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Literature summary for 5.6.2.1 extracted from

  • Gokduman, K.
    Strategies targeting DNA topoisomerase I in cancer chemotherapy camptothecins, nanocarriers for camptothecins, organic non-camptothecin compounds and metal complexes (2016), Curr. Drug Targets, 17, 1928-1939 .
    View publication on PubMed
Search for more literature for 5.6.2.1

Inhibitors

Inhibitors Comment Organism Structure
14-chloromethyl-12H-5,11adiazadibenzo[b,h]fluoren-11-one
-
 Homo sapiens
ARC-111
-
 Homo sapiens
camptothecin
-
 Homo sapiens
diaqua(2,2'-diamino-4,4'-bi-1,3-thiazole)oxosulfato-vanadium(IV) tetrahydrate
-
 Homo sapiens
edotecarin
-
 Homo sapiens
GENZ-644282
-
 Homo sapiens
gold(III) complex
-
 Homo sapiens
indimitecan
-
 Homo sapiens
indotecan
-
 Homo sapiens
irinotecan
-
 Homo sapiens
platinum(II) complex
-
 Homo sapiens
SN-38
-
 Homo sapiens
topotecan
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
786-O cell
-
 Homo sapiens
-
A-2780 cell
-
 Homo sapiens
-
breast cancer cell
-
 Homo sapiens
-
cervical cancer cell line
-
 Homo sapiens
-
GLC-4 cell
-
 Homo sapiens
-
H-460 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
kidney cancer cell
-
 Homo sapiens
-
lung cancer cell
-
 Homo sapiens
-
mammary epithelial cell
-
 Homo sapiens
-
MCF-10A cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
ovarian carcinoma cell
-
 Homo sapiens
-
small cell lung cancer cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
DNA topoisomerase I
-
 Homo sapiens
Topo I
-
 Homo sapiens