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Literature summary for 5.6.2.1 extracted from

  • Khadka, D.B.; Le, Q.M.; Yang, S.H.; Van, H.T.; Le, T.N.; Cho, S.H.; Kwon, Y.; Lee, K.T.; Lee, E.S.; Cho, W.J.
    Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase I inhibitors (2011), Bioorg. Med. Chem., 19, 1924-1929.
    View publication on PubMed
Search for more literature for 5.6.2.1

Inhibitors

Inhibitors Comment Organism Structure
11-hexyl-5-(4-methylpiperazin-1-yl)-11H-indeno[1,2-c]isoquinolin-11-ol
-
 Homo sapiens
11-methyl-5-(4-methylpiperazin-1-yl)-11H-indeno[1,2-c]isoquinolin-11-ol
-
 Homo sapiens
2,3-dimethoxy-6-methyl-5H-[1,3]dioxolo[5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione i.e. NSC 314622 Homo sapiens
3-arylisoquinoline
-
 Homo sapiens
5-(4-ethylpiperazin-1-yl)-11H-indeno[1,2-c]isoquinolin-11-ol
-
 Homo sapiens
5-(4-ethylpiperazin-1-yl)-11H-indeno[1,2-c]isoquinolin-11-one
-
 Homo sapiens
5-(4-ethylpiperazin-1-yl)-11H-indeno[1,2-c]isoquinoline
-
 Homo sapiens
5-(4-methyl-1,4-diazepan-1-yl)-11H-indeno[1,2-c]isoquinolin-11-one
-
 Homo sapiens
5-(4-methyl-1,4-diazepan-1-yl)-11H-indeno[1,2-c]isoquinoline
-
 Homo sapiens
5-(4-methylpiperazin-1-yl)-11H-indeno[1,2-c]isoquinolin-11-ol
-
 Homo sapiens
5-(4-methylpiperazin-1-yl)-11H-indeno[1,2-c]isoquinolin-11-one
-
 Homo sapiens
5-(4-methylpiperazin-1-yl)-11H-indeno[1,2-c]isoquinoline
-
 Homo sapiens
5-(butylamino)-11H-indeno[1,2-c]isoquinolin-11-one
-
 Homo sapiens
5-(morpholin-4-yl)-11H-indeno[1,2-c]isoquinolin-11-ol
-
 Homo sapiens
5-(morpholin-4-yl)-11H-indeno[1,2-c]isoquinolin-11-one
-
 Homo sapiens
5-(morpholin-4-yl)-11H-indeno[1,2-c]isoquinolin-11-yl acetate
-
 Homo sapiens
5-(morpholin-4-yl)-11H-indeno[1,2-c]isoquinoline
-
 Homo sapiens
5-(piperazin-1-yl)-11H-indeno[1,2-c]isoquinolin-11-one
-
 Homo sapiens
indeno[1,2-c]isoquinolinone
-
 Homo sapiens
additional information various 5-amino group-substituted indeno[1,2-c]isoquinolines display potent topoisomerase I inhibitory activity as well as cytotoxicities against five different human tumor cell lines. Molecular modelling and docking using protein structure PDB ID 1SC7 Homo sapiens
N-butyl-11H-indeno[1,2-c]isoquinolin-5-amine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
Col-2 cell
-
 Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-
HT-1080 cell
-
 Homo sapiens
-
SNU-638 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information substrate is supercoiled pBR322 DNA Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Topoisomerase I
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens