Inhibitors | Comment | Organism | Structure |
---|---|---|---|
colcemid | microtubule inhibitor, arrests cells in M phase, followed by induction of apotosis, 1 and 5 ng/ml colcemid display only modest cytotoxic effects. 10, 50 and 100 ng/ml induce pronounced cell death as measured by flow cytometry analysis | Homo sapiens | |
additional information | tumor suppressor p53 not only plays a key role in the regulation of the htopoI response to UV-C irradiation but also to treatment with colcemid | Homo sapiens | |
Tumor necrosis factor alpha | TNFalpha induces receptor-mediated apotosis. Receptor-mediated apoptosis induced by TNFalpha results in a very strong htopoI damage response, further indicating a general involvement of htopoI in apoptosis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
hTopoI | - |
Homo sapiens |
Topoisomerase I | - |
Homo sapiens |