumarin
Ala-Ala-Phe-MCA or AAF-MCA
-
-
?
L-allyl-Gly-7-amido-4-carbamoylmethylcoumarin + H2O
L-allyl-Gly + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-alpha-aminobutyryl-Gly + H2O
L-alpha-aminobutyrate + Gly
-
-
-
-
?
L-Arg(NO2)-7-amido-4-carbamoylmethylcoumarin + H2O
L-Arg(NO2) + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
L-Arg-4-nitroanilide + H2O
L-Arg + 4-nitroaniline
L-Arg-7-amido-4-carbamoylmethylcoumarin + H2O
L-Arg + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Arg-L-Phe + H2O
L-Arg + L-Phe
-
-
-
?
L-arginine 4-methylcoumaryl-7-amide + H2O
L-arginine + 7-amino-4-methylcoumarin
Arg-MCA
-
-
?
L-Asn-2-naphthylamide + H2O
L-Asn + 2-naphthylamine
-
-
-
-
?
L-Asp(Bzl)-7-amido-4-carbamoylmethylcoumarin + H2O
L-Asp(Bzl) + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Asp-4-nitroanilide + H2O
L-Asp + 4-nitroaniline
-
14% of the activity with L-Ala-4-nitroanilide
-
-
?
L-Asp-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Asp
-
assay at pH 8.0, 37°C
-
-
?
L-Cha-7-amido-4-carbamoylmethylcoumarin + H2O
L-Cha + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Cys-Gly + H2O
L-Cys + Gly
-
-
-
-
?
L-cystinyl-bis-Gly + H2O
2 Gly + L-cysteine
-
-
-
-
?
L-Gln-2-naphthylamide + H2O
L-Gln + 2-naphthylamine
-
-
-
-
?
L-Gln-7-amido-4-carbamoylmethylcoumarin + H2O
L-Gln + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Gln-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Gln
-
assay at pH 8.0, 37°C
-
-
?
L-Glu(Bzl)-7-amido-4-carbamoylmethylcoumarin + H2O
L-Glu(Bzl) + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Glu-2-naphthylamide + H2O
L-Glu + 2-naphthylamine
-
-
-
-
?
L-Glu-4-nitroanilide + H2O
L-Glu + 4-nitroaniline
-
12% of the activity with L-Ala-4-nitroanilide
-
-
?
L-hArg-7-amido-4-carbamoylmethylcoumarin + H2O
L-hArg + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-hCha-7-amido-4-carbamoylmethylcoumarin + H2O
L-hCha + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-His-2-naphthylamide + H2O
L-His + 2-naphthylamine
-
-
-
-
?
L-hLeu-7-amido-4-carbamoylmethylcoumarin + H2O
L-hLeu + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-hPhe-7-amido-4-carbamoylmethylcoumarin + H2O
L-hPhe + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-hSer(Bzl)-7-amido-4-carbamoylmethylcoumarin + H2O
L-hSer(Bzl) + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-hSer-7-amido-4-carbamoylmethylcoumarin + H2O
L-hSer + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-hTyr-7-amido-4-carbamoylmethylcoumarin + H2O
L-hTyr + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Igl-7-amido-4-carbamoylmethylcoumarin + H2O
L-Igl + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Ile-2-naphthylamide + H2O
L-Ile + 2-naphthylamine
-
-
-
-
?
L-Leu-2-naphthylamide + H2O
L-Leu + 2-naphthylamine
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroanilide
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
L-Leu-7-amido-4-carbamoylmethylcoumarin + H2O
L-Leu + 7-amino-4-carbamoylmethylcoumarin
L-Leu-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Leu
-
assay at pH 8.0, 37°C
-
-
?
L-Leu-7-amido-4-methylcoumarin + H2O
L-Leu + 7-amino-4-methylcoumarin
L-Leu-L-Arg + H2O
L-Leu + L-Arg
L-Leu-L-Met + H2O
L-Leu + L-Met
L-Leu-p-nitroanilide + H2O
L-Leu + p-nitroaniline
L-leucine 4-methylcoumaryl-7-amide + H2O
L-leucine + 7-amino-4-methylcoumarin
Leu-MCA
-
-
?
L-leucine-p-nitroanilide + H2O
L-Leu + p-nitroaniline
-
-
-
-
?
L-Lys-2-naphthylamide + H2O
L-Lys + 2-naphthylamine
L-Lys-4-nitroanilide
4-nitroaniline + L-Lys
-
assay at pH 8.0, 37°C
-
-
?
L-Lys-4-nitroanilide + H2O
L-Lys + 4-nitroaniline
L-Lys-7-amido-4-carbamoylmethylcoumarin + H2O
L-Lys + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Lys-L-Arg + H2O
L-Lys + L-Arg
-
25.5fold as active as L-Lys-L-Lys
-
-
?
L-Lys-L-Lys + H2O
L-Lys
-
-
-
-
?
L-Lys-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin + H2O
?
L-Lys-L-Phe + H2O
L-Lys + L-Phe
-
-
-
?
L-lysine 4-methylcoumaryl-7-amide + H2O
L-lysine + 7-amino-4-methylcoumarin
Lys-MCA, low activity
-
-
?
L-Met-2-naphthylamide + H2O
L-Met + 2-naphthylamine
L-Met-4-nitroanilide + H2O
L-Met + 4-nitroaniline
L-Met-7-amido-4-carbamoylmethylcoumarin + H2O
L-Met + 7-amino-4-carbamoylmethylcoumarin
L-Met-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Met
-
assay at pH 8.0, 37°C
-
-
?
L-Met-7-amido-4-methylcoumarin + H2O
L-Met + 7-amino-4-methylcoumarin
L-methionine 4-methylcoumaryl-7-amide + H2O
L-methionine + 7-amino-4-methylcoumarin
Met-MCA
-
-
?
L-neopentyl-Gly-7-amido-4-carbamoylmethylcoumarin + H2O
L-neopentyl-Gly + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Nle-7-amido-4-carbamoylmethylcoumarin + H2O
L-Nle + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Nva-7-amido-4-carbamoylmethylcoumarin + H2O
L-Nva + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Phe-2-naphthylamide + H2O
L-Phe + 2-naphthylamine
L-Phe-4-nitroanilide + H2O
L-Phe + 4-nitroaniline
L-Phe-7-amido-4-carbamoylmethylcoumarin + H2O
L-Phe + 7-amino-4-carbamoylmethylcoumarin
L-Phe-L-Arg + H2O
L-Phe + L-Arg
-
51.8fold as active as L-Lys-L-Lys
-
-
?
L-Phe-L-Phe + H2O
L-Phe
-
39.2fold as active as L-Lys-L-Lys
-
-
?
L-Phe-L-Phe + H2O
L-Phe + L-Phe
-
-
-
?
L-phenylalanine 4-methylcoumaryl-7-amide + H2O
L-phenylalanine + 7-amino-4-methylcoumarin
Phe-MCA
-
-
?
L-Pro-2-naphthylamide + H2O
L-Pro + 2-naphthylamine
-
16.1% of the activity with L-Ala-2-naphthylamide
-
-
?
L-Pro-4-nitroanilide + H2O
L-Pro + 4-nitroaniline
L-Pro-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Pro
-
assay at pH 8.0, 37°C
-
-
?
L-propargyl-Gly-7-amido-4-carbamoylmethylcoumarin + H2O
L-propargyl-Gly + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Ser-2-naphthylamide + H2O
L-Ser + 2-naphthylamine
-
low activity
-
-
?
L-Ser-4-nitroanilide + H2O
L-Ser + 4-nitroaniline
-
slow activity
-
-
?
L-Thr-2-naphthylamide + H2O
L-Thr + 2-naphthylamine
-
-
-
-
?
L-Thr-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Thr
-
assay at pH 8.0, 37°C
-
-
?
L-Trp-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Trp
-
assay at pH 8.0, 37°C
-
-
?
L-Tyr-2-naphthylamide + H2O
L-Tyr + 2-naphthylamine
L-Tyr-4-nitroanilide + H2O
L-Tyr + 4-nitroaniline
-
-
-
-
?
L-Tyr-7-amido-4-carbamoylmethylcoumarin + H2O
L-Tyr + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Tyr-7-amido-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-Tyr
-
assay at pH 8.0, 37°C
-
-
?
L-Tyr-Gly + H2O
L-Tyr + Gly
-
-
-
-
?
L-Tyr-L-Arg + H2O
L-Tyr + L-Arg
-
best substrate among dipeptides, 57.9fold as active as L-Lys-L-Lys
-
-
?
L-Tyr-L-Phe + H2O
L-Tyr + L-Phe
-
-
-
?
L-Val-2-naphthylamide + H2O
L-Val + 2-naphthylamine
-
-
-
-
?
L-Val-4-nitroanilide + H2O
L-Val + 4-nitroaniline
Leu-2-naphthylamide + H2O
Leu + 2-naphthylamine
Leu-4-methylcoumarin 7-amide + H2O
Leu + 7-amino-4-methylcoumarin
-
-
-
?
Leu-Ala + H2O
Leu + Ala
-
-
-
?
Leu-beta-naphthylamide + H2O
Leu + beta-naphthylamine
-
16% activity compared to Ala-beta-naphthylamide
-
-
?
Leu-enkephalin + H2O
Leu + enkephalin
-
-
-
-
?
Leu-enkephalin-L-Tyr-Gly + H2O
Leu + enkephalin-L-Tyr-Gly
-
-
-
-
?
Leu-p-nitroanilide + H2O
Leu + p-nitroaniline
Leu5-enkephalin + H2O
tyrosin + (2-5)Leu5-enkephalin
leucine enkephalin + H2O
?
-
model peptide drug
-
?
LVVYPWTQRF + H2O
L-Leu + VVYPWTQRF
-
i.e. LVV-H7, human hemorphin
-
-
?
Lys-4-methylcoumarin 7-amide + H2O
Lys + 7-amino-4-methylcoumarin
-
-
-
?
Lys-4-nitroanilide + H2O
Lys + 4-nitroaniline
Lys-beta-naphthylamide + H2O
Lys + beta-naphthylamine
-
6.7% activity compared to Ala-beta-naphthylamide
-
-
?
Lys-des-Arg9-bradykinin + H2O
?
-
-
-
-
?
Lys-p-nitroanilide + H2O
Lys + p-nitroaniline
-
-
-
?
lysyl-bradykinin + H2O
?
-
-
-
-
?
Met-2-naphthylamide + H2O
Met + 2-naphthylamine
-
-
-
?
Met-beta-naphthylamide + H2O
Met + beta-naphthylamine
-
8.9% activity compared to Ala-beta-naphthylamide
-
-
?
Met-enkephalin + H2O
Met + enkephalin
-
-
-
-
?
Met-enkephalin-L-Tyr-Gly + H2O
Met + enkephalin L-Tyr-Gly
-
-
-
-
?
Met-Lys-bradykinin + H2O
Met + Lys + bradykinin
-
-
-
-
?
Met5-enkephalin + H2O
tyrosin + (2-5)Met5-enkephalin
monocyte chemotactic protein MCP-1 + H2O
?
-
-
-
-
?
Mr 160000 component
?
-
Mr 160000 component of basement membrane, aminopeptidase N plays role in melanoma invasion of basement membrane
-
-
?
N-formyl-Met-Leu-Phe + H2O
?
-
-
-
-
?
Neurokinin A + H2O
?
-
-
-
-
?
oxidized insulin B chain + H2O
?
-
assay at pH 8.0, 37°C
-
-
?
Pro-beta-naphthylamide + H2O
Pro + beta-naphthylamine
-
16.1% activity compared to Ala-beta-naphthylamide
-
-
?
Ser-beta-naphthylamide + H2O
Ser + beta-naphthylamine
somatostatin + H2O
?
-
-
-
-
?
spinorphin + H2O
?
-
-
-
-
?
Substance P + H2O
?
-
-
-
-
?
thymopentin + H2O
?
-
-
-
-
?
tripeptides + H2O
dipeptides + amino acids
Type IV collagen + H2O
?
-
-
-
-
?
VVYPWTQRF + H2O
L-Val + VYPWTQRF
-
i.e. VV-H7, fragment of human hemorphin. 43% of the activity with LVVYPWTQRF
-
-
?
VYPWTQRF + H2O
L-Val + YPWTQRF
-
i.e. V-H7, fragment of human hemorphin. 46% of the activity with LVVYPWTQRF
-
-
?
additional information
?
-
7-N-(beta-alanyl)amino-1,2,4-trimethyl-3H-phenoxazin-3-one + H2O
7-N-amino-1,2,4-trimethyl-3H-phenoxazin-3-one + beta-alanine
-
-
-
-
?
7-N-(beta-alanyl)amino-1,2,4-trimethyl-3H-phenoxazin-3-one + H2O
7-N-amino-1,2,4-trimethyl-3H-phenoxazin-3-one + beta-alanine
-
-
-
-
?
7-N-(beta-alanyl)amino-1,2-dimethyl-3H-phenoxazin-3-one + H2O
7-N-amino-1,2-dimethyl-3H-phenoxazin-3-one + beta-alanine
-
-
-
-
?
7-N-(beta-alanyl)amino-1,2-dimethyl-3H-phenoxazin-3-one + H2O
7-N-amino-1,2-dimethyl-3H-phenoxazin-3-one + beta-alanine
-
-
-
-
?
Ala-2-naphthylamide + H2O
Ala + 2-naphthylamine
-
-
-
?
Ala-2-naphthylamide + H2O
Ala + 2-naphthylamine
-
-
-
?
Ala-2-naphthylamide + H2O
Ala + 2-naphthylamine
-
-
-
?
Ala-2-naphthylamide + H2O
Ala + 2-naphthylamine
-
-
-
?
Ala-2-naphthylamide + H2O
Ala + 2-naphthylamine
-
-
-
?
Ala-4-nitroanilide + H2O
Ala + 4-nitroaniline
-
-
?
Ala-4-nitroanilide + H2O
Ala + 4-nitroaniline
-
-
?
Ala-4-nitroanilide + H2O
Ala + 4-nitroaniline
-
-
-
?
Ala-beta-naphthylamide + H2O
Ala + beta-naphthylamine
-
100% activity, preferred substrate
-
-
?
Ala-beta-naphthylamide + H2O
Ala + beta-naphthylamine
-
-
-
?
Ala-Gly + H2O
Ala + Gly
-
-
-
?
Ala-Gly + H2O
Ala + Gly
-
-
-
?
Ala-p-nitroanilide + H2O
Ala + p-nitroaniline
-
-
-
?
Ala-p-nitroanilide + H2O
Ala + p-nitroaniline
-
-
-
?
Ala-p-nitroanilide + H2O
Ala + p-nitroaniline
-
-
-
?
Ala-p-nitroanilide + H2O
Ala + p-nitroaniline
-
-
-
?
Ala-p-nitroanilide + H2O
Ala + p-nitroaniline
-
-
-
?
Ala-p-nitroanilide + H2O
Ala + p-nitroaniline
-
-
-
?
Ala-p-nitroanilide + H2O
Ala + p-nitroaniline
-
-
-
?
Ala-p-nitroanilide + H2O
Ala + p-nitroaniline
-
-
-
?
aminoacyl peptide
?
-
-
-
-
?
aminoacyl peptide
?
-
-
-
-
?
aminoacyl peptide
?
-
-
-
-
?
aminoacyl peptide
?
-
-
-
-
?
aminoacyl peptide
?
-
-
-
-
?
aminoacyl peptide
?
-
-
-
?
aminoacyl peptide
?
-
-
-
-
?
aminoacyl peptide
?
-
-
-
?
aminoacyl peptide
?
-
-
-
-
?
aminoacyl peptide
?
-
-
-
-
?
aminoacyl peptide
?
-
-
-
-
?
aminoacyl peptide
?
-
-
-
-
?
aminoacyl peptide + H2O
alanyl peptides + H2O
-
release of positively charged and uncharged amino acids from N-terminus, unable to cleave peptide bond on N-terminal side of proline residue, oligopeptides hydrolyzed faster than tri- or dipeptides, highest activity with lysyl derivatives
-
?
aminoacyl peptide + H2O
alanyl peptides + H2O
-
-
-
?
aminoacyl peptide + H2O
alanyl peptides + H2O
-
not glutathione
-
?
aminoacyl peptide + H2O
alanyl peptides + H2O
-
fast hydrolysis with Ala in N-terminal position
-
?
aminoacyl peptide + H2O
alanyl peptides + H2O
-
free alpha-amino or alpha-imino group required
-
?
aminoacyl-2-naphthylamide + H2O
amino acid + 2-naphthylamine
-
-
-
?
aminoacyl-2-naphthylamide + H2O
amino acid + 2-naphthylamine
-
preference for substrates having hydrophobic or basic amino terminal residues with no beta-branching
-
?
aminoacyl-2-naphthylamide + H2O
amino acid + 2-naphthylamine
-
-
-
?
aminoacyl-2-naphthylamide + H2O
amino acid + 2-naphthylamine
-
-
-
?
aminoacyl-p-nitroanilide + H2O
amino acid + nitroaniline
-
decreasing activity in the following order: Leu- , 100%, Ala- , 88%, Met- , 77%, Lys- , 36%, Arg- , 29%, Pro- , 9%
-
?
aminoacyl-p-nitroanilide + H2O
amino acid + nitroaniline
-
-
-
?
aminoacyl-p-nitroanilide + H2O
amino acid + nitroaniline
-
-
-
?
aminoacyl-p-nitroanilide + H2O
amino acid + nitroaniline
-
-
-
?
aminoacyl-p-nitroanilide + H2O
amino acid + nitroaniline
-
-
-
?
angiotensin III + H2O
angiotensin IV + Arg
-
the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview
-
-
ir
angiotensin III + H2O
angiotensin IV + Arg
-
i.e. Arg-Val-Tyr-Ile-His-Pro-Phe
i.e. Val-Tyr-Ile-His-Pro-Phe
-
ir
angiotensin III + H2O
angiotensin IV + L-Arg
-
-
-
-
?
angiotensin III + H2O
angiotensin IV + L-Arg
-
-
-
-
?
beta-alanyl-7-amino-1-pentyl-3H-phenoxazin-3-one + H2O
7-amino-1-pentyl-3H-phenoxazin-3-one + beta-alanine
-
i.e. 1-pentylresorufamine
the product is a very good chromophore, having a low degree of diffusion in nutrient media for growing bacterial cultures and a bright red colour
-
?
beta-alanyl-7-amino-1-pentyl-3H-phenoxazin-3-one + H2O
7-amino-1-pentyl-3H-phenoxazin-3-one + beta-alanine
-
i.e. 1-pentylresorufamine
the product is a very good chromophore, having a low degree of diffusion in nutrient media for growing bacterial cultures and a bright red colour
-
?
beta-CN f193-209 + H2O
?
bitter peptide of aged Cheddar cheese, analysis of degradation pattern by enzyme
-
-
?
beta-CN f193-209 + H2O
?
bitter peptide of aged Cheddar cheese, analysis of degradation pattern by enzyme
-
-
?
Cys-Gly + H2O
Cys + Gly
-
-
-
-
?
Cys-Gly + H2O
Cys + Gly
-
-
-
-
?
Cys-Gly + H2O
Cys + Gly
-
-
-
-
?
Cys-Gly + H2O
Cys + Gly
-
-
-
-
?
dipeptides + H2O
amino acids
-
not: Leu-Pro
-
?
dipeptides + H2O
amino acids
-
-
-
?
dipeptides + H2O
amino acids
-
not: D-Ala-Gly, Val-Gly, Asp-Gly, Gly-D-Ala, Pro-containing peptides
-
?
dipeptides + H2O
amino acids
-
not: D-Ala-Gly, Val-Gly, Asp-Gly, Gly-D-Ala, Pro-containing peptides
-
?
dipeptides + H2O
amino acids
-
-
-
?
enkephalin
?
-
may be involved in enkephalin neurotransmitter inactivation
-
-
?
enkephalin
?
-
may be involved in enkephalin neurotransmitter inactivation
-
-
?
enkephalin + H2O
?
-
enkephalins comprising L,L- and L,D-peptide bonds
-
-
?
enkephalin + H2O
?
-
hydrolysis of the Tyr1-Gly2 bond
-
-
?
enkephalin + H2O
?
-
hydrolysis of the Tyr1-Gly2 bond
-
-
?
enkephalin + H2O
?
-
hydrolysis of the Tyr1-Gly2 bond
-
-
?
enkephalin + H2O
?
-
hydrolysis of the Tyr1-Gly2 bond
-
-
?
Gly-2-naphthylamide + H2O
Gly + 2-naphthylamine
-
-
-
?
Gly-2-naphthylamide + H2O
Gly + 2-naphthylamine
-
-
-
-
?
Gly-4-nitroanilide + H2O
Gly + 4-nitroaniline
-
low activity
-
-
?
Gly-4-nitroanilide + H2O
Gly + 4-nitroaniline
hydrolytic activity on 4-nitroanilides in decreasing order: L-Ala, L-Lys, L-Leu, L-Met, L-Gly
-
-
?
Gly-4-nitroanilide + H2O
Gly + 4-nitroaniline
hydrolytic activity on 4-nitroanilides in decreasing order: L-Ala, L-Lys, L-Leu, L-Met, L-Gly
-
-
?
Gly-4-nitroanilide + H2O
Gly + 4-nitroaniline
-
-
-
-
?
Gly-4-nitroanilide + H2O
Gly + 4-nitroaniline
-
-
-
-
?
Gly-4-nitroanilide + H2O
Gly + 4-nitroaniline
-
14% of the activity with L-Ala-4-nitroanilide
-
-
?
Gly-4-nitroanilide + H2O
Gly + 4-nitroaniline
-
low activity
-
-
?
insecticidal crystal protein
?
from Bacillus thuringensis, binds to aminopeptidase N
-
-
?
insecticidal crystal protein
?
from Bacillus thuringensis, binds to aminopeptidase N
-
-
?
L-Ala-2-naphthylamide + H2O
L-Ala + 2-naphthylamine
-
preferred substrate
-
-
?
L-Ala-2-naphthylamide + H2O
L-Ala + 2-naphthylamine
-
best substrate
-
-
?
L-Ala-2-naphthylamide + H2O
L-Ala + 2-naphthylamine
-
best substrate
-
-
?
L-Ala-2-naphthylamide + H2O
L-Ala + 2-naphthylamine
-
-
-
-
?
L-Ala-2-naphthylamide + H2O
L-Ala + 2-naphthylamine
-
best substrate
-
-
?
L-Ala-2-naphthylamide + H2O
L-Ala + 2-naphthylamine
-
-
-
-
?
L-Ala-2-naphthylamide + H2O
L-Ala + 2-naphthylamine
-
-
-
-
?
L-Ala-2-naphthylamide + H2O
L-Ala + 2-naphthylamine
-
-
-
-
?
L-Ala-2-naphthylamide + H2O
L-Ala + 2-naphthylamine
-
-
-
-
?
L-Ala-2-naphthylamide + H2O
L-Ala + 2-naphthylamine
-
-
-
-
?
L-Ala-2-naphthylamide + H2O
L-Ala + 2-naphthylamine
-
preferred substrate
-
-
?
L-Ala-2-naphthylamide + H2O
L-Ala + 2-naphthylamine
-
-
-
-
?
L-Ala-2-naphthylamide + H2O
L-Ala + 2-naphthylamine
-
-
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
-
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
preferred substrate
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
hydrolytic activity on 4-nitroanilides in decreasing order: L-Ala, L-Lys, L-Leu, L-Met, L-Gly
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
hydrolytic activity on 4-nitroanilides in decreasing order: L-Ala, L-Lys, L-Leu, L-Met, L-Gly
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
preferred substrate
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
-
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
best substrate
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
-
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
-
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
preferred substrate
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
-
663574, 663607, 663842, 665112, 665231, 665244, 665708, 665710, 665958, 666997, 683303, 683811, 683894 -
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
-
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
-
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
best substrate
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
-
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
-
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
-
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
-
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
-
-
-
?
L-Ala-7-amido-4-carbamoylmethylcoumarin + H2O
L-Ala + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Ala-7-amido-4-carbamoylmethylcoumarin + H2O
L-Ala + 7-amino-4-carbamoylmethylcoumarin
-
-
-
?
L-Ala-7-amido-4-carbamoylmethylcoumarin + H2O
L-Ala + 7-amino-4-carbamoylmethylcoumarin
-
-
-
?
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
-
-
-
?
L-Ala-p-nitroanilide + H2O
L-Ala + p-nitroaniline
-
-
-
?
L-Ala-p-nitroanilide + H2O
L-Ala + p-nitroaniline
-
-
-
?
L-Ala-p-nitroanilide + H2O
L-Ala + p-nitroaniline
-
-
-
-
?
L-Ala-p-nitroanilide + H2O
L-Ala + p-nitroaniline
-
-
695995, 696753, 697036, 697302, 697385, 697396, 697439, 697497, 698298, 698381, 699938, 701038, 701354 -
-
?
L-Ala-p-nitroanilide + H2O
L-Ala + p-nitroaniline
-
-
-
-
?
L-Ala-p-nitroanilide + H2O
L-Ala + p-nitroaniline
-
-
-
-
?
L-alaninyl 4-methoxy-2-naphthylamide + H2O
L-alanine + 4-methoxy-2-naphthylamine
-
-
-
?
L-alaninyl 4-methoxy-2-naphthylamide + H2O
L-alanine + 4-methoxy-2-naphthylamine
-
-
-
?
L-alaninyl 4-methoxy-2-naphthylamide + H2O
L-alanine + 4-methoxy-2-naphthylamine
-
-
-
?
L-alaninyl 4-methoxy-2-naphthylamide + H2O
L-alanine + 4-methoxy-2-naphthylamine
-
-
-
?
L-alaninyl 4-methoxy-2-naphthylamide + H2O
L-alanine + 4-methoxy-2-naphthylamine
-
-
-
?
L-alanyl-2-naphthylamide + H2O
L-alanine + 2-naphthylamine
-
-
-
?
L-alanyl-2-naphthylamide + H2O
L-alanine + 2-naphthylamine
-
-
-
?
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
-
16.9% of the activity with L-Ala-2-naphthylamide
-
-
?
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
-
-
-
-
?
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
-
-
-
-
?
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
-
-
-
-
?
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
-
-
-
-
?
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
-
-
-
-
?
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
-
-
-
-
?
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
-
-
-
-
?
L-Arg-4-nitroanilide + H2O
L-Arg + 4-nitroaniline
-
-
-
-
?
L-Arg-4-nitroanilide + H2O
L-Arg + 4-nitroaniline
-
low activity
-
-
?
L-Arg-4-nitroanilide + H2O
L-Arg + 4-nitroaniline
-
-
-
-
?
L-Arg-4-nitroanilide + H2O
L-Arg + 4-nitroaniline
-
-
-
-
?
L-Arg-4-nitroanilide + H2O
L-Arg + 4-nitroaniline
-
-
-
-
?
L-Arg-4-nitroanilide + H2O
L-Arg + 4-nitroaniline
-
-
-
-
?
L-Arg-4-nitroanilide + H2O
L-Arg + 4-nitroaniline
-
40% of the activity with L-Lys-4-nitroanilide
-
-
?
L-Arg-4-nitroanilide + H2O
L-Arg + 4-nitroaniline
-
40% of the activity with L-Lys-4-nitroanilide
-
-
?
L-Leu-2-naphthylamide + H2O
L-Leu + 2-naphthylamine
-
16.0% of the activity with L-Ala-2-naphthylamide
-
-
?
L-Leu-2-naphthylamide + H2O
L-Leu + 2-naphthylamine
-
-
-
-
?
L-Leu-2-naphthylamide + H2O
L-Leu + 2-naphthylamine
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroanilide
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroanilide
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
hydrolytic activity on 4-nitroanilides in decreasing order: L-Ala, L-Lys, L-Leu, L-Met, L-Gly
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
hydrolytic activity on 4-nitroanilides in decreasing order: L-Ala, L-Lys, L-Leu, L-Met, L-Gly
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
very low activity
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
27% of the activity with L-Ala-4-nitroanilide
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
best substrate
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
9.5% of the activity with L-Lys-4-nitroanilide
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
9.5% of the activity with L-Lys-4-nitroanilide
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
synthetic substrate
-
?
L-Leu-7-amido-4-carbamoylmethylcoumarin + H2O
L-Leu + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Leu-7-amido-4-carbamoylmethylcoumarin + H2O
L-Leu + 7-amino-4-carbamoylmethylcoumarin
70% of the activity with L-Ala-7-amido-4-carbamoylmethylcoumarin
-
-
?
L-Leu-7-amido-4-carbamoylmethylcoumarin + H2O
L-Leu + 7-amino-4-carbamoylmethylcoumarin
70% of the activity with L-Ala-7-amido-4-carbamoylmethylcoumarin
-
-
?
L-Leu-7-amido-4-methylcoumarin + H2O
L-Leu + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Leu-7-amido-4-methylcoumarin + H2O
L-Leu + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Leu-7-amido-4-methylcoumarin + H2O
L-Leu + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Leu-7-amido-4-methylcoumarin + H2O
L-Leu + 7-amino-4-methylcoumarin
-
-
-
?
L-Leu-L-Arg + H2O
L-Leu + L-Arg
-
50fold as active as L-Lys-L-Lys
-
-
?
L-Leu-L-Arg + H2O
L-Leu + L-Arg
-
50fold as active as L-Lys-L-Lys
-
-
?
L-Leu-L-Met + H2O
L-Leu + L-Met
-
49.4fold as active as L-Lys-L-Lys
-
-
?
L-Leu-L-Met + H2O
L-Leu + L-Met
-
49.4fold as active as L-Lys-L-Lys
-
-
?
L-Leu-p-nitroanilide + H2O
L-Leu + p-nitroaniline
-
-
-
-
?
L-Leu-p-nitroanilide + H2O
L-Leu + p-nitroaniline
-
-
-
-
?
L-Leu-p-nitroanilide + H2O
L-Leu + p-nitroaniline
-
-
-
-
?
L-Lys-2-naphthylamide + H2O
L-Lys + 2-naphthylamine
-
6.7% of the activity with L-Ala-2-naphthylamide
-
-
?
L-Lys-2-naphthylamide + H2O
L-Lys + 2-naphthylamine
-
-
-
-
?
L-Lys-2-naphthylamide + H2O
L-Lys + 2-naphthylamine
-
-
-
-
?
L-Lys-4-nitroanilide + H2O
L-Lys + 4-nitroaniline
-
-
-
-
?
L-Lys-4-nitroanilide + H2O
L-Lys + 4-nitroaniline
hydrolytic activity on 4-nitroanilides in decreasing order: L-Ala, L-Lys, L-Leu, L-Met, L-Gly
-
-
?
L-Lys-4-nitroanilide + H2O
L-Lys + 4-nitroaniline
hydrolytic activity on 4-nitroanilides in decreasing order: L-Ala, L-Lys, L-Leu, L-Met, L-Gly
-
-
?
L-Lys-4-nitroanilide + H2O
L-Lys + 4-nitroaniline
-
3% of the activity with L-Ala-4-nitroanilide
-
-
?
L-Lys-4-nitroanilide + H2O
L-Lys + 4-nitroaniline
-
-
-
-
?
L-Lys-4-nitroanilide + H2O
L-Lys + 4-nitroaniline
-
-
-
-
?
L-Lys-4-nitroanilide + H2O
L-Lys + 4-nitroaniline
-
-
-
-
?
L-Lys-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin + H2O
?
-
i.e.B-9958
-
-
?
L-Lys-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin + H2O
?
-
i.e.B-9958
-
-
?
L-Met-2-naphthylamide + H2O
L-Met + 2-naphthylamine
-
8.9% of the activity with L-Ala-2-naphthylamide
-
-
?
L-Met-2-naphthylamide + H2O
L-Met + 2-naphthylamine
-
-
-
-
?
L-Met-4-nitroanilide + H2O
L-Met + 4-nitroaniline
-
-
-
-
?
L-Met-4-nitroanilide + H2O
L-Met + 4-nitroaniline
-
preferred substrate
-
-
?
L-Met-4-nitroanilide + H2O
L-Met + 4-nitroaniline
hydrolytic activity on 4-nitroanilides in decreasing order: L-Ala, L-Lys, L-Leu, L-Met, L-Gly
-
-
?
L-Met-4-nitroanilide + H2O
L-Met + 4-nitroaniline
hydrolytic activity on 4-nitroanilides in decreasing order: L-Ala, L-Lys, L-Leu, L-Met, L-Gly
-
-
?
L-Met-4-nitroanilide + H2O
L-Met + 4-nitroaniline
-
-
-
-
?
L-Met-4-nitroanilide + H2O
L-Met + 4-nitroaniline
-
-
-
-
?
L-Met-4-nitroanilide + H2O
L-Met + 4-nitroaniline
-
24% of the activity with L-Ala-4-nitroanilide
-
-
?
L-Met-4-nitroanilide + H2O
L-Met + 4-nitroaniline
-
-
-
-
?
L-Met-4-nitroanilide + H2O
L-Met + 4-nitroaniline
-
5.7% of the activity with L-Lys-4-nitroanilide
-
-
?
L-Met-7-amido-4-carbamoylmethylcoumarin + H2O
L-Met + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Met-7-amido-4-carbamoylmethylcoumarin + H2O
L-Met + 7-amino-4-carbamoylmethylcoumarin
99% of the activity with L-Ala-7-amido-4-carbamoylmethylcoumarin
-
-
?
L-Met-7-amido-4-carbamoylmethylcoumarin + H2O
L-Met + 7-amino-4-carbamoylmethylcoumarin
99% of the activity with L-Ala-7-amido-4-carbamoylmethylcoumarin
-
-
?
L-Met-7-amido-4-methylcoumarin + H2O
L-Met + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Met-7-amido-4-methylcoumarin + H2O
L-Met + 7-amino-4-methylcoumarin
-
-
-
?
L-Phe-2-naphthylamide + H2O
L-Phe + 2-naphthylamine
-
-
-
-
?
L-Phe-2-naphthylamide + H2O
L-Phe + 2-naphthylamine
-
-
-
-
?
L-Phe-4-nitroanilide + H2O
L-Phe + 4-nitroaniline
-
-
-
-
?
L-Phe-4-nitroanilide + H2O
L-Phe + 4-nitroaniline
-
-
-
-
?
L-Phe-4-nitroanilide + H2O
L-Phe + 4-nitroaniline
-
slow activity
-
-
?
L-Phe-4-nitroanilide + H2O
L-Phe + 4-nitroaniline
-
6.8% of the activity with L-Lys-4-nitroanilide
-
-
?
L-Phe-7-amido-4-carbamoylmethylcoumarin + H2O
L-Phe + 7-amino-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Phe-7-amido-4-carbamoylmethylcoumarin + H2O
L-Phe + 7-amino-4-carbamoylmethylcoumarin
76% of the activity with L-Ala-7-amido-4-carbamoylmethylcoumarin
-
-
?
L-Pro-4-nitroanilide + H2O
L-Pro + 4-nitroaniline
-
low activity
-
-
?
L-Pro-4-nitroanilide + H2O
L-Pro + 4-nitroaniline
-
low activity
-
-
?
L-Tyr-2-naphthylamide + H2O
L-Tyr + 2-naphthylamine
-
-
-
-
?
L-Tyr-2-naphthylamide + H2O
L-Tyr + 2-naphthylamine
-
-
-
-
?
L-Val-4-nitroanilide + H2O
L-Val + 4-nitroaniline
-
-
-
?
L-Val-4-nitroanilide + H2O
L-Val + 4-nitroaniline
-
very low activity
-
-
?
L-Val-4-nitroanilide + H2O
L-Val + 4-nitroaniline
-
low activity
-
-
?
Leu-2-naphthylamide + H2O
Leu + 2-naphthylamine
-
-
-
?
Leu-2-naphthylamide + H2O
Leu + 2-naphthylamine
-
-
-
?
Leu-2-naphthylamide + H2O
Leu + 2-naphthylamine
-
-
-
-
?
Leu-2-naphthylamide + H2O
Leu + 2-naphthylamine
-
-
-
-
?
Leu-2-naphthylamide + H2O
Leu + 2-naphthylamine
-
-
-
?
Leu-2-naphthylamide + H2O
Leu + 2-naphthylamine
-
-
-
-
?
Leu-Gly + H2O
Leu + Gly
-
-
-
?
Leu-Gly + H2O
Leu + Gly
-
-
-
?
Leu-p-nitroanilide + H2O
Leu + p-nitroaniline
-
-
-
?
Leu-p-nitroanilide + H2O
Leu + p-nitroaniline
-
-
-
?
Leu-p-nitroanilide + H2O
Leu + p-nitroaniline
-
-
-
?
Leu-p-nitroanilide + H2O
Leu + p-nitroaniline
-
-
?
Leu-p-nitroanilide + H2O
Leu + p-nitroaniline
-
-
-
?
Leu5-enkephalin + H2O
tyrosin + (2-5)Leu5-enkephalin
-
-
-
-
?
Leu5-enkephalin + H2O
tyrosin + (2-5)Leu5-enkephalin
-
-
-
-
?
Leu5-enkephalin + H2O
tyrosin + (2-5)Leu5-enkephalin
-
-
-
?
Lys-4-nitroanilide + H2O
Lys + 4-nitroaniline
-
-
?
Lys-4-nitroanilide + H2O
Lys + 4-nitroaniline
-
-
?
Met5-enkephalin + H2O
tyrosin + (2-5)Met5-enkephalin
-
-
-
-
?
Met5-enkephalin + H2O
tyrosin + (2-5)Met5-enkephalin
-
-
-
?
Phe-Gly + H2O
Phe + Gly
-
-
-
-
?
Phe-Gly + H2O
Phe + Gly
-
-
-
?
Phe-Gly + H2O
Phe + Gly
-
-
-
?
Ser-beta-naphthylamide + H2O
Ser + beta-naphthylamine
-
1.4% activity compared to Ala-beta-naphthylamide
-
-
?
Ser-beta-naphthylamide + H2O
Ser + beta-naphthylamine
-
-
-
-
?
tripeptides + H2O
dipeptides + amino acids
-
not: Gly-Pro-Ala
-
?
tripeptides + H2O
dipeptides + amino acids
-
-
-
?
tripeptides + H2O
dipeptides + amino acids
-
-
-
?
tripeptides + H2O
dipeptides + amino acids
-
-
-
?
tuftsin + H2O
?
-
-
-
-
?
tuftsin + H2O
?
-
the first peptidic bond of this tuftsin is hydrolyzed by CD13, generating an antagonist that competes for receptor binding and thus regulating tuftsin functions
-
-
?
additional information
?
-
APN is a specific binding protein, and a putative midgut receptor, for Bacillus thuringiensis Cry11Ba toxin
-
-
?
additional information
?
-
-
APN is a specific binding protein, and a putative midgut receptor, for Bacillus thuringiensis Cry11Ba toxin
-
-
?
additional information
?
-
APN is a specific binding protein, and a putative midgut receptor, for Bacillus thuringiensis Cry11Ba toxin
-
-
?
additional information
?
-
-
substrate specificity, overview, no activity with L-Gly-4-nitroanilide and L-Pro-4-nitroanilide, the enzyme binds to Cry1Ac toxin of Bacillus thuringiensis, not with Cry1Aa or Cey1Ab toxins, the interaction is inhibited by GalNAc
-
-
?
additional information
?
-
-
the enzyme binds the Bacillus thuringiensis Cry1Aa toxin acting as a receptor, binding site structure and localization on the enzyme determined by immunohistochemistry, overview
-
-
?
additional information
?
-
-
the enzyme prefers substrates with N-terminal nonpolar amino acids, isoyzme APN1 binds the Cry1Ac toxin from Bacillus thuringiensis via an N-acetylglucosamine moiety
-
-
?
additional information
?
-
-
L-Ser-2-naphthylamide is a poor substrate, L-Glu-2-naphthylamide is no substrate
-
-
?
additional information
?
-
-
no activity with Glu-beta-naphthylamide
-
-
?
additional information
?
-
-
substrate specificity, overview
-
-
?
additional information
?
-
-
the enzyme hydrolyzes several peptides with N-terminal L-amino acids, but not with N-terminal D-amino acids, no activity with L-Asp-L-Asp
-
-
?
additional information
?
-
-
the enzyme prefers substrates with N-terminal L-Ala residues
-
-
?
additional information
?
-
-
the enzyme plays a role in behaviour and nervous system excitability
-
-
?
additional information
?
-
-
isozyme APN1 shows preference for leucine amides, but also hydrolyzes Ile, Trp, Phe, Val, and His amides, no activity with Ser, Pro, Ala, Gly, and ARg derivatives
-
-
?
additional information
?
-
-
aminopeptidase regulation mechanisms and biological functions, overview
-
-
?
additional information
?
-
-
no activity with L-Val-4-nitroanilide, L-Met-4-nitroanilide, and L-Pro-4-nitroanilide
-
-
?
additional information
?
-
no activity with L-Asp-L-Phe
-
-
?
additional information
?
-
-
no activity with L-Asp-L-Phe
-
-
?
additional information
?
-
-
the virus receptor APN is not involved in antibody-dependent enhancement of feline infectious peritonitis virus infection
-
-
?
additional information
?
-
-
substrate specificity, overview
-
-
?
additional information
?
-
-
the enzyme is involved in embryonic angiogenesis and development promoting vascular growth and endothelial cell proliferation
-
-
?
additional information
?
-
the aminopeptidase N3 is a putative receptor for Bacillus thuringiensis insecticidal Cry1Ac toxin
-
-
?
additional information
?
-
-
the isozymes have different roles in digestion
-
-
?
additional information
?
-
-
substrate specificity, overview
-
-
?
additional information
?
-
-
enzyme plays a critical role in angiogenesis
-
?
additional information
?
-
APN/CD13 plays multiple roles in morphogenesis during angiogenesis in vascular endothelium, enzyme inhibition by RNAi results in inhibition of capillary tube formation of umbilical vein endothelil cells
-
-
?
additional information
?
-
-
APN/CD13 plays multiple roles in morphogenesis during angiogenesis in vascular endothelium, enzyme inhibition by RNAi results in inhibition of capillary tube formation of umbilical vein endothelil cells
-
-
?
additional information
?
-
-
functional co-localization of monocytic enzyme with the Fc gamma receptors CD32 and CD64 as part of a multimeric receptor complex, overview
-
-
?
additional information
?
-
-
mechanism of APN signaling, enzyme inhibition has anti-proliferative effect and causes strong immunosuppression both in vitro and in vivo including growth arrest, induction of immunosuppressive cytokines, e.g. TGF-beta1, reduced expression of inflammatory or T-cell stimulating cytokines, e.g. interleukin-2 and interleukin-12, and mosulation of T-cell signalling pathways, overview, catalytic mechanism, ligand binding structure, active site structure, dynamic opening and closing
-
-
?
additional information
?
-
the ectoenzyme acts as a receptor for human coronavirus 229E, in vivo infection of primary embryonic cells and bone marrow dendritic cells
-
-
?
additional information
?
-
-
the ectoenzyme acts as a receptor for human coronavirus 229E, in vivo infection of primary embryonic cells and bone marrow dendritic cells
-
-
?
additional information
?
-
-
the enzyme acts as a cellsuface receptor for cells leading to rapid FcgammaRI-mediated phagocytosis of the cells, functionally interacts and partially co-localizes with FcgammaRs in monocytes, cross-linking of cells via the cytoplasmic portion of the enzyme triggers intracellular signalling, overview
-
-
?
additional information
?
-
the enzyme acts as receptor for the human coronavirus 229E
-
-
?
additional information
?
-
-
the enzyme acts as receptor for the human coronavirus 229E
-
-
?
additional information
?
-
-
the enzyme can associate with tumor-associated antigen L6, TAL6, and enhance the motility of human lung cancer cells and their adhesion to extracellular matrix, overview
-
-
?
additional information
?
-
-
the enzyme expression is regulated on gingival fibroblasts in response to T-cell-derived cytokines, e.g. interleukin-4 and interleukin-13, overview
-
-
?
additional information
?
-
-
the enzyme in granulocytes may cooperate with neprilysin, the enzyme is involved in the metabolism of certain vasoactive peptides in vascular cells in the brain, the enzyme mediates human cytomegalovirus infection, the enzym regulates the cycle-dependent bioavailability of interleukin-8 in the endometrium, the enzyme's activity is regulated by estrogen
-
-
?
additional information
?
-
-
the enzyme is involved in angiogenesis and cell proliferation
-
-
?
additional information
?
-
-
the enzyme is involved in hydrolysis of neutral or basic amino acids from the N-terminus of bioactive peptides, or of amide or arylamide derivatives of amino acids, the enzyme promotes malignant angiogenesis/tumorigenesis, cell proliferation and tumor cell growth, and is involved in several diseases, e.g. inflammatory, overview, detailed catalytic machanism
-
-
?
additional information
?
-
-
the enzyme is involved in infection of cells with human cytomegalovirus and in pathogenesis, enzyme inhibition reduces the infection rate, infection induces the production of anti-CD13 antibodies, overview
-
-
?
additional information
?
-
-
the enzyme is involved in postsecretory processing of neuropeptides and peptide hormones
-
-
?
additional information
?
-
-
the enzyme is involved in signal transduction and monocytic cell adhesion mediating the binding to IgG-receptor FcgammaRs, the enzyme expression is down-regulated during homotypic aggregation, while the enzyme induced the homoypic aggregation, overview
-
-
?
additional information
?
-
-
the enzyme might contribute to extracellular matrix degradation, the enzyme shows increased surface expression in cases of malignant transformation, inflamation, or T-cell activation
-
-
?
additional information
?
-
-
the enzyme negatively regulates tumor necrosis factor-alpha-induced apoptosis in human neutrophils via inhibition of TNF receptor I shedding, mechanism, overview
-
-
?
additional information
?
-
-
the enzyme plays a role in the modulation of kinins, neuropeptides, and chemotactic mediators as well as in adhesion and cell-cell interactions, it participates in antigen processing and presentation, trimming of peptides protrusing out of MHC class II molecules, and acts in inflammatory processes, interleukin-10 and TGF-beta are involved in enzyme upregulation in monocytes and U-937 cells, overview
-
-
?
additional information
?
-
-
the enzyme plays an important role in tumor cell invasion, the enzyme regulation involves the basic fibroblast growth factor
-
-
?
additional information
?
-
-
the enzyme serves as receptor for coronaviruses, modulates bioactive peptide responses, e.g. vasopressin release, and influences immune functions and major biological processess, such as cell proliferation, secretion, invasion, and angiogenesis, overview, enzyme inhibition affects these processes, overview
-
-
?
additional information
?
-
-
the inhibition of APN results in decreased growth of cultured keratinocytes
-
-
?
additional information
?
-
-
the membrane enzyme is involved in keratinocyte growth and differentiation, inhibition of the enzyme contributes to inhibition of DNA synthesis in proliferating cells
-
-
?
additional information
?
-
-
enzyme inhibition causes strong immunosuppression both in vitro and in vivo
-
-
?
additional information
?
-
-
substrate specificity, overview, chain length influencs the activity rate, dipeptides are readily hydrolyzed, the enzyme prefers substrates with N-terminal L-Ala residues, the specificity for N-terminal residues is descending order is Ala, Phe, Tyr, Leu, Arg, Thr, Trp, Lys, Ser, Asp, His, Val. Pro- and alpha- or gamma-Glu-derivatives are slowly hydrolyzed, when a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide
-
-
?
additional information
?
-
-
the enzyme prefers neutral N-terminal amino acid substrates
-
-
?
additional information
?
-
-
role for CD13 in plasma membrane organization. Peptidase activity of CD13 is required for this regulatory activity
-
-
?
additional information
?
-
-
where initial removal of the NH2-terminal dipeptide from CXCL11 by CD26 allows for further truncation by CD13
-
-
?
additional information
?
-
-
aminopeptidase N removes N-terminal amino acids from unsubstituted oligopeptides, amide or arylamide, with the exception of peptides with Pro in the penultimate position, the order of favored substrates is Ala>Phe>Tyr>Leu>Arg>Thr>Trp>Lys> Ser>Asp>His>Val
-
-
?
additional information
?
-
-
CD13 degrades the chemokine CXCL11, downregulates CXCR4 and modulates stromal cell-derived factor-1 (also known as CXCL12)-induced migration
-
-
?
additional information
?
-
-
CD13 hydrolyzes synthetic oligopeptides corresponding to the N terminus of interleukin-1a, interleukin-1b and interleukin-2, although natural interleukin-2 and G-CSF are resistant to hydrolysis
-
-
?
additional information
?
-
-
CD13 is a receptor for human coronavirus 229E and human cytomegalovirus
-
-
?
additional information
?
-
-
in vitro, CD13 participates in the metabolism of glutathione, somatostatin, thymopentin, neurokinin A, splenopentin, nociceptin (orphanin) FQ, and peptides derived from the thrombin receptor
-
-
?
additional information
?
-
-
aminopeptidase regulation mechanisms and biological functions, overview
-
-
?
additional information
?
-
-
broad substrate specificity, the enzyme prefers N-terminal alkaline and aliphatic amino acid substrates showing high activity with peptides possessing N-terminal Lys or Leu residues and, to a lesser extent, Ala residues
-
-
?
additional information
?
-
-
aminopeptidase regulation mechanisms and biological functions, overview
-
-
?
additional information
?
-
-
broad substrate specificity, the enzyme prefers N-terminal alkaline and aliphatic amino acid substrates showing high activity with peptides possessing N-terminal Lys or Leu residues and, to a lesser extent, Ala residues
-
-
?
additional information
?
-
-
aminopeptidase regulation mechanisms and biological functions, overview
-
-
?
additional information
?
-
-
broad substrate specificity, the enzyme prefers N-terminal alkaline and aliphatic amino acid substrates showing high activity with peptides possessing N-terminal Lys or Leu residues and, to a lesser extent, Ala residues
-
-
?
additional information
?
-
-
the enzyme acts as major receptor for the CryIAc toxin of Bacillus thuringiensis
-
-
?
additional information
?
-
-
Cry1AC toxin induces APN shedding from midgut epithelial cells into the luminal fluid, and depletion of the membrane-anchored enzyme on the midgut epithelial cells
-
-
?
additional information
?
-
-
the enzyme binds the Cry1Ac toxin from Bacillus thuringiensis
-
-
?
additional information
?
-
-
substrate specificity, the enzyme prefers substrates with Ala or Met residues at the N-terminus, overview
-
-
?
additional information
?
-
-
insulin affects the lysosomal enzyme activity in kidney and liver, overview
-
-
?
additional information
?
-
-
the enzyme is involved in infection of cells with murine cytomegalovirus and in pathogenesis, enzyme inhibition reduces the infection rate, infection induces the production of anti-CD13 antibodies, overview
-
-
?
additional information
?
-
-
no activity with 4-nitroanilides of Pro, Ile, Val, and Phe
-
-
?
additional information
?
-
-
substrate specificity, overview, chain length influencs the activity rate, dipeptides are readily hydrolyzed, the enzyme prefers substrates with N-terminal L-Ala residues, the specificity for N-terminal residues is descending order is Ala, Phe, Tyr, Leu, Arg, Thr, Trp, Lys, Ser, Asp, His, Val. Pro- and alpha- or gamma-Glu-derivatives are slowly hydrolyzed, when a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide
-
-
?
additional information
?
-
-
aminopeptidase regulation mechanisms and biological functions, overview
-
-
?
additional information
?
-
-
the enzyme prefers N-terminal alkaline and aliphatic amino acid substrates showing high activity with peptides possessing N-terminal Ala, Arg, Lys or Leu residues
-
-
?
additional information
?
-
-
synthesis and activity of chromogenic phenoxazinone substrates, phenoxazinones are the chromophores in a number of synthetic dyestuffs and natural coloured matters and the phenoxazinone chromophore has been found in a number of mould metabolites and other natural products, overview
-
-
?
additional information
?
-
-
synthesis and activity of chromogenic phenoxazinone substrates, phenoxazinones are the chromophores in a number of synthetic dyestuffs and natural coloured matters and the phenoxazinone chromophore has been found in a number of mould metabolites and other natural products, overview
-
-
?
additional information
?
-
-
the enzyme is involved in the transport and degradation of extracellular peptides, aminopeptidase regulation mechanisms and biological functions, overview
-
-
?
additional information
?
-
-
the enzyme prefers N-terminal alkaline and aliphatic amino acid substrates showing high activity with peptides possessing N-terminal Ala, Arg, Lys or Leu residues
-
-
?
additional information
?
-
-
the enzyme is involved in hematopoiesis and bone growth, increased enzyme expression occurs during angiogenesis associated with cancer development
-
-
?
additional information
?
-
-
substrate specificity, overview, chain length influencs the activity rate, dipeptides are readily hydrolyzed, the enzyme prefers substrates with N-terminal L-Ala residues, the specificity for N-terminal residues is descending order is Ala, Phe, Tyr, Leu, Arg, Thr, Trp, Lys, Ser, Asp, His, Val. Pro- and alpha- or gamma-Glu-derivatives are slowly hydrolyzed, when a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide
-
-
?
additional information
?
-
enzyme preferentially cleaves neutral and nonpolar amino acids such as alanine, methionine, leucine, and phenylalanine at the P1 position, substrates with basic amino acids such as lysine and arginine at the P1 position are less cleaved. Pyroglutamic acid, and Bz-Arginine, are not cleaved at all
-
-
?
additional information
?
-
the peptidase that hydrolyzes AAF-MCA is the soluble form of aminopeptidase N/CD13, and caution is required when using AAF-MCA as a substrate for tripeptidyl peptidase assays. No activity with Pyr-MCA and Bz-Arg-MCA
-
-
?
additional information
?
-
enzyme preferentially cleaves neutral and nonpolar amino acids such as alanine, methionine, leucine, and phenylalanine at the P1 position, substrates with basic amino acids such as lysine and arginine at the P1 position are less cleaved. Pyroglutamic acid, and Bz-Arginine, are not cleaved at all
-
-
?
additional information
?
-
the peptidase that hydrolyzes AAF-MCA is the soluble form of aminopeptidase N/CD13, and caution is required when using AAF-MCA as a substrate for tripeptidyl peptidase assays. No activity with Pyr-MCA and Bz-Arg-MCA
-
-
?
additional information
?
-
-
no activity with N-terminal Leu-substrates
-
-
?
additional information
?
-
-
aminopeptidase regulation mechanisms and biological functions, overview
-
-
?
additional information
?
-
-
broad substrate specificity, the enzyme prefers N-terminal alkaline and aliphatic amino acid substrates showing high activity with peptides possessing N-terminal Lys or Leu residues and, to a lesser extent, Ala residues
-
-
?
additional information
?
-
-
the enzyme might be involved in the turnover of intracellular peptides
-
-
?
additional information
?
-
-
no activity with L-Val-4-nitroanilide, L-Glu-4-nitroanilide, and L-Asp-4-nitroanilide, no activity with N-alpha-benzoyl-L-Arg-2-naphthylamide
-
-
?
additional information
?
-
-
no hydrolysis of Lys-Pro and Pro-Phe bond
-
-
?
additional information
?
-
-
no hydrolysis of Lys-Pro and Pro-Phe bond
-
-
?
additional information
?
-
-
the brain enzyme is involved in termination of the action of neuropeptides, especially of enkephalins and angiotensin III, the kidney enzyme contributes to the extracellular catabolism of glutathione, the intestinal enzyme acts as a receptor for the transmissible gastroenteritis virus, a coronavirus, causing fatal diarrhea in newborn pigs
-
-
?
additional information
?
-
-
the enzyme activity in muscle decreases during Jinhua ham processing, e.g. salting, with increasing levels of free amino acids which is important for the ham flavor, overview
-
-
?
additional information
?
-
-
the enzyme plays a key role in tumor cell invasion and angiogenesis, enzyme inhibition by psammaplin A suppresses the invasion and tube formation of endothelial cells stimulated by basic fibroblast growth factor, and proliferation of cancer and endothelial cells, overview
-
-
?
additional information
?
-
-
substrate specificity, overview, chain length influencs the activity rate, dipeptides are readily hydrolyzed, the enzyme prefers substrates with N-terminal L-Ala residues, the specificity for N-terminal residues is descending order is Ala, Phe, Tyr, Leu, Arg, Thr, Trp, Lys, Ser, Asp, His, Val. Pro- and alpha- or gamma-Glu-derivatives are slowly hydrolyzed, when a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide. Glu350 is involved in catalysis, the enzyme in lung is identical with the p146 type II alveolar epithelial cell antigen
-
-
?
additional information
?
-
-
in combination with CD26/dipeptidyl peptidase IV, aminopeptidase N processes chemokine ligand CXCL11, but not CXCL8, to generate truncated CXCL11 forms. The truncated CXCL11 fails to induce an intracellular calcium increase but is still able to bind and desensitize CXCR3 for intact CXCL11 signaling. Truncated CXCL11 fails to attract lymphocytes, and further processing by aminopeptidase N results in significant reduction of inhibition of HMVEC migration
-
-
?
additional information
?
-
-
no substrate: YPWTQRF, i.e. fragment H7 of human hemorphin
-
-
?
additional information
?
-
-
broad substrate specificity for N-terminal amino acid residues, no activity with Asp-2-naphthylamide, the enzyme prefers tri- and tetrapeptides to di- and pentapeptides
-
-
?
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(+)-4-hydroxypanduratin A
-
54.8% inhibition at 0.03 mM
(+)-isopanduratin A
-
29.3% inhibition at 0.03 mM
(+)-krachaizin A
-
27.9% inhibition at 0.03 mM
(+)-krachaizin B
-
76.2% inhibition at 0.03 mM
(+)-panduratin A
-
61.4% inhibition at 0.03 mM
(-)-4-hydroxypanduratin A
-
39.6% inhibition at 0.03 mM
(-)-isopanduratin A
-
95.3% inhibition at 0.03 mM
(-)-krachaizin A
-
21.7% inhibition at 0.03 mM
(-)-krachaizin B
-
51.0% inhibition at 0.03 mM
(-)-panduratin A
-
95.2% inhibition at 0.03 mM
(1-amino-2-anilinoethyl)phosphonic acid
(1-amino-2-cyclohexylethyl)phosphonic acid
-
-
(1-amino-2-cyclopentylethyl)phosphonic acid
-
-
(1-amino-2-methylpropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
(1-amino-2-phenylethyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
(1-amino-2-[[(4-methoxyphenyl)methyl]amino]ethyl)phosphonic acid
(1-amino-3-cyclohexylpropyl)phosphonic acid
-
-
(1-amino-3-cyclopentylpropyl)phosphonic acid
-
-
(1-amino-3-methylbutyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
(1-amino-3-methylbutyl)(1-hydroxypentyl)phosphinic acid
-
-
(1-amino-3-methylbutyl)(2-benzyl-3-oxo-3-phenylpropyl)phosphinic acid
-
-
(1-amino-3-methylbutyl)phosphinic acid
-
-
(1-amino-3-methylbutyl)[amino(phenyl)methyl]phosphinic acid
-
-
(1-amino-3-phenylbutyl)phosphonic acid
-
-
(1-amino-3-phenylpropyl)(2-benzyl-3-oxo-3-phenylpropyl)phosphinic acid
-
-
(1-amino-3-phenylpropyl)phosphinic acid
(1-amino-3-phenylpropyl)phosphonic acid
-
-
(1-amino-4-carbamimidamidobutyl)phosphonic acid
-
-
(1-amino-4-cyclohexylbutyl)phosphonic acid
-
-
(1-amino-5-phenylpentyl)phosphonic acid
-
-
(1-aminobutyl)(1-amino-3-methylbutyl)phosphinic acid
-
-
(1-aminobutyl)(1-hydroxy-2-phenylethyl)phosphinic acid
(1-aminobutyl)[amino(phenyl)methyl]phosphinic acid
-
-
(1-aminoethyl)(1-amino-3-methylbutyl)phosphinic acid
-
-
(1-aminoethyl)(2-benzyl-3-oxo-3-phenylpropyl)phosphinic acid
-
-
(1-aminoethyl)[amino(phenyl)methyl]phosphinic acid
-
-
(1-aminoethyl)[hydroxy[4-(propan-2-yl)phenyl]methyl]phosphinic acid
(1-aminohexyl)((2-(methoxycarbonyl)benzyl)carbamothioyl)phosphinic acid
(1-aminopentyl)(1-hydroxy-2-phenylpropyl)phosphinic acid
(1-aminopentyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
(1-aminopentyl)[hydroxy(4-hydroxyphenyl)methyl]phosphinic acid
(1-aminopropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
(1-benzyl-1H-imidazol-4-yl)methyl 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucylalaninate
-
-
(1S)-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethanaminium acetate
-
IC50: 70 nM
(1S)-2-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethanaminium acetate
-
IC50: 50 nM
(1S)-3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butan-1-aminium acetate
-
IC50: 74 nM
(2E)-3-[(1-aminoethyl)(hydroxy)phosphoryl]-2-methylprop-2-enoic acid
-
-
(2E)-N-[(2R)-2-amino-3-phenylpropyl]-3-(3,4-dihydroxyphenyl)-acrylamide hydrochloride
-
-
(2E)-N-[(2R)-2-Amino-3-phenylpropyl]-3-phenylacrylamide hydrochloride
-
-
(2E,2'E)-N,N'-[disulfanediyldi(ethane-2,1-diyl)]bis[3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanamide]
-
PsA, isolated from a marine sponge, inhibits the enzyme non-competitively and suppresses angiogenesis in vitro, IC50 is 0.018 mM
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-coumaroyl)amino]-propanamide
-
-
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-methoxycinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
-
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
-
-
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
-
-
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
-
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-coumaroyl)amino]-propanamide
-
-
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-methoxycinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
-
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
-
-
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
-
-
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
-
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-coumaroyl)amino]-propanamide
-
-
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-methoxycinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
-
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
-
-
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-coumaroyl)amino]-propanamide
-
-
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-methoxycinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
-
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
-
-
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-coumaroyl)amino]-propanamide
-
-
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-methoxycinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
-
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
-
-
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
-
-
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
-
(2R)-N-[5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-coumaroyl)amino]-propanamide
-
-
(2R)-N-[5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-methoxycinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
-
(2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
-
(2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
-
-
(2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
-
-
(2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
-
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)-amino]-propanamide
-
-
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(p-coumaroyl)amino]-propanamide
-
-
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(p-methoxycinnamoyl)amino]-propanamide
-
-
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
(2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-N-pentylpropanamide
-
-
(2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-N-phenethylpropanamide
-
-
(2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-N-propylpropanamide
-
-
(2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propanoic acid
-
moderate APN inhibition
(2R,3S)-2-amino-3-hydroxy-N-((S)-1-(hydroxyamino)-1-oxo-3-phenylpropan-2-yl)-3-(4-nitrophenyl)propanamide
-
-
(2R,3S)-2-amino-3-hydroxy-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-3-(4-nitrophenyl)propanamide
-
-
(2R,3S)-2-amino-3-hydroxy-N-(4-hydroxyphenethyl)-3-(4-nitrophenyl) propanamide
-
-
(2R,3S)-2-amino-3-hydroxy-N-(4-methoxybenzyl)-3-(4-nitrophenyl)propanamide
-
-
(2R,3S)-2-amino-3-hydroxy-N-isopropyl-3-(4-nitrophenyl)propanamide
-
-
(2R,3S)-2-amino-N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-3-hydroxy-3-(4-nitrophenyl)propanamide
-
-
(2R,3S)-2-amino-N-(2-chlorophenethyl)-3-hydroxy-3-(4-nitrophenyl)propanamide
-
-
(2R,3S)-2-amino-N-(4-fluorobenzyl)-3-hydroxy-3-(4-nitrophenyl)propanamide
-
-
(2R,3S)-2-amino-N-butyl-3-hydroxy-3-(4-nitrophenyl)propanamide
-
-
(2R,3S)-2-amino-N-cyclohexyl-3-hydroxy-3-(4-nitrophenyl)propanamide
-
-
(2S)-2,5-amino-N-[(2R)-2-amino-3-phenylpropyl]-valeramide hydrochloride
-
-
(2S)-2,6-amino-N-[(2R)-2-amino-3-phenylpropyl]caproylamide hydrochloride
-
-
(2S)-2-amino-3-hydroxyl-N-[(2R)-2-amino-3-phenylpropyl]propionamide hydrochloride
-
-
(2S)-2-amino-3-methyl-N-[(2R)-2-amino-3-phenylpropyl]propionamide hydrochloride
-
-
(2S)-2-amino-3-thiol-N-[(2R)-2-amino-3-phenylpropyl]propionamide hydrochloride
-
-
(2S)-2-amino-4-methyl-N-[(2R)-2-amino-3-phenylpropyl]valeramide hydrochloride
-
-
(2S)-2-amino-4-methylthio-N-[(2R)-2-amino-3-phenylpropyl]butyramide hydrochloride
-
-
(2S)-2-amino-N-[(2R)-2-amino-3-phenylpropyl]-propionamide hydrochloride
-
-
(2S)-2-amino-N-[(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3-phenylpropanamide
-
-
(2S,3R)-3-amino-2-hydroxy-4-phenyl-N-1,3-thiazol-2-ylbutanamide
-
-
(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl-L-valine
-
-
(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl-L-valyl-L-prolyl-(trans-4-hydroxy-L-proline)
-
i.e. MR387A
(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl-L-valyl-L-prolyl-L-proline
-
i.e. MR378B
(2S,3R)-3-amino-2-hydroxy-N-1H-imidazo[4,5-c]pyridin-4-yl-4-phenylbutanamide
-
-
(2S,3R)-3-amino-N-(2,6-dihydroxypyrimidin-4-yl)-2-hydroxy-4-phenylbutanamide
-
-
(2S,3R)-3-amino-N-(5-amino-1,3-thiazol-2-yl)-2-hydroxy-4-phenylbutanamide
-
-
(2S,3R)-3-amino-N-1,3-benzothiazol-2-yl-2-hydroxy-4-phenylbutanamide
-
-
(2Z)-3-amino-3,4-dihydronaphthalen-2(1H)-one O-(2-phenylethyl)oxime hydrochloride
-
-
(2Z)-3-amino-3,4-dihydronaphthalen-2(1H)-one O-(3-phenylpropyl)oxime hydrochloride
-
-
(2Z)-3-amino-3,4-dihydronaphthalen-2(1H)-one O-(4-phenylbutyl)oxime hydrochloride
-
-
(2Z)-3-amino-3,4-dihydronaphthalen-2(1H)-one O-benzyloxime hydrochloride
-
-
(2Z)-3-amino-3,4-dihydronaphthalen-2(1H)-one O-methyloxime hydrochloride
-
-
(2Z)-3-amino-3,4-dihydronaphthalen-2(1H)-one oxime hydrochloride
-
-
(3-Hydroxycarbamoyl-2-phenyl-propionylamino)-phenyl-acetic acid
-
-
(3S)-3-(D-alanylamino)-2-([[(1S)-1-aminoethyl][(3r)-tricyclo[3.3.1.13,7]dec-1-yloxy]phosphoryl]methyl)-5-methylhexanoic acid
-
-
(3S)-N-hydroxy-2-(phenylsulfonyl)-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxamide
-
-
(3S)-N-hydroxy-2-(phenylsulfonyl)-6,11-dioxa-2-azaspiro[4.6]undecane-3-carboxamide
-
-
(3S)-N-hydroxy-2-(phenylsulfonyl)-6,12-dioxa-2-azaspiro[4.7]dodecane-3-carboxamide
-
-
(3S)-N-hydroxy-2-[(4-methylphenyl)sulfonyl]-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxamide
-
-
(3S)-N-hydroxy-2-[(4-methylphenyl)sulfonyl]-6,11-dioxa-2-azaspiro[4.6]undecane-3-carboxamide
-
-
(3S)-N-hydroxy-2-[(4-methylphenyl)sulfonyl]-6,12-dioxa-2-azaspiro[4.7]dodecane-3-carboxamide
-
-
(4R)-4-(hexanoylamino)-N-hydroxy-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinamide
(4R)-4-([(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino)-N-hydroxy-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinamide
-
IC50: 2.1 nM
(4R)-4-[[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]-N-hydroxy-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinamide
-
-
(4S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(1-methoxy-1-oxopropan-2-ylamino)-5-oxopentanoic acid
-
-
(4S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(1-methoxy-3-methyl-1-oxobutan-2-ylamino)-5-oxopentanoic acid
-
-
(4S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(3-(4-fluorophenyl)-1-methoxy-1-oxopropan-2-ylamino)-5-oxopentanoic acid
-
-
(4S,E)-5-(1,4-dimethoxy-1,4-dioxobutan-2-ylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
-
-
(aminomethyl)(1-amino-3-methylbutyl)phosphinic acid
-
-
(aminomethyl)[amino(phenyl)methyl]phosphinic acid
-
-
(R)-4-(4-carboxy-2-(3,4,5-trimethoxybenzamido)butanamido)-2-hydroxybenzoic acid
-
-
(R)-4-(4-carboxy-2-(3,4,5-trimethoxybenzamido)butanamido)benzoic acid
-
-
(R)-5-(2,4-difluorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
-
(R)-5-(2,5-dichlorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
-
(R)-5-(2-chloroethylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
-
(R)-5-(2-nicotinoylhydrazinyl)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
-
(R)-5-(3-bromobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
-
(R)-5-(3-chloro-4-fluorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
-
(R)-5-(3-iodobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
-
(R)-5-(4-aminophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
-
(R)-5-(4-bromo-2-fluorobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
-
(R)-5-(4-bromophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
-
(R)-5-(4-chloro-2-fluorobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
-
(R)-5-(4-chlorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
-
(R)-5-(4-fluorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
-
(R)-5-(4-nitrophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
-
(R)-5-oxo-5-(2-(thiazole-2-carbonyl)hydrazinyl)-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
-
(R)-5-oxo-5-(thiazol-2-ylamino)-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
-
(R)-5-oxo-5-4-[(1,3-thiazole-2-amino)sulfonyl]phenylamino-4-[(3,4,5-trimethoxybenzamido)]pentanoic acid
-
-
(R)-5-[4-(aminosulfonyl)phenylamino]-5-oxo-4-[(3,4,5-trimethoxybenzamido)]pentanoic acid
-
-
(S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-(1H-indol-2-yl)propanoic acid
-
-
(S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-methylbutanoic acid
-
-
(S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-methylpentanoic acid
-
-
(S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-phenylpropanoic acid
-
-
(S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-4-methylpentanoic acid
-
-
(S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-N-hydroxy-4-methylpentanamide
-
-
(S)-2-((S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-phenylpropanamido)-3-phenylpropanoic acid
-
-
(S)-2-((S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-4-methylpentanamido)-3-phenylpropanoic acid
-
-
(S)-2-amino-N-((S)-1-(2-(hydroxyamino)-2-oxoethyl)-2,6-dioxopiperidin-3-yl)-2-((R)-pyrrolidin-2-yl)acetamide
-
-
(S)-2-amino-N-((S)-1-(2-(hydroxyamino)-2-oxoethyl)-2,6-dioxopiperidin-3-yl)-3-phenylpropanamide
-
displays a substantial potential inhibitory effect on APN/CD13 activity more potently than bestatin. In the concentration range of 0.0008-0.5 mM, the mean optical density of APN/CD13 activity is reduced by 30%, 53.1%, 63.1%, 68.5%, and 70.8%, respectively, for a 30 min exposure and 37.2%, 56.7%, 66.5%, 73.8%, and 76.2%, respectively, for a 60 min exposure
(S,E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)-N1,N5-bis(2-fluorophenyl)pentanediamide
-
-
(S,E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)-N1,N5-bis(4-fluorophenyl)pentanediamide
-
-
(S,E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)-N1,N5-di-p-tolylpentanediamide
-
-
(S,E)-2-[3-(3,4-dimethoxyphenyl)acrylamido]-N1,N5-[(R)-1,4-dimethoxy-1,4-dioxobutan]pentanediamide
-
-
(S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(2-fluorophenylamino)-5-oxopentanoic acid
-
-
(S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(2-methoxy-2-oxoethylamino)-5-oxopentanoic acid
-
-
(S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(4-fluorophenylamino)-5-oxopentanoic acid
-
-
(S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(ethylamino)-5-oxopentanoic acid
-
-
(S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(isopropylamino)-5-oxopentanoic acid
-
-
(S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(methylamino)-5-oxopentanoic acid
-
-
(S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxo-5-(propylamino)pentanoic acid
-
-
(S,E)-5-(2-chlorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
-
-
(S,E)-5-(3,5-difluorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
-
-
(S,E)-5-(3-chlorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
-
-
(S,E)-5-(4-bromophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
-
-
(S,E)-5-(4-chlorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
-
-
(S,E)-5-(benzylamino)-4-(3-(3,4-dimethoxyphenyl)-acrylamido)-5-oxopentanoic acid
-
-
(S,E)-5-(p-toluidino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
-
-
(S,E)-N1,N5-bis(3,5-difluorophenyl)-2-(3-(3,4-dimethoxyphenyl)acrylamido)pentanediamide
-
-
(S,E)-N1,N5-bis(4-bromophenyl)-2-(3-(3,4-dimethoxyphenyl)acrylamido)pentanediamide
-
-
(S,E)-N1,N5-bis(4-chlorophenyl)-2-(3-(3,4-dimethoxyphenyl)acrylamido)pentanediamide
-
-
1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride
-
-
1,4-dihydro-3H-isochromen-3-one
-
-
1,4-dihydro-3H-isothiochromen-3-one
-
-
1-(3-amino-1,2,3,4-tetrahydronaphthalen-2-yl)ethanone hydrochloride
-
-
1-amino-2-ethylbutylphosphonic acid monophenyl ester
-
-
1-amino-2-methylbutylphosphonic acid monophenyl ester
-
-
1-amino-2-methylpropyl(benzylcarbamoyl)phosphinic acid
-
-
1-amino-2-methylpropyl(hexylcarbamothioyl)phosphinic acid
1-amino-2-methylpropyl(isobutylcarbamothioyl)phosphinic acid
1-amino-2-methylpropyl(methylcarbamothioyl)phosphinic acid
1-amino-2-methylpropyl(phenylcarbamoyl)phosphinic acid
-
-
1-amino-2-methylpropylphosphonic acid monophenyl ester
-
-
1-amino-2-phenylethylphosphonic acid monophenyl ester
-
-
1-amino-3-methylbutyl(2-(methoxycarbonyl)benzylcarbamothioyl)phosphinic acid
1-amino-3-methylbutyl(benzylcarbamothioyl)phosphinic acid
1-amino-3-methylbutyl(hexylcarbamothioyl)phosphinic acid
1-amino-3-methylbutyl(methylcarbamothioyl)phosphinic acid
1-amino-3-methylbutyl(phenethylcarbamothioyl)phosphinic acid
1-amino-3-phenylpropyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
1-amino-3-phenylpropyl(4-(ethoxycarbonyl)benzylcarbamothioyl)phosphinic acid
1-amino-3-phenylpropyl(4-methoxybenzylcarbamothioyl)phosphinic acid
1-amino-3-phenylpropyl(benzylcarbamothioyl)phosphinic acid
1-amino-3-phenylpropyl(propylcarbamothioyl)phosphinic acid
1-amino-3-phenylpropylphosphonic acid mono-(2,3,5-trimethylphenyl) ester
-
-
1-amino-3-phenylpropylphosphonic acid mono-(2,5-dimethylphenyl) ester
-
-
1-amino-3-phenylpropylphosphonic acid mono-(3,4-dimethylphenyl) ester
-
-
1-amino-3-phenylpropylphosphonic acid mono-(4-(1,1,3,3-tetramethyl)butylphenyl) ester
-
-
1-amino-3-phenylpropylphosphonic acid mono-(4-carboxyphenyl) ester
-
-
1-amino-3-phenylpropylphosphonic acid mono-(4-ethylphenyl) ester
-
-
1-amino-3-phenylpropylphosphonic acid mono-(4-isopropylphenyl) ester
-
-
1-amino-3-phenylpropylphosphonic acid mono-(4-methoxyphenyl) ester
-
-
1-amino-3-phenylpropylphosphonic acid mono-(4-tert-butylphenyl) ester
-
-
1-amino-3-phenylpropylphosphonic acid monophenyl ester
-
-
1-amino-4-methylpentyl(benzylcarbamoyl)phosphinic acid
-
-
1-amino-4-methylpentyl(phenylcarbamoyl)phosphinic acid
-
-
1-aminobutyl(2-(methoxycarbonyl)phenethylcarbamothioyl)phosphinic acid
1-aminobutyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
1-aminobutyl(4-(ethoxycarbonyl)phenethylcarbamothioyl)phosphinic acid
1-aminobutyl(4-methoxybenzylcarbamothioyl)phosphinic acid
1-aminobutyl(4-methoxyphenethylcarbamothioyl)phosphinic acid
1-aminobutyl(benzylcarbamothioyl)phosphinic acid
1-aminobutyl(phenethylcarbamothioyl)phosphinic acid
1-aminoethyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
1-aminoethyl(4-(ethoxycarbonyl)benzylcarbamothioyl)phosphinic acid
1-aminoethyl(4-methoxybenzylcarbamothioyl)phosphinic acid
1-aminoethyl(benzylcarbamothioyl)phosphinic acid
1-aminoethyl(phenethylcarbamothioyl)phosphinic acid
1-aminoethylphosphonic acid mono-(2,3,5-trimethylphenyl) ester
-
-
1-aminoethylphosphonic acid mono-(4-ethylphenyl) ester
-
-
1-aminoethylphosphonic acid mono-(4-tert-butylphenyl) ester
-
-
1-aminohexyl(4-methoxyphenethylcarbamothioyl)phosphinic acid
-
-
1-aminohexyl(phenethylcarbamothioyl)phosphinic acid
-
-
1-aminohexylphosphonic acid monophenyl ester
-
-
1-aminopentyl(2-(methoxycarbonyl)benzylcarbamothioyl)phosphinic acid
1-aminopentyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
1-aminopentyl(4-methoxybenzylcarbamothioyl)phosphinic acid
1-aminopentyl(benzylcarbamothioyl)phosphinic acid
1-aminopentyl(phenethylcarbamothioyl)phosphinic acid
1-aminopentylphosphonic acid mono-(2,5-dimethylphenyl) ester
-
-
1-aminopentylphosphonic acid mono-(3,4-dimethylphenyl) ester
-
-
1-aminopentylphosphonic acid mono-(4-carboxyphenyl) ester
-
-
1-aminopentylphosphonic acid mono-(4-methoxyphenyl) ester
-
-
1-aminopentylphosphonic acid mono-(4-methylphenyl) ester
-
-
1-aminopentylphosphonic acid monophenyl ester
-
-
1-aminopropyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
1-aminopropylphosphonic acid mono-(2,5-dimethylphenyl) ester
-
-
1-aminopropylphosphonic acid mono-(3,4-dimethylphenyl) ester
-
-
1-aminopropylphosphonic acid mono-(4-carboxyphenyl) ester
-
-
1-aminopropylphosphonic acid mono-(4-methylphenyl) ester
-
-
1-aminopropylphosphonic acid mono-(4-tert-butylphenyl) ester
-
-
1-methyl cyclohexan bestatin
-
i.e. BE15, strong inhibition
2',3-dinitro-3'-methoxy-flavone-8-acetic acid
-
75% inhibition at 1 mM
2',3-dinitro-5'-methoxy-flavone-8-acetic acid
-
80% inhibition at 1 mM
2',3-dinitroflavone-8-acetic acid
2'-nitro-flavone-8-acetic acid
-
highly cytotoxic, 83% inhibition at 1 mM
2(S)-amino-5-methylpentanal
-
-
2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-3-iodotyrosine
2,2'-bipyridine
-
90% inhibition at 5 mM
2,4-dihydroxy-6-phenethylbenzoic acid methyl ester
-
22.8% inhibition at 0.03 mM
2,6-dihydroxy-4-methoxydihydrochalcone
-
14.8% inhibition at 0.03 mM
2-(1-ethylcyclopentyl)ethanamine-CO-Tyr-Ile-His-Pro-Phe-OH
-
low potency inhibitor
2-([[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]amino)propaneperoxoic acid
-
-
2-amino-1,4-dihydroisoquinolin-3(2H)-one
-
-
2-amino-1,4-dihydrophenanthren-3(2H)-one hydrochloride
-
-
2-amino-2-phenylethanethiol
-
IC50: 25 nM
2-amino-3-(benzyloxy)propane-1-thiol
-
IC50: 56 nM
2-amino-3-(methylsulfanyl)propane-1-thiol
-
IC50: 20 nM
2-amino-3-(methylsulfinyl)propane-1-thiol
-
IC50: 21 nM
2-amino-3-(tert-butylsulfanyl)propane-1-thiol
-
IC50: 40 nM
2-amino-3-cyclohexylpropane-1-thiol
-
IC50: 45 nM
2-amino-3-phenylpropane-1-thiol
-
IC50: 30 nM
2-amino-4-(methylsulfanyl)butane-1-thiol
-
IC50: 11 nM
2-amino-4-(methylsulfinyl)butane-1-thiol
-
IC50: 20 nM
2-amino-4-methylpentane-1-thiol
-
IC50: 22 nM
2-amino-4-methylsulfanyl-butane-1-thiol
-
-
2-amino-4-methylsulfonyl-butane-thiol
-
selective inhibitor of APN
2-amino-N-[(2R)-2-amino-3-phenylpropyl]acetamide hydrochloride
-
-
2-cinnamamido-4-(3-nitrophenylamino)-4-oxobutanoic acid
-
-
2-cinnamamido-4-(4-nitrophenylamino)-4-oxobutanoic acid
-
-
2-cinnamamido-4-(dodecylamino)-4-oxobutanoic acid
-
-
2-cinnamamido-4-(hexylamino)-4-oxobutanoic acid
-
-
2-cinnamamido-4-(isopropylamino)-4-oxobutanoic acid
-
-
2-cinnamamido-4-(naphthalene-1-ylamino)-4-oxobutanoic acid
-
-
2-cinnamamido-4-(octylamino)-4-oxobutanoic acid
-
-
2-cinnamamido-4-oxo-4-(pentylamino) butanoic acid
-
-
2-cinnamamido-4-oxo-4-(phenylamino) butanoic acid
-
-
2-cinnamamido-4-oxo-4-(propylamino) butanoic acid
-
-
2-cinnamamido-N1-hydroxy-N4-(3-nitrophenyl)succinamide
-
-
2-cinnamamido-N1-hydroxy-N4-(4-nitrophenyl)succinamide
-
-
2-cinnamamido-N1-hydroxy-N4-(naphthalene-1-yl)succinamide
-
-
2-cinnamamido-N1-hydroxy-N4-isopropylsuccinamide
-
-
2-cinnamamido-N1-hydroxy-N4-octylsuccinamide
-
-
2-cinnamamido-N1-hydroxy-N4-pentylsuccinamide
-
-
2-cinnamamido-N1-hydroxy-N4-phenylsuccinamide
-
-
2-cinnamamido-N1-hydroxy-N4-propylsuccinamide
-
-
2-cinnamamido-N4-dodecyl-N1-hydroxysuccinamide
-
-
2-cinnamamido-N4-hexyl-N1-hydroxysuccinamide
-
-
2-hydroxy-1,4-dihydroisoquinolin-3(2H)-one
-
-
2-mercaptoethane sulfonic acid
-
80% residual activity at 10 mM
2-mercaptoethanol
-
21.6% inhibition at 10 mM; 78.4% residual activity in the presence of 10 mM
2-[[(1-amino-3-methylbutyl)(hydroxy)phosphoryl]amino]-4-methylpentanoic acid
-
-
2-[[(1-amino-3-methylbutyl)(hydroxy)phosphoryl]methyl]-4-methylpentanoic acid
-
-
2-[[(1-amino-3-methylbutyl)hydroxyphosphinyl]methyl]-4-methylpentanoic acid
-
(R)-isomer and 1:1 ratio of the 2 diastereomers
2-[[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]methyl]-4-methylpentanoic acid
-
-
2-[[(1-amino-4-phenylbutyl)hydroxyphosphinyl]methyl]-3-(4-hydroxyphenyl)propionic acid
-
-
2-[[(1-amino-4-phenylbutyl)hydroxyphosphinyl]methyl]-3-phenylpropionic acid
-
-
2-[[(1-amino-4-phenylbutyl)hydroxyphosphinyl]methyl]-4-methylpentanoic acid
-
-
2-{[(1-aminoethyl)(hydroxy)phosphoryl]methyl}decanoic acid
-
-
3,3'-dinitro-4'-methoxy-flavone-8-acetic acid
-
61% inhibition at 1 mM
3,3'-dinitroflavone-8-acetic acid
-
44% inhibition at 1 mM
3,4'-dinitroflavone-8-acetic acid
-
63% inhibition at 1 mM
3,4-dihydronaphthalen-2(1H)-one
-
-
3-(hydroperoxy(hydroxy)phosphino)-1,2,3,4-tetrahydronaphthalen-2-amine
-
-
3-amino-1,2,3,4-tetrahydronaphthalene-2-carbohydroxamic acid
-
-
3-amino-1,2,3,4-tetrahydronaphthalene-2-phosphonic acid
-
-
3-amino-1-(2-phenylethyl)-3,4-dihydronaphthalen-2(1H)-one hydrochloride
-
-
3-amino-1-hydroxypropan-2-one derivatives
-
-
-
3-amino-2-(2-hydroxyphenyl)-4-oxo-4H-1-benzopyran-8-acetic acid methoxymethyl ester
-
highly cytotoxic, 19% inhibition at 1 mM
3-amino-2-hydroxypropionaldehyde derivatives
-
-
-
3-amino-2-tetralone derivatives
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(2-phenylethyl)oxime
-
-
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(3-phenylpropyl)oxime
-
-
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(4-phenylbutyl)oxime
-
-
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(5-phenylpentyl)oxime
-
-
3-amino-3,4-dihydro-1H-naphthalen-2-one O-benzyloxime
-
-
3-amino-3,4-dihydro-1H-naphthalen-2-one O-methyloxime
-
-
3-amino-3,4-dihydro-1H-naphthalen-2-one oxime
-
-
3-amino-3,4-dihydroquinolin-2(1H)-one hydrochloride
-
-
3-amino-flavone-8-acetic acid
-
33% inhibition at 1 mM
3-amino-N-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxamide hydrochloride
-
-
3-amino-N-[(2R)-2-amino-3-phenylpropyl]propionamide hydrochloride
-
-
3-nitro-2'-benzyloxy-flavone-8-acetic acid
-
cytotoxic, 76% inhibition at 1 mM
3-nitro-2'-carboxybenzyl-flavone-8-acetic acid
-
cytotoxic, 77% inhibition at 1 mM
3-nitro-2'-carboxymethyl-flavone-8-acetic acid
-
slightly cytotoxic, 66% inhibition at 1 mM
3-nitro-2'-chloro-flavone-8-acetic acid
-
slightly cytotoxic, 76% inhibition at 1 mM
3-nitro-2-(2-benzyloxyphenyl)-4-oxo-4H-1-benzopyran-8-acetic acid methoxymethyl ester
-
highly cytotoxic, 32% inhibition at 1 mM
3-nitro-2-(2-nitrophenyl)-4-oxo-4H-1-benzopyran-8-acetic acid methoxymethyl ester
-
highly cytotoxic, 48% inhibition at 1 mM
3-nitro-4'-methoxy-flavone-8-acetic acid
-
cytotoxic, 64% inhibition at 1 mM
3-nitro-flavone
-
30% inhibition at 1 mM
3-nitro-flavone-8-acetaldehyde
-
cytotoxic, 51% inhibition at 1 mM
3-nitroflavone-8-acetic acid
-
68% inhibition at 1 mM
3-[(1-amino-3-methylbutyl)(hydroxy)phosphoryl]propanoic acid
-
-
3-[(1-amino-3-methylbutyl)hydroxyphosphinyl]-propionic acid
-
-
3-[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]-2-(4-hydroxybenzyl)propanoic acid
3-[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]-2-benzylpropanoic acid
3-[(1-aminoethyl)(hydroxy)phosphoryl]-2-methylpropanoic acid
-
-
4,7-dimethyl-1,10 phenanthroline
-
-
-
4-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)butanoic acid
-
-
4-(2-(((1-aminobutyl)(hydroxy)phosphoryl)methanethioamido)ethyl)benzoic acid
4-(2-amino-3-sulfanylpropyl)phenol
-
IC50: 45 nM
4-(2-chlorophenylamino)-2-cinnamamido-4-oxobutanoic acid
-
-
4-(3-chlorophenylamino)-2-cinnamamido-4-oxobutanoic acid
-
-
4-(4-chlorophenylamino)-2-cinnamamido-4-oxobutanoic acid
-
-
4-(benzylamino)-2-cinnamamido-4-oxobutanoic acid
-
-
4-(butylamino)-2-cinnamamido-4-oxobutanoic acid
-
-
5,6-dehydrokawain
-
17.7% inhibition at 0.03 mM
5,7-dihydroxy-8-geranylflavanone
-
28.9% inhibition at 0.03 mM
6-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)hexanoic acid
-
-
6-amino-N-[(2R)-2-amino-3-phenylpropyl]caproylamide hydrochloride
-
-
6-hydroxy-6-oxo-N-1,3-thiazol-2-yl-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide
-
-
6-hydroxy-N-(methoxycarbonyl)-6-oxo-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide
-
-
6-hydroxy-N-(methoxycarbonyl)-N-methyl-6-oxo-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide
-
-
6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucyl-N-hydroxyglycinamide
-
-
7,4'-dihydroxy-5-methoxyflavanone
-
14.4% inhibition at 0.03 mM
7-methoxy-5-hydroxy-8-geranylflavanone
-
17.0% inhibition at 0.03 mM
9-(4-hydroxyphenyl)-1,10-phenanthroline
-
-
adhesion/signaling-inducing antibody 452
-
-
-
alpha1-amino-3-phenylpropyl(alpha2-hydroxy-3-phenylpropyl)phosphinic acid
alpinetin
-
36.4% inhibition at 0.03 mM
anti-CD antibody WM15
-
-
-
anti-CD13 antibody WM15
-
anti-CD13 monoclonl antibody WM15
-
apigenin
-
26% inhibition at 0.1 mM, 42% at 0.3 mM
Bacillus thuringiensis Cry toxin
-
-
Bacillus thuringiensis Cry1Aa toxin
-
Bacillus thuringiensis Cry1Ab toxin
-
baicalein
-
42% inhibition at 0.3 mM
benzo[c]phenanthridine derivatives
-
natural inhibitors
-
beta-amino-alpha-hydroxyl-phenyl butanic acid-valine
-
i.e. AHPA-Val, competitive with hydrolysis of L-Tyr-L-Gly. Enhances Met-enkephalin-induced twitch inhibition of ileum preparations
beta-amino-alpha-hydroxyphenylbutanoic acid
-
i.e. AHPA, or AHPA-VAl, natural inhibitor isolated from Streptomyces neyagawaensis strain SL-387, IC50: 0.0012-0.0056 mM
bis(1-amino-3-methylbutyl)phosphinic acid
-
-
bis(1-amino-3-phenylpropyl)phosphinic acid
-
-
bis[amino(phenyl)methyl]phosphinic acid
-
-
cardamonin
-
37.2% inhibition at 0.03 mM
copper
1 mM, 5% resiudal activity
coronavirus infection inhibitor Y2-K
-
-
-
cyclohexylmethyl N-[(2S)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucinate
-
-
D-Arg-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin
dipeptides
-
inhibit the enzyme at high concentration in the medium
EC27
-
selective APN inhibitor
EGTA
15% inhibition at 5 mM; 5 mM, 85% residual activity
epsilon-amino-n-caproic acid
-
70% inhibition at 100 mM
ethyl (S)-2-(3-(2-aminoacetamido)-2,6-dioxopiperidin-1-yl)acetate
-
-
ethyl D-cysteinate
-
strong, competitive inhibition, IC50: 350 nM
ethyl [(3S)-2,6-dioxo-3-(phenylalanylamino)piperidin-1-yl]acetate
-
-
ethyl [(3S)-2,6-dioxo-3-(tryptophylamino)piperidin-1-yl]acetate
-
-
ethyl [(3S)-2,6-dioxo-3-(tyrosylamino)piperidin-1-yl]acetate
-
-
ethyl [(3S)-2,6-dioxo-3-(valylamino)piperidin-1-yl]acetate
-
-
ethyl [(3S)-3-(alanylamino)-2,6-dioxopiperidin-1-yl]acetate
-
-
ethyl [(3S)-3-(histidylamino)-2,6-dioxopiperidin-1-yl]acetate
-
-
ethyl [(3S)-3-(isoleucylamino)-2,6-dioxopiperidin-1-yl]acetate
-
-
ethyl [(3S)-3-(leucylamino)-2,6-dioxopiperidin-1-yl]acetate
-
-
ethyl [(3S)-3-(lysylamino)-2,6-dioxopiperidin-1-yl]acetate
-
-
ethyl [(3S)-3-(methionylamino)-2,6-dioxopiperidin-1-yl]acetate
-
-
ethyl [(3S)-3-{[(2S)-2-amino-2-(pyrrolidin-2-yl)acetyl]amino}-2,6-dioxopiperidin-1-yl]acetate
-
-
Fe3+
-
39.9% residual activity in the presence of 1 mM; 60.1% inhibition at 1 mM
flavone
-
5% inhibition at 1 mM
flavone-8-acetic acid
-
30% inhibition at 1 mM
flavone-8-acetic acid derivatives
-
-
-
geraniol
-
7.6% inhibition at 0.03 mM
geranyl-2,4-dihydroxy-6-phenylbenzoate
-
89.4% inhibition at 0.03 mM
glycyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
-
-
glycyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
-
-
H-(R)-beta2-homo-Val-Tyr-Ile-His-Pro-beta3-homo-Phe-OH
-
low potency inhibitor
H-(R)-beta2-homo-Val-Tyr-Ile-His-Pro-Phe-OH
-
low potency inhibitor
H-(S)-beta2-homo-Val-Tyr-Ile-His-Pro-Phe-OH
-
low potency inhibitor
H-beta2-homo-Leu-Tyr-Ile-His-Pro-beta3-homo-Phe-OH
-
low potency inhibitor
H-beta2-homo-Nle-Tyr-Ile-His-Pro-Phe-OH
-
low potency inhibitor
H-beta3-homo-Val-Tyr-Ile-His-Pro-Phe-OH
-
low potency inhibitor
H-Val-beta2-homo-Tyr-Ile-His-Pro-Phe-OH
-
low potency inhibitor
H-Val-beta3-homo-Tyr-Ile-His-Pro-Phe-OH
-
low potency inhibitor
H-Val-Tyr-beta2-homo-Leu-His-Pro-Phe-OH
-
low potency inhibitor
H-Val-Tyr-beta3-homo-Ile-His-Pro-Phe-OH
-
low potency inhibitor
H-Val-Tyr-Ile-beta3-homo-His-Pro-Phe-OH
-
low potency inhibitor
H-Val-Tyr-Ile-His-(R)-beta2-homo-Pro-Phe-OH
-
low potency inhibitor
H-Val-Tyr-Ile-His-beta3-homo-Pro-Phe-OH
-
low potency inhibitor
H-Val-Tyr-Ile-His-Pro-beta2-homo-Pro-Phe-OH
-
low potency inhibitor
H-Val-Tyr-Ile-His-Pro-beta3-homo-Phe-OH
-
low potency inhibitor
H-Val-Tyr-Ile-His-Pro-Phe-OH
-
low potency inhibitor
iodoacetate
-
38.8% residual activity in the presence of 10 mM
K+
-
17.7% inhibition at 1 mM; 82.3% residual activity in the presence of 1 mM
kaempferol
-
13.7% inhibition at 0.03 mM
kaempferol 3-O-beta -D-glucopyranosyl-(1-'4)-a -L-rhamnopyranosyl-7-O-alpha -L-rhamnopyranoside
-
13.8% inhibition at 0.03 mM
kaempferol 3-O-beta-D-(3''-acetylglucopyranosyl)-7-O-alpha-L-2'''-O-[(S)-2-methylbutanoyl]rhamnopyranoside
-
16.4% inhibition at 0.03 mM
kaempferol 3-O-beta-D-(3''-O-acetylglucopyranocyl)-7-O-alpha-L-3'''-O-[(S)-2-methylbutanoyl]rhamnopyranoside
-
23.7% inhibition at 0.03 mM
kaempferol 3-O-beta-D-(3''-O-acetylglucopyranosyl)-7-O-alpha-L-(2'''-O-isobutyryl)rhamnopyranoside
-
21.7% inhibition at 0.03 mM
kaempferol 3-O-beta-D-glucopyranoside
-
31.7% inhibition at 0.03 mM
kaempferol 3-O-beta-D-glucopyranosyl-7-O-(3''-O-isobutyryl)rhamnopyranoside
-
26.9% inhibition at 0.03 mM
kaempferol 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside
-
19.1% inhibition at 0.03 mM
kaempferol 7-O-alpha-L-rhamnopyranoside
-
12.5% inhibition at 0.03 mM
L-Ala
-
at micromolar concentrations
L-alanyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
-
-
L-Arg
-
at micromolar concentrations
L-cysteinyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
-
-
L-cysteinyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
-
-
L-Glu
-
at micromolar concentrations
L-iso-glutamine inhibitors
-
diverse derivatives, IC50 of 0.016-0.053 mM
-
L-isoleucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
-
-
L-isoleucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
-
-
L-isoleucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
-
-
L-leucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
-
-
L-leucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
-
-
L-leucyl-N1-[(2R)-2-amino-3-phenylpropyl]-Lcysteinamide hydrochloride
-
-
L-Lys-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin
L-lysyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
-
-
L-lysyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
-
-
L-Met
-
at micromolar concentrations
L-methionyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
-
-
L-methionyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
-
-
L-methionyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
-
-
L-ornithyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
-
-
L-phenylalanyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide
-
-
L-phenylalanyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
-
-
L-phenylalanyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
-
-
L-tyrosyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
-
-
L-Val-L-Tyr-L-Ile-2-aminomethylphenylacetic acid
-
inhibits both IRAP, EC 3.4.11.2, and aminopeptidase N and induces proliferation of stem cells at low concentrations
L-valyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
-
-
L-valyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
-
-
Leu
-
at micromolar concentrations
leupeptin
-
24% inhibition at 0.1 mM
luteolin
-
60.2% inhibition at 0.03 mM
Metal chelating agents
-
-
-
metal chelators
-
strong inhibition
-
Methicillin
-
Ki: 4.61 mM
methyl (2S)-1-(methylsulfonyl)-4-oxopyrrolidine-2-carboxylate
-
-
methyl (2S)-1-[(4-methylphenyl)sulfonyl]-4-oxopyrrolidine-2-carboxylate
-
-
methyl (2S)-4-oxo-1-(phenylsulfonyl)pyrrolidine-2-carboxylate
-
-
methyl (2S,4R)-4-hydroxy-1-(methylsulfonyl)pyrrolidine-2-carboxylate
-
-
methyl (2S,4R)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxylate
-
-
methyl (2S,4R)-4-hydroxy-1-[(4-methylphenyl)sulfonyl]pyrrolidine-2-carboxylate
-
-
methyl (4R)-4-([(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino)-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinate
-
IC50: 0.9 nM
methyl (4R)-4-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinate
-
-
methyl 2-([[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]amino)-4-(methylperoxy)-4-oxobutanoate
-
-
methyl 2-chloro-N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]alaninate
-
-
methyl 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucyl-(4R)-4-(benzyloxy)prolinate
-
-
methyl 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucyl-L-methioninate
-
-
methyl 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucylserinate
-
-
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]-D-phenylalaninate
-
-
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]-L-phenylalaninate
-
-
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]cysteinate
-
-
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]glycinate
-
-
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]histidinate
-
-
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]isoleucinate
-
-
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]leucinate
-
-
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]methioninate
-
-
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]threoninate
-
-
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]tryptophanate
-
-
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]tyrosinate
-
-
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]valinate
-
-
methyl N2-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]-N5-(nitrocarbamimidoyl)ornithinate
-
-
methyl N2-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]lysinate
-
-
methyl [(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetate
-
-
multiflorin B
-
32.8% inhibition at 0.03 mM
multinoside A
-
15.3% inhibition at 0.03 mM
myricetin
-
48% inhibition at 0.3 mm
N-((3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl)-3,4,5-trimethoxybenzamide
-
-
N-((3S)-1-[2-(methylhistidinyl)-2-oxoethyl]-2,6-dioxopiperidin-3-yl)-3,4,5-trimethoxybenzamide
-
-
N-(1-(2-aminophenyl)-2,6-dioxopiperidin-3-yl)-3,4,5-trimethoxybenzamide
-
-
N-(4-aminophenyl)-6-hydroxy-6-oxo-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide
-
-
N-(4-chlorophenyl)-6-hydroxy-6-oxo-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide
-
-
N-ethylmaleimide
-
43-58% inhibition at 2 mM
N-hydroxy-2-(2-methylpropyl)-N'-(4-phenylbutyl)propanediamide
-
-
N-hydroxy-2-(naphthalen-2-ylsulfanyl)-acetamide
-
-
N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide
-
inhibitor with a metal-chelating hydroxamate group, potent inhibition, anti-angiogenic activity and inhibition of basic fibroblast growth factor-induced invasion of aortic endothelial cells
N-hydroxy-2-(naphthalene-2-ylsulfanyl)acetamide
-
-
N-[(1-hydroxy-3-methylbutyl)oxyphosphinyl]glycine dilithium salt
-
-
N-[(2R)-2-amino-3-phenylpropyl]-2-phenylacetamide hydrochloride
-
-
N-[(2R)-2-amino-3-phenylpropyl]-2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetamide hydrochloride
-
-
N-[(2R)-2-amino-3-phenylpropyl]-3,5-dinitrobenzamide hydrochloride
-
-
N-[(2R)-2-amino-3-phenylpropyl]-3-phenylpropanamide hydrochloride
-
-
N-[(2R)-2-amino-3-phenylpropyl]-4-phenylbutanamide hydrochloride
-
-
N-[(2R)-2-amino-3-phenylpropyl]-L-glutamamide hydrochloride
-
-
N-[(2S)-2-(([(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl)methyl)-4-methylpentanoyl]-L-phenylalanine
-
IC50: 2.3 nM
N-[(2S)-3-([(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl)-2-(biphenyl-4-ylmethyl)propanoyl]-L-alanine
-
IC50: 5.3 nM
N-[(2S)-3-([(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl)-2-benzylpropanoyl]phenylalanine
-
IC50: 1.5 nM
N-[(2S)-3-([(1R)-1-aminoethyl](hydroxy)phosphoryl)-2-(4-bromobenzyl)propanoyl]-L-alanine
-
IC50: 1.9 nM
N-[(2S)-3-([(1R)-1-aminoethyl](hydroxy)phosphoryl)-2-(biphenyl-4-ylmethyl)propanoyl]alanine
-
IC50: 2.9 nM
N-[(2S)-3-([(R)-amino(phenyl)methyl](hydroxy)phosphoryl)-2-(biphenyl-4-ylmethyl)propanoyl]-L-alanine
-
IC50: 4.8 nM
N-[(2S)-3-([(R)-amino(phenyl)methyl](hydroxy)phosphoryl)-2-(biphenyl-4-ylmethyl)propanoyl]-L-serine
-
IC50: 4.9 nM
N-[(2S)-3-([(R)-amino(phenyl)methyl](hydroxy)phosphoryl)-2-(biphenyl-4-ylmethyl)propanoyl]-L-threonine
-
IC50: 10.2 nM
N-[(2S)-3-([(R)-amino(phenyl)methyl](hydroxy)phosphoryl)-2-(biphenyl-4-ylmethyl)propanoyl]glycine
-
IC50: 32.8 nM
N-[(2S)-3-([(R)-amino(phenyl)methyl](hydroxy)phosphoryl)-2-benzylpropanoyl]-L-phenylalanine
-
IC50: 4.2 nM
N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]benzamide
-
-
N-[(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3,4,5-trimethoxybenzamide
N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-glycine amide
-
-
N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-glycine amide
-
-
N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-glycine amide
-
-
N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-glycine amide
-
-
N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-glycine amide
-
-
N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-glycine amide
-
-
N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-glycine amide
-
-
N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-glycine amide
-
-
N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-glycine amide
-
-
N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-glycine amide
-
-
N-[5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-glycine amide
-
-
N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-glycine amide
-
-
N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-glycine amide
-
-
N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-glycine amide
-
-
N-[[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]methy]tyrosine
-
-
N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}alaninamide
-
-
N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}glycinamide
-
-
N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}isoleucinamide
-
-
N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}leucinamide
-
-
N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}lysinamide
-
-
N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}phenylalaninamide
-
-
N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}tyrosinamide
-
-
N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}valinamide
-
-
N1-[(2R)-2-amino-3-phenylpropyl]-N-(2,4-dichlorobenzoyl)-L-cysteinamide hydrochloride
-
-
N1-[(2R)-2-amino-3-phenylpropyl]-N-(2,4-dichlorobenzoyl)-L-phenylalaninamide hydrochloride
-
-
N1-[(2R)-2-amino-3-phenylpropyl]-N-(3,5-dinitrobenzoyl)-L-phenylalaninamide hydrochloride
-
-
N1-[(2R)-2-amino-3-phenylpropyl]-N-(3-phenylpropanoyl)-L-phenylalaninamide hydrochloride
-
-
N1-[(2R)-2-amino-3-phenylpropyl]-N-(4-chlorobutanoyl)-L-phenylalaninamide hydrochloride
-
-
N1-[(2R)-2-amino-3-phenylpropyl]-N-(4-methoxybenzoyl)-L-phenylalaninamide hydrochloride
-
-
N1-[(2R)-2-amino-3-phenylpropyl]-N-(4-nitrobenzoyl)-Lphenylalaninamide hydrochloride
-
-
N1-[(2R)-2-amino-3-phenylpropyl]-N-(6-aminohexanoyl)-L-cysteinamide hydrochloride
-
-
N1-[(2R)-2-amino-3-phenylpropyl]-N-(6-aminohexanoyl)-L-leucinamide hydrochloride
-
-
N1-[(2R)-2-amino-3-phenylpropyl]-N-(6-aminohexanoyl)-L-phenylalaninamide hydrochloride
-
-
N4-(2-chlorophenyl)-2-cinnamamido-N1-hydroxysuccinamide
-
-
N4-(3-chlorophenyl)-2-cinnamamido-N1-hydroxysuccinamide
-
-
N4-(4-chlorophenyl)-2-cinnamamido-N1-hydroxysuccinamide
-
-
N4-benzyl-2-cinnamamido-N1-hydroxysuccinamide
-
-
N4-butyl-2-cinnamamido-N1-hydroxysuccinamide
-
-
N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-(pyrazin-2-ylcarbonyl)-L-lysinamide
-
-
N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-(pyridin-3-ylcarbonyl)-L-lysinamide
-
-
N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-[(2E)-3-phenylprop-2-enoyl]-L-lysinamide
-
-
N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-[(3-nitrophenyl)carbonyl]-L-lysinamide
-
-
N6-[(benzyloxy)carbonyl]-N2-(2,4-dichlorobenzoyl)-L-lysine
-
-
N6-[(benzyloxy)carbonyl]-N2-(2,4-dichlorobenzoyl)-N1-hydroxy-L-lysinamide
-
-
N6-[(benzyloxy)carbonyl]-N2-(2-thienylcarbonyl)-L-lysine
-
-
N6-[(benzyloxy)carbonyl]-N2-(2-thienylcarbonyl)-N1-hydroxy-L-lysinamide
-
-
N6-[(benzyloxy)carbonyl]-N2-(3-nitrobenzoyl)-L-lysine
-
-
N6-[(benzyloxy)carbonyl]-N2-(3-nitrobenzoyl)-N1-hydroxy-L-lysinamide
-
-
N6-[(benzyloxy)carbonyl]-N2-(4-bromobenzoyl)-L-lysine
-
-
N6-[(benzyloxy)carbonyl]-N2-(4-bromobenzoyl)-N1-hydroxy-L-lysinamide
-
-
N6-[(benzyloxy)carbonyl]-N2-(4-nitrobenzoyl)-L-lysine
-
-
N6-[(benzyloxy)carbonyl]-N2-(4-nitrobenzoyl)-N1-hydroxy-L-lysinamide
-
-
N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-L-lysine
N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-N1-hydroxy-L-lysinamide
-
-
N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-L-lysine
N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-N1-hydroxy-L-lysinamide
-
-
N6-[(benzyloxy)carbonyl]-N2-2-furoyl-L-lysine
-
-
N6-[(benzyloxy)carbonyl]-N2-2-furoyl-N1-hydroxy-L-lysinamide
-
-
N6-[(benzyloxy)carbonyl]-N2-cinnamoyl-L-lysine
-
-
N6-[(benzyloxy)carbonyl]-N2-cinnamoyl-N1-hydroxy-L-lysinamide
-
-
N6-[(benzyloxy)carbonyl]-N2-isonicotinoyl-L-lysine
-
-
N6-[(benzyloxy)carbonyl]-N2-isonicotinoyl-N1-hydroxy-L-lysinamide
-
-
N6-[(benzyloxy)carbonyl]-N2-[(2,4-dichlorophenyl)carbonyl]-L-lysine
-
-
N6-[(benzyloxy)carbonyl]-N2-[(2,4-dichlorophenyl)carbonyl]-N-hydroxy-L-lysinamide
-
-
N6-[(benzyloxy)carbonyl]-N2-[(2E)-3-phenylprop-2-enoyl]-L-lysine
-
-
N6-[(benzyloxy)carbonyl]-N2-[(3-nitrophenyl)carbonyl]-L-lysine
-
-
N6-[(benzyloxy)carbonyl]-N2-[(4-bromophenyl)carbonyl]-L-lysine
-
-
N6-[(benzyloxy)carbonyl]-N2-[(4-bromophenyl)carbonyl]-N-hydroxy-L-lysinamide
-
-
o-phenanthroline
1 mM, no residual activity
PC-18
-
inhibition of enzyme in angiotensin type 1 receptor-blocked rats augments the natriuretic response to angiotensin III
pepstatin A
-
22.3% inhibition at 1 mM; 77.7% residual activity in the presence of 1 mM
phenyl [amino(phenyl)methyl]phosphonate
-
-
phenylmethylsulfonyl fluoride
slight inhibition
Phenylmethylsulfonylfluoride
-
complete inhibition in the presence of 1 mM
pinocembrin
-
13.3% inhibition at 0.03 mM
pinostrobin
-
10.5% inhibition at 0.03 mM
polycarbophil-cysteine conjugates
-
cysteine linked to polycarbophil by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride, strong inhibitor, protects leucine enkephalin against degradation by the enzyme
-
Pro
-
at micromolar concentrations
pseudoglutamyl aminophosphinic peptides
-
-
-
quercetin
-
18.1% inhibition at 0.03 mM
quercetin 3-O-beta-D-glucopyranosyl-7-O-alpha-L-3'''-O-[(2S)-2-methylbutanoyl]-rhamnopyranoside
-
36.2% inhibition at 0.03 mM
quercetin 3-O-glucoside
-
41.8% inhibition at 0.03 mM
quercetin-3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside
-
12.6% inhibition at 0.03 mM
S-carboxymethyl-L-cysteine
-
33% residual activity at 10 mM
S-carboxymethyl-L-cysteinyl-glycine
-
57% residual activity at 10 mM
S-carboxymethyl-L-glutathione
-
75% residual activity at 10 mM
SCN-
-
4.2% residual activity in the presence of 1 mM
sinocrassoside A1
-
31.4% inhibition at 0.03 mM
sinocrassoside A10
-
28.7% inhibition at 0.03 mM
sinocrassoside A2
-
35.7% inhibition at 0.03 mM
sinocrassoside A4
-
26.9% inhibition at 0.03 mM
sinocrassoside A5
-
21.7% inhibition at 0.03 mM
sinocrassoside A6
-
16.4% inhibition at 0.03 mM
sinocrassoside A7
-
23.7% inhibition at 0.03 mM
sinocrassoside A9
-
19.9% inhibition at 0.03 mM
sinocrassoside B1
-
33.9% inhibition at 0.03 mM
sinocrassoside B2
-
39.4% inhibition at 0.03 mM
sinocrassoside B3
-
36.2% inhibition at 0.03 mM
sinocrassoside B4
-
32.1% inhibition at 0.03 mM
sinocrassoside B5
-
28.3% inhibition at 0.03 mM
sinocrassoside C1
-
12.4% inhibition at 0.03 mM
sinocrassoside D1
-
35.1% inhibition at 0.03 mM
sinocrassoside D3
-
23.2% inhibition at 0.03 mM
SO42-
-
14% residual activity in the presence of 1 mM
sulfate
-
86% inhibition at 1 M
tert-butyl bestatin
-
i.e. BE17, the BE15 derivative has a dual inhibitory effect on invasion and motility on tumor and endothelial cells
tert-butyl N-[(2S)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucinate
-
-
Thiocyanide
-
95.8% inhibition at 1 M
Zinc
1 mM, 1% resiudal activity
[(3S)-2,6-dioxo-3-(phenylalanylamino)piperidin-1-yl]acetic acid
-
-
[(3S)-2,6-dioxo-3-(tyrosylamino)piperidin-1-yl]acetic acid
-
-
[(3S)-2,6-dioxo-3-(valylamino)piperidin-1-yl]acetic acid
-
-
[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetic acid
-
-
[(3S)-3-(alanylamino)-2,6-dioxopiperidin-1-yl]acetic acid
-
-
[(3S)-3-(glycylamino)-2,6-dioxopiperidin-1-yl]acetic acid
-
-
[(3S)-3-(isoleucylamino)-2,6-dioxopiperidin-1-yl]acetic acid
-
-
[(3S)-3-(leucylamino)-2,6-dioxopiperidin-1-yl]acetic acid
-
-
[(3S)-3-(lysylamino)-2,6-dioxopiperidin-1-yl]acetic acid
-
-
[(3S)-3-{[(2S)-2-amino-2-(pyrrolidin-2-yl)acetyl]amino}-2,6-dioxopiperidin-1-yl]acetic acid
-
-
[1-amino-2-(cyclohexylamino)ethyl]phosphonic acid
[1-amino-3-(4-hydroxyphenyl)propyl]phosphonic acid
-
-
[3-nitro-2-(2-nitrophenyl)-4-oxo-4H-chromen-8-yl]acetic acid
-
IC50: 0.025 mM
[3-[(1-amino-ethyl)-hydroxy-phosphinoyl]-2-phenyl-propionylamino]-phenyl-acetic acid
-
-
[amino(cyclobutyl)methyl]phosphonic acid
-
-
[amino(cyclohexyl)methyl]phosphonic acid
-
-
[amino(cyclopropyl)methyl]phosphonic acid
-
-
[amino(phenyl)methyl](1-amino-3-phenylpropyl)phosphinic acid
-
-
[amino(phenyl)methyl](1-hydroxy-3-methylbutyl)phosphinic acid
[amino(phenyl)methyl](1-hydroxy-3-phenylpropyl)phosphinic acid
[amino(phenyl)methyl](1-hydroxyethyl)phosphinic acid
[amino(phenyl)methyl](1-hydroxypentyl)phosphinic acid
-
-
[amino(phenyl)methyl][hydroxy(phenyl)methyl]phosphinic acid
[amino[4-(1-methylethyl)phenyl]methyl]phosphonic acid
-
-
[[(1-amino-3-methylbutyl)(hydroxy)phosphoryl]amino]acetic acid
-
-
(1-amino-2-anilinoethyl)phosphonic acid
-
(1-amino-2-anilinoethyl)phosphonic acid
-
(1-amino-2-methylpropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
(1-amino-2-methylpropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
(1-amino-2-methylpropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
(1-amino-2-phenylethyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
(1-amino-2-phenylethyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
(1-amino-2-phenylethyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
(1-amino-2-[[(4-methoxyphenyl)methyl]amino]ethyl)phosphonic acid
-
(1-amino-2-[[(4-methoxyphenyl)methyl]amino]ethyl)phosphonic acid
-
(1-amino-3-methylbutyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
(1-amino-3-methylbutyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
(1-amino-3-methylbutyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
(1-amino-3-phenylpropyl)phosphinic acid
-
-
(1-amino-3-phenylpropyl)phosphinic acid
-
-
(1-aminobutyl)(1-hydroxy-2-phenylethyl)phosphinic acid
-
-
(1-aminobutyl)(1-hydroxy-2-phenylethyl)phosphinic acid
-
-
(1-aminobutyl)(1-hydroxy-2-phenylethyl)phosphinic acid
-
-
(1-aminoethyl)[hydroxy[4-(propan-2-yl)phenyl]methyl]phosphinic acid
-
-
(1-aminoethyl)[hydroxy[4-(propan-2-yl)phenyl]methyl]phosphinic acid
-
-
(1-aminoethyl)[hydroxy[4-(propan-2-yl)phenyl]methyl]phosphinic acid
-
-
(1-aminohexyl)((2-(methoxycarbonyl)benzyl)carbamothioyl)phosphinic acid
-
-
(1-aminohexyl)((2-(methoxycarbonyl)benzyl)carbamothioyl)phosphinic acid
-
-
(1-aminohexyl)((2-(methoxycarbonyl)benzyl)carbamothioyl)phosphinic acid
-
-
(1-aminopentyl)(1-hydroxy-2-phenylpropyl)phosphinic acid
-
-
(1-aminopentyl)(1-hydroxy-2-phenylpropyl)phosphinic acid
-
-
(1-aminopentyl)(1-hydroxy-2-phenylpropyl)phosphinic acid
-
-
(1-aminopentyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
(1-aminopentyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
(1-aminopentyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
(1-aminopentyl)[hydroxy(4-hydroxyphenyl)methyl]phosphinic acid
-
-
(1-aminopentyl)[hydroxy(4-hydroxyphenyl)methyl]phosphinic acid
-
-
(1-aminopentyl)[hydroxy(4-hydroxyphenyl)methyl]phosphinic acid
-
-
(1-aminopropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
(1-aminopropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
(1-aminopropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
-
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
-
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
-
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
-
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
-
-
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
-
-
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
-
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
-
(4R)-4-(hexanoylamino)-N-hydroxy-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinamide
-
IC50: 7.7 nM
(4R)-4-(hexanoylamino)-N-hydroxy-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinamide
-
-
1,10-phenanthroline
-
97% inhibition after 10 min at 10 mM
1,10-phenanthroline
-
isozyme APN1
1,10-phenanthroline
80% inhibition at 0.01 mM
1,10-phenanthroline
0.01 mM, complete inhibition
1,10-phenanthroline
-
complete inhibition
1,10-phenanthroline
-
strong inhibition
1,10-phenanthroline
-
100% inhibition at 1 mM
1,10-phenanthroline
-
99% inhibition at 0.4 mM, Ki: 0.067 mM
1,10-phenanthroline
-
92.5% inhibition at 1 mM
1,10-phenanthroline
-
the inhibition is completely reversible by Zn2+, but not by other metal ions such as Mg2+ or Ca2+, partially by Co2+ or Mn2+
1,10-phenanthroline
complete inhibition at 1 mM
1,10-phenanthroline
-
100% inhibition at 1 mM
1,10-phenanthroline
-
0.005 mM, 5% residual activity
1-amino-2-methylpropyl(hexylcarbamothioyl)phosphinic acid
-
-
1-amino-2-methylpropyl(hexylcarbamothioyl)phosphinic acid
-
-
1-amino-2-methylpropyl(hexylcarbamothioyl)phosphinic acid
-
-
1-amino-2-methylpropyl(isobutylcarbamothioyl)phosphinic acid
-
-
1-amino-2-methylpropyl(isobutylcarbamothioyl)phosphinic acid
-
-
1-amino-2-methylpropyl(isobutylcarbamothioyl)phosphinic acid
-
-
1-amino-2-methylpropyl(methylcarbamothioyl)phosphinic acid
-
-
1-amino-2-methylpropyl(methylcarbamothioyl)phosphinic acid
-
-
1-amino-2-methylpropyl(methylcarbamothioyl)phosphinic acid
-
-
1-amino-3-methylbutyl(2-(methoxycarbonyl)benzylcarbamothioyl)phosphinic acid
-
-
1-amino-3-methylbutyl(2-(methoxycarbonyl)benzylcarbamothioyl)phosphinic acid
-
-
1-amino-3-methylbutyl(2-(methoxycarbonyl)benzylcarbamothioyl)phosphinic acid
-
-
1-amino-3-methylbutyl(benzylcarbamothioyl)phosphinic acid
-
-
1-amino-3-methylbutyl(benzylcarbamothioyl)phosphinic acid
-
-
1-amino-3-methylbutyl(benzylcarbamothioyl)phosphinic acid
-
-
1-amino-3-methylbutyl(hexylcarbamothioyl)phosphinic acid
-
-
1-amino-3-methylbutyl(hexylcarbamothioyl)phosphinic acid
-
-
1-amino-3-methylbutyl(hexylcarbamothioyl)phosphinic acid
-
-
1-amino-3-methylbutyl(methylcarbamothioyl)phosphinic acid
-
-
1-amino-3-methylbutyl(methylcarbamothioyl)phosphinic acid
-
-
1-amino-3-methylbutyl(methylcarbamothioyl)phosphinic acid
-
-
1-amino-3-methylbutyl(phenethylcarbamothioyl)phosphinic acid
-
-
1-amino-3-methylbutyl(phenethylcarbamothioyl)phosphinic acid
-
-
1-amino-3-methylbutyl(phenethylcarbamothioyl)phosphinic acid
-
-
1-amino-3-phenylpropyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
-
-
1-amino-3-phenylpropyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
-
-
1-amino-3-phenylpropyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
-
-
1-amino-3-phenylpropyl(4-(ethoxycarbonyl)benzylcarbamothioyl)phosphinic acid
-
-
1-amino-3-phenylpropyl(4-(ethoxycarbonyl)benzylcarbamothioyl)phosphinic acid
-
-
1-amino-3-phenylpropyl(4-(ethoxycarbonyl)benzylcarbamothioyl)phosphinic acid
-
-
1-amino-3-phenylpropyl(4-methoxybenzylcarbamothioyl)phosphinic acid
-
-
1-amino-3-phenylpropyl(4-methoxybenzylcarbamothioyl)phosphinic acid
-
-
1-amino-3-phenylpropyl(4-methoxybenzylcarbamothioyl)phosphinic acid
-
-
1-amino-3-phenylpropyl(benzylcarbamothioyl)phosphinic acid
-
-
1-amino-3-phenylpropyl(benzylcarbamothioyl)phosphinic acid
-
-
1-amino-3-phenylpropyl(benzylcarbamothioyl)phosphinic acid
-
-
1-amino-3-phenylpropyl(propylcarbamothioyl)phosphinic acid
-
-
1-amino-3-phenylpropyl(propylcarbamothioyl)phosphinic acid
-
-
1-amino-3-phenylpropyl(propylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(2-(methoxycarbonyl)phenethylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(2-(methoxycarbonyl)phenethylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(2-(methoxycarbonyl)phenethylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(4-(ethoxycarbonyl)phenethylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(4-(ethoxycarbonyl)phenethylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(4-(ethoxycarbonyl)phenethylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(4-methoxybenzylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(4-methoxybenzylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(4-methoxyphenethylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(4-methoxyphenethylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(4-methoxyphenethylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(benzylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(benzylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(benzylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(phenethylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(phenethylcarbamothioyl)phosphinic acid
-
-
1-aminobutyl(phenethylcarbamothioyl)phosphinic acid
-
-
1-aminoethyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
-
-
1-aminoethyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
-
-
1-aminoethyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
-
-
1-aminoethyl(4-(ethoxycarbonyl)benzylcarbamothioyl)phosphinic acid
-
-
1-aminoethyl(4-(ethoxycarbonyl)benzylcarbamothioyl)phosphinic acid
-
-
1-aminoethyl(4-(ethoxycarbonyl)benzylcarbamothioyl)phosphinic acid
-
-
1-aminoethyl(4-methoxybenzylcarbamothioyl)phosphinic acid
-
-
1-aminoethyl(4-methoxybenzylcarbamothioyl)phosphinic acid
-
-
1-aminoethyl(4-methoxybenzylcarbamothioyl)phosphinic acid
-
-
1-aminoethyl(benzylcarbamothioyl)phosphinic acid
-
-
1-aminoethyl(benzylcarbamothioyl)phosphinic acid
-
-
1-aminoethyl(benzylcarbamothioyl)phosphinic acid
-
-
1-aminoethyl(phenethylcarbamothioyl)phosphinic acid
-
-
1-aminoethyl(phenethylcarbamothioyl)phosphinic acid
-
-
1-aminoethyl(phenethylcarbamothioyl)phosphinic acid
-
-
1-aminopentyl(2-(methoxycarbonyl)benzylcarbamothioyl)phosphinic acid
-
-
1-aminopentyl(2-(methoxycarbonyl)benzylcarbamothioyl)phosphinic acid
-
-
1-aminopentyl(2-(methoxycarbonyl)benzylcarbamothioyl)phosphinic acid
-
-
1-aminopentyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
-
-
1-aminopentyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
-
-
1-aminopentyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
-
-
1-aminopentyl(4-methoxybenzylcarbamothioyl)phosphinic acid
-
-
1-aminopentyl(4-methoxybenzylcarbamothioyl)phosphinic acid
-
-
1-aminopentyl(4-methoxybenzylcarbamothioyl)phosphinic acid
-
-
1-aminopentyl(benzylcarbamothioyl)phosphinic acid
-
-
1-aminopentyl(benzylcarbamothioyl)phosphinic acid
-
-
1-aminopentyl(benzylcarbamothioyl)phosphinic acid
-
-
1-aminopentyl(phenethylcarbamothioyl)phosphinic acid
-
-
1-aminopentyl(phenethylcarbamothioyl)phosphinic acid
-
-
1-aminopentyl(phenethylcarbamothioyl)phosphinic acid
-
-
1-aminopropyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
-
-
1-aminopropyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
-
-
1-aminopropyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
-
-
2',3-dinitroflavone-8-acetic acid
-
reversible, competitive, selective, potent, and noncytotoxic inhibitor, 88% inhibition at 1 mM
2',3-dinitroflavone-8-acetic acid
-
-
2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-3-iodotyrosine
-
[125I]-isotope, i.e. [125I]RB 129, highly potent and selective inhibitor, radiolabeled, study of binding properties and kinetics
2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-3-iodotyrosine
-
iodinated RB129
2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-3-iodotyrosine
-
[125I]-isotope, i.e. [125I]RB 129, highly potent and selective inhibitor, radiolabeled, study of binding properties and kinetics
2,2'-dipyridyl
-
isozyme APN1
3-amino-2-tetralone derivatives
-
-
3-amino-2-tetralone derivatives
-
Ki: 0.000020 - 0.03 mM, not inhibitory or poor inhibitors to EC 3.4.11.7, EC 3.4.11.6, EC 3.4.11.1
3-[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]-2-(4-hydroxybenzyl)propanoic acid
-
-
3-[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]-2-(4-hydroxybenzyl)propanoic acid
-
-
3-[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]-2-benzylpropanoic acid
-
-
3-[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]-2-benzylpropanoic acid
-
-
4-(2-(((1-aminobutyl)(hydroxy)phosphoryl)methanethioamido)ethyl)benzoic acid
-
-
4-(2-(((1-aminobutyl)(hydroxy)phosphoryl)methanethioamido)ethyl)benzoic acid
-
-
4-(2-(((1-aminobutyl)(hydroxy)phosphoryl)methanethioamido)ethyl)benzoic acid
-
-
4-chloromercuribenzoate
-
-
4-chloromercuribenzoate
-
100% inhibition at 1 mM
8-hydroxyquinoline
-
91% inhibition at 3 mM
actinonin
-
IC50: 148 microM
actinonin
-
isozyme APN4: IC50 is 0.148 mM, inhibits also isozyme APN1
actinonin
-
100% inhibition at 0.1 mM
actinonin
-
IC50: 0.000075 mM, kidney enzyme
actinonin
-
natural competitive inhibitor, IC50: 0.0002 mM
actinonin
-
competitive, moderate inhibition of keratinocyte growth
actinonin
-
IC50 is 0.0031 mM
actinonin
-
synthetic inhibitor, complete inhibition of plasma enzyme at 0.1 mM
actinonin
-
inhibition results in supppressed proliferation, enhanced terminal differentiation, and slightly decreased total neutral lipid production in sebocytes. In presence of inhibitor, cytokine IL-1 receptor antagonist is significantly upregulated and inhibitor suppresses proliferation and cytokine IL-2 production in Propionibacterium acnes-stimulated T-cells
actinonin
-
actinonin, an inhibitor of aminopeptidase N, may modulate chemokine secretion in the lung and thus attenuate the development of lung fibrosis
actinonin
-
slight inhibition
actinonin
-
almost complete inhibition at 0.1 mM
actinonin
-
IC50: 0.002 mM, specific inhibitor
alpha1-amino-3-phenylpropyl(alpha2-hydroxy-3-phenylpropyl)phosphinic acid
-
very potent inhibitor of APN
alpha1-amino-3-phenylpropyl(alpha2-hydroxy-3-phenylpropyl)phosphinic acid
-
very potent inhibitor of APN
alpha1-amino-3-phenylpropyl(alpha2-hydroxy-3-phenylpropyl)phosphinic acid
-
very potent inhibitor of APN
amastatin
-
IC50: 7.6 microM
amastatin
-
isozyme APN4: IC50 is 0.0076 mM, inhibits also isozyme APN1
amastatin
-
strong inhibition
amastatin
-
competitive with hydrolysis of L-Tyr-L-Gly. Enhances Met-enkephalin-induced twitch inhibition of ileum preparations
amastatin
-
100% inhibition at 0.1 mM
amastatin
-
inhibits the enzyme and blocks the metabolism of brain angiotensin II and III
amastatin
-
natural competitive inhibitor from Streptomyces sp.
amastatin
-
competitive, isolated from Streptomyces sp. strain ME98-M3, modulates blood pressure
amastatin
0.1 mM, 1% residual activity; 99% inhibiton at 0.1 mM
amastatin
-
almost complete inhibition at 0.001 mM
amastatin
-
slow, tight-binding inhibitor which involves a conformational change in the enzyme-inhibitor complex
amastatin
-
strong inhibition
angiotensin IV
-
-
angiotensin IV
-
low potency inhibitor
anti-CD13 antibody WM15
-
-
-
anti-CD13 antibody WM15
-
enzyme blocking, commercial preparation
-
anti-CD13 monoclonl antibody WM15
-
inhibits enzyme activity, but not chemotactic activity
-
anti-CD13 monoclonl antibody WM15
-
-
-
antipain
-
47% inhibition at 0.1 mM
antipain
-
0.074 mM, 46% residual activity
arginine
-
-
arphamenine A
-
42% inhibition at 0.5 mM
arphamenine A
-
slight inhibition
Bacillus thuringiensis Cry1Aa toxin
specific binding to APN isoforms, enzyme is the major toxin receptor in the midgut of insects
-
Bacillus thuringiensis Cry1Aa toxin
specific binding to APN isoforms, enzyme is the major toxin receptor in the midgut of insects
-
Bacillus thuringiensis Cry1Ab toxin
specific binding to APN isoforms, enzyme is the major toxin receptor in the midgut of insects
-
Bacillus thuringiensis Cry1Ab toxin
specific binding to APN isoforms, enzyme is the major toxin receptor in the midgut of insects
-
bestatin
-
poor inhibitor, IC50: 3.25 mM
bestatin
-
3.2% residual activity in the presence of 1 mM; 97% inhibition at 1 mM
bestatin
55% inhibition at 0.25 mM
bestatin
-
92.5% inhibition at 0.005 mM
bestatin
-
strong inhibition
bestatin
-
strong inhibition
bestatin
-
the N-terminus of bestatin is recognized by residues E121 and E264
bestatin
-
strong inhibition
bestatin
-
96% inhibition at 0.1 mM
bestatin
-
strong inhibition, cytotoxic, 85% inhibition at 1 mM
bestatin
-
73% inhibition at 0.005 mM
bestatin
-
inhibits enzyme activity and cell growth, e.g. of leukocytes, overview, IC50: 0.0004 mM, kidney enzyme
bestatin
-
inhibits the enzyme and blocks the metabolism of brain angiotensin II and III
bestatin
-
inhibits enzyme expression and activity
bestatin
-
narural competitive inhibitor, inhibits enzyme activity, but not chemotactic activity, IC50: 0.007-0.0169 mM
bestatin
-
competitive, low inhibition of keratinocyte growth
bestatin
-
IC50 is 0.01 mM
bestatin
-
83.7% inhibition at 1 mM
bestatin
-
competitive, slow-binding inhibitor, from Streptomyces olivoreticuli strain MD976-C7, modulates cell growth and maturation, overview
bestatin
-
acts as an anti-tumor agent in lung squamous cell carcinoma cells and prolonged survival time of patients with completely resected stage I lung squamous cell carcinoma
bestatin
-
inhibition results in supppressed proliferation, enhanced terminal differentiation, and slightly decreased total neutral lipid production in sebocytes. In presence of inhibitor, cytokine IL-1 receptor antagonist is significantly upregulated and inhibitor suppresses proliferation and cytokine IL-2 production in Propionibacterium acnes-stimulated T-cells
bestatin
-
i.e. N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutyryl]-L-leucine
bestatin
-
i.e. [(2S, 3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine hydroxide, slow binding inhibitor of APN
bestatin
-
i.e. [2S, 3R]-3-amino-2-hydroxy-(4-phenylbutanoyl)-L-leucine
bestatin
-
inhibits the enzyme, and the melanoma cell-induced angiogenesis in a dorsal air sac assay after oral administration to mice, intraperitoneal administration after orthotopic implantation of B16-B16 melanoma cells into mice reduces the number of vessels oriented towards the established primary tumor on the dorsal side
bestatin
-
72.2% inhibition at 0.005 mM
bestatin
-
84% inhibition at 0.005 mM
bestatin
-
52% inhibition at 0.005 mM
bestatin
0.1 mM, 7% residual activity; 93% inhibiton at 0.1 mM
bestatin
-
0.13 mM, 30% residual activity
bestatin
-
almost complete inhibition at 0.1 mM
bestatin
-
transition state analogue of Phe-Leu, competitive
bestatin
-
-
665112, 678587, 683242, 695929, 696626, 696720, 696739, 696755, 696756, 707722, 707734, 707744, 708385, 710669
betulinic acid
-
natural inhibitor isolated from birch tree, IC50: 0.0073 mM, a selectively apoptosis-inducing agent, overview
betulinic acid
-
pentycyclic compound, from Betula sp. and other sources, overview, modulates cell growth and maturation, overview
bradykinin
-
inhibition is enhanced by substance P
bradykinin
-
bradykinin is resistant to hydrolysis by CD13, acting rather as a natural inhibitor
Ca2+
slight inhibition
Ca2+
-
50-60% inhibition at 1 mM
Cd2+
-
98% inhibition at 1 mM
Cd2+
-
1 mM, 9.2% residual activity
chymostatin
-
72% inhibition at 0.1 mM
chymostatin
-
0.1 mM, 35% residual activity
Co2+
-
2% residual activity in the presence of 1 mM; 98% inhibition at 1 mM
Co2+
-
50-60% inhibition at 1 mM
Co2+
-
40% inhibition at 1 mM
Co2+
58% inhibition at 1 mM
Co2+
-
68% inhibition at 0.2 mM
Cu2+
-
-
Cu2+
-
1.6% residual activity in the presence of 1 mM; 98.4% inhibition at 1 mM
Cu2+
-
96% inhibition at 1 mM
Cu2+
95% inhibition at 1 mM
Cu2+
-
100% inhibition at 0.2 mM
curcumin
-
natural inhibitor isolated from Curcuma longa, non-toxic, inhibits also tumor cell invasion and carcinogenesis in several organs, overview
curcumin
-
from Curcuma longa rhizome, inhibits the enzyme and the initiation of carcinogenesis, overview, modulates cell growth and maturation, overview
curcumin
-
31.9% inhibition at 0.03 mM
D-Arg-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin
-
competitive to L-Ala-4-nitroanilide, additionally inhibitory to kinin B1 receptor
D-Arg-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin
-
competitive to L-Ala-4-nitroanilide, additionally inhibitory to kinin B1 receptor
dithiothreitol
-
inhibits at high concentrations, 40-42% inhibition at 10 mM
dithiothreitol
-
no significant inhibition by thiol compounds
EDTA
-
only 27% inhibition at 300 mM, 50% inhibition after incubation for 12 h with 300 mM
EDTA
complete inhibition at 2.5 mM
EDTA
2.5 mM, complete inhibition
EDTA
-
no inhibition, restores activity after inhibition by metal ions
EDTA
-
42% inhibition at 2 mM
EDTA
-
14% inhibition at 1 mM
EDTA
-
35.5% inhibition at 5 mM
EDTA
-
100% inhibition at 1 mM and pH 6.0, no inhibition at pH 8.0
EDTA
-
60-80% inhibition at 20 mM
EDTA
-
100% inhibition at 5 mM
EDTA
23% inhibition at 5 mM; 5 mM, 77% residual activity
EDTA
-
68% inhibition at 1 mM
EDTA
-
1 mM, 6% residual activity
EDTA
-
27-30% inhibition at 1 mM
ethanol
-
-
Hg2+
complete inhibition at 1 mM
Hg2+
1 mM, complete inhibition
Hg2+
-
71% inhibition at 1 mM
iodoacetamide
-
IC50: 0.098 mM, kidney enzyme
iodoacetamide
-
9-11% inhibition at 2 mM
iodoacetic acid
-
61.2% inhibition at 10 mM
iodoacetic acid
-
100% inhibition at 2 mM
iodoacetic acid
-
83% inhibition at 1 mM
L-Lys-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin
-
competitive to L-Ala-4-nitroanilide
L-Lys-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin
-
competitive to L-Ala-4-nitroanilide
lapstatin
-
natural competitive inhibitor from Streptomyces sp., IC50: 0.0005 mM
leucine
-
-
leuhistin
-
100% inhibition at 0.1 mM
leuhistin
-
natural inhibitor isolated from Bacilus laterosporus strain BMI156-14F1, strong, competitive inhibition
leuhistin
-
from Bacillus letraosporus strain BM156-14F1, competitive, modulates cell growth and maturation, overview
methionine
-
-
methionine
-
79% inhibition at 5 mM
Mg2+
-
45.1% inhibition at 1 mM; 54.9% residual activity in the presence of 1 mM
Mg2+
14% inhibition at 1 mM
Mg2+
-
50-60% inhibition at 1 mM
Mg2+
-
not inhibitory at 1 mM
Mg2+
-
not inhibitory at 0.2 mM
Mn2+
-
9% inhibition at 1 mM
Mn2+
-
5% residual activity in the presence of 1 mM; 94.9% inhibition at 1 mM
Mn2+
-
50-60% inhibition at 1 mM
Mn2+
-
16% inhibition at 1 mM
Mn2+
44% inhibition at 1 mM
Mn2+
-
not inhibitory at 0.2 mM
N-[(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3,4,5-trimethoxybenzamide
-
-
N-[(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3,4,5-trimethoxybenzamide
-
-
N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-L-lysine
-
-
N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-L-lysine
-
-
N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-L-lysine
-
-
N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-L-lysine
-
-
Ni2+
-
-
Ni2+
71% inhibition at 1 mM
PAQ-22
-
IC50: 0.00029 mM, kidney enzyme
PC18
-
selective APN inhibitor
pefabloc
40% inhibition at 0.005 mM
pefabloc
-
1 mM, 45% residual activity
pepstatin
slight inhibition
phebestin
-
IC50: 0.000015 mM, kidney enzyme
phebestin
-
natural competitive inhibitor from Streptomyces sp.
phebestin
-
frpm Streptomyces sp. strain MJ716-m3
phenylalanine
-
-
phenylalanine
-
Ki: 0.67 mM
phenylalanine
-
79% inhibition at 5 mM
PMSF
-
complete inhibition at 1 mM
PMSF
-
4.5% inhibition at 1 mM
probestin
-
IC50: 74 microM
probestin
-
isozyme APN4: IC50 is 0.074 mM, inhibits also isozyme APN1
probestin
-
IC50: 0.000016 mM, kidney enzyme
probestin
-
natural competitive inhibitor from Streptomyces sp., IC50: 0.00005 mM
probestin
-
from Streptomyces azureus strain MH663-2F6, competitive, modulates cell growth and maturation, overview
psammaplin A
-
natural inhibitor isolated from a marine sponge, non-competitive, highly cytotoxic, IC50: 0.007-0.018 mM, overview
psammaplin A
-
from Psammaplysilla sp., Dysidea sp., and Throrectopsamma xana, non-competitive, modulates cell growth and maturation, overview
puromycin
-
25.8% residual activity in the presence of 1 mM; 74.2% inhibition at 1 mM
puromycin
-
34.1% inhibition at 0.05 mM
puromycin
-
strong inhibition
puromycin
-
93% inhibition at 1 mM
puromycin
-
67% inhibition at 0.1 mM
puromycin
-
Ki: 0.0125 mM
puromycin
-
78.1% inhibition at 0.05 mM
puromycin
-
IC50: 0.0031 mM, kidney enzyme
puromycin
-
natural inhibitor
puromycin
-
39.5% inhibition at 0.05 mM
puromycin
-
74.3% inhibition at 0.05 mM
puromycin
-
Ki: 0.1 mM, low sensitivity to puromycin
puromycin
-
41.5% inhibition at 0.05 mM
puromycin
-
very weak inhibition
RB129
-
-
RB3014
-
APN inhibitor, IC50: 30 nM
RB3014
-
IC50: 0.000025 mM, kidney enzyme
Substance P
-
-
Substance P
-
competitive, high inhibition of keratinocyte growth
tryptophan
-
-
tryptophan
-
63% inhibition at 5 mM
tyrosine
-
-
tyrosine
-
59% inhibition at 2.25 mM
ubenimex
-
-
Zn2+
-
inhibits at concentrations above 0.1 mM
Zn2+
-
80% inhibition at 1 mM
Zn2+
-
2.2% residual activity in the presence of 1 mM; 97.8% inhibition at 1 mM
Zn2+
complete inhibition at 1 mM
Zn2+
1 mM, complete inhibition
Zn2+
-
recombinant enzyme
Zn2+
-
96% inhibition at 1 mM
Zn2+
-
slight inhibition, as ferrocyanide, iodate, and phosphate, Ki value depends on solubility of the salt
Zn2+
99% inhibition at 1 mM
Zn2+
-
73% inhibition at 0.2 mM
Zn2+
-
1 mM, 36% residual activity
[1-amino-2-(cyclohexylamino)ethyl]phosphonic acid
-
[1-amino-2-(cyclohexylamino)ethyl]phosphonic acid
-
[amino(phenyl)methyl](1-hydroxy-3-methylbutyl)phosphinic acid
-
-
[amino(phenyl)methyl](1-hydroxy-3-methylbutyl)phosphinic acid
-
-
[amino(phenyl)methyl](1-hydroxy-3-methylbutyl)phosphinic acid
-
-
[amino(phenyl)methyl](1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
[amino(phenyl)methyl](1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
[amino(phenyl)methyl](1-hydroxy-3-phenylpropyl)phosphinic acid
-
-
[amino(phenyl)methyl](1-hydroxyethyl)phosphinic acid
-
-
[amino(phenyl)methyl](1-hydroxyethyl)phosphinic acid
-
-
[amino(phenyl)methyl](1-hydroxyethyl)phosphinic acid
-
-
[amino(phenyl)methyl][hydroxy(phenyl)methyl]phosphinic acid
-
-
[amino(phenyl)methyl][hydroxy(phenyl)methyl]phosphinic acid
-
-
[amino(phenyl)methyl][hydroxy(phenyl)methyl]phosphinic acid
-
-
additional information
-
no inhibition by EDTA
-
additional information
no or poor inhibition by leupeptin, PMSF, E64, and pepstatin
-
additional information
-
no or poor inhibition by leupeptin, PMSF, E64, and pepstatin
-
additional information
not inhibitory: leupeptin
-
additional information
-
not inhibitory: leupeptin
-
additional information
-
no inhibition with PMSF and 4-(2-aminoethyl)-benzenesulfonyl fluoride
-
additional information
-
detection of en endogenous inhibior
-
additional information
-
poor or no inhibition by Fe2+
-
additional information
-
-
-
additional information
-
structural features of natural peptide hormone inhibitors, overview
-
additional information
-
enzyme inhibitors can act as anti-hypertensive drugs
-
additional information
-
inhibitory potency of bestatin and derivatives on enzyme activity, umbilical vein endothelial cell vessel formation, and cell invasion and migration, overview
-
additional information
-
inhibitor binding site and mechanism, the enzyme is also inhibited by hydroxamate, carboxylate, sulfhydryl, and sulfodiimide derivatives of phosphoric acid, by beta-amino-thiol reagents, and alpha-aminophosphonates, overview
-
additional information
-
inhibition by a CD13 blocking antibody, no inhibition by pepstatin, leupeptin, or aprotinin alone or in combination
-
additional information
-
the enzyme expression is down-regulated during homotypic aggregation, while the enzyme induced the homotypic aggregation, overview, CD13-mediated homotypic aggregation is inhibited by several MAP kinase inhibitors, e.g. herbimycin, phosphatidylinositol-3-kinase inhibitor LY294002, MEK1 inhibitor PD98059, p38 inhibitor SB203580, genistein, and, to a lesser extent, Ro-31-8220 and bisindolylmaleimide I, which are inhibitors of protein kinase C
-
additional information
-
no inhibition by pepstatin, phosphoramidon, and aprotinin
-
additional information
-
enzyme inhibitors: chemistry, biological evaluations, and therapeutic prospects, behaviour in clinical trials, overview
-
additional information
-
inhibitory potency in decreasing order: angiotensin IV, angiotensin III, divalinal/angiotensin IV, LVV-hemorphin 7, angiotensin 4-8, angiotensin III
-
additional information
-
not inhibited by PAQ-22; there is a significant reduction of APN mRNA and protein expression, as well as enzymatic activity, in high-grade meningiomas
-
additional information
-
not inhibited by trans-(3S,5R,6R,9S)-megastigman-7-ene-3,5,6,9-tetraol 3-O-glucoside and trans-(3S,5R,6R,9S)-megastigman-7-ene-3,5,6,9-tetraol 9-O-glucoside
-
additional information
-
Tie-2 antisense (but not Tie-2 sense) treatment significantly reduces CD13 expression and abolishes angiopoieting-1-induced CD13 expression in pericytes
-
additional information
-
the neuropeptide substance P inhibits enkephalin cleavage by CD13
-
additional information
-
neither BNP7787 (i.e. disodium 2,2'-dithio-bis-ethane sulfonate, also named dimesna or Tavocept) nor S-carboxymethyl-L-cysteinyl-glutamate, nor NaCl inhibit human APN
-
additional information
-
no inhibition by antipain, E64, leupeptin, chymostatin, PCMB, PMSF, amastatin, and puromycin
-
additional information
-
insulin treatment, by injection in vivo, slighly reduces the lysosomal enzyme level in the kidney and the liver, overview
-
additional information
-
no inhibition by EDTA and PMSF
-
additional information
-
competition study of inhibitors
-
additional information
-
the enzyme is puromycin-insensitive
-
additional information
-
the enzyme is puromycin-insensitive
-
additional information
-
no inhibition by PMSF
-
additional information
-
computational inhibitor design, inhibition mechanism, structural requirements of phosphinate inhibitors for binding and inhibition, overview
-
additional information
-
-
-
additional information
-
no inhibition by psammaplin A analogues psammaplin B, psammaplin C, psammaplin A-1, psammaplin C-1, and psammplin D
-
additional information
-
no inhibition by sulfhydryl reagents
-
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0.00025 - 0.0011
(1-amino-2-methylpropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
0.00066 - 0.0016
(1-amino-2-phenylethyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
0.00042 - 0.001
(1-amino-3-methylbutyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
0.003
(1-amino-3-methylbutyl)(1-hydroxypentyl)phosphinic acid
Homo sapiens
-
-
0.004
(1-amino-3-methylbutyl)[amino(phenyl)methyl]phosphinic acid
Homo sapiens
-
-
0.00191
(1-amino-3-phenylpropyl)phosphinic acid
Neisseria meningitidis
-
pH 7.5, 37°C
0.00166
(1-amino-3-phenylpropyl)phosphonic acid
Neisseria meningitidis
-
pH 7.5, 37°C
0.00191
(1-amino-4-carbamimidamidobutyl)phosphonic acid
Neisseria meningitidis
-
pH 7.5, 37°C
0.05
(1-aminobutyl)(1-amino-3-methylbutyl)phosphinic acid
Homo sapiens
-
-
0.00095 - 0.002
(1-aminobutyl)(1-hydroxy-2-phenylethyl)phosphinic acid
0.017
(1-aminobutyl)[amino(phenyl)methyl]phosphinic acid
Homo sapiens
-
-
0.155
(1-aminoethyl)(1-amino-3-methylbutyl)phosphinic acid
Homo sapiens
-
-
0.046
(1-aminoethyl)[amino(phenyl)methyl]phosphinic acid
Homo sapiens
-
-
0.00087 - 0.0035
(1-aminoethyl)[hydroxy[4-(propan-2-yl)phenyl]methyl]phosphinic acid
0.02
(1-aminohexyl)((2-(methoxycarbonyl)benzyl)carbamothioyl)phosphinic acid
0.00022 - 0.00086
(1-aminopentyl)(1-hydroxy-2-phenylpropyl)phosphinic acid
0.00021 - 0.00052
(1-aminopentyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
0.0058 - 0.0093
(1-aminopentyl)[hydroxy(4-hydroxyphenyl)methyl]phosphinic acid
0.0006 - 0.0024
(1-aminopropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
0.0297
(1-benzyl-1H-imidazol-4-yl)methyl 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucylalaninate
Homo sapiens
-
-
0.00007
(1S)-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethanaminium acetate
Homo sapiens
-
IC50: 70 nM
0.00005
(1S)-2-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethanaminium acetate
Homo sapiens
-
IC50: 50 nM
0.000074
(1S)-3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butan-1-aminium acetate
Homo sapiens
-
IC50: 74 nM
0.4918
(2E)-N-[(2R)-2-amino-3-phenylpropyl]-3-(3,4-dihydroxyphenyl)-acrylamide hydrochloride
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.5958
(2E)-N-[(2R)-2-Amino-3-phenylpropyl]-3-phenylacrylamide hydrochloride
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.018
(2E,2'E)-N,N'-[disulfanediyldi(ethane-2,1-diyl)]bis[3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanamide]
Sus scrofa
-
PsA, isolated from a marine sponge, inhibits the enzyme non-competitively and suppresses angiogenesis in vitro, IC50 is 0.018 mM
0.3089
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.1149
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0353
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-coumaroyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1082
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-methoxycinnamoyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.2966
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.2966
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1073
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.1073
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.2875
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.1526
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1049
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-coumaroyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1346
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-methoxycinnamoyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.2058
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.2058
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0964
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.0964
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1905
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.1834
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1154
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-coumaroyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0907
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-methoxycinnamoyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.169
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.169
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1153
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
0.0698
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.0314
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0688
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-coumaroyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0785
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-methoxycinnamoyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0399
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.0399
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0488
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
0.1178
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.2062
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1268
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-coumaroyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1411
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-methoxycinnamoyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.107
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.107
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.3378
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.3378
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0847
(2R)-N-[5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0541
(2R)-N-[5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-coumaroyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0446
(2R)-N-[5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl]-2-[(p-methoxycinnamoyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.3178
(2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.3091
(2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.3091
(2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1678
(2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.1678
(2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1701
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)-amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.2156
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(cinnamoyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1239
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(p-coumaroyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1311
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(p-methoxycinnamoyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1416
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
0.3732
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
0.5217
(2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-N-pentylpropanamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.1063
(2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-N-phenethylpropanamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.1699 - 0.1832
(2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-N-propylpropanamide
0.1402
(2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propanoic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0313
(2R,3S)-2-amino-3-hydroxy-N-((S)-1-(hydroxyamino)-1-oxo-3-phenylpropan-2-yl)-3-(4-nitrophenyl)propanamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.1163
(2R,3S)-2-amino-3-hydroxy-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-3-(4-nitrophenyl)propanamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0514
(2R,3S)-2-amino-3-hydroxy-N-(4-hydroxyphenethyl)-3-(4-nitrophenyl) propanamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.1447
(2R,3S)-2-amino-3-hydroxy-N-(4-methoxybenzyl)-3-(4-nitrophenyl)propanamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.2507
(2R,3S)-2-amino-3-hydroxy-N-isopropyl-3-(4-nitrophenyl)propanamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0903
(2R,3S)-2-amino-N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-3-hydroxy-3-(4-nitrophenyl)propanamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.1368
(2R,3S)-2-amino-N-(2-chlorophenethyl)-3-hydroxy-3-(4-nitrophenyl)propanamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.3025
(2R,3S)-2-amino-N-(4-fluorobenzyl)-3-hydroxy-3-(4-nitrophenyl)propanamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.2326
(2R,3S)-2-amino-N-butyl-3-hydroxy-3-(4-nitrophenyl)propanamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.2513
(2R,3S)-2-amino-N-cyclohexyl-3-hydroxy-3-(4-nitrophenyl)propanamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0505
(2S)-2,5-amino-N-[(2R)-2-amino-3-phenylpropyl]-valeramide hydrochloride
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1642
(2S)-2,6-amino-N-[(2R)-2-amino-3-phenylpropyl]caproylamide hydrochloride
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0337
(2S)-2-amino-3-hydroxyl-N-[(2R)-2-amino-3-phenylpropyl]propionamide hydrochloride
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.476
(2S)-2-amino-3-methyl-N-[(2R)-2-amino-3-phenylpropyl]propionamide hydrochloride
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0211
(2S)-2-amino-3-thiol-N-[(2R)-2-amino-3-phenylpropyl]propionamide hydrochloride
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1424
(2S)-2-amino-4-methyl-N-[(2R)-2-amino-3-phenylpropyl]valeramide hydrochloride
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1187
(2S)-2-amino-4-methylthio-N-[(2R)-2-amino-3-phenylpropyl]butyramide hydrochloride
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
1
(2S)-2-amino-N-[(2R)-2-amino-3-phenylpropyl]-propionamide hydrochloride
Sus scrofa
-
IC50 above 1.0 mM, in 50 mM PBS, pH 7.2, at 37°C
1.88
(2S)-2-amino-N-[(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3-phenylpropanamide
Homo sapiens
-
in PBS buffer, at 37°C
0.0578
(3S)-N-hydroxy-2-(phenylsulfonyl)-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxamide
Homo sapiens
-
-
0.0827
(3S)-N-hydroxy-2-(phenylsulfonyl)-6,11-dioxa-2-azaspiro[4.6]undecane-3-carboxamide
Homo sapiens
-
-
0.1067
(3S)-N-hydroxy-2-(phenylsulfonyl)-6,12-dioxa-2-azaspiro[4.7]dodecane-3-carboxamide
Homo sapiens
-
-
0.0485
(3S)-N-hydroxy-2-[(4-methylphenyl)sulfonyl]-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxamide
Homo sapiens
-
-
0.0618
(3S)-N-hydroxy-2-[(4-methylphenyl)sulfonyl]-6,11-dioxa-2-azaspiro[4.6]undecane-3-carboxamide
Homo sapiens
-
-
0.0732
(3S)-N-hydroxy-2-[(4-methylphenyl)sulfonyl]-6,12-dioxa-2-azaspiro[4.7]dodecane-3-carboxamide
Homo sapiens
-
-
0.05
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-1,2,3,4-tetrahydro-1lambda~6~-thieno[3,2-e][1,2]thiazine-6-sulfonamide
Homo sapiens
-
IC50 is 0.05 mM
0.0000077
(4R)-4-(hexanoylamino)-N-hydroxy-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinamide
0.0000021
(4R)-4-([(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino)-N-hydroxy-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinamide
Homo sapiens
-
IC50: 2.1 nM
0.0000021
(4R)-4-[[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]-N-hydroxy-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinamide
Homo sapiens
-
-
0.0551
(4S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(1-methoxy-1-oxopropan-2-ylamino)-5-oxopentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0692
(4S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(1-methoxy-3-methyl-1-oxobutan-2-ylamino)-5-oxopentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0437
(4S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(3-(4-fluorophenyl)-1-methoxy-1-oxopropan-2-ylamino)-5-oxopentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0605
(4S,E)-5-(1,4-dimethoxy-1,4-dioxobutan-2-ylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.076
(aminomethyl)(1-amino-3-methylbutyl)phosphinic acid
Homo sapiens
-
-
0.042
(aminomethyl)[amino(phenyl)methyl]phosphinic acid
Homo sapiens
-
-
0.0578
(R)-4-(4-carboxy-2-(3,4,5-trimethoxybenzamido)butanamido)-2-hydroxybenzoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0658
(R)-4-(4-carboxy-2-(3,4,5-trimethoxybenzamido)butanamido)benzoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0896
(R)-5-(2,4-difluorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0804
(R)-5-(2,5-dichlorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.805
(R)-5-(2-chloroethylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0724
(R)-5-(2-nicotinoylhydrazinyl)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.1769
(R)-5-(3-bromobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0785
(R)-5-(3-chloro-4-fluorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0659
(R)-5-(3-iodobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0234
(R)-5-(4-aminophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0512
(R)-5-(4-bromo-2-fluorobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0419
(R)-5-(4-bromophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0456
(R)-5-(4-chloro-2-fluorobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.04
(R)-5-(4-chlorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0243
(R)-5-(4-fluorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0877
(R)-5-oxo-5-(2-(thiazole-2-carbonyl)hydrazinyl)-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.1076
(R)-5-oxo-5-(thiazol-2-ylamino)-4-(3,4,5-trimethoxybenzamido)pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0401
(R)-5-oxo-5-4-[(1,3-thiazole-2-amino)sulfonyl]phenylamino-4-[(3,4,5-trimethoxybenzamido)]pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.1026
(R)-5-[4-(aminosulfonyl)phenylamino]-5-oxo-4-[(3,4,5-trimethoxybenzamido)]pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.1622
(S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-(1H-indol-2-yl)propanoic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.1599
(S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-methylbutanoic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.1028
(S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-methylpentanoic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0604
(S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-phenylpropanoic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0856
(S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-4-methylpentanoic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.054
(S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-N-hydroxy-4-methylpentanamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0071
(S)-2-((S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-phenylpropanamido)-3-phenylpropanoic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0346
(S)-2-((S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-4-methylpentanamido)-3-phenylpropanoic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0097
(S)-2-amino-N-((S)-1-(2-(hydroxyamino)-2-oxoethyl)-2,6-dioxopiperidin-3-yl)-2-((R)-pyrrolidin-2-yl)acetamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.4052
(S,E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)-N1,N5-bis(2-fluorophenyl)pentanediamide
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.3713
(S,E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)-N1,N5-bis(4-fluorophenyl)pentanediamide
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.3347
(S,E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)-N1,N5-di-p-tolylpentanediamide
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
2.132
(S,E)-2-[3-(3,4-dimethoxyphenyl)acrylamido]-N1,N5-[(R)-1,4-dimethoxy-1,4-dioxobutan]pentanediamide
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0568
(S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(2-fluorophenylamino)-5-oxopentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0504
(S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(2-methoxy-2-oxoethylamino)-5-oxopentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0234
(S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(4-fluorophenylamino)-5-oxopentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.1843
(S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(ethylamino)-5-oxopentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.2072
(S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(isopropylamino)-5-oxopentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.1258
(S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-(methylamino)-5-oxopentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.2375
(S,E)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxo-5-(propylamino)pentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0383
(S,E)-5-(2-chlorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0986
(S,E)-5-(3,5-difluorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0805
(S,E)-5-(3-chlorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0581
(S,E)-5-(4-bromophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0345
(S,E)-5-(4-chlorophenylamino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.1776
(S,E)-5-(benzylamino)-4-(3-(3,4-dimethoxyphenyl)-acrylamido)-5-oxopentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0207
(S,E)-5-(p-toluidino)-4-(3-(3,4-dimethoxyphenyl)acrylamido)-5-oxopentanoic acid
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.5776
(S,E)-N1,N5-bis(4-bromophenyl)-2-(3-(3,4-dimethoxyphenyl)acrylamido)pentanediamide
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.4052
(S,E)-N1,N5-bis(4-chlorophenyl)-2-(3-(3,4-dimethoxyphenyl)acrylamido)pentanediamide
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.012 - 0.179
1,10-phenanthroline
0.1
1-amino-2-ethylbutylphosphonic acid monophenyl ester
Sus scrofa
-
IC50 above 0.1 mM, in sodium phosphate buffer (pH 7.2), at 25°C
0.0093
1-amino-2-methylbutylphosphonic acid monophenyl ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.00093
1-amino-2-methylpropyl(benzylcarbamoyl)phosphinic acid
Homo sapiens
-
-
0.00118 - 0.00505
1-amino-2-methylpropyl(hexylcarbamothioyl)phosphinic acid
0.0019 - 0.01535
1-amino-2-methylpropyl(isobutylcarbamothioyl)phosphinic acid
0.01015 - 0.02135
1-amino-2-methylpropyl(methylcarbamothioyl)phosphinic acid
0.16
1-amino-2-methylpropyl(phenylcarbamoyl)phosphinic acid
Homo sapiens
-
-
0.014
1-amino-2-methylpropylphosphonic acid monophenyl ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0082
1-amino-2-phenylethylphosphonic acid monophenyl ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.02
1-amino-3-methylbutyl(2-(methoxycarbonyl)benzylcarbamothioyl)phosphinic acid
0.0028 - 0.0082
1-amino-3-methylbutyl(benzylcarbamothioyl)phosphinic acid
0.0005 - 0.0017
1-amino-3-methylbutyl(hexylcarbamothioyl)phosphinic acid
0.01056 - 0.02
1-amino-3-methylbutyl(methylcarbamothioyl)phosphinic acid
0.0042 - 0.02
1-amino-3-methylbutyl(phenethylcarbamothioyl)phosphinic acid
0.00047 - 0.00165
1-amino-3-phenylpropyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
0.0114 - 0.02
1-amino-3-phenylpropyl(4-(ethoxycarbonyl)benzylcarbamothioyl)phosphinic acid
0.00038 - 0.00265
1-amino-3-phenylpropyl(4-methoxybenzylcarbamothioyl)phosphinic acid
0.0013 - 0.0025
1-amino-3-phenylpropyl(benzylcarbamothioyl)phosphinic acid
0.00056 - 0.00145
1-amino-3-phenylpropyl(propylcarbamothioyl)phosphinic acid
0.005
1-amino-3-phenylpropylphosphonic acid mono-(2,3,5-trimethylphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.015
1-amino-3-phenylpropylphosphonic acid mono-(2,5-dimethylphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0022
1-amino-3-phenylpropylphosphonic acid mono-(3,4-dimethylphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0063
1-amino-3-phenylpropylphosphonic acid mono-(4-(1,1,3,3-tetramethyl)butylphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.022
1-amino-3-phenylpropylphosphonic acid mono-(4-carboxyphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.013
1-amino-3-phenylpropylphosphonic acid mono-(4-ethylphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0005
1-amino-3-phenylpropylphosphonic acid mono-(4-isopropylphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0029
1-amino-3-phenylpropylphosphonic acid mono-(4-methoxyphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0019
1-amino-3-phenylpropylphosphonic acid mono-(4-tert-butylphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0061
1-amino-3-phenylpropylphosphonic acid monophenyl ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.00053
1-amino-4-methylpentyl(benzylcarbamoyl)phosphinic acid
Homo sapiens
-
-
0.035
1-amino-4-methylpentyl(phenylcarbamoyl)phosphinic acid
Homo sapiens
-
-
0.02
1-aminobutyl(2-(methoxycarbonyl)phenethylcarbamothioyl)phosphinic acid
0.00145 - 0.00195
1-aminobutyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
0.02
1-aminobutyl(4-(ethoxycarbonyl)phenethylcarbamothioyl)phosphinic acid
0.00068
1-aminobutyl(4-methoxybenzylcarbamothioyl)phosphinic acid
0.00215 - 0.00245
1-aminobutyl(4-methoxyphenethylcarbamothioyl)phosphinic acid
0.00125 - 0.0021
1-aminobutyl(benzylcarbamothioyl)phosphinic acid
0.00135 - 0.0036
1-aminobutyl(phenethylcarbamothioyl)phosphinic acid
0.00245 - 0.00345
1-aminoethyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
0.02
1-aminoethyl(4-(ethoxycarbonyl)benzylcarbamothioyl)phosphinic acid
0.00112 - 0.02
1-aminoethyl(4-methoxybenzylcarbamothioyl)phosphinic acid
0.000145 - 0.0022
1-aminoethyl(benzylcarbamothioyl)phosphinic acid
0.0042 - 0.0087
1-aminoethyl(phenethylcarbamothioyl)phosphinic acid
0.014
1-aminoethylphosphonic acid mono-(2,3,5-trimethylphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0083
1-aminoethylphosphonic acid mono-(4-ethylphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0082
1-aminoethylphosphonic acid mono-(4-tert-butylphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.00025
1-aminohexyl(4-methoxyphenethylcarbamothioyl)phosphinic acid
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.00073
1-aminohexyl(phenethylcarbamothioyl)phosphinic acid
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0048
1-aminohexylphosphonic acid monophenyl ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.02
1-aminopentyl(2-(methoxycarbonyl)benzylcarbamothioyl)phosphinic acid
0.00036 - 0.00077
1-aminopentyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
0.00025 - 0.00105
1-aminopentyl(4-methoxybenzylcarbamothioyl)phosphinic acid
0.00062 - 0.0015
1-aminopentyl(benzylcarbamothioyl)phosphinic acid
0.00025 - 0.00073
1-aminopentyl(phenethylcarbamothioyl)phosphinic acid
0.2
1-aminopentylphosphonic acid mono-(2,5-dimethylphenyl) ester
Sus scrofa
-
IC50 above 0.2 mM, in sodium phosphate buffer (pH 7.2), at 25°C
0.0014
1-aminopentylphosphonic acid mono-(3,4-dimethylphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.055
1-aminopentylphosphonic acid mono-(4-carboxyphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.21
1-aminopentylphosphonic acid mono-(4-methoxyphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.001
1-aminopentylphosphonic acid mono-(4-methylphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0056
1-aminopentylphosphonic acid monophenyl ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0016 - 0.0025
1-aminopropyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
0.12
1-aminopropylphosphonic acid mono-(2,5-dimethylphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.003
1-aminopropylphosphonic acid mono-(3,4-dimethylphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.2
1-aminopropylphosphonic acid mono-(4-carboxyphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.007
1-aminopropylphosphonic acid mono-(4-methylphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0011
1-aminopropylphosphonic acid mono-(4-tert-butylphenyl) ester
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0189
2-([[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]amino)propaneperoxoic acid
Homo sapiens
-
-
0.00002
2-amino-1,4-dihydrophenanthren-3(2H)-one hydrochloride
Homo sapiens
-
-
0.000025
2-amino-2-phenylethanethiol
Homo sapiens
-
IC50: 25 nM
0.000056
2-amino-3-(benzyloxy)propane-1-thiol
Homo sapiens
-
IC50: 56 nM
0.00002
2-amino-3-(methylsulfanyl)propane-1-thiol
Homo sapiens
-
IC50: 20 nM
0.000021
2-amino-3-(methylsulfinyl)propane-1-thiol
Homo sapiens
-
IC50: 21 nM
0.00004
2-amino-3-(tert-butylsulfanyl)propane-1-thiol
Homo sapiens
-
IC50: 40 nM
0.000045
2-amino-3-cyclohexylpropane-1-thiol
Homo sapiens
-
IC50: 45 nM
0.00003
2-amino-3-phenylpropane-1-thiol
Homo sapiens
-
IC50: 30 nM
0.000011
2-amino-4-(methylsulfanyl)butane-1-thiol
Homo sapiens
-
IC50: 11 nM
0.00002
2-amino-4-(methylsulfinyl)butane-1-thiol
Homo sapiens
-
IC50: 20 nM
0.000022
2-amino-4-methylpentane-1-thiol
Homo sapiens
-
IC50: 22 nM
1
2-amino-N-[(2R)-2-amino-3-phenylpropyl]acetamide hydrochloride
Sus scrofa
-
IC50 above 1.0 mM, in 50 mM PBS, pH 7.2, at 37°C
1.781
2-cinnamamido-4-(3-nitrophenylamino)-4-oxobutanoic acid
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.2731
2-cinnamamido-4-(4-nitrophenylamino)-4-oxobutanoic acid
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.962
2-cinnamamido-4-(dodecylamino)-4-oxobutanoic acid
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.3878
2-cinnamamido-4-(hexylamino)-4-oxobutanoic acid
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
2.2
2-cinnamamido-4-(isopropylamino)-4-oxobutanoic acid
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.7392
2-cinnamamido-4-(naphthalene-1-ylamino)-4-oxobutanoic acid
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.2322
2-cinnamamido-4-(octylamino)-4-oxobutanoic acid
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.204
2-cinnamamido-4-oxo-4-(pentylamino) butanoic acid
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.2324
2-cinnamamido-4-oxo-4-(phenylamino) butanoic acid
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
9.108
2-cinnamamido-4-oxo-4-(propylamino) butanoic acid
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
1.44
2-cinnamamido-N1-hydroxy-N4-(3-nitrophenyl)succinamide
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.189
2-cinnamamido-N1-hydroxy-N4-(4-nitrophenyl)succinamide
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
2.05
2-cinnamamido-N1-hydroxy-N4-(naphthalene-1-yl)succinamide
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.0659
2-cinnamamido-N1-hydroxy-N4-isopropylsuccinamide
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.0185
2-cinnamamido-N1-hydroxy-N4-octylsuccinamide
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.0174
2-cinnamamido-N1-hydroxy-N4-pentylsuccinamide
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.115
2-cinnamamido-N1-hydroxy-N4-phenylsuccinamide
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.036
2-cinnamamido-N1-hydroxy-N4-propylsuccinamide
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.4382
2-cinnamamido-N4-dodecyl-N1-hydroxysuccinamide
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.0181
2-cinnamamido-N4-hexyl-N1-hydroxysuccinamide
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.5
3-amino-1,2,3,4-tetrahydronaphthalene-2-phosphonic acid
Sus scrofa
-
-
0.00008
3-amino-1-(2-phenylethyl)-3,4-dihydronaphthalen-2(1H)-one hydrochloride
Homo sapiens
-
-
0.0005
3-amino-2-tetralone
Sus scrofa
-
-
0.79
3-amino-3,4-dihydro-1H-naphthalen-2-one O-benzyloxime
Sus scrofa
-
-
1.8
3-amino-3,4-dihydro-1H-naphthalen-2-one oxime
Sus scrofa
-
-
0.4086
3-amino-N-[(2R)-2-amino-3-phenylpropyl]propionamide hydrochloride
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.00007
3-[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]-2-(4-hydroxybenzyl)propanoic acid
Neisseria meningitidis
-
pH 7.5, 37°C
0.000397
3-[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]-2-benzylpropanoic acid
Neisseria meningitidis
-
pH 7.5, 37°C
2.891
4-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)butanoic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.02
4-(2-(((1-aminobutyl)(hydroxy)phosphoryl)methanethioamido)ethyl)benzoic acid
0.000045
4-(2-amino-3-sulfanylpropyl)phenol
Homo sapiens
-
IC50: 45 nM
0.2634
4-(2-chlorophenylamino)-2-cinnamamido-4-oxobutanoic acid
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.7186
4-(3-chlorophenylamino)-2-cinnamamido-4-oxobutanoic acid
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.3485
4-(4-chlorophenylamino)-2-cinnamamido-4-oxobutanoic acid
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.2068
4-(benzylamino)-2-cinnamamido-4-oxobutanoic acid
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.189
4-(butylamino)-2-cinnamamido-4-oxobutanoic acid
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
1.389
6-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)hexanoic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.1643
6-amino-N-[(2R)-2-amino-3-phenylpropyl]caproylamide hydrochloride
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0228
6-hydroxy-6-oxo-N-1,3-thiazol-2-yl-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide
Homo sapiens
-
-
0.0532
6-hydroxy-N-(methoxycarbonyl)-6-oxo-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide
Homo sapiens
-
-
0.0414
6-hydroxy-N-(methoxycarbonyl)-N-methyl-6-oxo-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide
Homo sapiens
-
-
0.0161
6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucyl-N-hydroxyglycinamide
Homo sapiens
-
-
0.000075 - 0.148
actinonin
0.00006 - 0.0004
alpha1-amino-3-phenylpropyl(alpha2-hydroxy-3-phenylpropyl)phosphinic acid
0.0012 - 0.0056
beta-amino-alpha-hydroxyphenylbutanoic acid
Homo sapiens
-
i.e. AHPA, or AHPA-VAl, natural inhibitor isolated from Streptomyces neyagawaensis strain SL-387, IC50: 0.0012-0.0056 mM
0.0073
betulinic acid
Homo sapiens
-
natural inhibitor isolated from birch tree, IC50: 0.0073 mM, a selectively apoptosis-inducing agent, overview
0.05
bis(1-amino-3-methylbutyl)phosphinic acid
Homo sapiens
-
-
0.00083
bis(1-amino-3-phenylpropyl)phosphinic acid
Homo sapiens
-
-
0.0006
bis[amino(phenyl)methyl]phosphinic acid
Homo sapiens
-
-
0.0237
ethyl (S)-2-(3-(2-aminoacetamido)-2,6-dioxopiperidin-1-yl)acetate
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.00035
ethyl D-cysteinate
Homo sapiens
-
strong, competitive inhibition, IC50: 350 nM
0.0381
ethyl [(3S)-2,6-dioxo-3-(phenylalanylamino)piperidin-1-yl]acetate
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0207
ethyl [(3S)-2,6-dioxo-3-(tryptophylamino)piperidin-1-yl]acetate
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0169
ethyl [(3S)-2,6-dioxo-3-(tyrosylamino)piperidin-1-yl]acetate
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0288
ethyl [(3S)-2,6-dioxo-3-(valylamino)piperidin-1-yl]acetate
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0643
ethyl [(3S)-3-(alanylamino)-2,6-dioxopiperidin-1-yl]acetate
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0189
ethyl [(3S)-3-(histidylamino)-2,6-dioxopiperidin-1-yl]acetate
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0233
ethyl [(3S)-3-(isoleucylamino)-2,6-dioxopiperidin-1-yl]acetate
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0308
ethyl [(3S)-3-(leucylamino)-2,6-dioxopiperidin-1-yl]acetate
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.041
ethyl [(3S)-3-(lysylamino)-2,6-dioxopiperidin-1-yl]acetate
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.042
ethyl [(3S)-3-(methionylamino)-2,6-dioxopiperidin-1-yl]acetate
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0321
ethyl [(3S)-3-{[(2S)-2-amino-2-(pyrrolidin-2-yl)acetyl]amino}-2,6-dioxopiperidin-1-yl]acetate
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.1737
glycyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
Homo sapiens
-
-
3.244
glycyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
Homo sapiens
-
-
0.098
iodoacetamide
Homo sapiens
-
IC50: 0.098 mM, kidney enzyme
0.5215
L-alanyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
Homo sapiens
-
-
0.0492
L-cysteinyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
Homo sapiens
-
-
0.0103
L-cysteinyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
Homo sapiens
-
-
0.016 - 0.053
L-iso-glutamine inhibitors
Homo sapiens
-
diverse derivatives, IC50 of 0.016-0.053 mM
-
0.0148
L-isoleucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
Homo sapiens
-
-
0.1476
L-isoleucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
Homo sapiens
-
-
0.1579
L-isoleucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
Homo sapiens
-
-
0.1421
L-leucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
Homo sapiens
-
-
0.1809
L-leucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
Homo sapiens
-
-
0.045
L-leucyl-N1-[(2R)-2-amino-3-phenylpropyl]-Lcysteinamide hydrochloride
Homo sapiens
-
-
0.0086
L-lysyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
Homo sapiens
-
-
0.0895
L-lysyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
Homo sapiens
-
-
0.0088
L-methionyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
Homo sapiens
-
-
0.0165
L-methionyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
Homo sapiens
-
-
0.0304
L-methionyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
Homo sapiens
-
-
0.0332
L-ornithyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
Homo sapiens
-
-
0.0155
L-phenylalanyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide
Homo sapiens
-
-
0.0155
L-phenylalanyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0098
L-phenylalanyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
Homo sapiens
-
-
0.1969
L-tyrosyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
Homo sapiens
-
-
0.0585
L-valyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
Homo sapiens
-
-
0.0588
L-valyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
Homo sapiens
-
-
0.0005
lapstatin
Homo sapiens
-
natural competitive inhibitor from Streptomyces sp., IC50: 0.0005 mM
0.0926
methyl (2S)-1-(methylsulfonyl)-4-oxopyrrolidine-2-carboxylate
Homo sapiens
-
-
0.0549
methyl (2S)-1-[(4-methylphenyl)sulfonyl]-4-oxopyrrolidine-2-carboxylate
Homo sapiens
-
-
0.0758
methyl (2S)-4-oxo-1-(phenylsulfonyl)pyrrolidine-2-carboxylate
Homo sapiens
-
-
0.0416
methyl (2S,4R)-4-hydroxy-1-(methylsulfonyl)pyrrolidine-2-carboxylate
Homo sapiens
-
-
0.0538
methyl (2S,4R)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxylate
Homo sapiens
-
-
0.0384
methyl (2S,4R)-4-hydroxy-1-[(4-methylphenyl)sulfonyl]pyrrolidine-2-carboxylate
Homo sapiens
-
-
0.0000009
methyl (4R)-4-([(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino)-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinate
Homo sapiens
-
IC50: 0.9 nM
0.0000009
methyl (4R)-4-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinate
Homo sapiens
-
-
0.0217
methyl 2-([[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]amino)-4-(methylperoxy)-4-oxobutanoate
Homo sapiens
-
-
0.05
methyl 2-chloro-N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]alaninate
Homo sapiens
-
-
0.0302
methyl 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucyl-(4R)-4-(benzyloxy)prolinate
Homo sapiens
-
-
0.0507
methyl 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucyl-L-methioninate
Homo sapiens
-
-
0.0368
methyl 6-oxidanyl-6-oxidanylidene-N-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucylserinate
Homo sapiens
-
-
0.011
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]-D-phenylalaninate
Homo sapiens
-
-
0.0462
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]-L-phenylalaninate
Homo sapiens
-
-
0.0503
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]cysteinate
Homo sapiens
-
-
0.0554
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]glycinate
Homo sapiens
-
-
0.0052
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]histidinate
Homo sapiens
-
-
0.0493
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]isoleucinate
Homo sapiens
-
-
0.0462
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]leucinate
Homo sapiens
-
-
0.0207
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]methioninate
Homo sapiens
-
-
0.0519
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]threoninate
Homo sapiens
-
-
0.0431
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]tryptophanate
Homo sapiens
-
-
0.0448
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]tyrosinate
Homo sapiens
-
-
0.0214
methyl N-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]valinate
Homo sapiens
-
-
0.042
methyl N2-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]-N5-(nitrocarbamimidoyl)ornithinate
Homo sapiens
-
-
0.0381
methyl N2-[[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetyl]lysinate
Homo sapiens
-
-
0.0634
methyl [(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetate
Homo sapiens
-
-
0.0031
N-((3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl)-3,4,5-trimethoxybenzamide
Sus scrofa
-
pH 7.2, 37°C
0.0052
N-((3S)-1-[2-(methylhistidinyl)-2-oxoethyl]-2,6-dioxopiperidin-3-yl)-3,4,5-trimethoxybenzamide
Sus scrofa
-
pH 7.2, 37°C
0.104
N-(1-(2-aminophenyl)-2,6-dioxopiperidin-3-yl)-3,4,5-trimethoxybenzamide
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0234
N-(4-aminophenyl)-6-hydroxy-6-oxo-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide
Homo sapiens
-
-
0.0243
N-(4-chlorophenyl)-6-hydroxy-6-oxo-N2-[(3,4,5-trimethoxyphenyl)carbonyl]-L-norleucinamide
Homo sapiens
-
-
1
N-[(2R)-2-amino-3-phenylpropyl]-2-phenylacetamide hydrochloride
Sus scrofa
-
IC50 above 1.0 mM, in 50 mM PBS, pH 7.2, at 37°C
1
N-[(2R)-2-amino-3-phenylpropyl]-2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetamide hydrochloride
Sus scrofa
-
IC50 above 1.0 mM, in 50 mM PBS, pH 7.2, at 37°C
0.2045
N-[(2R)-2-amino-3-phenylpropyl]-3,5-dinitrobenzamide hydrochloride
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.2895
N-[(2R)-2-amino-3-phenylpropyl]-3-phenylpropanamide hydrochloride
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
1
N-[(2R)-2-amino-3-phenylpropyl]-4-phenylbutanamide hydrochloride
Sus scrofa
-
IC50 above 1.0 mM, in 50 mM PBS, pH 7.2, at 37°C
1
N-[(2R)-2-amino-3-phenylpropyl]-L-glutamamide hydrochloride
Sus scrofa
-
IC50 above 1.0 mM, in 50 mM PBS, pH 7.2, at 37°C
0.0000023
N-[(2S)-2-(([(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl)methyl)-4-methylpentanoyl]-L-phenylalanine
Homo sapiens
-
IC50: 2.3 nM
0.0000053
N-[(2S)-3-([(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl)-2-(biphenyl-4-ylmethyl)propanoyl]-L-alanine
Homo sapiens
-
IC50: 5.3 nM
0.0000015
N-[(2S)-3-([(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl)-2-benzylpropanoyl]phenylalanine
Homo sapiens
-
IC50: 1.5 nM
0.0000019
N-[(2S)-3-([(1R)-1-aminoethyl](hydroxy)phosphoryl)-2-(4-bromobenzyl)propanoyl]-L-alanine
Homo sapiens
-
IC50: 1.9 nM
0.0000029
N-[(2S)-3-([(1R)-1-aminoethyl](hydroxy)phosphoryl)-2-(biphenyl-4-ylmethyl)propanoyl]alanine
Homo sapiens
-
IC50: 2.9 nM
0.0000048
N-[(2S)-3-([(R)-amino(phenyl)methyl](hydroxy)phosphoryl)-2-(biphenyl-4-ylmethyl)propanoyl]-L-alanine
Homo sapiens
-
IC50: 4.8 nM
0.0000049
N-[(2S)-3-([(R)-amino(phenyl)methyl](hydroxy)phosphoryl)-2-(biphenyl-4-ylmethyl)propanoyl]-L-serine
Homo sapiens
-
IC50: 4.9 nM
0.0000102
N-[(2S)-3-([(R)-amino(phenyl)methyl](hydroxy)phosphoryl)-2-(biphenyl-4-ylmethyl)propanoyl]-L-threonine
Homo sapiens
-
IC50: 10.2 nM
0.0000328
N-[(2S)-3-([(R)-amino(phenyl)methyl](hydroxy)phosphoryl)-2-(biphenyl-4-ylmethyl)propanoyl]glycine
Homo sapiens
-
IC50: 32.8 nM
0.0000042
N-[(2S)-3-([(R)-amino(phenyl)methyl](hydroxy)phosphoryl)-2-benzylpropanoyl]-L-phenylalanine
Homo sapiens
-
IC50: 4.2 nM
0.0031
N-[(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3,4,5-trimethoxybenzamide
0.2342
N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-glycine amide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.2389
N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-glycine amide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.2213
N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-glycine amide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1162
N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-glycine amide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1152
N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-glycine amide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0602
N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-glycine amide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0522
N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-glycine amide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0459
N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-glycine amide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.3455
N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-glycine amide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1484
N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-glycine amide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.9156
N-[5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-glycine amide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1573
N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-glycine amide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.7273
N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-glycine amide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.9701
N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-glycine amide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.00329
N-[[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]methy]tyrosine
Neisseria meningitidis
-
pH 7.5, 37°C
0.0109
N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}alaninamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0094
N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}glycinamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0092
N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}isoleucinamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0053
N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}leucinamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0094
N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}lysinamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0018
N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}phenylalaninamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0073
N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}tyrosinamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0125
N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}valinamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
1.049
N1-[(2R)-2-amino-3-phenylpropyl]-N-(2,4-dichlorobenzoyl)-L-cysteinamide hydrochloride
Homo sapiens
-
-
2.263
N1-[(2R)-2-amino-3-phenylpropyl]-N-(2,4-dichlorobenzoyl)-L-phenylalaninamide hydrochloride
Homo sapiens
-
-
0.2772
N1-[(2R)-2-amino-3-phenylpropyl]-N-(3,5-dinitrobenzoyl)-L-phenylalaninamide hydrochloride
Homo sapiens
-
-
0.366
N1-[(2R)-2-amino-3-phenylpropyl]-N-(3-phenylpropanoyl)-L-phenylalaninamide hydrochloride
Homo sapiens
-
-
0.6928
N1-[(2R)-2-amino-3-phenylpropyl]-N-(4-chlorobutanoyl)-L-phenylalaninamide hydrochloride
Homo sapiens
-
-
0.1736
N1-[(2R)-2-amino-3-phenylpropyl]-N-(4-methoxybenzoyl)-L-phenylalaninamide hydrochloride
Homo sapiens
-
-
1.39
N1-[(2R)-2-amino-3-phenylpropyl]-N-(4-nitrobenzoyl)-Lphenylalaninamide hydrochloride
Homo sapiens
-
-
0.2024
N1-[(2R)-2-amino-3-phenylpropyl]-N-(6-aminohexanoyl)-L-cysteinamide hydrochloride
Homo sapiens
-
-
1.457
N1-[(2R)-2-amino-3-phenylpropyl]-N-(6-aminohexanoyl)-L-leucinamide hydrochloride
Homo sapiens
-
-
1.539
N1-[(2R)-2-amino-3-phenylpropyl]-N-(6-aminohexanoyl)-L-phenylalaninamide hydrochloride
Homo sapiens
-
-
0.0866
N4-(2-chlorophenyl)-2-cinnamamido-N1-hydroxysuccinamide
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
1.206
N4-(3-chlorophenyl)-2-cinnamamido-N1-hydroxysuccinamide
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.1915
N4-(4-chlorophenyl)-2-cinnamamido-N1-hydroxysuccinamide
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.0651
N4-benzyl-2-cinnamamido-N1-hydroxysuccinamide
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.0111
N4-butyl-2-cinnamamido-N1-hydroxysuccinamide
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.097
N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-(pyrazin-2-ylcarbonyl)-L-lysinamide
Homo sapiens
-
-
0.0912 - 0.0943
N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-(pyridin-3-ylcarbonyl)-L-lysinamide
0.5696
N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-[(2E)-3-phenylprop-2-enoyl]-L-lysinamide
Homo sapiens
-
-
0.0958
N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-[(3-nitrophenyl)carbonyl]-L-lysinamide
Homo sapiens
-
-
0.1272
N6-[(benzyloxy)carbonyl]-N2-(2,4-dichlorobenzoyl)-L-lysine
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0132
N6-[(benzyloxy)carbonyl]-N2-(2,4-dichlorobenzoyl)-N1-hydroxy-L-lysinamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
1.247
N6-[(benzyloxy)carbonyl]-N2-(2-thienylcarbonyl)-L-lysine
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1591
N6-[(benzyloxy)carbonyl]-N2-(2-thienylcarbonyl)-N1-hydroxy-L-lysinamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.108
N6-[(benzyloxy)carbonyl]-N2-(3-nitrobenzoyl)-L-lysine
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0958
N6-[(benzyloxy)carbonyl]-N2-(3-nitrobenzoyl)-N1-hydroxy-L-lysinamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.188
N6-[(benzyloxy)carbonyl]-N2-(4-bromobenzoyl)-L-lysine
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1119
N6-[(benzyloxy)carbonyl]-N2-(4-bromobenzoyl)-N1-hydroxy-L-lysinamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.2022
N6-[(benzyloxy)carbonyl]-N2-(4-nitrobenzoyl)-L-lysine
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1079
N6-[(benzyloxy)carbonyl]-N2-(4-nitrobenzoyl)-N1-hydroxy-L-lysinamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1974
N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-L-lysine
0.097
N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-N1-hydroxy-L-lysinamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1668 - 0.2196
N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-L-lysine
0.0943
N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-N1-hydroxy-L-lysinamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
1.121
N6-[(benzyloxy)carbonyl]-N2-2-furoyl-L-lysine
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1587
N6-[(benzyloxy)carbonyl]-N2-2-furoyl-N1-hydroxy-L-lysinamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.2151
N6-[(benzyloxy)carbonyl]-N2-cinnamoyl-L-lysine
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.5696
N6-[(benzyloxy)carbonyl]-N2-cinnamoyl-N1-hydroxy-L-lysinamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.2916
N6-[(benzyloxy)carbonyl]-N2-isonicotinoyl-L-lysine
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0912
N6-[(benzyloxy)carbonyl]-N2-isonicotinoyl-N1-hydroxy-L-lysinamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1272
N6-[(benzyloxy)carbonyl]-N2-[(2,4-dichlorophenyl)carbonyl]-L-lysine
Homo sapiens
-
-
0.0132
N6-[(benzyloxy)carbonyl]-N2-[(2,4-dichlorophenyl)carbonyl]-N-hydroxy-L-lysinamide
Homo sapiens
-
-
0.2151
N6-[(benzyloxy)carbonyl]-N2-[(2E)-3-phenylprop-2-enoyl]-L-lysine
Homo sapiens
-
-
0.1108
N6-[(benzyloxy)carbonyl]-N2-[(3-nitrophenyl)carbonyl]-L-lysine
Homo sapiens
-
-
0.188
N6-[(benzyloxy)carbonyl]-N2-[(4-bromophenyl)carbonyl]-L-lysine
Homo sapiens
-
-
0.1119
N6-[(benzyloxy)carbonyl]-N2-[(4-bromophenyl)carbonyl]-N-hydroxy-L-lysinamide
Homo sapiens
-
-
0.00029
PAQ-22
Homo sapiens
-
IC50: 0.00029 mM, kidney enzyme
0.000015
phebestin
Homo sapiens
-
IC50: 0.000015 mM, kidney enzyme
0.021
phenyl [amino(phenyl)methyl]phosphonate
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.000016 - 0.074
probestin
0.007 - 0.018
psammaplin A
Homo sapiens
-
natural inhibitor isolated from a marine sponge, non-competitive, highly cytotoxic, IC50: 0.007-0.018 mM, overview
0.0031
puromycin
Homo sapiens
-
IC50: 0.0031 mM, kidney enzyme
0.000025 - 0.00003
RB3014
0.0169
[(3S)-2,6-dioxo-3-(phenylalanylamino)piperidin-1-yl]acetic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0113
[(3S)-2,6-dioxo-3-(tyrosylamino)piperidin-1-yl]acetic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0158
[(3S)-2,6-dioxo-3-(valylamino)piperidin-1-yl]acetic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0498
[(3S)-2,6-dioxo-3-[[(3,4,5-trimethoxyphenyl)carbonyl]amino]piperidin-1-yl]acetic acid
Homo sapiens
-
-
0.0215
[(3S)-3-(alanylamino)-2,6-dioxopiperidin-1-yl]acetic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0154
[(3S)-3-(glycylamino)-2,6-dioxopiperidin-1-yl]acetic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0166
[(3S)-3-(isoleucylamino)-2,6-dioxopiperidin-1-yl]acetic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0221
[(3S)-3-(leucylamino)-2,6-dioxopiperidin-1-yl]acetic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0141
[(3S)-3-(lysylamino)-2,6-dioxopiperidin-1-yl]acetic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0132
[(3S)-3-{[(2S)-2-amino-2-(pyrrolidin-2-yl)acetyl]amino}-2,6-dioxopiperidin-1-yl]acetic acid
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.025
[3-nitro-2-(2-nitrophenyl)-4-oxo-4H-chromen-8-yl]acetic acid
Homo sapiens
-
IC50: 0.025 mM
0.00071
[amino(phenyl)methyl](1-amino-3-phenylpropyl)phosphinic acid
Homo sapiens
-
-
0.0044 - 0.012
[amino(phenyl)methyl](1-hydroxy-3-methylbutyl)phosphinic acid
0.00024 - 0.0022
[amino(phenyl)methyl](1-hydroxy-3-phenylpropyl)phosphinic acid
0.0152 - 0.048
[amino(phenyl)methyl](1-hydroxyethyl)phosphinic acid
0.028
[amino(phenyl)methyl](1-hydroxypentyl)phosphinic acid
Homo sapiens
-
-
0.00046 - 0.0015
[amino(phenyl)methyl][hydroxy(phenyl)methyl]phosphinic acid
0.00025
(1-amino-2-methylpropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0005
(1-amino-2-methylpropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
Homo sapiens
-
-
0.0005
(1-amino-2-methylpropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0011
(1-amino-2-methylpropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00066
(1-amino-2-phenylethyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00093
(1-amino-2-phenylethyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0016
(1-amino-2-phenylethyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00042
(1-amino-3-methylbutyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00092
(1-amino-3-methylbutyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.001
(1-amino-3-methylbutyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
Homo sapiens
-
-
0.001
(1-amino-3-methylbutyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00095
(1-aminobutyl)(1-hydroxy-2-phenylethyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0012
(1-aminobutyl)(1-hydroxy-2-phenylethyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.002
(1-aminobutyl)(1-hydroxy-2-phenylethyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00087
(1-aminoethyl)[hydroxy[4-(propan-2-yl)phenyl]methyl]phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0012
(1-aminoethyl)[hydroxy[4-(propan-2-yl)phenyl]methyl]phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0035
(1-aminoethyl)[hydroxy[4-(propan-2-yl)phenyl]methyl]phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
(1-aminohexyl)((2-(methoxycarbonyl)benzyl)carbamothioyl)phosphinic acid
Homo sapiens
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
(1-aminohexyl)((2-(methoxycarbonyl)benzyl)carbamothioyl)phosphinic acid
Rattus norvegicus
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
(1-aminohexyl)((2-(methoxycarbonyl)benzyl)carbamothioyl)phosphinic acid
Sus scrofa
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.00022
(1-aminopentyl)(1-hydroxy-2-phenylpropyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00046
(1-aminopentyl)(1-hydroxy-2-phenylpropyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00086
(1-aminopentyl)(1-hydroxy-2-phenylpropyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00021
(1-aminopentyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00022
(1-aminopentyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00052
(1-aminopentyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0058
(1-aminopentyl)[hydroxy(4-hydroxyphenyl)methyl]phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0062
(1-aminopentyl)[hydroxy(4-hydroxyphenyl)methyl]phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0093
(1-aminopentyl)[hydroxy(4-hydroxyphenyl)methyl]phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0006
(1-aminopropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0013
(1-aminopropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0024
(1-aminopropyl)(1-hydroxy-3-phenylpropyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.1153
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1153
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.0488
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0488
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.1416
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1416
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.3732
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.3732
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.1699
(2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-N-propylpropanamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.1832
(2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-N-propylpropanamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0000077
(4R)-4-(hexanoylamino)-N-hydroxy-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinamide
Homo sapiens
-
-
0.0000077
(4R)-4-(hexanoylamino)-N-hydroxy-1-[(3,4,5-trimethoxyphenyl)carbonyl]-L-prolinamide
Homo sapiens
-
IC50: 7.7 nM
0.012
1,10-phenanthroline
Homo sapiens
-
pH 7.4, 37°C, presence of 0.05 mM EDTA
0.027
1,10-phenanthroline
Homo sapiens
-
pH 7.4, 37°C, presence of 0.005 mM EDTA
0.046
1,10-phenanthroline
Sus scrofa
-
pH 7.4, 37°C, presence of 0.05 mM EDTA
0.119
1,10-phenanthroline
Sus scrofa
-
pH 7.4, 37°C, presence of 0.005 mM EDTA
0.178
1,10-phenanthroline
Sus scrofa
-
pH 7.4, 37°C
0.179
1,10-phenanthroline
Homo sapiens
-
pH 7.4, 37°C
0.00118
1-amino-2-methylpropyl(hexylcarbamothioyl)phosphinic acid
Homo sapiens
-
-
0.00118
1-amino-2-methylpropyl(hexylcarbamothioyl)phosphinic acid
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0012
1-amino-2-methylpropyl(hexylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0017
1-amino-2-methylpropyl(hexylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00505
1-amino-2-methylpropyl(hexylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0019
1-amino-2-methylpropyl(isobutylcarbamothioyl)phosphinic acid
Homo sapiens
-
-
0.0019
1-amino-2-methylpropyl(isobutylcarbamothioyl)phosphinic acid
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0048
1-amino-2-methylpropyl(isobutylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00895
1-amino-2-methylpropyl(isobutylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.01535
1-amino-2-methylpropyl(isobutylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.01015
1-amino-2-methylpropyl(methylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0146
1-amino-2-methylpropyl(methylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.02135
1-amino-2-methylpropyl(methylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-amino-3-methylbutyl(2-(methoxycarbonyl)benzylcarbamothioyl)phosphinic acid
Homo sapiens
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-amino-3-methylbutyl(2-(methoxycarbonyl)benzylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-amino-3-methylbutyl(2-(methoxycarbonyl)benzylcarbamothioyl)phosphinic acid
Sus scrofa
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.0028
1-amino-3-methylbutyl(benzylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0051
1-amino-3-methylbutyl(benzylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0082
1-amino-3-methylbutyl(benzylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0005
1-amino-3-methylbutyl(hexylcarbamothioyl)phosphinic acid
Homo sapiens
-
-
0.0005
1-amino-3-methylbutyl(hexylcarbamothioyl)phosphinic acid
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.00096
1-amino-3-methylbutyl(hexylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0014
1-amino-3-methylbutyl(hexylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0017
1-amino-3-methylbutyl(hexylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.01056
1-amino-3-methylbutyl(methylcarbamothioyl)phosphinic acid
Homo sapiens
-
-
0.01056
1-amino-3-methylbutyl(methylcarbamothioyl)phosphinic acid
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0108
1-amino-3-methylbutyl(methylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-amino-3-methylbutyl(methylcarbamothioyl)phosphinic acid
Homo sapiens
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-amino-3-methylbutyl(methylcarbamothioyl)phosphinic acid
Sus scrofa
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.0042
1-amino-3-methylbutyl(phenethylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0054
1-amino-3-methylbutyl(phenethylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-amino-3-methylbutyl(phenethylcarbamothioyl)phosphinic acid
Homo sapiens
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.00047
1-amino-3-phenylpropyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00155
1-amino-3-phenylpropyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00165
1-amino-3-phenylpropyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0114
1-amino-3-phenylpropyl(4-(ethoxycarbonyl)benzylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-amino-3-phenylpropyl(4-(ethoxycarbonyl)benzylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-amino-3-phenylpropyl(4-(ethoxycarbonyl)benzylcarbamothioyl)phosphinic acid
Sus scrofa
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.00038
1-amino-3-phenylpropyl(4-methoxybenzylcarbamothioyl)phosphinic acid
Homo sapiens
-
-
0.00038
1-amino-3-phenylpropyl(4-methoxybenzylcarbamothioyl)phosphinic acid
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.00064
1-amino-3-phenylpropyl(4-methoxybenzylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00265
1-amino-3-phenylpropyl(4-methoxybenzylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00265
1-amino-3-phenylpropyl(4-methoxybenzylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0013
1-amino-3-phenylpropyl(benzylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0023
1-amino-3-phenylpropyl(benzylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0025
1-amino-3-phenylpropyl(benzylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00056
1-amino-3-phenylpropyl(propylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00135
1-amino-3-phenylpropyl(propylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00145
1-amino-3-phenylpropyl(propylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-aminobutyl(2-(methoxycarbonyl)phenethylcarbamothioyl)phosphinic acid
Homo sapiens
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-aminobutyl(2-(methoxycarbonyl)phenethylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-aminobutyl(2-(methoxycarbonyl)phenethylcarbamothioyl)phosphinic acid
Sus scrofa
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.00145
1-aminobutyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00145
1-aminobutyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00195
1-aminobutyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-aminobutyl(4-(ethoxycarbonyl)phenethylcarbamothioyl)phosphinic acid
Homo sapiens
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-aminobutyl(4-(ethoxycarbonyl)phenethylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-aminobutyl(4-(ethoxycarbonyl)phenethylcarbamothioyl)phosphinic acid
Sus scrofa
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.00068
1-aminobutyl(4-methoxybenzylcarbamothioyl)phosphinic acid
Homo sapiens
-
-
0.00068
1-aminobutyl(4-methoxybenzylcarbamothioyl)phosphinic acid
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.00215
1-aminobutyl(4-methoxyphenethylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00215
1-aminobutyl(4-methoxyphenethylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00245
1-aminobutyl(4-methoxyphenethylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00125
1-aminobutyl(benzylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0016
1-aminobutyl(benzylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0021
1-aminobutyl(benzylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00135
1-aminobutyl(phenethylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00228
1-aminobutyl(phenethylcarbamothioyl)phosphinic acid
Homo sapiens
-
-
0.00228
1-aminobutyl(phenethylcarbamothioyl)phosphinic acid
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.00255
1-aminobutyl(phenethylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0036
1-aminobutyl(phenethylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00245
1-aminoethyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00252
1-aminoethyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00345
1-aminoethyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-aminoethyl(4-(ethoxycarbonyl)benzylcarbamothioyl)phosphinic acid
Homo sapiens
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-aminoethyl(4-(ethoxycarbonyl)benzylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-aminoethyl(4-(ethoxycarbonyl)benzylcarbamothioyl)phosphinic acid
Sus scrofa
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.00112
1-aminoethyl(4-methoxybenzylcarbamothioyl)phosphinic acid
Homo sapiens
-
-
0.00112
1-aminoethyl(4-methoxybenzylcarbamothioyl)phosphinic acid
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.02
1-aminoethyl(4-methoxybenzylcarbamothioyl)phosphinic acid
Homo sapiens
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-aminoethyl(4-methoxybenzylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-aminoethyl(4-methoxybenzylcarbamothioyl)phosphinic acid
Sus scrofa
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.000145
1-aminoethyl(benzylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0019
1-aminoethyl(benzylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0022
1-aminoethyl(benzylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0042
1-aminoethyl(phenethylcarbamothioyl)phosphinic acid
Homo sapiens
-
-
0.0042
1-aminoethyl(phenethylcarbamothioyl)phosphinic acid
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0052
1-aminoethyl(phenethylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0058
1-aminoethyl(phenethylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0087
1-aminoethyl(phenethylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-aminopentyl(2-(methoxycarbonyl)benzylcarbamothioyl)phosphinic acid
Homo sapiens
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-aminopentyl(2-(methoxycarbonyl)benzylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
1-aminopentyl(2-(methoxycarbonyl)benzylcarbamothioyl)phosphinic acid
Sus scrofa
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.00036
1-aminopentyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00061
1-aminopentyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00077
1-aminopentyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00025
1-aminopentyl(4-methoxybenzylcarbamothioyl)phosphinic acid
Homo sapiens
-
-
0.00046
1-aminopentyl(4-methoxybenzylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00064
1-aminopentyl(4-methoxybenzylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00105
1-aminopentyl(4-methoxybenzylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00062
1-aminopentyl(benzylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0011
1-aminopentyl(benzylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0015
1-aminopentyl(benzylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00025
1-aminopentyl(phenethylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00062
1-aminopentyl(phenethylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00071
1-aminopentyl(phenethylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00073
1-aminopentyl(phenethylcarbamothioyl)phosphinic acid
Homo sapiens
-
-
0.0016
1-aminopropyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00165
1-aminopropyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0025
1-aminopropyl(3-(methylthio)propylcarbamothioyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
4-(2-(((1-aminobutyl)(hydroxy)phosphoryl)methanethioamido)ethyl)benzoic acid
Homo sapiens
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
4-(2-(((1-aminobutyl)(hydroxy)phosphoryl)methanethioamido)ethyl)benzoic acid
Rattus norvegicus
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.02
4-(2-(((1-aminobutyl)(hydroxy)phosphoryl)methanethioamido)ethyl)benzoic acid
Sus scrofa
-
IC50 above 0.02 mM, at 37°C in 100 mM Tris-HCl, pH 7.5
0.000075
actinonin
Homo sapiens
-
IC50: 0.000075 mM, kidney enzyme
0.0002
actinonin
Homo sapiens
-
natural competitive inhibitor, IC50: 0.0002 mM
0.002
actinonin
Sus scrofa
-
IC50: 0.002 mM, specific inhibitor
0.0031
actinonin
Homo sapiens
-
IC50 is 0.0031 mM
0.148
actinonin
Bombyx mori
-
IC50: 148 microM
0.148
actinonin
Bombyx mori
-
isozyme APN4: IC50 is 0.148 mM, inhibits also isozyme APN1
0.00006
alpha1-amino-3-phenylpropyl(alpha2-hydroxy-3-phenylpropyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00022
alpha1-amino-3-phenylpropyl(alpha2-hydroxy-3-phenylpropyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0004
alpha1-amino-3-phenylpropyl(alpha2-hydroxy-3-phenylpropyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0076
amastatin
Bombyx mori
-
IC50: 7.6 microM
0.0076
amastatin
Bombyx mori
-
isozyme APN4: IC50 is 0.0076 mM, inhibits also isozyme APN1
0.0004
bestatin
Homo sapiens
-
inhibits enzyme activity and cell growth, e.g. of leukocytes, overview, IC50: 0.0004 mM, kidney enzyme
0.0021
bestatin
Sus scrofa
-
in sodium phosphate buffer (pH 7.2), at 25°C
0.0024
bestatin
Sus scrofa
-
pH 7.2, 37°C
0.0024
bestatin
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.003
bestatin
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0031
bestatin
Homo sapiens
-
-
0.0035
bestatin
Sus scrofa
-
-
0.0036
bestatin
Sus scrofa
-
in 0.05 mM PBS, pH 7.2, at 37°C
0.0063
bestatin
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.007 - 0.0169
bestatin
Homo sapiens
-
narural competitive inhibitor, inhibits enzyme activity, but not chemotactic activity, IC50: 0.007-0.0169 mM
0.0085
bestatin
Homo sapiens
-
in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C
0.01
bestatin
Homo sapiens
-
IC50 is 0.01 mM
0.0131
bestatin
Sus scrofa
-
in 50 mM PBS, pH 7.2 at 37°C
0.0155
bestatin
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.0169
bestatin
Homo sapiens
-
-
0.162
bestatin
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
3.25
bestatin
Bombyx mori
-
poor inhibitor, IC50: 3.25 mM
0.0031
N-[(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3,4,5-trimethoxybenzamide
Homo sapiens
-
-
0.0031
N-[(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3,4,5-trimethoxybenzamide
Sus scrofa
-
in 50 mM PBS buffer, pH 7.2, at 37°C
0.0912
N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-(pyridin-3-ylcarbonyl)-L-lysinamide
Homo sapiens
-
-
0.0943
N6-[(benzyloxy)carbonyl]-N-hydroxy-N2-(pyridin-3-ylcarbonyl)-L-lysinamide
Homo sapiens
-
-
0.1974
N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-L-lysine
Homo sapiens
-
-
0.1974
N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-L-lysine
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.1668
N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-L-lysine
Homo sapiens
-
-
0.1668
N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-L-lysine
Sus scrofa
-
in 50 mM PBS, pH 7.2, at 37°C
0.2196
N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-L-lysine
Homo sapiens
-
-
0.000016
probestin
Homo sapiens
-
IC50: 0.000016 mM, kidney enzyme
0.00005
probestin
Homo sapiens
-
-
0.00005
probestin
Sus scrofa
-
IC50: 50 nM
0.00005
probestin
Homo sapiens
-
natural competitive inhibitor from Streptomyces sp., IC50: 0.00005 mM
0.074
probestin
Bombyx mori
-
IC50: 74 microM
0.074
probestin
Bombyx mori
-
isozyme APN4: IC50 is 0.074 mM, inhibits also isozyme APN1
0.000025
RB3014
Homo sapiens
-
IC50: 0.000025 mM, kidney enzyme
0.00003
RB3014
Gallus gallus
-
APN inhibitor, IC50: 30 nM
0.0044
[amino(phenyl)methyl](1-hydroxy-3-methylbutyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0047
[amino(phenyl)methyl](1-hydroxy-3-methylbutyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.012
[amino(phenyl)methyl](1-hydroxy-3-methylbutyl)phosphinic acid
Homo sapiens
-
-
0.012
[amino(phenyl)methyl](1-hydroxy-3-methylbutyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00024
[amino(phenyl)methyl](1-hydroxy-3-phenylpropyl)phosphinic acid
Homo sapiens
-
-
0.00024
[amino(phenyl)methyl](1-hydroxy-3-phenylpropyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00073
[amino(phenyl)methyl](1-hydroxy-3-phenylpropyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0022
[amino(phenyl)methyl](1-hydroxy-3-phenylpropyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0152
[amino(phenyl)methyl](1-hydroxyethyl)phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0182
[amino(phenyl)methyl](1-hydroxyethyl)phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.048
[amino(phenyl)methyl](1-hydroxyethyl)phosphinic acid
Homo sapiens
-
-
0.048
[amino(phenyl)methyl](1-hydroxyethyl)phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00046
[amino(phenyl)methyl][hydroxy(phenyl)methyl]phosphinic acid
Rattus norvegicus
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.00055
[amino(phenyl)methyl][hydroxy(phenyl)methyl]phosphinic acid
Homo sapiens
-
-
0.00055
[amino(phenyl)methyl][hydroxy(phenyl)methyl]phosphinic acid
Sus scrofa
-
at 37°C in 100 mM Tris-HCl, pH 7.5
0.0015
[amino(phenyl)methyl][hydroxy(phenyl)methyl]phosphinic acid
Homo sapiens
-
at 37°C in 100 mM Tris-HCl, pH 7.5
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